Creation versus destruction of T cell epitopes in the class II MHC pathway

Annals of the New York Academy of Sciences

Volumn 987, Issue , 2003, Pages 9-14

  Watts, C ^a   Moss, C X ^a   Mazzeo, D ^a   West, M A ^a   Matthews, S P ^a   Li, D N ^a   Manoury, B ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

AEP; Antigen processing; Class II MHC; Proteases

Indexed keywords

CHAPERONE; EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEINASE; TETANUS TOXIN;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; BRUGIA MALAYI; CONFERENCE PAPER; HUMAN; IMMUNOLOGICAL TOLERANCE; MYCOBACTERIUM; NONHUMAN; PATHOGENESIS; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; T LYMPHOCYTE;

BRUGIA; BRUGIA MALAYI; MYCOBACTERIUM;

EID: 0038579799     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2003.tb06028.x     Document Type: Conference Paper

References (35)

1. SERWOLD, T. et al. 2002. ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum. Nature 419: 480-483.
2. York, I.A. et al. 2002. The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat. Immunol. 3: 1177-1184.
3. LENNON-DUMENIL, A.M. et al. 2002. A closer look at proteolysis and MHC-class-II-restricted antigen presentation. Curr. Opin. Immunol. 14: 15-21.
4. WATTS, C. 2001. Antigen processing in the endocytic compartment. Curr. Opin. Immunol. 13: 26-31.
5. RIESE, R.J. & H.A. CHAPMAN. 2000. Cathepsins and compartmentalization in antigen presentation. Curr. Opin. Immunol. 12: 102-113.
6. TURK, B., D. TURK & V. TURK. 2000. Lysosomal cysteine proteases: more than scavengers. Biochim. Biophys. Acta 1477: 98-111.
7. WATTS, C. et al. 1998. Modulation by epitope-specific antibodies of class II MHC-restricted presentation of the tetanus toxin antigen. Immunol. Rev. 164: 11-16.
8. CHEN, J.M. et al. 1997. Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase. J. Biol. Chem. 272: 8090-8098.
9. MANOURY, B. et al. 1998. An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation [see comments]. Nature 396: 695-699.
10. KEMBHAVI, A.A. et al. 1993. The two cysteine endopeptidases of legume seeds: purification and characterization by use of specific fluorometric assays. Arch. Biochem. Biophys. 303: 208-213.
11. ANTONIOU, A.N. et al. 2000. Control of antigen presentation by a single protease cleavage site. Immunity 12: 391-398.
12. LEE, P., G.R. MATSUEDA & P.M. ALLEN. 1988. T cell recognition of fibrinogen. A determinant on the A alpha-chain does not require processing. J. Immunol. 140: 1063-1068.
13. SETTE, A. et al. 1989. Capacity of intact proteins to bind to MHC class II molecules. J. Immunol. 143: 1265-1267.
14. BUSCH, R. et al. 1996. Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum. EMBO J. 15: 418-428.
15. DENG, H. et al. 1993. Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease. J. Exp. Med. 178: 1675-1680.
16. DAVIDSON, H.W. et al. 1991. Processed antigen binds to newly synthesized MHC class II molecules in antigen-specific B lymphocytes. Cell 67: 105-116.
17. CASTELLINO, E et al. 1998. Large protein fragments as substrates for endocytic antigen capture by MHC class II molecules. J. Immunol. 161: 4048-4057.
18. STERN, L.J. & D.C. WILEY. 1994. Antigenic peptide binding by class I and class II histocompatibility proteins. Structure 2:245-251.
19. SERCARZ, E.E. et al. 1993. Dominance and crypticity of T cell antigenic determinants. Annu. Rev. Immunol. 11: 729-766.
20. MANOURY, B. et al. 2002. Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP. Nat. Immunol. 3: 169-174.
21. BECK, H. et al. 2001. Cathepsin S and an asparagine-specific endoprotease dominate the proteolytic processing of human myelin basic protein in vitro. Eur. J. Immunol. 31: 3726-3736.
22. HEATH, V.L. et al. 1998. Intrathymic expression of genes involved in organ specific autoimmune disease. J. Autoimmun. 11: 309-318.
23. PRIBYL, T.M. et al. 1993. The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems. Proc. Natl. Acad. Sci. USA 90: 10695-10699.
24. TARGONI, O.S. & P.V. LEHMANN. 1998. Endogenous myelin basic protein inactivates the high avidity T cell repertoire. J. Exp. Med. 187: 2055-2063.
25. HARRINGTON, C.J. et al. 1998. Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein. Immunity 8: 571-580.
26. PLOEGH, H.L. 1998. Viral strategies of immune evasion. Science 280: 248-253.
27. MERESSE, S. et al. 1999. Controlling the maturation of pathogen-containing vacuoles: a matter of life and death. Nat. Cell Biol. 1: E183-8. java/Propub/cellbio/ncb1199_E183.fulltextjava/Propub/ cellbio/ncb1199_E183.abstract.
28. PIERRE, P. & R. MELLMAN. 1998. Development regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells. Cell 93: 1135-1145.
29. MANOURY, B. et al. 2001. Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing. Curr. Biol. 11: 447-451.
30. ALVAREZ-FERNANDEZ, M. et al. 1999. Inhibition of mammalian legumain by some cystatins is due to a novel second reactive site. J. Biol. Chem. 272: 19195-19203.
31. DRIESSEN, C., A.M. LENNON-DUMENIL & H.L. PLOEGH. 2001. Individual cathepsins degrade immune complexes internalized by antigen-presenting cells via Fcgamma receptors. Eur. J. Immunol. 31: 1592-1601.
32. PLUGER, E.B. et al. 2002. Specific role for cathepsin S in the generation of antigenic peptides in vivo. Eur. J. Immunol. 32: 467-476.
33. HSIEH, C.S. et al. 2002. A role for cathepsin L and cathepsin S in peptide generation for MHC class II presentation. J. Immunol. 168: 2618-2625.
34. RIESE, R.J. et al. 1998. Cathepsin S activity regulates antigen presentation and immunity. J. Clin. Invest. 101: 2351-2363.
35. SAEGUSA, K. et al. 2002. Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity. J. Clin. Invest. 110: 361-369.