Dynamics of Phosphoinositides in Membrane Retrieval and Insertion

Annual Review of Physiology

Volumn 65, Issue , 2003, Pages 791-815

  Czech, Michael P ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Cellular localization of PtdIns(3,4,5)P3 and PtdIns(4,5)P2, PH, PX, and FYVE domains; Endocytosis; Exocytosis; PI 3 kinase signaling

Indexed keywords

COAT PROTEIN; LIPID; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL;

CATALYSIS; CELL MEMBRANE; CELLULAR DISTRIBUTION; ENDOCYTOSIS; ENDOSOME; EUKARYOTIC CELL; EXOCYTOSIS; HUMAN; INTRACELLULAR MEMBRANE; LIPID ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN TARGETING; REVIEW; ANIMAL; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ANIMALS; CELL MEMBRANE; ENDOCYTOSIS; HUMANS; PHOSPHATIDYLINOSITOLS; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

EID: 0038650888     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.65.092101.142522     Document Type: Review

References (135)

1. Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, et al. 2001. Synthesis and function of 3-phosphorylated inositol lipids. Annu. Rev. Biochem. 70:535-602
2. Fruman DA, Meyers RE, Cantley LC. 1998. Phosphoinositide kinases. Annu. Rev. Biochem. 67:481-507
3. Tolias KF, Cantley LC. 1999. Pathways for phosphoinositide synthesis. Chem. Phys. Lipids 98:69-77
4. Takenawa T, Itoh T. 2001. Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane. Biochim. Biophys. Acta 1533:190-206
5. Takenawa T, Itoh T, Fukami K. 1999. Regulation of phosphatidylinositol 4,5-bisphosphate levels and its roles in cytoskeletal re-organization and malignant transformation. Chem. Phys. Lipids 98:13-22
6. Finger FP, Hughes TE, Novick P. 1998. Sec3p is a spatial landmark for polarized secretion in budding yeast. Cell 92:559-71
7. 6a. Hsu SC, Hazuka CD, Foletti DL, Scheller RH. 1999. Targeting vesicles to specific sites on the plasma membrane: the role of sec6/8 complex. Trends Cell Biol. 9(4): 150-53
8. 6b. Lipshutz JH, Mostov KE. 2002. Exocytosis: the many masters of the exocyst. Curr. Biol. 12:R212-14
9. Kirchhausen T. 2000. Three ways to make a vesicle. Nat. Rev. Mol. Cell. Biol. 1:187-98
10. Brodin L, Low P, Shupliakov O. 2000. Sequential steps in clathrin-mediated synaptic vesicle endocytosis. Curr. Opin. Neurobiol. 10:312-20
11. Cullen PJ, Cozier GE, Banting G, Mellor H. 2001. Modular phosphoinositide-binding domains - their role in signalling and membrane trafficking. Curr. Biol. 11: R882-93
12. Balla T, Varnai P. 2002. Visualizing cellular phosphoinositide pools with GFP-fused protein-modules. Sci. STKE 2002: L3
13. Hurley JH, Meyer T. 2001. Subcellular targeting by membrane lipids. Curr. Opin. Cell Biol. 13:146-52
14. Misra S, Miller GJ, Hurley JH. 2001. Recognizing phosphatidylinositol 3-phosphate. Cell 107:559-62
15. Corvera S. 2001. Phosphatidylinositol 3-kinase and the control of endosome dynamics: new players defined by structural motifs. Traffic 2:859-66
16. Simonsen A, Stenmark H. 2001. PX domains: attracted by phosphoinositides. Nat. Cell Biol. 3:E179-82
17. Sato TK, Overduin M, Emr SD. 2001. Location, location, location: membrane targeting directed by PX domains. Science 294:1881-85
18. Lemmon MA, Ferguson KM. 2001. Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides. Biochem. Soc. Trans. 29:377-84
