The role of class I HLH genes in neural development - Have they been overlooked?

BioEssays

Volumn 25, Issue 7, 2003, Pages 709-716

  Heng, Julian Ik Tsen ^a   Tan, Seong Seng ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; HELIX LOOP HELIX PROTEIN; NERVE CELL ADHESION MOLECULE;

ARTICLE; CELL COMMUNICATION; DIMERIZATION; DNA BINDING; DOWN REGULATION; DROSOPHILA; GENE FUNCTION; HUMAN; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROBIOLOGY; NEUROTRANSMISSION; NONHUMAN; PHENOTYPIC VARIATION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; TRANSCRIPTION REGULATION;

ANIMALS; BRAIN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HELIX-LOOP-HELIX MOTIFS; HUMANS; MODELS, GENETIC; MODELS, NEUROLOGICAL; NEURONS;

HOMO;

EID: 0038166946     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.10299     Document Type: Article

References (79)

1. Massari ME, Murre C. Helix-loop-helix proteins: regulators of transcription in eukaryotic organisms. Mol Cell Biol 2000;20:429-440.
2. Schuurmans C, Guillemot F. Molecular mechanisms underlying cell fate specification in the developing telencephalon. Curr Opin Neurobiol 2002; 12:26-34.
3. Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science 1999;284:770-776.
4. Bertrand N, Castro DS, Guillemot F. Proneural genes and the specification of neural cell types. Nat Rev Neurosci 2002;3:517-530.
5. Murre C, Bain G, van Dijk MA, Engel I, Furnari BA, Massari ME, Matthews JR, Quong MW, Rivera RR, Stuiver MH. Structure and function of helix-loop-helix proteins Biochim Biophys Acta 1994;1218:129-135.
6. Littlewood TD, Evan GI. 1998. Helix-Loop-Helix Transcription Factors, 3rd ed., New York: Oxford University Press, Oxford.
7. Moore AW, Barbel S, Jan LY, Jan YN. A genomewide survey of basic helix-loop-helix factors in Drosophila. Proc Natl Acad Sci USA 2000;97: 10436-10441.
8. Peyrefitte S, Kahn D, Haenlin M. New members of the Drosophila Myc transcription factor subfamily revealed by a genome-wide examination for basic helix-loop-helix genes. Mech Dev 2001;104:99-104
9. Atchley WR, Fitch WM. A natural classification of the basic helix-loop-helix class of transcription factors. Proc Natl Acad Sci USA 1997;94: 5172-5176.
10. Atchley WR, Wollenberg KR, Fitch WM, Terhalle W, Dress AW. Correlations among amino acid sites in bHLH protein domains: an information theoretic analysis. Mol Biol Evol 2000;17:164-178.
11. Norton JD. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. J Cell Sci 2000;113:3897-3905
12. Kageyama R, Ishibashi M, Takebayashi K, Tomita K. bHLH transcription factors and mammalian neuronal differentiation. Int J Biochem Cell Biol 1997;29:1389-1399.
13. Jarman AP, Sun Y, Jan LY, Jan YN. Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors. Development 1995;121:2019-2030.
14. Ghysen A, Dambly-Chaudiere C. From DNA to form: the achaete-scute complex. Genes Dev 1988;2:495-501.
15. Wainwright SM, Ish-Horowicz D. Point mutations in the Drosophila hairy gene demonstrate in vivo requirements for basic, helix-loop-helix, and WRPW domains. Mol Cell Biol 1992;12:2475-2483.
16. Lyden D, et al. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts [see comments]. Nature 1999; 401:670-677.
17. Ishibashi M, Ang SL, Shiota K, Nakanishi S, Kageyama R, Guillemot F. Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev 1995;9:3136-3148.
18. Cau E, Gradwohl G, Casarosa S, Kageyama R, Guillemot F. Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium. Development 2000;127:2323-2332.
19. Hassa B, Vaessin H. Daughterless is required for the expression of cell cycle genes in peripheral nervous system precursors of Drosophila embryos. Dev Genet 1997;21:117-122.
20. Vaessin H, Brand M, Jan LY, Jan YN. Daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo. Development 1994;120:935-945.
21. Moore AW, Jan LY, Jan YN. Hamlet, a binary genetic switch between single- and multiple-dendrite neuron morphology. Science 2002;297: 1355-1358.
22. Smith JE 3rd, Cronmiller C. The Drosophila daughterless gene autoregulates and is controlled by both positive and negative cis regulation. Development 2001;128:4705-4714
23. Portman DS, Emmons SW. The basic helix-loop-helix transcription factors LIN-32 and HLH-2 function together in multiple steps of a C. elegans neuronal sublineage. Development 2000;127:5415-5426.
