Thyroid-specific expression of IFN-γ limits experimental autoimmune thyroiditis by suppressing lymphocyte activation in cervical lymph nodes

Journal of Immunology

Volumn 170, Issue 11, 2003, Pages 5523-5529

  Barin, Jobert G ^a   Afanasyeva, Marina ^a,b   Talor, Monica V ^a   Rose, Noel R ^a,b   Lynne Burek, C ^a,b   Caturegli, Patrizio ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY; THYROGLOBULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CERVICAL LYMPH NODE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; HASHIMOTO DISEASE; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

EID: 0038528321     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.11.5523     Document Type: Article

References (53)

1. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16:34.
2. Liew, F. Y. 2002. Th1 and Th2 cells: a historical perspective. Nat. Rev. Immunol. 2:55.
3. O'Shea, J. J., A. Ma. and P. Lipsky. 2002. Cytokines and autoimmunity. Nat. Rev. Immunol. 2:37.
4. Campbell, I. L., T. W. Kay, L. Oxbrow, and L. C. Harrison. 1991. Essential role for interferon-γ and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J. Clin. Invest. 87:739.
5. Wang, B., I. Andre, A. Gonzalez, J. D. Katz, M. Aguet, C. Benoist, and D. Mathis. 1997. Interferon-γ impacts at multiple points during the progression of autoimmune diabetes. Proc. Natl. Acad. Sci. USA 94:13844.
6. h4 mice. J. Immunol. 169:3999.
7. Billiau, A., H. Heremans, F. Vandekerckhove, R. Dijkmans, H. Sobis, E. Meulepas, and H. Carton. 1988. Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-γ. J. Immunol. 140:1506.
8. Duong, T. T., J. St. Louis, J. J. Gilbert, F. D. Finkelman, and G. H. Strejan. 1992. Effect of anti-interferon-γ and anti-interleukin-2 monoclonal antibody treatment on the development of actively and passively induced experimental allergic encephalomyelitis in the SJL/J mouse. J. Neuroimmunol. 36:105.
9. Furlan, R., E. Brambilla, F. Ruffini, P. L. Poliani, A. Bergami, P. C. Marconi, D. M. Franciotta, G. Penna, G. Comi, L. Adorini, and G. Martino. 2001. Intrathecal delivery of IFN-γ protects C57BL/6 mice from chronic-progressive experimental autoimmune encephalomyelitis by increasing apoptosis of central nervous system-infiltrating lymphocytes. J. Immunol. 167:1821.
10. Caspi, R. R., C. C. Chan, B. G. Grubbs, P. B. Silver, B. Wiggert, C. F. Parsa, S. Bahmanyar, A. Billiau, and H. Heremans. 1994. Endogenous systemic IFN-γ has a protective role against ocular autoimmunity in mice. J. Immunol. 152:890.
11. Tarrant, T. K., P. B. Silver, J. L. Wahlsten, L. V. Rizzo, C. C. Chan, B. Wiggert, and R. R. Caspi. 1999. Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon γ, nitric oxide, and apoptosis. J. Exp. Med. 189:219.
12. + myeloid cells. J. Immunol. 163:3503.
13. Afanasyeva, M., Y. Wang, Z. Kaya, E. A. Stafford, K. M. Dohmen, A. A. Sadighi Akha, and N. R. Rose. 2001. Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-γ-independent pathway. Circulation 104:3145.
14. Eriksson, U., M. O. Kurrer, W. Sebald, F. Brombacher, and M. Kopf. 2001. Dual role of the IL-12/IFN-γ axis in the development of autoimmune myocarditis: induction by IL-12 and protection by IFN-γ. J. Immunol. 167:5464.
15. Jacobson, D. L., S. J. Gange, N. R. Rose, and N. M. Graham. 1997. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin. Immunol. Immunopathol. 84:223.
16. Drugarin, D., S. Negru, A. Koreck, I. Zosin, and C. Cristea. 2000. The pattern of a Th1 cytokine in autoimmune thyroiditis. Immunol. Lett. 71:73.
