Systemic lipopolysaccharide and interleukin-1β activate the interleukin 6: STAT intracellular signaling pathway in neurons of mouse trigeminal ganglion

Neuroscience Letters

Volumn 281, Issue 1, 2000, Pages 61-64

  Kobierski, Linda A ^a   Srivastava, Smita ^a   Borsook, David ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Interleukin 6; Interleukin 1 ; Lipopoysaccharide; Signal transducer and activator of transcription; Transcription factor; Trigeminal ganglion

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; STAT1 PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; GENETIC TRANSCRIPTION; GRAM NEGATIVE INFECTION; IMMUNE RESPONSE; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRIGEMINUS GANGLION;

ANIMALS; DNA-BINDING PROTEINS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICE; MICE, KNOCKOUT; NEURONS; PROTEIN BINDING; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRIGEMINAL GANGLION;

EID: 0033967026     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00953-2     Document Type: Article

References (19)

1. Arai K.I., Lee F., Miyajima A., Miyatake S., Arai N., Yokota T. Cytokines: coordinators of immune and inflammatory responses. Annu. Rev. Biochem. 59:1990;783-836.
2. Banks W.A., Ortiz L., Plotkin S.R., Kastin A.J. Human Interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism. J. Pharm. Exp. Ther. 259:1991;988-996.
3. Cunha F.Q., Poole S., Lorenzetti B.B., Ferreira S.H. The pivotal role of tumor necrosis factor α in the development of inflammatory hyperalgesia. Br. J. Pharmacol. 107:1992;660-664.
4. Dinarello C.A. The interleukin-1 family: 10 years of discovery. FASEB J. 8:1994;14-25.
5. Ferreira S.H., Lorenzetti B.B., Bristow A.F., Poole S. Interleukin-1β as a potent hyperalgesic agent antagonized by a tripeptide analogue. Nature. 334:1988;698-700.
6. Heinrich P.C., Behrmann I., Muller-Newen G., Schaper F., Graeve L. Interleukin-6-type signalling through the gp130/Jak/STAT pathway. Biochem. J. 334:1998;297-314.
7. Hua X.-Y., Chen P., Fox A., Myers R.R. Involvement of cytokines in lipopolysaccharide-induced facilitation of CGRP release from capsacin-sensitive nerves in the trachea: studies with Interleukin-1β and Tumor Necrosis Factor-α J. Neurosci. 16:1996;4742-4748.
8. Ihle J.N., Thierfelder W., Teglund S., Stravapodis D., Wang D., Feng J., Parganas E. Signaling by the cytokine receptor superfamily. Ann. N.Y. Acad. Sci. 865:1998;1-9.
9. Kopf M., Baumann H., Freer G., Freudenberg M., Lamers M., Kishimoto T., Zinkernagel R., Bluethmann H., Kohler G. Imparied immune and acute-phase responses in interleukin-6-deficient mice. Nature. 368:1994;339-342.
10. Morrison D.C., Ryan J.L. Endotoxins and disease mechanisms. Annu. Rev. Med. 38:1987;417-432.
11. Rivest S., Torres G., Rivier C. Differential effects of central and peripheral injection of interleukin-1 beta on brain c-fos expression and neuroendocrine functions. Brain Res. 587:1992;13-23.
12. Safieh-Garabedian B., Poole S., Allchorne A., Winter J., Woolf C.J. Contribution of interleukin-1β to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia. Br. J. Pharmacol. 15:1995;1265-1275.
13. Sehgal P.B. Regulation of IL-6 gene expression. Res. Immunol. 143:1992;724-734.
14. Sorkin L.S., Xiao W.-H., Wagner R., Myers R.R. Tumor Necrosis Factor-α induces ectopic activity in nociceptive primary afferent fibres. Neuroscience. 81:1997;255-262.
15. Vallieres L., Rivest S. Regulation of the genes encoding Interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine Interleukin-1β J. Neurochem. 69:1997;1668-1683.
16. Van Koughnet K., Smirnova O., Hyman S.E., Borsook D. Proenkephalin transgene regulation in the paraventricular nucleus of the hypothalamus by lipopolysaccharide and Interleukin-1β J. Comp. Neurol. 405:1999;199-215.
17. Watkins L.R., Maier S.F., Goehler L.E. Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states. Pain. 63:1995;289-302.
18. Watkins L.R., Wiertelak E.P., Goehler L.E., Smith K.P., Martin D., Maier S.F. Characterization of cytokine-induced hyperalgesia. Brain Res. 654:1994;15-26.
19. Woolf C.J., Costigan M. Transcriptional and post-translational plasticity and the generation of inflammatory pain. Proc. Natl. Acad. Sci. USA. 96:1999;7723-7730.