19. Stenmark H, Aasland R, Toh BH, D'Arrigo A. 1996. Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger. J. Biol. Chem. 271:24048-54
20. Gillooly DJ, Morrow IC, Lindsay M, Gould R, Bryant NJ, et al. 2000. Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells. EMBO J. 19:4577-88
21. Dumas JJ, Merithew E, Sudharshan E, Rajamani D, Hayes S, et al. 2001. Multivalent endosome targeting by homodimeric EEA1. Mol. Cell 8:947-58
22. Hayes S, Chawla A, Corvera S. 2002. TGFbeta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2. J. Cell Biol. 158(7): 1239-49
23. Xu Y, Hortsman H, Seet L, Wong SH, Hong W. 2001. SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P. Nat. Cell Biol. 3:658-66
24. Ellson CD, Gobert-Gosse S, Anderson KE, Davidson K, Erdjument-Bromage H, et al. 2001. PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat. Cell Biol. 3:679-82
25. Kanai F, Liu H, Field SJ, Akbary H, Matsuo T, et al. 2001. The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat. Cell Biol. 3:675-78
26. Virbasius JV, Song X, Pomerleau DP, Zhan Y, Zhou GW, et al. 2001. Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate. Proc. Natl. Acad. Sci. USA 98:12908-13
27. Cheever ML, Sato TK, de Beer T, Kutateladze TG, Emr SD, et al. 2001. Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes. Nat. Cell Biol. 3:613-18
28. Song X, Xu W, Zhang A, Huang G, Liang X, et al. 2001. Phox homology domains specifically bind phosphatidylinositol phosphates. Biochemistry, 40:8940-44
29. 2 on the Golgi complex. Nat. Cell Biol. 1:280-87
30. Bravo J, Karathanassis D, Pacold CM, Pacold ME, Ellson CD, et al. 2001. The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate. Mol. Cell 8:829-39
31. Levine TP, Munro S. 2002. Targeting of Golgi-specific pleckstrin homology domains involves both Ptdlns 4-kinase-dependent and -independent components. Curr. Biol. 12:695-704
32. Ferguson KM, Kavran JM, Sankaran VG, Fournier E, Isakoff SJ, et al. 2000. Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. Mol. Cell 6:373-84
33. Ferguson KM, Lemmon MA, Schlessinger J, Sigler PB. 1995. Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain. Cell 83:1037-46
34. 3: complex roles at the cell surface. Cell 100:603-6
35. Currie RA, Walker KS, Gray A, Deak M, Casamayor A, et al. 1999. Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. Biochem. J. 337:575-83
36. Klarlund JK, Tsiaras W, Holik JJ, Chawla A, Czech MP. 2000. Distinct polyphosphoinositide binding selectivities for pleckstrin homology domains of GRP1-like proteins based on diglycine versus triglycine motifs. J. Biol. Chem. 275: 32816-21
37. Dowler S, Currie RA, Campbell DG, Deak M, Kular G, et al. 2000. Identification of pleckstrin-homology-domain containing proteins with novel phosphoinositide-binding specificities. Biochem. J. 351:19-31
38. Kavran JM, Klein DE, Lee A, Falasca M, Isakoff SJ, et al. 1998. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. J. Biol. Chem. 273:30497-508
39. Miaczynska M, Zerial M. 2002. Mosaic organization of the endocytic pathway. Exp. Cell Res. 272:8-14
40. Simonsen A, Wurmser AE, Emr SD, Stenmark H. 2001. The role of phosphoinositides in membrane transport. Curr. Opin. Cell Biol. 13:485-92
41. Claing A, Laporte SA, Caron MG, Lefkowitz RJ. 2002. Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and arrestin proteins. Prog. Neurobiol. 66:61-79
42. Stauffer TP, Ahn S, Meyer T. 1998. Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells. Curr. Biol. 8:343-46
