Recombinant IκB kinases α and β are direct kinases of IκBα

Journal of Biological Chemistry

Volumn 273, Issue 46, 1998, Pages 30736-30741

  Li, Jun ^a   Peet, Gregory W ^a   Pullen, Steven S ^a   Schembri King, Josephine ^a   Warren, Thomas C ^a   Marcu, Kenneth B ^b   Kehry, Marilyn R ^a   Barton, Randall ^a   Jakes, Scott ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE; PROTEIN SUBUNIT; THREONINE; TRANSCRIPTION FACTOR; CHUK PROTEIN, HUMAN; DNA BINDING PROTEIN; I KAPPA B; I KAPPA B KINASE; IKBKB PROTEIN, HUMAN; IKBKE PROTEIN, HUMAN; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN;

ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME PURIFICATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; REGULATORY MECHANISM; ANIMAL; ARMYWORM; KINETICS; LEUKEMIA CELL LINE; METABOLISM; PHOSPHORYLATION;

ANIMALS; CATALYSIS; DNA-BINDING PROTEINS; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; JURKAT CELLS; KINETICS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; SPODOPTERA;

EID: 0032514803     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.46.30736     Document Type: Article

References (22)

1. Baldwin, A. S. (1996) Annu. Rev. Immunol. 14, 649-681
2. Traenckner E. B., Pahl H. L., Henkel, T., Schmidt, K. N., Wilk, S., and Baeuerle, P. A. (1995) EMBO J. 14, 2876-2883
3. DiDonato, J., Mercurio, F., Rosette, C., Wu-Li, J., Suyang, H., Ghosh, S., and Karin M. (1996) Mol. Cell. Biol. 16, 1295-1304
4. Whiteside, S. T., Epinat, J.-C., Rice, N. R., and Israel, A. (1997) EMBO J. 16, 1413-1426
5. Chen, Z., Hagler, J., Palombella, V. J., Melandri, F., Scherer, D., Ballard, D., and Maniatis, T. (1995) Genes Dev. 9, 1586-1597
6. DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., and Karin, M. (1997) Nature 388, 548-554
7. Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J. W., Young, D. B., Barbosa, M., Mann, M., Manning, A., and Rao, A. (1997) Science 278, 860-865
8. Regnier, C. H., Song, H. Y., Gao, X., Goeddel, D. V., Cao, Z., and Rothe, M. (1997) Cell 90, 373-383
9. Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M., nd Karin, M. (1997) Cell 91, 243-252
10. Woronicz, J. D., Gao, X., Cao, Z., Rothe, M., and Goeddel, D. V. (1997) Science 278, 866-869
11. Malinin, N. L., Boldin, M. P., Kovalenko, A. V., and Wallach, D. (1997) Nature 385, 540-544
12. Nakano, H., Shindo, M., Sakon, S., Nishinaka, S., Mihara, M., Yagita, H., and Okumura, K. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 3537-3542
13. Maniatis, T. (1997) Science 278, 818-819
14. King, L. A., and Possee, R. D. (1992) The Baculovirus Expression System: A Laboratory Guide, Chapman and Hall Ltd., London
15. Novy, R., Yaeger, K., Berg, J., and Mierendorf, R. (1995) inNovations 3, 9-11
16. LaVille, E. R., DiBlasio, E. A., Koviac, S., Grant, K. L., Schendel, P. F., and McCoy, J. M. (1993) Bio/Technology 11, 187-193
17. Burke, J. R., Miller, K. R., Wood, M. K., and Meyers, C. A. (1998) J. Biol. Chem. 273, 12041-12046
18. Copeland, R. A. (1996) Enzymes, pp. 265-268, VCH Publishers, Inc., New York
19. Bhatnagar, D., Roskoski, R. J., Rosendahl, M. S., and Leonard, N. J. (1983) Biochemistry 22, 6310-6317
20. LoGrasso, P. V., Frantz, B., Rolando, A. M., O'Keefe, S. J., Hermes, J. D., and O'Neil, E. A. (1997) Biochemistry 36, 10422-10427
21. Yin, M. J., Christerson, L. B., Yamamoto, Y., Kwak, Y., Xu, S., Mercurio, F., Barbosa, M., Cobb, M. H., and Gaynor, R. B. (1998) Cell 93, 875-884
22. Ling, L., Cao, Z., and Goeddel, D. V. (1998) Proc. Natl. Acad. Sci. V. S. A. 95, 3792-3797