메뉴 건너뛰기




Volumn 4, Issue 3, 2003, Pages 333-341

MLN-519: Millennium/PAION

Author keywords

[No Author keywords available]

Indexed keywords

ALTEPLASE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BORTEZOMIB; CLASTOLACTACYSTIN BETA LACTONE; LACTACYSTIN BETA LACTONE; PN 05; PROTEASOME INHIBITOR; UNCLASSIFIED DRUG;

EID: 0038417000     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (29)

References (64)
  • 1
    • 0028180516 scopus 로고
    • A β-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line
    • 165898
    • 165898 A β-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Fenteany G, Standaert RF, Reichard GA, Corey EJ, Schreiber SL Proc Natl Acad Sci USA 1994 91 8 3358-3362
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.8 , pp. 3358-3362
    • Fenteany, G.1    Standaert, R.F.2    Reichard, G.A.3    Corey, E.J.4    Schreiber, S.L.5
  • 2
    • 0027980321 scopus 로고
    • The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
    • 202077
    • 202077 The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Palombella VJ, Rando OJ, Goldberg AL, Maniatis T Cell 1994 78 5 773-785
    • (1994) Cell , vol.78 , Issue.5 , pp. 773-785
    • Palombella, V.J.1    Rando, O.J.2    Goldberg, A.L.3    Maniatis, T.4
  • 3
    • 0029033981 scopus 로고
    • Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
    • 202093
    • 202093 Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Fenteany G, Standaert RF, Lane WS, Choi S, Corey EJ, Schreiber SL Science 1995 268 5211 726-731
    • (1995) Science , vol.268 , Issue.5211 , pp. 726-731
    • Fenteany, G.1    Standaert, R.F.2    Lane, W.S.3    Choi, S.4    Corey, E.J.5    Schreiber, S.L.6
  • 5
    • 0038655075 scopus 로고    scopus 로고
    • PS-519, a novel proteasome inhibitor, reduces infarction in a rat model of ischemia/reperfusion brain injury
    • 306910; Abs 86.11
    • 306910 PS-519, a novel proteasome inhibitor, reduces infarction in a rat model of ischemia/reperfusion brain injury. Phillips JB, Williams A, Dave JR, Elliott P, Tortella FC Abstr Soc Neurosci 1998 24 Pt 1 Abs 86.11
    • (1998) Abstr Soc Neurosci , vol.24 , Issue.PART 1
    • Phillips, J.B.1    Williams, A.2    Dave, J.R.3    Elliott, P.4    Tortella, F.C.5
  • 6
    • 0033083426 scopus 로고    scopus 로고
    • Cardioprotective effects of a novel proteasome inhibitor following ischemia and reperfusion in the isolated perfused rat heart
    • 319977; note
    • 319977 Cardioprotective effects of a novel proteasome inhibitor following ischemia and reperfusion in the isolated perfused rat heart. Campbell B, Adams J, Shin YK, Lefer AM J Mol Cell Cardiol 1999 31 2 467-476 Proteasome inhibitors reduce neutrophil invasion of ischemic cardiac tissue and improve cardiac function.
    • (1999) J Mol Cell Cardiol , vol.31 , Issue.2 , pp. 467-476
    • Campbell, B.1    Adams, J.2    Shin, Y.K.3    Lefer, A.M.4
  • 7
    • 0037640713 scopus 로고    scopus 로고
    • ProScript receives SBIR grant for novel stroke treatment
    • 320224; 05 April
    • 320224 ProScript receives SBIR grant for novel stroke treatment. ProScript Inc Press Release 1999 05 April
    • (1999) ProScript Inc Press Release
  • 8
    • 0032908247 scopus 로고    scopus 로고
    • Neuroprotection for acute stroke: Making clinical trials work
    • 324971; note
    • 324971 Neuroprotection for acute stroke: Making clinical trials work. Muir KW, Grosset DG Stroke 1999 30 1 180-182 Re-evaluates clinical trial methodology to optimize the likelihood of identifying efficacious drugs in the future. There is currently little evidence from animal focal ischemia models for the protection of white matter, glia or subcortical neurons. Thus the logical target population for initial clinical trials is patients with middle cerebral artery stroke involving the cerebral cortex.