24. Krause M, Park M, Zhang JM, Yuan J, Harfe B, Xu SQ, Greenwald I, Cole M, Paterson B, Fire A. A C. elegans E/Daughterless bHLH protein marks neuronal but not striated muscle development. Development 1997;124: 2179-2189.
25. Murre C, et al. Interactions between heterologous helix-loop -helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 1989;58:537-544.
26. Henthorn P, Kiledjian M, Kadesch T. Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif. Science 1990;247:467-470.
27. Soosaar A, Chiaramello A, Zuber MX, Neuman T. Expression of basic helix-loop-helix transcription factor ME2 during brain development and in the regions of neuronal plasticity in the adult brain. Brain Res Mol Brain Res 1994;25:176-180.
28. Hu JS, Olson EN, Kingston RE. HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors. Mol Cell Biol 1992;12:1031-1042.
29. Chiaramello A, Soosaar A, Neuman T, Zuber MX. Differential expression and distinct DNA-binding specificity of ME1a and ME2 suggest a unique role during differentiation and neuronal plasticity. Brain Res Mol Brain Res 1995;29:107-118.
30. Neuman T, Keen A, Knapik E, Shain D, Ross M, Nornes HO, Zuber MX. ME1 and GE1: basic helix-loop-helix transcription factors expressed at high levels in the developing nervous system and in morphogenetically active regions. Eur J Neurosci 1993;5:311-318.
31. Murre C, McCaw PS, Baltimore D. A new DNA binding and dimerisation motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 1989;56:777-783.
32. Goldfarb AN, Lewandowska K, Pennell CA. Identification of a highly conserved module in E proteins required for in vivo helix-loop -helix dimerisation. J Biol Chem 1998;273:2866-2873.
33. Quong MW, Romanow WJ, Murre C. E protein function in lymphocyte development Annu Rev Immunol 2002;20:301-322.
34. Rivera R, Murre C. The regulation and function of the Id proteins in lymphocyte development. Oncogene 2001;20:8308-8316.
35. Engel I, Murre C, The function of E- and Id proteins in lymphocyte development. Nat Rev Immunol 2001;1:193-199.
36. Bain G, et al. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 1994;79: 885-892.
37. Zhuang Y, Soriano P, Weintraub H. The helix-loop-helix gene E2A is required for B cell formation. Cell 1994;79:875-884.
38. Zhuang Y, Cheng P, Weintraub H. B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. Mol Cell Biol 1996;16:2898-2905.
39. Bergqvist I, Eriksson M, Saarikettu J, Eriksson B, Corneliussen B, Grundstrom T, Holmberg D. The basic helix-loop-helix transcription factor E2-2 is involved in T lymphocyte development. Eur J Immunol 2000;30:2857-2863.
40. Zhuang Y, Barndt RJ, Pan L, Kelley R, Dai M. Functional replacement of the mouse E2A gene with a human HEB cDNA. Mol Cell Biol 1998;18: 3340-3349.
41. Watada H, Kajimoto Y, Umayahara Y, Matsuoka T, Morishima T, Yamasaki Y, Kawamori R, Kamada T. Ubiquitous, but variable, expression of two alternatively spliced mRNAs encoding mouse homologues of transcription factors E47 and E12. Gene 1995;153:255-259
42. Roberts VJ, Steenbergen R, Murre C. Localization of E2A mRNA expression in developing and adult rat tissues. Proc Natl Acad Sci USA 1993; 90:7583-7587.
43. Alvarez-Buylla A, Garcia-Verdugo JM, Tramontin AD. A unified hypothesis on the lineage of neural stem cells. Nat Rev Neurosci 2001;2:287-293.
44. Deshpande G, Stukey J, Schedl P. Scute (sis-b) function in Drosophila sex determination. Mol Cell Biol 1995;15:4430-4440.
45. Yang D, Lu H, Hong Y, Jinks TM, Estes PA, Erickson JW. Interpretation of X chromosome dose at Sex-lethal requires non-E-box sites for the basic helix-loop-helix proteins SISB and daughterless. Mol Cell Biol 2001;21: 1581-1592.
46. Farah MH, Olson JM, Sucic HB, Hume RI, Tapscott SJ, Turner DL. Generation of neurons by transient expression of neural bHLH proteins in mammalian cells. Development 2000;127:693-702
47. Zhuang Y, Kim CG, Bartelmez S, Cheng P, Groudine M, Weintraub H. Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, or neurogenesis. Proc Natl Acad Sci USA 1992;89:12132-12136.
48. Loveys DA, Streiff MB, Kato GJ. E2A basic helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein. Nucleic Acids Res 1996;24:2813-2820.
49. Pagliuca A, Gallo P, De Luca P, Lania L. Class A helix-loop-helix proteins are positive regulators of several cyclin-dependent kinase inhibitors' promoter activity and negatively affect cell growth. Cancer Res 2000;60:1376-1382
