Metabotropic glutamate receptor 5 (mGluR5)-mediated phosphoinositide hydrolysis and NMDA-potentiating effects are blunted in the striatum of aged rats: A possible additional mechanism in striatal senescence

European Journal of Neuroscience

Volumn 17, Issue 10, 2003, Pages 2047-2055

  Domenici, Maria Rosaria ^a   Pintor, Annita ^a   Potenza, Rosa Luisa ^a   Gaudi, Simona ^a   Grò, Maria Cristina ^a   Passarelli, Francesca ^b   Reggio, Rosaria ^a   Galluzzo, Mariangela ^a   Massotti, Marino ^a   Popoli, Patrizia ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Aging; Electrophysiological effects; Metabotropic glutamate receptors 5; mGluR5 and PLC 1 expression; Phosphoinositide hydrolysis

Indexed keywords

2 CHLORO 5 HYDROXYPHENYLGLYCINE; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR AGONIST; N METHYL DEXTRO ASPARTIC ACID; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE C; PHOSPHOLIPASE C BETA1; UNCLASSIFIED DRUG;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; CORPUS STRIATUM; FUNCTIONAL DISEASE; HYDROLYSIS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENESCENCE; SIGNAL TRANSDUCTION;

AGING; ANIMALS; CORPUS STRIATUM; GENE EXPRESSION; HYDROLYSIS; IMMUNOBLOTTING; ISOENZYMES; MALE; MEMBRANE POTENTIALS; ORGAN CULTURE TECHNIQUES; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPASE C; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 0038472309     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2003.02649.x     Document Type: Article

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