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Volumn 10, Issue 11, 2000, Pages 1269-1272

Cytotoxic halogenoacrylic derivatives of distamycin A

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLIC ACID DERIVATIVE; DISTAMYCIN A DERIVATIVE; PNU 151807; TALLIMUSTINE; UNCLASSIFIED DRUG;

EID: 0034608544     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00204-3     Document Type: Article
Times cited : (37)

References (18)
  • 2
    • 0002223415 scopus 로고
    • See e.g., JAI Press Inc., and references therein
    • See e.g., Aristoff, P. A. In Advances in Medicinal Chemistry; JAI Press Inc., 1993; Vol. 2, pp 67-110 and references therein.
    • (1993) In Advances in Medicinal Chemistry , vol.2 , pp. 67-110
    • Aristoff, P.A.1
  • 8
    • 84889154670 scopus 로고    scopus 로고
    • note
    • 6) are given. (Varian 200 and 300 MHz spectrometer, δ in ppm, TMS as internal standard): (1) 2.62 (t, 6.5 Hz, 2H), 3.45 (m, 2H), 3.81 (s, 3H), 3.84 (s, 3H), 3.85 (s, 3H), 6.20 (d, J=2.8 Hz, 1H), 6.68 (d, J=2.8 Hz, 1H), 6.91 (d, J=1.7 Hz, 1H), 7.01-7.04 (m, 2H), 7.18 (d, J=1.7 Hz, 1H), 7.20-7.24 (m, 2H), 8.18 (t, J=5.7 Hz, 1H), 8.60 (bs, 2H), 8.96 (bs, 2H), 9.88 (s, 1H), 9.93 (s, 1H), 10.29 (s, 1H); (2) 2.60 (t, J=6.6 Hz, 2H), 5.54 (d, J=1.6 Hz, 1H), 5.92 (d, J=1.6 Hz, 1H); (3) 5.98 (d, J=2.1 Hz, 1H), 6.40 (d, J=2.1 Hz, 1H); (4) 5.28 (dd, J=15,8, 3.5 Hz, 1H), 5.58 (dd, J=47.8, 3.5 Hz, 1H); (5) 6.59 (d, J=13.1 Hz, 1H), 7.29 (d, J=13.1 Hz, 1H); (6) 6.48 (d, J=8.0 Hz, 1H), 6.82 (d, J=8.0 Hz, 1H); 7 5.67 (dd, J=5.0, 1.2 Hz, 1H), 6.17 (dd, J=8.5, 1.2 Hz, 1H), 6.40 (dd, J=8.5, 5.0 Hz, 1H); (14), 3.81 (s, 3H), 3.84 (s, 3H), 6.22 (d, J=2.8 Hz, 1H), 6.71 (d, J=2.8 Hz, 1H), 6.94 (d, J=1.8 Hz, 1H), 7.03 (d, J=1.8 Hz, 1H), 7.20 (d, J=1.8 Hz, 1H), 7.22 (d, J=1.8 Hz, 1H); (15) 2.59 (t, J=6.5 Hz, 2H), 3.40-3.55 (m, 2H), 3.79 (s, 3H), 6.21 (d, J=2.8 Hz, 1H), 6.64 (d, J=2.8 Hz, 1H), 6.90 (d, J=1.8 Hz, 1H), 7.08 (d, J=1.8 Hz, 1H), 8.22 (t, J=5.6 Hz 1H), 8.58 (bs, 2H), 8.90 (bs, 2H),10.22 (s, 1H).
  • 16
    • 0022693818 scopus 로고
    • Dervan, P. B. Science 1986, 232, 464. Bardos, T.J.; Datta-Gupta, N.; Hebborn, P.; Triggle, D.J. J. Med. Chem. 1965, 8, 167.
    • (1986) Science , vol.232 , pp. 464
    • Dervan, P.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.