Sex differences in initial clearance of palmitate by human hepatocytes

European Journal of Clinical Investigation

Volumn 26, Issue 1, 1996, Pages 76-81

  Pond, S M ^a,b   Gordon, R A ^a   Bass, L ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b PRINCESS ALEXANDRA HOSPITAL   (Australia)

Author keywords

Cell membrane permeability; Fatty acid transport; Fatty acids; Gender; Human hepatocytes; Organ preservation

Indexed keywords

FATTY ACID; PALMITIC ACID;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; LIVER CLEARANCE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE;

EID: 0030041692     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1996.101246.x     Document Type: Article

References (30)

1. Sorrentino D, Zhou S-L, Kokkotou E, Berk PD. Sex differences in hepatic fatty acid uptake reflect a greater affinity of the transport system in females. Am J Physiol 1992;263:G380-5.
2. Pond SM, Gordon RA, Wu Z-Y, Weisiger RA, Bass L. Effects of gender and pregnancy on hcpatocellular uptake of palmitic acid: facilitation by albumin. Am J Physiol 1994;267:G656-62.
3. Caldwell J. Biological implications of xenobiotic metabolism. In: Arias IM, Jakoby WB, Popper H, Schachter D, Shafritz DA, eds. The Liver: Biology and Pathobiology. New York: Raven Press, 1988:355-62.
4. Azer SA, Stacey NH. Differential effects of cyclosporin A on the transport of bile acids by human hepatocytes. Biochem Pharmacol 1993;46:813-19.
5. Kreamer BL, Staecker JL, Sawada N, Sattler MJS Hsia, Pitot HC. Use of a low-speed, iso-density Percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations. In Vitro Cell Devel Biol 1986;22:201-11.
6. Berry MN, Friend DS. High-yield preparation of isolated rat liver parenchymal cells. A biochemical and fine structural study. J Cell Biol 1969;43:506-20.
7. Pond SM, Davis CK, Bogoyevitch MA, Gordon RA, Weisiger RA, Bass L. Uptake of palmitate by hepatocyte suspensions: facilitation by albumin? Am J Physiol 1992;262:G883-94.
8. Ashbrook JD, Spector AA, Santos EC, Fletcher JE. Long chain fatty acid binding to human plasma albumin. J Biol Chem 1975;250:2333-7.
9. Strom SC, Jirtle RL, Jones RS et al. Isolation, culture and transplantation of human hepatocytes. J Nat Cancer Inst 1982;68:771-8.
10. Houssin D, Capron M, Celier C, Cresteil T, Demaugre F, Beaune P. Evaluation of isolated human hepatocytes. Life Sci 1983;33:1805-9.
11. Gugen-Guillouzo C, Campion JP, Brissot P et al. High yield preparation of isolated human adult hepatocytes by enzymatic perfusion of the liver. Cell Biol Int Rep 1982;6:625-8.
12. Grant MH, Burke MD, Hawksworth GM, Duthie SJ, Engeset J, Petrie JC. Human adult hepatocytes in primary monolayer culture. Maintenance of mixed function oxidase and conjugation pathways of drug metabolism. Biochem Pharmacol 1987;36:2311-16.
13. Tee LB, Seddon T, Boobis AR, Davies DS. Drug metabolising activity of freshly isolated human hepatocytes. Br J Clin Pharmacol 1985;19:279-94.
14. Sandker GW, Weert B, Merema MT et al. Maintenance of viability and transport function after preservation of isolated rat hepatocytes in various simplified University of Wisconsin solutions. Biochem Pharmacol 1993;46:2093-6.
15. Sorrentino D, Van Ness K, Ribeiro I, Miller CM. Functional and morphological features of isolated hepatocytes preserved in University of Wisconsin solution. Hepatology 1991;14:331-9.
16. Bass NM, Barker ME, Manning JA, Jones AL, Ockner RK. Acinar heterogeneity of fatty acid binding protein expression in the livers of male, female and clofibrate-treated rats. Hepatology 1989;9:12-21.
17. Forker EL, Luxon BA, Snell M, Shurmantine WO. Effect of albumin binding on the hepatic transport of Rose Bengal: Surface-mediated dissociation of limited capacity. J Pharmacol Exp Ther 1982;223:342-7.
18. Hutter JF, Piper HM, Spieckermann PG. Kinetic analysis of myocardial fatty acid oxidation suggesting an albumin receptor mediated uptake process. J Mol Cell Cardiol 1984;16:219-26.
19. Fleischer AB, Shurmantine WO, Luxon BA, Forker EL. Palmitate uptake by hepatocyte monolayers. Effect of albumin binding. J Clin Invest 1986;77:964-70.
20. Weisiger RA, Ma W-L. Uptake of oleate from albumin solutions by rat liver: failure to detect catalysis of the dissociation of oleate from albumin by an albumin receptor. J Clin Invest 1987;79;1070-7.
21. Nunes R, Kiang D-L, Sorrentino D, Berk PD, 'Albumin-receptor' uptake kinetics do not require an intact lobular architecture and are not specific for albumin. J Hepatol 1988;7:293-304.
22. Weisiger RA, Pond SM, Bass L. Hepatic uptake protein-bound ligands: extended sinusoidal perfusion model. Am J Physiol 1991;261:G872-84.
23. Keiding S, Ott P, Bass L. Enhancement of unbound clearance of ICG by plasma proteins, demonstrated in human subjects and interpreted without assumption of facilitating structures. J Hepatol 1993;19:327-44.
24. Bass L, Pond SM. The puzzle of rates of cellular uptake of protein-bound ligands. In: Pecile A, Rescigno A, eds, Pharmacokinetics: Mathematical and Statistical Approaches to Metabolism and Distribution of Chemicals and Drugs. London: Plenum Press, 1988:245-69.
25. Cooper R, Noy N, Zakim D. A physical chemical model for cellular uptake of fatty acids: prediction of intracellular pool sizes. Biochemistry 1987;26:5890-6.
26. Noy N, Donnelly TM, Cooper RU, Zakim D. The physical chemical basis for sex-related differences in uptake of fatty acids by the liver. Biochim Biophys Acta 1989;1003:125-30.
27. Sorrentino D, Berk PD. Free fatty acids, albumin, and the sinusoidal plasma membrane: concepts, trends, and controversies. In: Tavoloni N and Berk PD, eds. Hepatic Transport and Bile Secretion, Physiology and Pathophysiology. New York, Raven Press, 1994:197-210.
28. Stremmel W, Strohmeyer F, Borchard F, Kochwa S, Berk P. Isolation and partial characterization of a fatty acid binding protein in rat liver plasma membranes. Proc Natl Acad Sci USA 1985;82:4-8.
29. Stump DD, Zhou SL, Berk PD. Comparison of plasma membrane KABP and mitochondrial isoform of aspartate amino-transferase from rat liver. Am J Physiol 1993;265:G894-902.
30. Schaffer JE, Lodish HF. Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell 1994;79:427-36.