17. Hamilton, F., M. Black, M. A. Farquharson, C. Stewart, and A. K. Foulis. 1991. Spatial correlation between thyroid epithelial cells expressing class II MHC molecules and interferon-γ-containing lymphocytes in human thyroid autoimmune disease. Clin. Exp. Immunol. 83:64.
18. Mariotti, S., G. F. del Prete, C. Mastromauro, M. de Carli, S. Romagnani, M. Ricci, and A. Pinchera. 1991. The autoimmune infiltrate of Basedow's disease: analysis of clonal level and comparison with Hashimoto's thyroiditis. Exp. Clin. Endocrinol. 97:139.
19. Roura-Mir, C., M. Catalfamo, M. Sospedra, L. Alcalde, R. Pujol-Borrell, and D. Jaraquemada. 1997. Single-cell analysis of intrathyroidal lymphocytes shows differential cytokine expression in Hashimoto's and Graves' disease. Eur. J. Immunol. 27:3290.
20. Twarog, F. J., and N. R. Rose. 1968. The production of thyroid autoantibodies in mice. J. Immunol. 101:242.
21. Nakamura, R. M., and W. O. Weigle. 1968. Experimental thyroiditis in complement intact and deficient mice following injections of heterologous thyroglobulins without adjuvant. Proc. Soc. Exp. Biol. Med. 129:412.
22. Vladutiu, A. O., and N. R. Rose. 1971. Autoimmune murine thyroiditis: relation to histocompatibility (H-2) type. Science 174:1137.
23. Beisel, K. W., C. S. David, A. A. Giraldo, Y. M. Kong, and N. R. Rose. 1982. Regulation of experimental autoimmune thyroiditis: mapping of susceptibility to the I-A subregion of the mouse H-2. Immunogenetics 15:427.
24. Kawakami, Y., N. Kuzuya, T. Watanabe, Y. Uchiyama, and K. Yamashita. 1990. Induction of experimental thyroiditis in mice by recombinant interferon γ administration. Acta Endocrinol. 122:41.
25. Tang, H., K. Mignon-Godefroy, P. L. Meroni, G. Garotta, J. Charreire, and F. Nicoletti. 1993. The effects of a monoclonal antibody to interferon-γ on experimental autoimmune thyroiditis (EAT): prevention of disease and decrease of EAT-specific T cells. Eur. J. Immunol. 23:275.
26. Stull, S. J., G. C. Sharp, M. Kyriakos, J. T. Bickel, and H. Braley-Mullen. 1992. Induction of granulomatous experimental autoinumme thyroiditis in mice with in vitro activated effector T cells and anti-IFN-γ antibody. J. Immunol. 149:2219.
27. Tang, H., G. C. Sharp, K. P. Peterson, and H. Braley-Mullen. 1998. IFN-γ deficient mice develop severe granulomatous experimental autoimmune thyroiditis with eosinophil infiltration in thyroids. J. Immunol. 160:5105.
28. Alimi, E., S. Huang, M. P. Brazillet, and J. Charreire. 1998. Experimental auto-immune thyroiditis (EAT) in mice lacking the IFN-γ receptor gene. Eur. J. Immunol. 28:201.
29. Stafford, E. A., and N. R. Rose. 2000. Newer insights into the pathogenesis of experimental autoimmune thyroiditis. Int. Rev. Immunol. 19:501.
30. Caturegli, P., M. Hejazi, K. Suzuki, O. Dohan, N. Carrasco, L. D. Kohn, and N. R. Rose. 2000. Hypothyroidism in transgenic mice expressing IFN-γ in the thyroid. Proc. Natl. Acad. Sci. USA 97:1719.
31. + nonobese diabetic mice develop insulitis and diabetes. J. Exp. Med. 178:793.
32. Rasooly, L., C. L. Burek, and N. R. Rose. 1996. Iodine-induced autoimmune thyroiditis in NOD-H-2h4 mice. Clin. Immunol. Immunopathol. 81:287.
33. Pichurin, P., L. Schwarz-Lauer, H. Braley-Mullen, C. Paras, O. Pichurina, J. C. Morris, B. Rapoport, and S. M. McLachlan. 2002. Peptide scanning for thyrotropin receptor T-cell epitopes in mice vaccinated with naked DNA. Thyroid 12:755.
