Sex differences in multiple steps in hepatic transport of palmitate support a balanced uptake mechanism

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 274, Issue 1 37-1, 1998, Pages

  Luxon, B A ^b   Holly, D C ^b   Milliano, M T ^b   Weisiger, R A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

Carrier proteins; Cytoplasmic transport; Diffusion gradients; Fatty acid binding proteins; Hepatic uptake; Kinetics; Long chain fatty acids; Mathematical models; Membrane transport; Multiple indicator dilution; Rate constants; Sex factors

Indexed keywords

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FATTY ACID TRANSPORT; FEMALE; LIVER; LIVER CELL CULTURE; LIVER CYTOSOL; LIVER METABOLISM; LIVER SINUSOID; MALE; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; TRANSPORT KINETICS;

EID: 0031937825     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1998.274.1.g52     Document Type: Article

References (44)

1. Barry, P. H., and J. M. Diamond. Effects of unstirred layers on membrane phenomena. Physiol. Rev. 64: 763-872, 1984.
2. Bass, N. M., R. M. Kaikaus, and R. K. Ockner. Physiology and molecular biology of hepatic cytosolic fatty acid-binding protein. In: Hepatic Transport and Bile Secretion: Physiology and Pathophysiology, edited by N. Tavoloni and P. D. Berk. New York: Raven, 1993, p. 421-446.
3. Blouin, A., R. P. Bolender, and E. R. Weibel. Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study. J. Cell Biol. 72: 441-455, 1977.
4. Burnett, D. A., N. Lysenko, J. A. Manning, and R. K. Ockner. Utilization of long chain fatty acids by rat liver: studies of the role of fatty acid binding protein. Gastroenterology 77: 241-249, 1979.
5. Elam, M., C. Simkevich, S. Solomon, H. Wilcox, and M. Heimberg. Stimulation of in vitro triglyceride synthesis in the rat hepatocyte by growth hormone treatment in vivo. Endocrinology 122: 1397-1402, 1988.
6. Folch, J., M. Lees, and G. H. Sloane-Stanley. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497-509, 1957.
7. Goresky, C. A., D. S. Daly, S. Mishkin, and I. M. Arias. Uptake of labeled palmitate by the intact liver: role of intracellular binding sites. Am. J. Physiol. 234 (Endocrinol. Metab. Gastrointest. Physiol. 3): E542-E553, 1978.
8. Greenway, C. V., and W. W. Lautt. Hepatic circulation. In: Handbook of Physiology. The Gastrointestinal System. Motility and Circulation. Bethesda, MD: Am. Physiol. Soc., 1989, p. 1519-1564.
9. Kaikaus, R. M., N. M. Bass, and R. K. Ockner. Functions of fatty acid binding proteins. Experientia 46: 617-630, 1990.
10. Kety, S. S. The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol. Rev. 3: 1-34, 1951.
11. Knutson, T. W., L. F. Knutson, D. L. Hogan, M. A. Koss, and J. I. Isenberg. Human proximal duodenal ion and water transport. Role of enteric nervous system and carbonic anhydrase. Dig. Dis. Sci. 40: 241-246, 1995.
12. Kushlan, M. C., J. L. Gollan, W. L. Ma, and R. K. Ockner. Sex differences in hepatic uptake of long chain fatty acids in single-pass perfused rat liver. J. Lipid Res. 22: 431-436, 1981.
13. Luby-Phelps, K., P. E. Castle, D. L. Taylor, and F. Lanni. Hindered diffusion of inert tracer particles in the cytoplasm of mouse 3T3 cells. Proc. Natl. Acad. Sci. USA 84: 4910-4913, 1987.
14. Luby-Phelps, K., D. L. Taylor, and F. Lanni. Probing the structure of cytoplasm. J. Cell Biol. 102: 2015-2022, 1986.
15. Luxon, B. A. Inhibition of binding to fatty acid binding protein reduces the intracellular transport of fatty acids. Am. J. Physiol. 271 (Gastrointest. Liver Physiol. 34): G113-G120, 1996.
16. Luxon, B. A., and E. L. Forker. Simulation and analysis of hepatic indicator dilution curves. Am. J. Physiol. 243 (Gastrointest. Liver Physiol. 6): G76-G89, 1982.
17. 3). Am. J. Physiol. 263 (Gastrointest. Liver Physiol. 26): G733-G741, 1992.
18. Luxon, B. A., and R. A. Weisiger. Extending the multiple indicator dilution method to include slow cytoplasmic diffusion. Math. Biosci. 113: 211-230, 1993.
19. Luxon, B. A., and R. A. Weisiger. Sex differences in intracellular fatty acid transport: role of cytoplasmic binding proteins. Am. J. Physiol. 265 (Gastrointest. Liver Physiol. 28): G831-G841, 1993.
20. Noy, N., T. M. Donnelly, and D. Zakim. Physical-chemical model for the entry of water-insoluble compounds into cells. Studies of fatty acid uptake by the liver. Biochemistry 25: 2013-2021, 1986.