43. Varnai P, Balla T. 1998. Visualization of phosphoinositides that bind pleckstrin homology domains: calcium-and agonist-induced dynamic changes and relationship to myo-[3H]inositol-labeled phosphoinositide pools. J. Cell Biol. 143: 501-10
44. 1. Biochem. J. 363:657-66
45. Tall EG, Spector I, Pentyala SN, Bitter I, Rebecchi MJ. 2000. Dynamics of phosphatidylinositol 4,5-bisphosphate in actin-rich structures. Curr. Biol. 10:743-46
46. Oatey PB, Venkateswarlu K, Williams AG, Fletcher LM, Foulstone EJ, et al. 1999. Confocal imaging of the subcellular distribution of phosphatidylinositol 3,4,5-trisphosphate in insulin-and PDGF-stimulated 3T3-L1 adipocytes. Biochem. J. 344(Pt 2):511-18
47. Gray A, Van Der Kaay J, Downes CP. 1999. The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo. Biochem. J. 344(Pt 3):929-36
48. Simons K, Toomre D. 2000. Lipid rafts and signal transduction. Nat. Rev. Mol. Cell Biol. 1:31-39
49. Pike LJ, Miller JM. 1998. Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover. J. Biol. Chem. 273:22298-304
50. Caroni P. 2001. New EMBO members' review: actin cytoskeleton regulation through modulation of PI(4,5)P(2) rafts. EMBO J. 20:4332-36
51. 2hydrolysis inhibits cortical actin dynamics: regulation at a global but not at a micrometer scale. Mol. Biol. Cell 13:3257-67
52. Sechi AS, Wehland J. 2000. The actin cytoskeleton and plasma membrane connection: PtdIns(4,5)P(2) influences cytoskeletal protein activity at the plasma membrane. J. Cell Sci. 113(Pt 21):3685-95
53. Odorizzi G, Babst M, Emr SD. 1998. Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body. Cell 95:847-58
54. Ikonomov OC, Sbrissa D, Shisheva A. 2001. Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve. J. Biol. Chem. 276: 26141-47
55. Taylor GS, Maehama T, Dixon JE. 2000. Inaugural article: myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate. Proc. Natl. Acad. Sci. USA 97:8910-15
56. Wishart MJ, Taylor GS, Slama JT, Dixon JE. 2001. PTEN and myotubularin phosphoinositide phosphatases: bringing bioinformatics to the lab bench. Curr. Opin. Cell Biol. 13:172-81
57. Kim SA, Taylor GS, Torgersen KM, Dixon JE. 2002. Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease. J. Biol. Chem. 277:4526-31
58. Blondeau F, Laporte J, Bodin S, Superti-Furga G, Payrastre B, et al. 2000. Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway. Hum. Mol. Genet. 9:2223-29
59. Walker DM, Urbe S, Dove SK, Tenza D, Raposo G, et al. 2001. Characterization of MTMR3, an inositol lipid 3-phosphatase with novel substrate specificity. Curr. Biol. 11:1600-5
60. Laporte J, Blondeau F, Gansmuller A, Lutz Y, Vonesch JL, et al. 2002. The PtdIns3P phosphatase myotubularin is a cytoplasmic protein that also localizes to Rac1-inducible plasma membrane ruffles. J. Cell Sci. 115:3105-17
61. Maehama T, Taylor GS, Dixon JE. 2001. PTEN and myotubularin: novel phosphoinositide phosphatases. Annu. Rev. Biochem. 70:247-79
62. Seminario MC, Wange RL. 2002. Signaling pathways of D3-phosphoinositide- binding kinases in T cells and their regulation by PTEN. Semin. Immunol. 14:27-36
63. Ono M, Bolland S, Tempst P, Ravetch JV. 1996. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB. Nature 383:263-66
64. Krystal G. 2000. Lipid phosphatases in the immune system. Semin. Immunol. 12: 397-403
