A molecular mechanism of enantiorecognition of tertiary alcohols by carboxylesterases

ChemBioChem

Volumn 4, Issue 6, 2003, Pages 485-493

  Henke, Erik ^a   Bornscheuer, Uwe T ^b   Schmid, Rolf D ^a   Pleiss, Jürgen ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

^b UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Enantioselectivity; Enzyme catalysis; Molecular modeling; Protein design; Tertiary alcohols

Indexed keywords

2 PHENYL 3 BUTIN 2 YL ACETATE; 4 NITROBENZYLESTERASE; ACETIC ACID DERIVATIVE; ACETYLCHOLINESTERASE; ALANINE; ALCOHOL DERIVATIVE; AMINO ACID; CARBOXYLESTERASE; ESTERASE; LINALOOL; LINALYL ACETATE; METHYL 1 PENTIN 1 YL ACETATE; TERTIARY ALCOHOL; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CATALYSIS; CATALYST; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; MOLECULAR MODEL; MOLECULAR RECOGNITION; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN MOTIF;

ALCOHOLS; BACILLUS SUBTILIS; BINDING SITES; CARBOXYLIC ESTER HYDROLASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

BACILLUS SUBTILIS;

EID: 0038236305     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200200518     Document Type: Article

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