50. Peverali FA, Ramqvist T, Saffrich R, Pepperkok R, Barone MV, Philipson L. Regulation of G1 progression by E2A and Id helix-loop-helix proteins. Embo J 1994;13:4291-4301.
51. Prabhu S, Ignatova A, Park ST, Sun XH. Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins. Mol Cell Biol 1997;17:5888-5896.
52. Sherr CJ, Roberts JM. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 1995;9:1149-1163
53. Elledge SJ. Cell cycle checkpoints: preventing an identity crisis. Science 1996;274:1664-1672.
54. Neuman K, Nornes HO, Neuman T. Helix-loop-helix transcription factors regulate Id2 gene promoter activity FEBS Lett 1995;374:279-283.
55. Larue L, Antos C, Butz S, Huber O, Delmas V, Dominis M, Kemler R. A role for cadherins in tissue formation. Development 1996;122:3185-3194
56. Redies C. Cadherins in the central nervous system. Prog Neurobiol 2000;61:611-648.
57. Perez-Moreno MA, Locascio A, Rodrigo I, Dhondt G, Portillo F, Nieto MA, Cano A. A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions. J Biol Chem 2001;276: 27424-27431.
58. Johnson JE, Birren SJ, Saito T, Anderson DJ. DNA binding and transcriptional regulatory activity of mammalian achaete-scute homologous (MASH) proteins revealed by interaction with a muscle-specific enhancer. Proc Natl Acad Sci USA 1992;89:3596-3600.
59. Shimizu C, Akazawa C, Nakanishi S, Kageyama R. MATH-2, a mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal, is specifically expressed in the nervous system. Eur J Biochem 1995;229:239-248.
60. Peyton M, Stellrecht CM, Naya FJ, Huang HP, Samora PJ, Tsai MJ. BETA3, a novel helix-loop-helix protein, can act as a negative regulator of BETA2 and MyoD-responsive genes. Mol Cell Biol 1996;16:626-633.
61. Sun XH, Copeland NG, Jenkins NA, Baltimore D. Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol 1991;11:5603-5611.
62. Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, Nakanishi S. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev 1992;6:2620-2634.
63. Akazawa C, Sasai Y, Nakanishi S. Kageyama R. Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system. J Biol Chem 1992;267:21879-21885.
64. Gradwohl G, Fode C, Guillemot F. Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors. Dev Biol 1996;180:227-241.
65. Kho CJ, Huggins GS, Endege WO, Hsieh CM, Lee ME, Haber E. Degradation of E2A proteins through a ubiquitin-conjugating enzyme, UbcE2A. J Biol Chem 1997;272:3845-3851.
66. Loveys DA, Streiff MB, Schaefer TS, Kato GJ. The mUBC9 murine ubiquitin conjugating enzyme interacts with the E2A transcription factors. Gene 1997;201:169-177.
67. Ma Q, Kintner C, Anderson DJ. Identification of neurogenin, a vertebrate neuronal determination gene. Cell 1996;87:43-52.
68. Sommer L, Ma Q, Andersen DJ. Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol Cell Neurosci 1996;8:221-241.
69. Lee JE. Basic helix-loop-helix genes in neural development. Curr Opin Neurobiol 1997;7:13-20
70. Kim M, Gunnersen J, Augustine C, Tan S. Region-specific expression of the helix-loop-helix gene BETA3 in developing and adult brains. Mech Dev 2002;114:125.
71. Heng JI, Tan SS. Cloning and Characterization of GRIPE, a Novel Interacting Partner of the Transcription Factor E12 in Developing Mouse Forebrain. J Biol Chem 2002;277:43152-43159.
72. Fode C, Ma Q, Casarosa S, Ang SL, Anderson DJ, Guillemot F. A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons. Genes Dev 2000;14:67-80.
73. Massari ME, Grant PA, Pray-Grant MG, Berger SL, Workman JL, Murre C. A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex. Mol Cell 1999;4:63-73.
74. Qiu Y, Sharma A, Stein R. p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene. Mol Cell Biol 1998;18:2957-2964
75. Greenbaum S, Zhuang Y. Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system. Proc Natl Acad Sci USA 2002;99:15030-15035.
76. Hallam S, Singer E, Waring D, Jin Y. The C. elegans NeuroD homolog cnd-1 functions in multiple aspects of motor neuron fate specification. Development 2000;127:4239-4252.
77. Wrischnik LA, Kenyon CJ. The role of lin-22, a hairy/enhancer of split homolog, in patterning the peripheral nervous system of C. elegans. Development 1997;124:2875-2888.
78. Casarosa S, Fode C, Guillemot F. Mash1 regulates neurogenesis in the ventral telencephalon. Development 1999;126:525-534.
79. Tomita K, Nakanishi S, Guillemot F, Kageyama R. Mashl promotes neuronal differentiation in the retina. Genes Cells 1996;1:765-774.