    • (1999) Stroke , vol.30 , Issue.1 , pp. 180-182
    • Muir, K.W.1    Grosset, D.G.2
  • 10
    • 0032844108 scopus 로고    scopus 로고
    • Proteasome inhibition: A novel mechanism to combat asthma
    • 357116; note
    • 357116 Proteasome inhibition: A novel mechanism to combat asthma. Elliott PJ, Pien CS, McCormack TA, Chapman ID, Adams J J Allergy Clin Immunol 1999 104 2 Pt 1 294-300 Demonstrates that proteasome inhibitors can reduce cellular infiltration in a model of asthma and that the effects are synergistic with steroids.
    • (1999) J Allergy Clin Immunol , vol.104 , Issue.2 PART 1 , pp. 294-300
    • Elliott, P.J.1    Pien, C.S.2    McCormack, T.A.3    Chapman, I.D.4    Adams, J.5
  • 11
    • 0037978728 scopus 로고    scopus 로고
    • Trauma, shock, inflammation and sepsis: Pathophysiology, immune consequences and therapy - Fifth World Congress, Munich, Germany
    • 358988; IDdb author
    • 358988 Trauma, shock, inflammation and sepsis: Pathophysiology, immune consequences and therapy - Fifth World Congress, Munich, Germany. IDdb author IDDB Meeting Report 2000 February 29-March 04
    • IDDB Meeting Report 2000 February 29-March 04
  • 12
    • 0037640712 scopus 로고    scopus 로고
    • Pharmacology of Cerebral Ischemia - Eighth International Symposium (Part II), Marburg, Germany
    • 378116; IDdb author
    • 378116 Pharmacology of Cerebral Ischemia - Eighth International Symposium (Part II), Marburg, Germany. IDdb author IDDB Meeting Report 2000 July 23-26
    • IDDB Meeting Report 2000 July 23-26
  • 13
    • 0037640711 scopus 로고    scopus 로고
    • The novel proteosome inhibitor PS-519 is neuroprotective in two models of focal ischemia when administered hours post occlusion
    • 387463; Abs 286.8
    • 387463 The novel proteosome inhibitor PS-519 is neuroprotective in two models of focal ischemia when administered hours post occlusion. O'Neill MJ, Rash K, Hsu MB, Bond A, Hicks CA, Murray TK, Elliot P, Clemens JA Abstr Soc Neurosci 2000 26 1 Abs 286.8
    • (2000) Abstr Soc Neurosci , vol.26 , Issue.1
    • O'Neill, M.J.1    Rash, K.2    Hsu, M.B.3    Bond, A.4    Hicks, C.A.5    Murray, T.K.6    Elliot, P.7    Clemens, J.A.8
  • 15
    • 0034037622 scopus 로고    scopus 로고
    • Proteasome inhibition measurements: Clinical application
    • 396071; note
    • 396071 Proteasome inhibition measurements: Clinical application. Lightcap ES, McCormack TA, Pien CS, Chau V, Adams J, Elliott PJ Clin Chem 2000 46 5 673-683 This research paper provides a reliable method for studying the pharmacodynamics of proteasome inhibitors.
    • (2000) Clin Chem , vol.46 , Issue.5 , pp. 673-683
    • Lightcap, E.S.1    McCormack, T.A.2    Pien, C.S.3    Chau, V.4    Adams, J.5    Elliott, P.J.6
  • 17
    • 0038316150 scopus 로고    scopus 로고
    • Targets newsletter: Emerging biotechs dive in Sept but positive events still move stocks
    • 427073; September 28
    • 427073 Targets newsletter: Emerging biotechs dive in Sept but positive events still move stocks. Reddoch JF Banc of America 2001 9 September 28
    • (2001) Banc of America , vol.9
    • Reddoch, J.F.1
  • 18
  • 19
    • 0038655069 scopus 로고    scopus 로고
