메뉴 건너뛰기




Volumn 66, Issue 4, 2002, Pages 237-245

Induction of IκB-kinase by cholecystokinin is mediated by trypsinogen activation in rat pancreatic lobules

Author keywords

Acute pancreatitis; Concentrations of cholecystokinin; I B kinase; NF B; Serine protease inhibitor; Trypsin activation; Trypsinogen

Indexed keywords

4 (2 AMINOETHYL)BENZENESULFONYL FLUORIDE; CELL ENZYME; CHOLECYSTOKININ; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NAFAMSTAT MESILATE; PHOSPHOTRANSFERASE; SERINE PROTEINASE INHIBITOR; TRYPSIN; TRYPSINOGEN; TUMOR NECROSIS FACTOR ALPHA; 4 (2 AMINOETHYL)BENZENESULFONYLFLUORIDE; 4-(2-AMINOETHYL)BENZENESULFONYLFLUORIDE; GUANIDINE DERIVATIVE; NAFAMSTAT; PROTEIN SERINE THREONINE KINASE; SULFONE; TRYPSIN INHIBITOR;

EID: 0038247596     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000068364     Document Type: Article
Times cited : (35)

References (33)
  • 1
    • 0026012825 scopus 로고
    • Evidence of intracellular activation of serine proteases in acute cerulein-induced pancreatitis in rats
    • Bialek R, Willemer S, Arnold R et al: Evidence of intracellular activation of serine proteases in acute cerulein-induced pancreatitis in rats. Scand J Gastroenterol 1991;26:190-196.
    • (1991) Scand J Gastroenterol , vol.26 , pp. 190-196
    • Bialek, R.1    Willemer, S.2    Arnold, R.3
  • 2
    • 0029775583 scopus 로고    scopus 로고
    • Edema and intrapancreatic trypsinogen activation precede glutathione depletion during caerulein pancreatitis
    • Grady T, Saluja A, Kaiser A et al: Edema and intrapancreatic trypsinogen activation precede glutathione depletion during caerulein pancreatitis. Am J Physiol 1996;271:G20-G26.
    • (1996) Am J Physiol , vol.271
    • Grady, T.1    Saluja, A.2    Kaiser, A.3
  • 3
    • 0030959639 scopus 로고    scopus 로고
    • Cerulein-induced in vitro activation of trypsinogen in rat pancreatic acini is mediated by cathepsin B
    • Saluja AK, Donovan EA et al: Cerulein-induced in vitro activation of trypsinogen in rat pancreatic acini is mediated by cathepsin B. Gastroenterology 1997;113:304-310.
    • (1997) Gastroenterology , vol.113 , pp. 304-310
    • Saluja, A.K.1    Donovan, E.A.2
  • 4
    • 0002884935 scopus 로고
    • Pancreatic secretory enzymes
    • Go VLW, DiMagno EP, Gardner JD et al (eds). New York, Raven Press
    • Rinderknecht H: Pancreatic secretory enzymes; in Go VLW, DiMagno EP, Gardner JD et al (eds): The Pancreas: Biology, Pathophysiology and Disease, ed 2. New York, Raven Press, 1993, pp 219-251.
    • (1993) The Pancreas: Biology, Pathophysiology and Disease, Ed 2 , pp. 219-251
    • Rinderknecht, H.1
  • 6
    • 0017324230 scopus 로고
    • Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue
    • Lampel M, Kern HF: Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue. Virchows Arch A Pathol Anat Histol 1977;373:97-117.
    • (1977) Virchows Arch A Pathol Anat Histol , vol.373 , pp. 97-117
    • Lampel, M.1    Kern, H.F.2
  • 8
    • 0033984954 scopus 로고    scopus 로고
    • Stress kinases and heat-shock proteins in the pancreas: Possible roles in normal function and disease
    • Schafer C, Williams JA: Stress kinases and heat-shock proteins in the pancreas: possible roles in normal function and disease. J Gastroenterol 2000;35:1-9.
    • (2000) J Gastroenterol , vol.35 , pp. 1-9
    • Schafer, C.1    Williams, J.A.2
  • 9
    • 0032590082 scopus 로고    scopus 로고
    • NF-κB/Rel activation in cerulein pancreatitis
    • Steinle AU, Weidenbach H, Wagner M et al: NF-κB/Rel activation in cerulein Pancreatitis. Gastroenterology 1999;116:420-430.
    • (1999) Gastroenterology , vol.116 , pp. 420-430
    • Steinle, A.U.1    Weidenbach, H.2    Wagner, M.3
  • 10
    • 0030726979 scopus 로고    scopus 로고
    • Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis
    • Grady T, Liang P, Ernst SA et al: Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis. Gastroenterology 1997;113:1966-1975.
