Codistribution of TAP and the granule membrane protein GRAMP-92 in rat caerulein-induced pancreatitis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 275, Issue 5 38-5, 1998, Pages

  Otani, Taiichi ^a,b   Chepilko, Sergei M ^c   Grendell, James H ^c   Gorelick, Fred S ^a,b,d  

^a Vet Aff Connecticut Hlthcare S ^*  (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WEILL CORNELL MEDICAL CENTER   (United States)

^d VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

Pancreas; Protease inhibitor; Trypsin; Trypsinogen; Trypsinogen activation peptide

Indexed keywords

CERULETIDE; GRANULE MEMBRANE PROTEIN GRAMP 92; NAFAMSTAT MESILATE; PROTEIN; TRYPSINOGEN; TRYPSINOGEN ACTIVATION PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; IMMUNOFLUORESCENCE; MALE; NONHUMAN; PANCREATITIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROCESSING; RAT;

EID: 0031767879     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1998.275.5.g999     Document Type: Article

References (20)

1. Bendayan, M., J. Roth, A. Perrelet, and L. Orci. Immunocy tochemical localization of secretory proteins in pancreas. J. Histochem. Cytochem. 28: 149-160, 1980.
2. Castle, J. D., and A. M. Castle. Two regulated secretory pathways for newly synthesized parotid salivary proteins are distinguished by doses of secretagogues. J. Cell Sci. 109: 2591-2599, 1996.
3. Chepilko, S. M., T. Otani, F. S. Gorelick, L. Mazzarelli, R. Wang, and J. H. Grendell. A novel approach to characterize the specificity of antibodies to trypsinogen activation peptide (Abstract). Pancreas 15: 431, 1997.
4. Figarella, C., B. Miszczuk-Jamska, and A. J. Barret. Possible lysosomal activation of pancreatic zymogens: activation of both human trypsinogens by cathepsin B and spontaneous acid activation of human trypsinogen. Biol. Chem. Hoppe-Seyler 369: 293-298, 1988.
5. Fujii, S., and Y. Hitomi. New synthetic inhibitors of Clr, Cl-esterase, thrombin, kallikrein and trypsin. Biochim. Biophys. Acta 661: 342-345, 1981.
6. Gorelick, F. S., G. Adler, and H. F. Kern. Cerulein-induced pancreatitis. In: The Pancreas: Biology, Pathobiology, and Disease, edited by V. L. W. Go, E. P. DiMagno, J. D. Gardner, E. Lebenthal, H. A. Reber, and G. A. Scheele. New York: Raven, 1993, p. 501-526.
7. Grady, T., M. Mah'moud, T. Otani, S. Rhee, M. M. Lerch, and F. S. Gorelick. Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury. Am. J. Physiol. 275 (Gastrointest. Liver Physiol. 38): G1010-G1017, 1998.
8. Grondin, G., and A. R. Beaudoin. Immunocytochernical and cytochemical demonstration of a novel selective lysosomal pathway (sIp) of secretion in the exocrine pancreas. J. Histochem. Cytochem. 44: 357-368, 1996.
9. Hofbauer, B., A. K. Saluja, M. M. Lerch, L. Bhagat, M. Bhatia, H. S. Lee, J. L. Frossard, G. Adler, and M. L. Steer. Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats. Am. J. Physiol. 275 (Gastrointest. Liver Physiol. 38): G352-G362, 1998.
10. Hurley, P. R., A. Cook, A. Jehanli, B. M. Austen, and J. Hermon-Taylor. Development of radioimmunoassays for free tetra-L-aspartyl-L-lysine trypsinogen activation peptides (TAP). J. Immunol. Methods 111: 195-203, 1988.
11. Klonowski-Stump, H., R. Lüthen, B. Han, N. Sata, D. Häussinger, and C. Niederau. Inhibition of cathepsin B does not affect the intracellular activation of trypsinogen by cerulein hyperstimulation in isolated rat pancreatic acinar cells. Pancreas 16: 96-101, 1998.
12. Klumperman, J., R. Kuliawat, J. M. Griffith, H. J. Geuze, and P. Arvan. Mannose 6-phosphate receptors are sorted from immature secretory granules via adaptor protein AP-1, clathrin, and syntaxin 6-positive vesicle. J. Cell Biol. 141-142: 359-371, 1998.
13. Laurie, S. M., M. B. Mixon, S. H. Brand, and J. D. Castle. A secretion granule membrane protein (GRAMP 92) is found in non-granule membranes including those of the endocytic pathway. Eur. J. Cell Biol. 58: 12-27, 1992.
14. Leach, S. D., I. M. Modlin, G. A. Scheele, and F. S. Gorelick. Intracellular activation of digestive zymogens in rat pancreatic acini. Stimulation by high doses of cholecystokinin. J. Clin. Invest. 87: 362-366, 1991.
15. Lüthen, R., C. Niederau, and J. H. Grendell. Intrapancreatic zymogen activation and levels of ATP and glutathione during caerulein pancreatitis in rats. Am. J. Physiol. 268 (Gastrointest. Liver Physiol. 31): G592-G604, 1995.
16. Lüthen, R. E., C. Niederau, R. L. Owen, M. Sarbia, and J. H. Grendell. Premature trypsinogen activation during cerulein-induced pancreatitis in rats occurs inside pancreatic acinar cells. Pancreas 17: 38-43, 1998.
17. Marino, C. R., L. M. Matovcik, F. S. Gorelick, and J. A. Cohn. Localization of the cystic fibrosis transmembrane conductance regulator in pancreas. J. Clin. Invest. 88: 712-716, 1991.
18. Mithofer, K., C. Fernandex-del Castillo, D. Rattner, and A. L. Warshaw. Subcellular kinetic of early typsinogen activation in acute rodent pancreatitis. Am. J. Physiol. 274 (Gastrointest. Liver Physiol. 37): G71-G79, 1998.
19. Nakae, Y., S. Naruse, M. Kitagawa, S. Hirao, R. Yamamoto, and T. Hayakawa. Activation of trypsinogen in experimental models of acute pancreatitis in rats. Pancreas 10: 306-313, 1995.
20. Niederau, C., and J. H. Grendell. Intracellular vacuoles in experimental acute pancreatitis in rats and mice are an acidified compartment. J. Clin. Invest. 81: 229-236, 1988.