    • Neuroprotection and ischemic brain injury in rats: Improved therapeutic window obtained with the proteasome inhibitor PS-519
    • 428419; Abs 864.8
    • 428419 Neuroprotection and ischemic brain injury in rats: Improved therapeutic window obtained with the proteasome inhibitor PS-519. Tortella FC, Williams A, Hale S, Elliot P Abstr Soc Neurosci 2001 27 Abs 864.8
    • (2001) Abstr Soc Neurosci , vol.27
    • Tortella, F.C.1    Williams, A.2    Hale, S.3    Elliot, P.4
  • 20
    • 0037640709 scopus 로고    scopus 로고
    • Millennium Pharmaceuticals Inc
    • 436401; January 7-10
    • 436401 Millennium Pharmaceuticals Inc. Hambrecht & Quist 2002 January 7-10 268
    • (2002) Hambrecht & Quist , pp. 268
  • 21
    • 0038655076 scopus 로고    scopus 로고
    • Wachovia Securities Integrated Oncology Conference
    • 437649; January 16
    • 437649 Wachovia Securities Integrated Oncology Conference. Millennium Pharmaceuticals Inc Company Presentation 2002 January 16
    • (2002) Millennium Pharmaceuticals Inc Company Presentation
  • 22
    • 0035736099 scopus 로고    scopus 로고
    • The proteasome: A new target for novel drug therapies
    • 441325
    • 441325 The proteasome: A new target for novel drug therapies. Elliot PJ, Ross JS Am J Clin Pathol 2001 116 5 637-646
    • (2001) Am J Clin Pathol , vol.116 , Issue.5 , pp. 637-646
    • Elliot, P.J.1    Ross, J.S.2
  • 23
    • 0035215010 scopus 로고    scopus 로고
    • Postischemic (6-hour) treatment with recombinant human tissue plasminogen activator and proteasome inhibitor PS-519 reduces infarction in a rat model of embolic focal cerebral ischemia
    • 441557; note
    • 441557 Postischemic (6-hour) treatment with recombinant human tissue plasminogen activator and proteasome inhibitor PS-519 reduces infarction in a rat model of embolic focal cerebral ischemia. Zhang L, Zhang ZG, Zhang RL, Lu M, Adams J, Elliott PJ, Chopp M Stroke 2001 32 12 2926-2931 MLN-519 improves neurological outcome and reduces infarct size. The combination treatment with MLN-519 and r-tPA extends the neuroprotective effect to at least 6 h after embolization.
    • (2001) Stroke , vol.32 , Issue.12 , pp. 2926-2931
    • Zhang, L.1    Zhang, Z.G.2    Zhang, R.L.3    Lu, M.4    Adams, J.5    Elliott, P.J.6    Chopp, M.7
  • 24
    • 0037640675 scopus 로고    scopus 로고
    • Millennium and PAION to collaborate on stroke program
    • 443497; March 14
    • 443497 Millennium and PAION to collaborate on stroke program. Millennium Pharmaceuticals Inc Press Release 2002 March 14
    • (2002) Millennium Pharmaceuticals Inc Press Release
  • 26
    • 0033918122 scopus 로고    scopus 로고
    • Proteasome inhibitor PS519 reduces infarction and attenuates leukocyte infiltration in a rat model of focal cerebral ischemia
    • 450963; note
    • 450963 Proteasome inhibitor PS519 reduces infarction and attenuates leukocyte infiltration in a rat model of focal cerebral ischemia. Phillips JB, Williams AJ, Adams J, Elliott PJ, Tortella FC Stroke 2001 31 7 1686-1693 MLN-519 mitigates infarction and improves neurological recovery in brain-injured rats, an effect partly caused by a reduction in the leukocyte inflammatory response.