65. Pesesse X, Dewaste V, De Smedt F, Laffargue M, Giuriato S, et al. 2001. The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells. J. Biol. Chem. 276:28348-55
66. Sasaoka T, Hori H, Wada T, Ishiki M, Haruta T, et al. 2001. SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes. Diabetologia 44:1258-67
67. Wada T, Sasaoka T, Funaki M, Hori H, Murakami S, et al. 2001. Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5′-phosphatase catalytic activity. Mol. Cell Biol. 21:1633-46
68. Clement S, Krause U, Desmedt F, Tanti JF, Behrends J, et al. 2001. The lipid phosphatase SHIP2 controls insulin sensitivity. Nature 409:92-97
69. Langille SE, Patki V, Klarlund JK, Buxton JM, Holik JJ, et al. 1999. ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1. J. Biol. Chem. 274:27099-104
70. Siddhanta U, McIlroy J, Shah A, Zhang Y, Backer JM. 1998. Distinct roles for the p110 and hVPS34 phosphatidylinositol 3′-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis. J. Cell Biol. 143:1647-59
71. Comer FI, Parent CA. 2002. PI 3-kinases and PTEN: how opposites chemoattract. Cell 109:541-44
72. Iijima M, Devreotes P. 2002. Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109:599-610
73. Funamoto S, Meili R, Lee S, Parry L, Firtel RA. 2002. Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 109:611-23
74. Wang F, Herzmark P, Weiner OD, Srinivasan S, Servant G, et al. 2002. Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat. Cell Biol. 4:513-18
75. Marshall JG, Booth JW, Stambolic V, Mak T, Balla T, et al. 2001. Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis. J. Cell Biol. 153:1369-80
76. Vieira OV, Botelho RJ, Rameh L, Brachmann SM, Matsuo T, et al. 2001. Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J. Cell Biol. 155:19-25
77. Booth JW, Trimble WS, Grinstein S. 2001. Membrane dynamics in phagocytosis. Semin. Immunol. 13:357-64
78. Lawlor MA, Alessi DR. 2001. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J. Cell Sci. 114:2903-10
79. Lang F, Cohen P. 2001. Regulation and physiological roles of serum-and glucocorticoid-induced protein kinase isoforms. Sci STKE 2001:RE17
80. Smith CI, Islam TC, Mattsson PT, Mohamed AJ, Nore BF, et al. 2001. The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species. BioEssays 23: 436-46
81. Bretscher MS, Aguado-Velasco C. 1998. EGF induces recycling membrane to form ruffles. Curr. Biol. 8:721-24
82. Greenberg S, Grinstein S. 2002. Phagocytosis and innate immunity. Curr. Opin. Immunol. 14:136-45
83. Holevinsky KO, Nelson DJ. 1998. Membrane capacitance changes associated with particle uptake during phagocytosis in macrophages. Biophys. J. 75:2577-86
84. Hackam DJ, Rotstein OD, Sjolin C, Schreiber AD, Trimble WS, et al. 1998. v-SNARE-dependent secretion is required for phagocytosis. Proc. Natl. Acad. Sci. USA 95:11691-96
85. Bajno L, Peng XR, Schreiber AD, Moore HP, Trimble WS, et al. 2000. Focal exocytosis of VAMP3-containing vesicles at sites of phagosome formation. J. Cell Biol. 149:697-706
86. Cox D, Tseng CC, Bjekic G, Greenberg S. 1999. A requirement for phosphatidylinositol 3-kinase in pseudopod extension. J. Biol. Chem. 274:1240-47
87. 83a. Yin JL, Janmey PA. 2003. Phosphoinositide regulation of the actin cytoskeleton. Annu. Rev. Physiol. 65:761-89
88. Moss J, Vaughan M. 1998. Molecules in the ARF orbit. J. Biol. Chem. 273:21431-34
