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Volumn 3, Issue 2, 2002, Pages 169-174

Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; AUTOANTIGEN; CYSTEINE PROTEINASE; ENCEPHALITOGENIC PROTEIN; EPITOPE; HLA DR2 ANTIGEN; MYELIN BASIC PROTEIN;

EID: 0036167693     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni754     Document Type: Article
Times cited : (182)

References (42)
  • 2
    • 0029939467 scopus 로고    scopus 로고
    • Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system
    • (1996) Cell , vol.85 , pp. 299-302
    • Steinman, L.1
  • 4
    • 0025370870 scopus 로고
    • T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis
    • (1990) Nature , vol.346 , pp. 183-187
    • Ota, K.1
  • 5
    • 0024997357 scopus 로고
    • Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals
    • (1990) J. Immunol. , vol.145 , pp. 540-548
    • Martin, R.1
  • 6
    • 0025044023 scopus 로고
    • HLA-DR2a is the dominant restriction molecule for the cytotoxic T cell response to myelin basic protein in DR2Dw2 individuals
    • (1990) J. Immunol. , vol.145 , pp. 2880-2885
    • Jaraquemada, D.1
  • 7
    • 0028120895 scopus 로고
    • Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones
    • (1994) J. Exp. Med. , vol.179 , pp. 279-290
    • Wucherpfennig, K.W.1
  • 8
    • 18544397838 scopus 로고    scopus 로고
    • T cell response to myelin basic protein in the context of the multiple sclerosis-associated HLA-DR15 haplotype: Peptide binding, immunodominance and effector functions of T cells
    • (1997) J. Neuroimmunol. , vol.77 , pp. 195-203
    • Vergelli, M.1
  • 9
    • 0027389119 scopus 로고
    • Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients
    • (1993) J. Clin. Invest. , vol.91 , pp. 616-628
    • Valli, A.1
  • 11
    • 0034678450 scopus 로고    scopus 로고
    • Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex
    • (2000) J. Exp. Med. , vol.191 , pp. 1395-1412
    • Krogsgaard, M.1
  • 12
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
    • (2000) Nature Med. , vol.6 , pp. 1167-1175
    • Bielekova, B.1
  • 13
    • 0033791462 scopus 로고    scopus 로고
    • Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial
    • (2000) Nature Med. , vol.6 , pp. 1176-1182
    • Kappos, L.1
  • 14
    • 0032719206 scopus 로고    scopus 로고
    • A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor
    • (1999) Nature Genet , vol.23 , pp. 343-347
    • Madsen, L.S.1
  • 15
    • 0027504747 scopus 로고
    • The human myelin basic protein gene is included within a 179-kilobase transcription unit: Expression in the immune and central nervous systems
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 10695-10699
    • Pribyl, T.M.1
  • 18
    • 0030992979 scopus 로고    scopus 로고
    • Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase
    • (1997) J. Biol. Chem. , vol.272 , pp. 8090-8098
    • Chen, J.M.1
  • 19
    • 0032542285 scopus 로고    scopus 로고
    • An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation
    • (1998) Nature , vol.396 , pp. 695-699
    • Manoury, B.1
  • 24
    • 0031568068 scopus 로고    scopus 로고
    • Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen
    • (1997) J. Immunol. , vol.158 , pp. 693-706
    • Volkmann, A.1    Zal, T.2    Stockinger, B.3
  • 26
    • 0032076555 scopus 로고    scopus 로고
    • Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein
    • (1998) Immunity , vol.8 , pp. 571-580
    • Harrington, C.J.1
  • 28
    • 0034610973 scopus 로고    scopus 로고
    • High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: Mechanisms of selection of the self-reactive repertoire
    • (2000) J. Exp. Med. , vol.191 , pp. 761-770
    • Anderson, A.C.1
  • 34
    • 0030937833 scopus 로고    scopus 로고
    • Capture and processing of exogenous antigens for presentation on MHC molecules
    • (1997) Annu. Rev. Immunol. , vol.15 , pp. 821-850
    • Watts, C.1
  • 36
    • 0026065533 scopus 로고
    • Sequence and structure determinants of the nonenzymatic deamidation of asparagine and glutamine residues in proteins
    • (1991) Protein Eng. , vol.4 , pp. 283-294
    • Wright, H.T.1
  • 37
    • 0035806321 scopus 로고    scopus 로고
    • T cell recognition of the dominant I-A(k)-restricted hen egg lysozyme epitope: Critical role for asparagine deamidation
    • (2001) J. Exp. Med. , vol.193 , pp. 1239-1246
    • McAdam, S.N.1
  • 38
    • 0028926223 scopus 로고
    • Molecular mimicry in T-cell mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
    • (1995) Cell , vol.80 , pp. 695-705
    • Wucherpfennig, K.1    Strominger, J.L.2
  • 41
    • 0031573151 scopus 로고    scopus 로고
    • Natural processing sites for human cathepsin E and capthepsin D in tetanus toxin. Implications for T cell epitope generation
    • (1997) J. Immunology , vol.159 , pp. 4693-4699
    • Hewitt, E.W.1
  • 42
    • 0025281091 scopus 로고
    • Endocytosis, intracellular trafficking, and processing of membrane IgG and monovalent antigen/membrane IgG complexes in B lymphocytes
    • (1990) J. Immunol. , vol.144 , pp. 4101-4109
    • Davidson, H.W.1    West, M.A.2    Watts, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.