    • (2000) Stroke , vol.31 , Issue.7 , pp. 1686-1693
    • Phillips, J.B.1    Williams, A.J.2    Adams, J.3    Elliott, P.J.4    Tortella, F.C.5
  • 27
    • 0037978727 scopus 로고    scopus 로고
    • Ischemic brain injury in rats: Attenuation of the inflammatory response with the proteasome inhibitor MLN519
    • 468308; Abs 695.11
    • 468308 Ischemic brain injury in rats: Attenuation of the inflammatory response with the proteasome inhibitor MLN519. Berti R, Moffett JR, Velarde LC, Elliott PJ, Yao C, Dave JR, Tortella FC Abstr Soc Neurosci 2002 28 Abs 695.11
    • (2002) Abstr Soc Neurosci , vol.28
    • Berti, R.1    Moffett, J.R.2    Velarde, L.C.3    Elliott, P.J.4    Yao, C.5    Dave, J.R.6    Tortella, F.C.7
  • 28
    • 0038655070 scopus 로고    scopus 로고
    • Brain neuroprotection with a 10 hour delayed injection of the proteasome inhibitor MLN519 following MCAO in the rat
    • 468345; Abs 695.2
    • 468345 Brain neuroprotection with a 10 hour delayed injection of the proteasome inhibitor MLN519 following MCAO in the rat. Elliott PJ, Williams AJ, Hale SL, Lu X-CM, Tortella FC Abstr Soc Neurosci 2002 28 Abs 695.2
    • (2002) Abstr Soc Neurosci , vol.28
    • Elliott, P.J.1    Williams, A.J.2    Hale, S.L.3    Lu, X.-C.M.4    Tortella, F.C.5
  • 29
    • 0036198493 scopus 로고    scopus 로고
    • Proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu model
    • 473268
    • 473268 Proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu model. Zollner TM, Podda M, Pien C, Elliott PJ, Kaufmann R, Boehncke WH J Clin Invest 2002 109 5 671-679
    • (2002) J Clin Invest , vol.109 , Issue.5 , pp. 671-679
    • Zollner, T.M.1    Podda, M.2    Pien, C.3    Elliott, P.J.4    Kaufmann, R.5    Boehncke, W.H.6
  • 30
    • 0033863764 scopus 로고    scopus 로고
    • Treatment of established relapsing experimental autoimmune encephalomyelitis with the proteasome inhibitor PS-519
    • 473270
    • 473270 Treatment of established relapsing experimental autoimmune encephalomyelitis with the proteasome inhibitor PS-519. Vanderlugt CL, Rahbe SM, Elliott PJ, Dal Canto MC, Miller SD J Autoimmun 2000 14 3 205-211
    • (2000) J Autoimmun , vol.14 , Issue.3 , pp. 205-211
    • Vanderlugt, C.L.1    Rahbe, S.M.2    Elliott, P.J.3    Dal Canto, M.C.4    Miller, S.D.5
  • 31
    • 0038316173 scopus 로고    scopus 로고
    • Proteasome inhibitor PS519 reduces delayed-type hypersensitivity response via inhibition of carbohydrate synthesis of cutaneous lymphocyte-associated antigen (CLA) and T-cell rolling
    • 473271
    • 473271 Proteasome inhibitor PS519 reduces delayed-type hypersensitivity response via inhibition of carbohydrate synthesis of cutaneous lymphocyte-associated antigen (CLA) and T-cell rolling. Podda M, Pien C, Ludwig R, Schultz J, Hardt Weinelt K, Boehncke WH, Elliot PJ, Kaufmann R, Zollner TM J Invest Dermatol 2002 119 3 731
    • (2002) J Invest Dermatol , vol.119 , Issue.3 , pp. 731
    • Podda, M.1    Pien, C.2    Ludwig, R.3    Schultz, J.4    Hardt Weinelt, K.5    Boehncke, W.H.6    Elliot, P.J.7    Kaufmann, R.8    Zollner, T.M.9
  • 32
    • 0036379624 scopus 로고    scopus 로고
    • Early clinical experience with the novel proteasome inhibitor PS-519
    • 473272; note
    • 473272 Early clinical experience with the novel proteasome inhibitor PS-519. Br J Clin Pharmacol 2002 54 3 269-276 Proteasome inhibition is well tolerated by healthy individuals at levels that are maximally neuroprotective in experimental conditions.