89. Klarlund JK, Guilherme A, Holik JJ, Virbasius JV, Chawla A, et al. 1997. Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science 275:1927-30
90. Klarlund JK, Rameh LE, Cantley LC, Buxton JM, Holik JJ, et al. 1998. Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273:1859-62
91. Chardin P, Paris S, Antonny B, Robineau S, Beraud-Dufour S, et al. 1996. A human exchange factor for ARF contains Sec7-and pleckstrin-homology domains. Nature 384:481-84
92. Kolanus W, Nagel W, Schiller B, Zeitlmann L, Godar S, et al. 1996. L2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule. Cell 86:233-42
93. Someya A, Sata M, Takeda K, Pacheco-Rodriguez G, Ferrans VJ, et al. 2001. ARF-GEP(100), a guanine nucleotide-exchange protein for ADP-ribosylation factor 6. Proc. Natl. Acad. Sci. USA 98: 2413-18
94. Derrien V, Couillault C, Franco M, Martineau S, Montcourrier P, et al. 2002. A conserved C-terminal domain of EFA6-family ARF6-guanine nucleotide exchange factors induces lengthening of microvilli-like membrane protrusions. J. Cell Sci. 115:2867-79
95. Jackson TR, Brown FD, Nie Z, Miura K, Foroni L, et al. 2000. ACAPs are arf6 GTPase-activating proteins that function in the cell periphery. J. Cell Biol. 151:627-38
96. Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, et al. 2002. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Mol. Cell 9:95-108
97. Song J, Khachikian Z, Radhakrishna H, Donaldson JG. 1998. Localization of endogenous ARF6 to sites of cortical actin rearrangement and involvement of ARF6 in cell spreading. J. Cell Sci. 111:2257-67
98. Radhakrishna H, Al-Awar O, Khachikian Z, Donaldson JG. 1999. ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements. J. Cell Sci. 112:855-66
99. 94a. Brown FD, Roselle AL, Yin HL, Balla T, Donaldson JG. 2001. Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic. J. Cell Biol. 154:1007-17
100. Yang CZ, Mueckler M. 1999. ADP-ribosylation factor 6 (ARF6) defines two insulin-regulated secretory pathways in adipocytes. J. Biol. Chem. 274:25297-300
101. Caumont AS, Vitale N, Gensse M, Galas MC, Casanova JE, et al. 2000. Identification of a plasma membrane-associated guanine nucleotide exchange factor for ARF6 in chromaffin cells. Possible role in the regulated exocytotic pathway. J. Biol. Chem. 275:15637-44
102. Zhang Q, Cox D, Tseng CC, Donaldson JG, Greenberg S. 1998. A requirement for ARF6 in Fcgamma receptor-mediated phagocytosis in macrophages. J. Biol. Chem. 273:19977-81
103. Brown FD, Rozelle AL, Yin HL, Balla T, Donaldson JG. 2001. Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic. J. Cell Biol. 154:1007-17
104. Min J, Okada S, Kanzaki M, Elmendorf JS, Coker KJ, et al. 1999. Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes. Mol. Cell 3:751-60
105. Bose A, Cherniack AD, Langille SE, Nicoloro SM, Buxton JM, et al. 2001. G11 signaling through ARF6 regulates F-actin mobilization and GLUT4 glucose transporter translocation to the plasma membrane. Mol. Cell. Biol. 21:5262-75
106. Lawrence JT, Birnbaum MJ. 2001. Adpribosylation factor 6 delineates separate pathways used by endothelin 1 and insulin for stimulating glucose uptake in 3T3-L1 adipocytes. Mol. Cell. Biol. 21:5276-85
107. Yamada E, Okada S, Saito T, Sato M, Ohshima K, et al. 2002. Akt/protein kinase b phosphorylates Synip and causes Synip dissociation from syntaxin4 after insulin stimulation. Diabetes 180-OR (Abstr.)