    • (1997) Gastroenterology , vol.113 , pp. 1966-1975
    • Grady, T.1    Liang, P.2    Ernst, S.A.3
  • 11
    • 0032246276 scopus 로고    scopus 로고
    • Early NF-κB activation is associated with hormone-induced pancreatitis
    • Gukovsky I, Gukovskaya AS, Blinman TA et al: Early NF-κB activation is associated with hormone-induced pancreatitis. Am J Physiol 1998;275:G1402-G1414.
    • (1998) Am J Physiol , vol.275
    • Gukovsky, I.1    Gukovskaya, A.S.2    Blinman, T.A.3
  • 12
    • 0033625715 scopus 로고    scopus 로고
    • NF-κB/Rel/IκB - Implications in gastrointestinal diseases
    • Schmid RM, Adler G: NF-κB/Rel/IκB - Implications in gastrointestinal diseases. Gastroenterology 2000;118:1208-1228.
    • (2000) Gastroenterology , vol.118 , pp. 1208-1228
    • Schmid, R.M.1    Adler, G.2
  • 13
    • 0030685825 scopus 로고    scopus 로고
    • IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation
    • Mercurio F, Zhu H, Murray BW et al: IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation. Science 1997;278:860-866.
    • (1997) Science , vol.278 , pp. 860-866
    • Mercurio, F.1    Zhu, H.2    Murray, B.W.3
  • 14
    • 0030613551 scopus 로고    scopus 로고
    • The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation
    • Zandi E, Rothwarf DM, Delhase M et al: The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 1997;91:243-252.
    • (1997) Cell , vol.91 , pp. 243-252
    • Zandi, E.1    Rothwarf, D.M.2    Delhase, M.3
  • 15
    • 0030610362 scopus 로고    scopus 로고
    • A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
    • DiDonato JA, Hayakawa M, Rothwarf DM et al: A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 1997;388:548-554.
    • (1997) Nature , vol.388 , pp. 548-554
    • DiDonato, J.A.1    Hayakawa, M.2    Rothwarf, D.M.3
  • 16
    • 0030611595 scopus 로고    scopus 로고
    • IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK
    • Woronicz JD, Gao X, Cao Z et al: IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK. Science 1997;278:866-869.
    • (1997) Science , vol.278 , pp. 866-869
    • Woronicz, J.D.1    Gao, X.2    Cao, Z.3
  • 18
    • 0029059443 scopus 로고
    • Acute hypercalcemia causes acute pancreatitis and ectopic trypsinogen activation in the rat
    • Mithofer K, Fernandez-del Castillo C, Frick TW et al: Acute hypercalcemia causes acute pancreatitis and ectopic trypsinogen activation in the rat. Gastroenterology 1995;109:239-246.
    • (1995) Gastroenterology , vol.109 , pp. 239-246
    • Mithofer, K.1    Fernandez-Del Castillo, C.2    Frick, T.W.3
  • 19
    • 0023811257 scopus 로고
    • Development of radioimmunoassays for free tetra-L-aspartyl-L-lysine trypsinogen activation peptides
    • Hurley PR, Cook A, Jehanli A et al: Development of radioimmunoassays for free tetra-L-aspartyl-L-lysine trypsinogen activation peptides. J Immunol Methods 1988;111:195-203.
    • (1988) J Immunol Methods , vol.111 , pp. 195-203
    • Hurley, P.R.1    Cook, A.2    Jehanli, A.3
  • 20
    • 12944305960 scopus 로고    scopus 로고
    • Raf induces NF-κB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation
    • Baumann B, Weber CK, Troppmair J et al: Raf induces NF-κB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation. Proc Natl Acad Sci USA 2000;97:4615-4620.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 4615-4620
    • Baumann, B.1    Weber, C.K.2    Troppmair, J.3
  • 21
    • 0032514803 scopus 로고    scopus 로고
    • Recombinant IκB kinases α and β are direct kinases of IκBα
    • Li J, Peet GW, Pullen SS et al: Recombinant IκB kinases α and β are direct kinases of IκBα. J Biol Chem 1998;273:30736-30741.
    • (1998) J Biol Chem , vol.273 , pp. 30736-30741
    • Li, J.1    Peet, G.W.2    Pullen, S.S.3
  • 22
    • 0032957613 scopus 로고    scopus 로고
    • Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini
    • Saluja AK, Bhagat L, Lee HS et al: Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini. Am J Physiol 1999;276:G835-G842.