    • (2002) Br J Clin Pharmacol , vol.54 , Issue.3 , pp. 269-276
    • Shah, I.M.1    Lees, K.R.2    Pien, C.P.3    Elliot, P.J.4
  • 33
    • 4243341767 scopus 로고    scopus 로고
    • Inhibition of proteasomes decreases superantigen-mediated T-cell activation and the severity of psoriasis in the SCID-Hu model
    • 473273
    • 473273 Inhibition of proteasomes decreases superantigen-mediated T-cell activation and the severity of psoriasis in the SCID-Hu model. Zollner TM, Podda M, Beschmann HA, Pien C, Elliott PJ, Kaufmann R, Boemcke WH Pneumologie 2002 56 Suppl 1 S49
    • (2002) Pneumologie , vol.56 , Issue.SUPPL. 1
    • Zollner, T.M.1    Podda, M.2    Beschmann, H.A.3    Pien, C.4    Elliott, P.J.5    Kaufmann, R.6    Boemcke, W.H.7
  • 35
    • 0038655046 scopus 로고    scopus 로고
    • Inhibition of proteasome reduces iNOS expression and behavioral dysfunction after intracerebral hemorrhage in rat
    • 473278
    • 473278 Inhibition of proteasome reduces iNOS expression and behavioral dysfunction after intracerebral hemorrhage in rat. Al-Senani FM, Shirzadi A, Strong R, Elliot P, Grotta J, Aronowski J Neurology 2001 56 8 A368
    • (2001) Neurology , vol.56 , Issue.8
    • Al-Senani, F.M.1    Shirzadi, A.2    Strong, R.3    Elliot, P.4    Grotta, J.5    Aronowski, J.6
  • 36
    • 0037640676 scopus 로고    scopus 로고
    • Effects of PS-519 combined with thrombolytic therapy in embolic stroke in rat
    • 473279
    • 473279 Effects of PS-519 combined with thrombolytic therapy in embolic stroke in rat. Li Z, Zheng Z, Chopp M, Elliot PJ, Adams J Stroke 2001 32 1 351
    • (2001) Stroke , vol.32 , Issue.1 , pp. 351
    • Li, Z.1    Zheng, Z.2    Chopp, M.3    Elliot, P.J.4    Adams, J.5
  • 37
    • 0033859279 scopus 로고    scopus 로고
    • Syntheses and biological evaluation of (+)-lactacystin and analogs
    • 473280; note
    • 473280 Syntheses and biological evaluation of (+)-lactacystin and analogs. Masse CE, Morgan AJ, Adams J, Panek JS Eur J Org Chem 2000 14 2513-2528 A substantial and detailed reference discussing the chemical attributes of lactacystin and synthetic pathways. A detailed and well-commented description of MLN-519 synthesis.
    • (2000) Eur J Org Chem , vol.14 , pp. 2513-2528
    • Masse, C.E.1    Morgan, A.J.2    Adams, J.3    Panek, J.S.4
  • 38
    • 0034600480 scopus 로고    scopus 로고
    • Neuroprotection in acute ischaemic stroke: A tale of for whom the bell tolls?
    • 477233
    • 477233 Neuroprotection in acute ischaemic stroke: A tale of for whom the bell tolls? Gorelick PB Lancet 2000 355 9219 1925-1926
    • (2000) Lancet , vol.355 , Issue.9219 , pp. 1925-1926
    • Gorelick, P.B.1
  • 39
    • 0034745233 scopus 로고    scopus 로고
    • Have randomized controlled trials of neuroprotective drugs been underpowered? An illustration of three statistical principles
    • 477239
    • 477239 Have randomized controlled trials of neuroprotective drugs been underpowered? An illustration of three statistical principles. Samsa GP, Matchar DB Stroke 2001 32 3 669-674
    • (2001) Stroke , vol.32 , Issue.3 , pp. 669-674
    • Samsa, G.P.1    Matchar, D.B.2
  • 40
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: An integrated view
    • 477241
    • 477241 Pathobiology of ischaemic stroke: An integrated view. Dirnagl U, Iadecola C, Moskowitz MA Trends Neurosci 1999 22 9 391-397
    • (1999) Trends Neurosci , vol.22 , Issue.9 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 41
    • 0035157347 scopus 로고    scopus 로고
    • Prognostic influence of increased C-reactive protein and fibrinogen levels in ischemic stroke
    • 477244
    • 477244 Prognostic influence of increased C-reactive protein and fibrinogen levels in ischemic stroke. Di Napoli M, Papa F, Bocola V Stroke 2001 32 1 133-138
    • (2001) Stroke , vol.32 , Issue.1 , pp. 133-138
    • Di Napoli, M.1    Papa, F.2    Bocola, V.3
  • 42
    • 0035067998 scopus 로고    scopus 로고
    • C-reactive protein in ischemic stroke: An independent prognostic factor
    • 477250
    • 477250 C-reactive protein in ischemic stroke: An independent prognostic factor. Di Napoli M, Papa F, Bocola V Stroke 2001 32 4 917-924
    • (2001) Stroke , vol.32 , Issue.4 , pp. 917-924
    • Di Napoli, M.1    Papa, F.2    Bocola, V.3
  • 43
    • 0029976817 scopus 로고    scopus 로고
    • An essential role for NK-κB in preventing TNF-α-induced cell death
    • 477255
    • 477255 An essential role for NK-κB in preventing TNF-α-induced cell death. Beg AA, Baltimore D Science 1996 274 5288 782-784
    • (1996) Science , vol.274 , Issue.5288 , pp. 782-784
    • Beg, A.A.1    Baltimore, D.2
  • 45
    • 0033824673 scopus 로고    scopus 로고
    • Proteasome inhibitors: From in vitro uses to clinical trials
    • 477268
    • 477268 Proteasome inhibitors: From in vitro uses to clinical trials. Rivett AJ, Gardner RC J Peptide Science 2000 6 9 478-488
    • (2000) J Peptide Science , vol.6 , Issue.9 , pp. 478-488
    • Rivett, A.J.1    Gardner, R.C.2
  • 46
    • 0033520753 scopus 로고    scopus 로고
    • A novel and efficient synthesis of a highly active analogue of clastrolactacystin β-lactone
    • 477271; note
    • 477271 A novel and efficient synthesis of a highly active analogue of clastrolactacystin β-lactone. Soucy F, Grenier L, Behnke M, Destree AT, McCormack TA, Adams JK, Plamondon L J Am Chem Soc 1999 121 43 9967-9976 This article details the synthesis and activity of MLN-519.
