Gender differences in the uptake of inorganic mercury by motor neurons

Neurotoxicology and Teratology

Volumn 19, Issue 4, 1997, Pages 287-293

  Pamphlett, Roger ^a   Ewan, Kenneth B R ^a   McQuilty, Robert ^a   Waley, Patricia ^a  

^a NONE

Author keywords

Gender; Inorganic mercury; Motor neuron disease; Motor neurons; Neurotoxicology

Indexed keywords

MERCURY;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOCHEMISTRY; DRUG UPTAKE; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY; LUMBAR SPINAL CORD; MALE; MASS SPECTROMETRY; MOTONEURON; MOTOR NEURON DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; TISSUE DISTRIBUTION;

ANIMALS; FEMALE; KIDNEY; MALE; MERCURIC CHLORIDE; MERCURY; MICE; MICE, INBRED BALB C; MOTOR NEURONS; SEX FACTORS; SPINAL CORD;

ANIMALIA;

EID: 0030742451     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0892-0362(97)00021-4     Document Type: Article

References (21)

1. Arvidson, B.: Inorganic mercury is transported from muscular nerve terminals to spinal and brainstem motoneurons. Muscle Nerve 15:1089-1094; 1992.
2. Chancellor, A. M.; Slattery, J. M.; Fraser, H.; Warlow, C. P.: Risk factors for motor neuron disease: A case-control study based on patients from the Scottish Motor Neuron Disease Register. J. Neurol. Neurosurg. Psychiatry 56:1200-1206; 1993.
3. Clarkson, T. W.; Hursh, J. B.; Sager, P. R.; Syverson, T. L. M.: Mercury. In: Clarkson, T. W.; Friberg, L.; Nordberg, G. F.; Sager, P. R., eds. Biological monitoring of toxic metals. New York: Plenum Press; 1988:199-246.
4. Danscher, G.: Applications of autometallography to heavy metal toxicology. Pharmacol. Toxicol. 69:414-423; 1991.
5. Ewan, K. B. R.; Pamphlett, R.: Increased inorganic mercury in spinal motor neurons following chelating agents. Neurotoxicology 17:343-350; 1996.
6. Hirayama, K.; Yasutake, A.: Sex and age differences in mercury distribution and excretion in methylmercury-administered mice. J. Toxicol. Environ. Health 18:49-60; 1986.
7. Hirayama, K.; Yasutake, A.; Inoue, M.: Effect of sex hormones on the fate of methylmercury and on glutathione metabolism in mice. Biochem. Pharmacol. 36:1919-1924; 1987.
8. Magos, L.; Peristianis, G. C.; Clarkson, T. W.; Brown, A.; Preston, S.; Snowden, R. T.: Comparative study of the sensitivity of male and female rats to methylmercury. Arch. Toxicol. 48:11-20; 1981.
9. Mitchell, J. D.: Heavy metals and trace elements in amyotrophic lateral sclerosis. Neurol. Clin. 5:43-60; 1987.
10. 2). Toxicol. Appl. Pharmacol. 103:303-323; 1990.
11. 2) per os. Environ. Res. 41:29-43; 1986.
12. Nielsen, J. B.; Andersen, O.: Disposition and retention of mercuric chloride in mice after oral and parenteral administration. J. Toxicol. Environ. Health 30:167-180; 1990.
13. Nielsen, J. B.; Andersen, O.: Methyl mercuric chloride toxico-kinetics in mice. I: effects of strain, sex, route of administration and dose. Pharmacol. Toxicol. 68:201-207; 1991.
14. Nielsen, J. B.; Anderson, O.: Oral mercuric chloride exposure in mice: effects of dose on intestinal absorption and relative organ distribution. Toxicology 59:1-10; 1989.
15. Norgaard, J. O. R.; Moller-Madsen, B.; Hertel, N.; Danscher, G.: Silver enhancement of tissue mercury: Demonstration of mercury in autometallographic silver grains from rat kidneys. J. Histochem. Cytochem. 37:1545-1547; 1989.
16. Pamphlett, R.; Waley, P.: Motor neuron uptake of low dose inorganic mercury. J. Neurol. Sci. 1996:63-67; 1996.
17. Prakash, Y. S.; Smithson, K. G.; Sieck, G. C.: Application of the Cavalieri principle in volume estimation using laser confocal microscopy. Neuroimage 1:325-333; 1994.
18. Tanaka, T.; Naganuma, A.; Kobayashi, K.; Imura, N.: An explanation for strain and sex differences in renal uptake of methyl-mercury in mice. Toxicology 69:317-329; 1991.
19. Tanaka, T.; Naganuma, A.; Miura, N.; Imura, N.: Role of testosterone in γ-glutamyltranspeptidase-dependent renal methylmercury uptake in mice. Toxicol. Appl. Pharmacol. 112:58-63; 1992.
20. Thomas, D. J.; Fisher, H. L.; Sumler, M. L.; Marcus, A. H.; Mushak, P.; Hall, L. L.: Sexual differences in the distribution and retention of organic and inorganic mercury in methyl mercury-treated rats. Environ. Res. 41:219-234; 1986.
21. Yasutake, A.; Hirayama, K.: Sex and strain differences of susceptibility to methylmercury toxicity in mice. Toxicology 51:47-55; 1988.