Investigation of the covalent modification of the catalytic triad of human cytomegalovirus protease by pseudo-reversible β-lactam inhibitors and a peptide chloromethylketone

Journal of Mass Spectrometry

Volumn 33, Issue 12, 1998, Pages 1246-1255

  Haley, Terry M ^a   Angier, S Jane ^a   Borthwick, Alan D ^a   Montgomery, Douglas S ^a   Purvis, Ian J ^a   Smart, Devi H ^a   Bessant, Christina ^a   Van Wely, Cathy ^a   Hart, Graham J ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

lactam; Acylenzyme; Chloromethylketone; Human cytomegalovirus protease; Mass spectrometry

Indexed keywords

ACETONE; BETA LACTAM; PROTEINASE; SERINE; TRYPSIN;

ACYLATION; ARTICLE; COVALENT BOND; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN CYTOMEGALOVIRUS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PEPTIDE MAPPING; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STOICHIOMETRY; TANDEM MASS SPECTROMETRY; TIME;

AMINO ACID CHLOROMETHYL KETONES; AMINO ACID SEQUENCE; BASE SEQUENCE; BETA-LACTAMS; CATALYTIC DOMAIN; CHROMATOGRAPHY, LIQUID; CLONING, MOLECULAR; CYTOMEGALOVIRUS; DNA, VIRAL; HUMANS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEASE INHIBITORS; SACCHAROMYCES CEREVISIAE; SERINE ENDOPEPTIDASES; TRYPSIN;

HUMAN HERPESVIRUS 5;

EID: 0032432105     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9888(199812)33:12<1246::AID-JMS743>3.0.CO;2-E     Document Type: Article

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