    • (1999) J Am Chem Soc , vol.121 , Issue.43 , pp. 9967-9976
    • Soucy, F.1    Grenier, L.2    Behnke, M.3    Destree, A.T.4    McCormack, T.A.5    Adams, J.K.6    Plamondon, L.7
  • 49
    • 0037215550 scopus 로고    scopus 로고
    • Delayed treatment with MLN519 reduces infarction and associated neurologic deficit caused by focal ischemic brain injury in rats via antiinflammatory mechanisms involving nuclear factor-κB activation, gliosis, and leukocyte infiltration
    • 477299; note
    • 477299 Delayed treatment with MLN519 reduces infarction and associated neurologic deficit caused by focal ischemic brain injury in rats via antiinflammatory mechanisms involving nuclear factor-κB activation, gliosis, and leukocyte infiltration. Williams AJ, Hale SL, Moffett JR, Dave JR, Elliott PJ, Adams J, Tortella FC J Cereb Blood Flow Metab 2003 23 1 75-87 Paper reporting that proteasome inhibitors reduce neutrophil invasion of brain tissue after ischemia, dramatically improving neurological outcome and reducing infarct size.
    • (2003) J Cereb Blood Flow Metab , vol.23 , Issue.1 , pp. 75-87
    • Williams, A.J.1    Hale, S.L.2    Moffett, J.R.3    Dave, J.R.4    Elliott, P.J.5    Adams, J.6    Tortella, F.C.7
  • 50
    • 0029912242 scopus 로고    scopus 로고
    • Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-κB
    • 477300
    • 477300 Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-κB. Griscavage JM, Wilk S, Ignarro LJ Proc Natl Acad Sci USA 1996 93 8 3308-3312
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.8 , pp. 3308-3312
    • Griscavage, J.M.1    Wilk, S.2    Ignarro, L.J.3
  • 52
    • 0036681984 scopus 로고    scopus 로고
    • Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons
    • 477302
    • 477302 Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons. Kikuchi S, Shinpo K, Takeuchi M, Tsuji S, Yabe I, Niino M, Tashiro K J Neurosci Res 2002 69 3 373-381
    • (2002) J Neurosci Res , vol.69 , Issue.3 , pp. 373-381
    • Kikuchi, S.1    Shinpo, K.2    Takeuchi, M.3    Tsuji, S.4    Yabe, I.5    Niino, M.6    Tashiro, K.7
  • 53
    • 0034663662 scopus 로고    scopus 로고
    • Proteasome inhibition results in increased poly-ADP-ribosylation: Implications for neuron death
    • 477304
    • 477304 Proteasome inhibition results in increased poly-ADP-ribosylation: Implications for neuron death. Keller JN, Markesbery WR J Neurosci Res 2000 61 4 436-442
    • (2000) J Neurosci Res , vol.61 , Issue.4 , pp. 436-442
    • Keller, J.N.1    Markesbery, W.R.2
  • 54
    • 0034669569 scopus 로고    scopus 로고
    • Dopamine induces proteasome inhibition in neural PC12 cell line
    • 477308
    • 477308 Dopamine induces proteasome inhibition in neural PC12 cell line. Keller JN, Huang FF, Dimayuga ER, Maragos WF Free Radic Biol Med 2000 29 10 1037-1042
    • (2000) Free Radic Biol Med , vol.29 , Issue.10 , pp. 1037-1042
    • Keller, J.N.1    Huang, F.F.2    Dimayuga, E.R.3    Maragos, W.F.4
  • 56
    • 0035451913 scopus 로고    scopus 로고
    • Proteasomes and proteasome inhibition in the central nervous system
    • 477312; note
    • 477312 Proteasomes and proteasome inhibition in the central nervous system. Ding Q, Keller JN Free Radic Biol Med A well-written update on proteasomes and proteasome inhibition in the central nervous systems.
