Design, synthesis, and biological activity of hybrid compounds between uramustine and DNA minor groove binder distamycin A

Journal of Medicinal Chemistry

Volumn 45, Issue 17, 2002, Pages 3630-3638

  Baraldi, Pier Giovanni ^a   Romagnoli, Romeo ^a   Guadix, Antonio Entrena ^b   Pineda de las Infantas, Maria Josè ^b   Gallo, Miguel Angel ^b   Espinosa, Antonio ^b   Martinez, Alberto ^b   Bingham, John P ^c   Hartley, John A ^c  

^a UNIVERSITY OF FERRARA   (Italy)

^b Facultad de Farmacia   (Spain)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 [1 METHYL 4 [1 METHYL 4 [1 METHYL 4 [N1 [5 BIS(2 CHLOROETHYL)AMINO 2,4 (1H,3H) PYRIMIDINEDIONE]ACETYLAMINO]PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PROPIONAMIDINE; 3 [1 METHYL 4 [1 METHYL 4 [1 METHYL 4 [N1 [5 BIS(2 CHLOROETHYL)AMINO 2,4 (1H,3H) PYRIMIDINEDIONE]BUTANOYLAMINO]PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PROPIONAMIDE; 3 [1 METHYL 4 [1 METHYL 4 [1 METHYL 4 [N1 [5 BIS(2 CHLOROETHYL)AMINO 2,4 (1H,3H) PYRIMIDINEDIONE]HEPTANOYLAMINO]PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PROPIONAMIDINE; 3 [1 METHYL 4 [1 METHYL 4 [1 METHYL 4 [N1 [5 BIS(2 CHLOROETHYL)AMINO 2,4 (1H,3H) PYRIMIDINEDIONE]HEXANOYLAMINO]PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PROPIONAMIDE; 3 [1 METHYL 4 [1 METHYL 4 [1 METHYL 4 [N1 [5 BIS(2 CHLOROETHYL)AMINO 2,4 (1H,3H) PYRIMIDINEDIONE]PENTANOYLAMINO]PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PROPIONAMIDINE; 3 [1 METHYL 4 [1 METHYL 4 [1 METHYL 4 [N1 [5 BIS(2 CHLOROETHYL)AMINO 2,4 (1H,3H) PYRIMIDINEDIONE]PROPANOYLAMINO]PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PROPIONAMIDE; ALKYLATING AGENT; CARBOXYLIC ACID; CYTOTOXIC AGENT; DISTAMYCIN A; TAQ POLYMERASE; UNCLASSIFIED DRUG; URAMUSTINE;

ALKYLATION; ARTICLE; CELL STRAIN K 562; COMPLEX FORMATION; COVALENT BOND; DNA FOOTPRINTING; DNA SEQUENCE; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; HYBRID; IC 50; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; DISTAMYCINS; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; URACIL MUSTARD;

EID: 0037103228     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm011113b     Document Type: Article

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