108. Audhya A, Emr SD. 2002. Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. Dev. Cell 2:593-605
109. Ekblad L, Jergil B. 2001. Localization of phosphatidylinositol4-kinase isoenzymes in rat liver plasma membrane domains. Biochim. Biophys. Acta 1531:209-21
110. 2, and cell movement - similar messages, different meanings? Dev. Cell 1:743-47
111. Toker A. 1998. The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate. Curr. Opin. Cell Biol. 10: 254-61
112. Honda A, Nogami M, Yokozeki T, Yamazaki M, Nakamura H, et al. 1999. Phosphatidylinositol 4-phosphate 5-kinase is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell 99:521-32
113. Botelho RJ, Teruel M, Dierckman R, Anderson R, Wells A, et al. 2000. Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. J. Cell Biol. 151:1353-68
114. D'Hondt K, Heese-Peck A, Riezman H. 2000. Protein and lipid requirements for endocytosis. Annu. Rev. Genet. 34:255-95
115. Jost M, Simpson F, Kavran JM, Lemmon MA, Schmid SL. 1998. Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation. Curr. Biol. 8:1399-402
116. Gaidarov I, Keen JH. 1999. Phosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrincoated pits. J. Cell Biol. 146:755-64
117. Ford MG, Pearse BM, Higgins MK, Vallis Y, Owen DJ, et al. 2001. Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes. Science 291:1051-55
118. Mao Y, Chen J, Maynard JA, Zhang B, Quiocho FA. 2001. A novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis. Cell 104:433-40
119. Itoh T, Koshiba S, Kigawa T, Kikuchi A, Yokoyama S, et al. 2001. Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis. Science 291:1047-51
120. Gaidarov I, Krupnick JG, Falck JR, Benovic JL, Keen JH. 1999. Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding. EMBO J. 18:871-81
121. Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ. 2002. Molecular architecture and functional model of the endocytic AP2 complex. Cell 109:523-35
122. Rohde G, Wenzel D, Haucke V. 2002. A phosphatidylinositol (4,5)-bisphosphate binding site within mu2-adaptin regulates clathrin-mediated endocytosis. J. Cell Biol. 158:209-14
123. Burger KN, Demel RA, Schmid SL, de Kruijff B. 2000. Dynamin is membrane-active: Lipid insertion is induced by phosphoinositides and phosphatidic acid. Biochemistry 39:12485-93
124. Stefan CJ, Audhya A, Emr SD. 2002. The yeast synaptojanin-like proteins control the cellular distribution of phosphatidylinositol (4,5)-bisphosphate. Mol. Biol. Cell 13:542-57
125. Harris TW, Hartwieg E, Horvitz HR, Jorgensen EM. 2000. Mutations in synaptojanin disrupt synaptic vesicle recycling. J. Cell Biol. 150:589-600
126. Cremona O, Di Paolo G, Wenk MR, Luthi A, Kim WT, et al. 1999. Essential role of phosphoinositide metabolism in synaptic vesicle recycling. Cell 99:179-88
127. Terebiznik MR, Vieira OV, Marcus SL, Slade A, Yip CM, et al. 2002. Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion of salmonella. Nat. Cell Biol. 4(10):766-73
128. Martin TF. 2002. Prime movers of synaptic vesicle exocytosis. Neuron 34:9-12
129. Cremona O, De Camilli P. 2001. Phosphoinositides in membrane traffic at the synapse. J. Cell Sci. 114:1041-52
130. Klenchin VA, Martin TF. 2000. Priming in exocytosis: attaining fusion-competence after vesicle docking. Biochimie 82:399-407
131. Hsuan J, Cockcroft S. 2001. The PITP family of phosphatidylinositol transfer proteins. Genome Biol. Rev. 2:3011
132. Martin TF. 2001. PI(4,5)P(2) regulation of surface membrane traffic. Curr. Opin. Cell Biol. 13:493-99
133. Osborne SL, Meunier FA, Schiavo G. 2001. Phosphoinositides as key regulators of synaptic function. Neuron 32:9-12
134. 2+-dependent exocytosis. J. Biol. Chem. 277: 22025-34
135. Bose A, Guilherme A, Robida SI, Coulter SMC, Zhou QL, et al. 2002. Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c. Nature. In press