    • (2001) Free Radic Biol Med , vol.31 , Issue.5 , pp. 574-584
    • Ding, Q.1    Keller, J.N.2
  • 57
    • 0033774103 scopus 로고    scopus 로고
    • Oxidative stress-associated impairment of proteasome activity during ischemia-reperfusion injury
    • 477316
    • 477316 Oxidative stress-associated impairment of proteasome activity during ischemia-reperfusion injury. Keller JN, Huang FF, Zhu H, Yu J, Ho YS, Kindy TS J Cereb Blood Flow Metab 2000 20 10 1467-1473
    • (2000) J Cereb Blood Flow Metab , vol.20 , Issue.10 , pp. 1467-1473
    • Keller, J.N.1    Huang, F.F.2    Zhu, H.3    Yu, J.4    Ho, Y.S.5    Kindy, T.S.6
  • 58
    • 0036454320 scopus 로고    scopus 로고
    • NMDA antagonists exacerbate neuronal death caused by proteasome inhibition in cultured cortical and striatal neurons
    • 477321
    • 477321 NMDA antagonists exacerbate neuronal death caused by proteasome inhibition in cultured cortical and striatal neurons. Snider BJ, Tee LY, Canzoniero LM, Babcock DJ, Choi DW Eur J Neurosci 2002 15 3 419-428
    • (2002) Eur J Neurosci , vol.15 , Issue.3 , pp. 419-428
    • Snider, B.J.1    Tee, L.Y.2    Canzoniero, L.M.3    Babcock, D.J.4    Choi, D.W.5
  • 60
    • 0037082124 scopus 로고    scopus 로고
    • Age-dependent declines in proteasome activity in the heart
    • 477326
    • 477326 Age-dependent declines in proteasome activity in the heart. Bulteau AL, Szweda LI, Friguet B Arch Biochem Biophys 2002 397 2 298-304
    • (2002) Arch Biochem Biophys , vol.397 , Issue.2 , pp. 298-304
    • Bulteau, A.L.1    Szweda, L.I.2    Friguet, B.3
  • 61
    • 0035939105 scopus 로고    scopus 로고
    • The expression of mRNAs for the proteasome complex is developmentally regulated in the rat mesencephalon
    • 477330
    • 477330 The expression of mRNAs for the proteasome complex is developmentally regulated in the rat mesencephalon. El-Khodor BF, Kholodilov NG, Yarygina O, Burke RE Dev Brain Res 2001 129 1 47-56
    • (2001) Dev Brain Res , vol.129 , Issue.1 , pp. 47-56
    • El-Khodor, B.F.1    Kholodilov, N.G.2    Yarygina, O.3    Burke, R.E.4
  • 62
    • 0035977412 scopus 로고    scopus 로고
    • Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins
    • 477333
    • 477333 Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins. Ageta H, Kato A, Fukazawa Y, Inokuchi K, Sugiyama H Brain Res Mol Brain Res 2001 97 2 186-189
    • (2001) Brain Res Mol Brain Res , vol.97 , Issue.2 , pp. 186-189
    • Ageta, H.1    Kato, A.2    Fukazawa, Y.3    Inokuchi, K.4    Sugiyama, H.5
  • 63
    • 0344065373 scopus 로고    scopus 로고
    • Recommendations for standards regarding preclinical neuroprotective and restorative drug development
    • 477387
    • 477387 Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke 1990 30 12 2752-2758
    • (1999) Stroke , vol.30 , Issue.12 , pp. 2752-2758
  • 64
    • 0035282213 scopus 로고    scopus 로고
    • IκB-independent control of NF-κB activity by modulatory phosphorylations
    • 479753
    • 479753 IκB-independent control of NF-κB activity by modulatory phosphorylations. Schmitz ML, Bacher S, Kracht M Trends Biochem Sci 2001 26 3 186-190
    • (2001) Trends Biochem Sci , vol.26 , Issue.3 , pp. 186-190
    • Schmitz, M.L.1    Bacher, S.2    Kracht, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.