34. Jeker, L. T., M. Hejazi, C. L. Burek, N. R. Rose, and P. Caturegli. 1999. Mouse thyroid primary culture. Biochim. Biophys. Acta 257:511.
35. Gorelik, L., and R. A. Flavell. 2002. Transforming growth factor-β in T-cell biology. Nat. Rev. Immunol. 2:46.
36. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
37. Bradley, L. M., V. C. Asensio, L. K. Schioetz, J. Harbertson, T. Krahl, G. Patstone, N. Woolf, I. L. Campbell, and N. Sarvetnick. 1999. Islet-specific Th1, but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes. J. Immunol. 162:2511.
38. Sobel, O. D., J. Han, J. Williams, J. W. Yoon, H. S. Jun, and B. Ahvazi. 2002. γ Interferon paradoxically inhibits the development of diabetes in the NOD mouse. J. Autoimmun. 19:129.
39. Gadina, M., D. Hilton, J. A. Johnston, A. Morinobu, A. Lighvani, Y. J. Zhou, R. Visconti, and J. J. O'Shea. 2001. Signaling by type I and II cytokine receptors: ten years after. Curr. Opin. Immunol. 13:363.
40. Alexander, W. S., R. Starr, J. E. Fenner, C. L. Scott, E. Handman, N. S. Sprigg, J. E. Corbin, A. L. Cornish, R. Darwiche, C. M. Owczarek, et al. 1999. SOCSI is a critical inhibitor of interferon γ signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98:597.
41. Marine, J. C., D. J. Topham, C. McKay, D. Wang, E. Parganas, D. Stravopodis, A. Yoshimura, and J. N. Ihle. 1999. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 98:609.
42. + myelopoiesis induced by CFA: a clue to the paradoxical effects of IFN-γ in autoimmune disease models. Trends Immunol. 22:367.
43. Ponta, H., L. Sherman, and P. A. Herrlich. 2003. CD44: from adhesion molecules to signalling regulators. Nat. Rev. Mol. Cell. Biol. 4:33.
44. Budd, R. C., J. C. Cerottini, C. Horvath, C. Bron, T. Pedrazzini, R. C. Howe, and H. R. MacDonald. 1987. Distinction of virgin and memory T lymphocytes: stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation. J. Immunol. 138:3120.
45. Hoglund, P., J. Mintern, C. Waltzinger, W. Heath, C. Benoist, and D. Mathis. 1999. Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes. J. Exp. Med. 189:331.
46. Green, E. A., E. E. Eynon, and R. A. Flavell. 1998. Local expression of TNFα in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens. Immunity 9:733.
47. Bottazzo, G. F., R. Pujol-Borrell, T. Hanafusa, and M. Feldmann. 1983. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet 2:1115.
48. Cohen, P. L., and R. A. Eisenberg. 1991. lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9:243.
49. Nishimura, H., M. Nose, H. Hiai, N. Minato, and T. Honjo. 1999. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11:141.
50. Nishimura, H., T. Okazaki, Y. Tanaka, K. Nakatani, M. Hara, A. Matsumori, S. Sasayama, A. Mizoguchi, H. Hiai, N. Minato, and T. Honjo. 2001. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 291:319.
51. Tomazic, V., and N. R. ROSE. 1976. Autoimmune murine thyroiditis. VIII. Role of different thyroid antigens in the induction of experimental autoimmune thyroiditis. Immunology 30:63.
52. Simon, L. L., J. M. Justen, A. A. Giraldo, C. J. Krco, and Y. C. Kong. 1986. Activation of cytotoxic T cells and effector cells in experimental autoimmune thyroiditis by shared determinants of mouse and human thyroglobulins. Clin. Immunol. Immunopathol. 39:345.
53. Nabozny, G. H., L. L. Simon, and Y. C. Kong. 1990. Suppression in experimental autoimmune thyroiditis: the role of unique and shared determinants on mouse thyroglobulin in self-tolerance. Cell Immunol. 131:140.