    • (1999) Am J Physiol , vol.276
    • Saluja, A.K.1    Bhagat, L.2    Lee, H.S.3
  • 23
    • 0029775583 scopus 로고    scopus 로고
    • Edema and intrapancreatic trypsinogen activation precede glutathione depletion during caerulein pancreatitis
    • Grady T, Saluja A, Kaiser A et al: Edema and intrapancreatic trypsinogen activation precede glutathione depletion during caerulein pancreatitis. Am J Physiol 1996;271:G20-G26.
    • (1996) Am J Physiol , vol.271
    • Grady, T.1    Saluja, A.2    Kaiser, A.3
  • 24
    • 0025979308 scopus 로고
    • Intracellular activation of digestive zymogens in rat pancreatic acini. Stimulation by high doses of cholecystokinin
    • Leach SD, Modlin IM, Scheele GA et al: Intracellular activation of digestive zymogens in rat pancreatic acini. Stimulation by high doses of cholecystokinin. J Clin Invest 1991;87:362-366.
    • (1991) J Clin Invest , vol.87 , pp. 362-366
    • Leach, S.D.1    Modlin, I.M.2    Scheele, G.A.3
  • 25
    • 0028966972 scopus 로고
    • Intrapancreatic zymogen activation and levels of ATP and glutathione during caerulein pancreatitis in rats
    • Luthen R, Niederau C, Grendell JH: Intrapancreatic zymogen activation and levels of ATP and glutathione during caerulein pancreatitis in rats. Am J Physiol 1995;268:G592-G604.
    • (1995) Am J Physiol , vol.268
    • Luthen, R.1    Niederau, C.2    Grendell, J.H.3
  • 26
    • 0030959639 scopus 로고    scopus 로고
    • Cerulein-induced in vitro activation of trypsinogen in rat pancreatic acini is mediated by cathepsin B
    • Saluja AK, Donovan EA, Yamanaka K et al: Cerulein-induced in vitro activation of trypsinogen in rat pancreatic acini is mediated by cathepsin B. Gastroenterology 1997;113:304-310.
    • (1997) Gastroenterology , vol.113 , pp. 304-310
    • Saluja, A.K.1    Donovan, E.A.2    Yamanaka, K.3
  • 27
    • 0344589358 scopus 로고    scopus 로고
    • Direct detection of premature protease activation in living pancreatic acinar cells
    • Kruger B, Lerch MM, Tessenow W: Direct detection of premature protease activation in living pancreatic acinar cells. Lab Invest 1998;78:763-764.
    • (1998) Lab Invest , vol.78 , pp. 763-764
    • Kruger, B.1    Lerch, M.M.2    Tessenow, W.3
  • 28
    • 0031767879 scopus 로고    scopus 로고
    • Co-distribution of TAP and the granule membrane protein GRAMP-92 in rat caerulein-induced pancreatitis
    • Otani T, Chepilko SM, Grendell JH et al: Co-distribution of TAP and the granule membrane protein GRAMP-92 in rat caerulein-induced pancreatitis. Am J Physiol 1998;275:G999-G1009.
    • (1998) Am J Physiol , vol.275
    • Otani, T.1    Chepilko, S.M.2    Grendell, J.H.3
  • 29
    • 0031867966 scopus 로고    scopus 로고
    • Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats
    • Hofbauer B, Saluja AK, Lerch MM et al: Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats. Am J Physiol 1998;275:G352-G362.
    • (1998) Am J Physiol , vol.275
    • Hofbauer, B.1    Saluja, A.K.2    Lerch, M.M.3
  • 31
    • 0011770646 scopus 로고    scopus 로고
    • CCK independently activates intracellular trypsinogen and NF-κB in rat pancreatic acinar cells
    • Han B, Ji B, Logsdon CD: CCK independently activates intracellular trypsinogen and NF-κB in rat pancreatic acinar cells. Am J Physiol 2001;49:C465-C472.
    • (2001) Am J Physiol , vol.49
    • Han, B.1    Ji, B.2    Logsdon, C.D.3
  • 32
  • 33
    • 0035010522 scopus 로고    scopus 로고
    • Serine protease inhibitor causes F-actin redistribution and inhibition of calcium-mediated secretion in pancreatic acini
    • Singh VP, Saluja A, Bhagat L, Hietaranta AJ et al: Serine protease inhibitor causes F-actin redistribution and inhibition of calcium-mediated secretion in pancreatic acini. Gastroenterology 2001;120:1818-1827.
    • (2001) Gastroenterology , vol.120 , pp. 1818-1827
    • Singh, V.P.1    Saluja, A.2    Bhagat, L.3    Hietaranta, A.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.