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ProScript receives SBIR grant for novel stroke treatment
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357116 Proteasome inhibition: A novel mechanism to combat asthma. Elliott PJ, Pien CS, McCormack TA, Chapman ID, Adams J J Allergy Clin Immunol 1999 104 2 Pt 1 294-300 Demonstrates that proteasome inhibitors can reduce cellular infiltration in a model of asthma and that the effects are synergistic with steroids.
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396071 Proteasome inhibition measurements: Clinical application. Lightcap ES, McCormack TA, Pien CS, Chau V, Adams J, Elliott PJ Clin Chem 2000 46 5 673-683 This research paper provides a reliable method for studying the pharmacodynamics of proteasome inhibitors.
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413240 Proteasome targeting in transplantation. Faia KL, Gao W, Csizmadia V, Shemmeri N, Pien CS, Adams J, Elliott P, Hancock WW Am J Transplantation 2001 1 1 Abs 118
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441557; note
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441557 Postischemic (6-hour) treatment with recombinant human tissue plasminogen activator and proteasome inhibitor PS-519 reduces infarction in a rat model of embolic focal cerebral ischemia. Zhang L, Zhang ZG, Zhang RL, Lu M, Adams J, Elliott PJ, Chopp M Stroke 2001 32 12 2926-2931 MLN-519 improves neurological outcome and reduces infarct size. The combination treatment with MLN-519 and r-tPA extends the neuroprotective effect to at least 6 h after embolization.
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450963 Proteasome inhibitor PS519 reduces infarction and attenuates leukocyte infiltration in a rat model of focal cerebral ischemia. Phillips JB, Williams AJ, Adams J, Elliott PJ, Tortella FC Stroke 2001 31 7 1686-1693 MLN-519 mitigates infarction and improves neurological recovery in brain-injured rats, an effect partly caused by a reduction in the leukocyte inflammatory response.
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477294 Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells. Gardner RC, Assinder SJ, Christie G, Mason GG, Markwell R, Wadsworth H, McLaughlin M, King R, Chabot-Fletcher MC, Breton JJ, Allsop D, Rivett AJ Biochem J 2000 346 Pt 2 447-454
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477297 Proteasome inhibition: A novel target for anti-stroke therapy. Elliott PJ, Shah I, Lees K, Pien C, Tortella F, Adams J Restorative Neurol Neurosci 2000 16 156
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Delayed treatment with MLN519 reduces infarction and associated neurologic deficit caused by focal ischemic brain injury in rats via antiinflammatory mechanisms involving nuclear factor-κB activation, gliosis, and leukocyte infiltration
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477299; note
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477299 Delayed treatment with MLN519 reduces infarction and associated neurologic deficit caused by focal ischemic brain injury in rats via antiinflammatory mechanisms involving nuclear factor-κB activation, gliosis, and leukocyte infiltration. Williams AJ, Hale SL, Moffett JR, Dave JR, Elliott PJ, Adams J, Tortella FC J Cereb Blood Flow Metab 2003 23 1 75-87 Paper reporting that proteasome inhibitors reduce neutrophil invasion of brain tissue after ischemia, dramatically improving neurological outcome and reducing infarct size.
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Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-κB
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477300 Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-κB. Griscavage JM, Wilk S, Ignarro LJ Proc Natl Acad Sci USA 1996 93 8 3308-3312
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477301 Proteasome inhibition ablates activation of NF-κB in myocardial reperfusion and reduces reperfusion injury. Pye J, Ardeshirpour F, McCain A, Bellinger DA, Merricks E, Adams J, Elliott PJ, Pien C, Fischer TH, Baldwin AS, Nichols TC Am J Physiol-Heart Circulat Physiol 2003 284 3 H919-H926 This paper reports that MLN-519 was safe and effective in reducing reperfusion injury in a model of myocardial infarction in pigs.
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477302 Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons. Kikuchi S, Shinpo K, Takeuchi M, Tsuji S, Yabe I, Niino M, Tashiro K J Neurosci Res 2002 69 3 373-381
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477304 Proteasome inhibition results in increased poly-ADP-ribosylation: Implications for neuron death. Keller JN, Markesbery WR J Neurosci Res 2000 61 4 436-442
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477308 Dopamine induces proteasome inhibition in neural PC12 cell line. Keller JN, Huang FF, Dimayuga ER, Maragos WF Free Radic Biol Med 2000 29 10 1037-1042
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477311 Ubiquitin-proteasome pathway as a new target for the prevention of restenosis. Meiners S, Laule M, Rother W, Guenther C, Prauka I, Muschick P, Baumann G, Kloetzel PM, Stangl K Circulation 2002 105 4 408-410
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477312 Proteasomes and proteasome inhibition in the central nervous system. Ding Q, Keller JN Free Radic Biol Med A well-written update on proteasomes and proteasome inhibition in the central nervous systems.
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477316 Oxidative stress-associated impairment of proteasome activity during ischemia-reperfusion injury. Keller JN, Huang FF, Zhu H, Yu J, Ho YS, Kindy TS J Cereb Blood Flow Metab 2000 20 10 1467-1473
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477321 NMDA antagonists exacerbate neuronal death caused by proteasome inhibition in cultured cortical and striatal neurons. Snider BJ, Tee LY, Canzoniero LM, Babcock DJ, Choi DW Eur J Neurosci 2002 15 3 419-428
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477324 Fibroblast cultures from healthy centenarians have an active proteasome. Chondrogianni N, Petropoulos I, Franceschi C, Friguet B, Gonos ES Exp Gerontol 2000 35 6-7 721-728
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477326 Age-dependent declines in proteasome activity in the heart. Bulteau AL, Szweda LI, Friguet B Arch Biochem Biophys 2002 397 2 298-304
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477330 The expression of mRNAs for the proteasome complex is developmentally regulated in the rat mesencephalon. El-Khodor BF, Kholodilov NG, Yarygina O, Burke RE Dev Brain Res 2001 129 1 47-56
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477333 Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins. Ageta H, Kato A, Fukazawa Y, Inokuchi K, Sugiyama H Brain Res Mol Brain Res 2001 97 2 186-189
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479753 IκB-independent control of NF-κB activity by modulatory phosphorylations. Schmitz ML, Bacher S, Kracht M Trends Biochem Sci 2001 26 3 186-190
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