21. Ockner, R. K., D. A. Burnett, N. Lysenko, and J. A. Manning. Sex differences in long chain fatty acid utilization and fatty acid binding protein concentration in rat liver. J. Clin. Invest. 64: 172-181, 1979.
22. Ockner, R. K., N. Lysenko, J. A. Manning, and S. E. Monroe. Sex steroid modulation of fatty acid utilization and fatty acid binding protein concentration in rat liver. J. Clin. Invest. 65: 1013-1022, 1980.
23. Piessens, R., and R. Huysmans. Algorithm 619: automatic numerical inversion of the Laplace transform. ACM Trans Math Software 10: 348-353, 1984.
24. Pond, S. M., R. A. Gordon, and L. Bass. Sex differences in initial clearance of palmitate by human hepatocytes. Eur. J. Clin. Invest. 26: 76-81, 1996.
25. Pond, S. M., R. A. Gordon, Z.-Y. Wu, R. A. Weisiger, and L. Bass. Effects of gender and pregnancy on hepatocellular uptake of palmitic acid: facilitation by albumin. Am. J. Physiol. 267 (Gastrointest. Liver Physiol. 30): G656-G662, 1994.
26. Ralston, M. L., and R. I. Jennrich. DUD, a derivative-free algorithm for nonlinear least squares. Technometrics 20: 7-14, 1978.
27. Schwab, A. Extension of the theory of the multiple-indicator dilution technique to metabolic systems with an arbitrary number of rate constants. Math. Biosci. 71: 57-79, 1984.
28. Schwab, A. J., F. D. Barker, C. A. Goresky, and K. S. Pang. Transfer of enalaprilat across rat liver cell membranes is barrier limited. Am. J. Physiol. 258 (Gastrointest. Liver Physiol. 21): G461-G475, 1990.
29. Soler-Argilaga, C., and M. Heimberg. Comparison of metabolism of free fatty acid by isolated perfused livers from male and female rats. J. Lipid Res. 17: 605-615, 1976.
30. Sorrentino, D., S.-L. Zhou, E. Kokkotou, and P. D. Berk. Sex differences in hepatic fatty acid uptake reflect a greater affinity of the membrane transport system in females. Am. J. Physiol. 263 (Gastrointest. Liver Physiol. 26): G380-G385, 1992.
31. 14C]oleate reflects membrane transport rather than intracellular metabolism or binding. Proc. Natl. Acad. Sci. USA 83: 3086-3090, 1986.
32. Sweetser, D. A., R. O. Heuckeroth, and J. I. Gordon. The metabolic significance of mammalian fatty-acid-binding proteins: abundant proteins in search of a function. Annu. Rev. Nutr. 7: 337-359, 1987.
33. Weisiger, R. A. Dissociation from albumin: a potentially rate-limiting step in the clearance of substances by the liver. Proc. Natl. Acad. Sci. USA 82: 1563-1567, 1985.
34. Weisiger, R. A. The role of albumin binding in hepatic organic anion transport. In: Hepatic Transport and Bile Secretion: Physiology and Pathophysiology, edited by N. Tavoloni and P. D. Berk. New York: Raven, 1993, p. 171-196.
35. Weisiger, R. A. When is a carrier not a membrane carrier? The cytoplasmic transport of amphipathic molecules. Hepatology 24: 1288-1295, 1996.
36. Weisiger, R. A. Impact of extracellular and intracellular diffusion barriers on hepatic uptake kinetics. In: Whole Organ Approaches to Cellular Metabolism, edited by J. B. Bassingth-waighte, C. A. Goresky, and J. H. Linehan. New York: Springer-Verlag, 1997.
37. 3): electrochemical driving forces. Am. J. Physiol. 262 (Gastrointest. Liver Physiol. 25): G1104-G1112, 1992.
38. Weisiger, R. A., and W. L. Ma. Uptake of oleate from albumin solutions by rat liver. Failure to detect catalysis of the dissociation of oleate from albumin by an albumin receptor. J. Clin. Invest. 79: 1070-1077, 1987.
39. Weisiger, R. A., S. M. Pond, and L. Bass. Hepatic uptake of protein-bound ligands: extended sinusoidal perfusion model. Am. J. Physiol. 261 (Gastrointest. Liver Physiol. 24): G872-G884, 1991.
40. Wolkoff, A. W., C. A. Goresky, J. Sellin, Z. Gatmaitan, and I. M. Arias. Role of ligandin in transfer of bilirubin from plasma into liver. Am. J. Physiol. 236 (Endocrinol. Metab. Gastrointest. Physiol. 5): E638-E648, 1979.
41. Wu-Rideout, M. Y. C., C. Elson, and E. Shrago. The role of fatty acid binding protein on the metabolism of fatty acids in isolated rat hepatocytes. Biochem. Biophys. Res. Commun. 71: 809-816, 1976.
42. Zakim, D., R. B. Cooper, and N. Noy. The uptake of fatty acids by the liver. Trans. Am. Clin. Climatol. Assoc. 99: 41-46, 1987.
43. Zammit, V. A. Mechanisms of regulation of the partition of fatty acids between oxidation and esterification in the liver. Prog. Lipid Res. 23: 39-67, 1984.
44. Zhou, S.-L., B. J. Potter, D. Stump, D. Sorrentino, and P. D. Berk. Quantitation of plasma membrane fatty acid-binding protein by enzyme dilution and monoclonal antibody based immunoassay. Mol. Cell. Biochem. 98: 183-189, 1990.