Class A helix-loop-helix proteins are positive regulators of several cyclin-dependent kinase inhibitors' promoter activity and negatively affect cell growth

Cancer Research

Volumn 60, Issue 5, 2000, Pages 1376-1382

  Pagliuca, Alfredo ^b   Gallo, Pasquale ^b   De Luca, Pasquale ^a   Lania, Luigi ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b European Institute of Oncology ^*

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; HELIX LOOP HELIX PROTEIN; TRANSCRIPTION FACTOR;

APOPTOSIS; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL GROWTH; GENE EXPRESSION; GENE EXPRESSION REGULATION; GROWTH REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; CELL DIVISION; CELL LINE; CYCLIN-DEPENDENT KINASES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HELIX-LOOP-HELIX MOTIFS; HUMANS; MICE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0034161879     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Kageyama, R., Ishibashi, M., Takebayashi, K., and Tomita, K. bHLH transcription factors and mammalian neuronal differentiation. Int. J. Biochem. Cell Biol., 29: 1389-1399, 1997.
2. Arnold, H. H., and Winter, B. Muscle differentiation: more complexity to the network of myogenic regulators. Curr. Opin. Genet. Dev., 8: 539-544, 1998.
3. Skerjanc, I. S., Truong, J., Filion, P., and McBurney, M. W. A splice variant of the ITF-2 transcript encodes a transcription factor that inhibits MyoD activity. J. Biol. Chem., 271: 3555-3561, 1996.
4. Zhang, Y., Babin, J., Feldhaus, A. L., Singh, H., Sharp, P. A., and Bina, M. HTF4: a new human helix-loop-helix protein. Nucleic Acids Res., 19: 4555-4558, 1991.
5. Murre, C., McCaw, P. S., and Baltimore. D. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell, 56: 777-783, 1989.
6. Lassar, A. B., Buskin, J. N., Lockshon, D., Davis, R. L., Apone, S., Hauschka, S. D., and Weintraub, H. MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer. Cell, 58: 823-831, 1989.
7. Lee, J. E., Hollenberg, S. M., Snider, L., Turner, D. L., Lipnick, N., and Weintraub, H. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science (Washington DC), 268: 836-844, 1995.
8. Aplan, P. D., Nakahara, K., Orkin, S. H., and Kirsch, I. R. The SCL gene product: a positive regulator of erythroid differentiation. EMBO J., 11: 4073-4081, 1992.
9. Saisanit, S., and Sun, X. H. A novel enhancer, the pro-B enhancer, regulates Idl gene expression in progenitor B cells. Mol. Cell. Biol., 15: 1513-1521, 1995.
10. Naya, F. J., Stellrecht, C. M., and Tsai, M. J. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev., 9: 1009-1019, 1995.
11. Weintraub, H., Genetta, T., and Kadesch, T. Tissue-specific gene activation by MyoD: determination of specificity by cis-acting repression elements. Genes Dev., 8: 2203-2211, 1994.
12. Benezra, R., Davis, R. L., Lockshon, D., Turner, D. L., and Weintraub, H. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell, 61: 49-59, 1990.
13. Christy, B. A., Sanders, L. K., Lau, L. F., Copeland, N. G., Jenkins, N. A., and Nathans, D. An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene. Proc. Natl. Acad. Sci. USA, 88: 1815-1819, 1991.
14. Ellmeier, W., Aguzzi, A., Kleiner, E., Kurzbauer, R., and Weith, A. Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development. EMBO J., 11: 2563-2571, 1992.
15. Hara, E., Yamaguchi, T., Nojima, H., Ide, T., Campisi, J., Okayama, H., and Oda, K. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. J. Biol. Chem., 269: 2139-2145, 1994.
16. Pagliuca, A., Bartoli, P. C., Saccone, S., Della Valle, G., and Lania, L. Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22. Genomics, 27: 200-203, 1995.
17. Riechmann, V., van Cruchten, I., and Sablitzky, F. The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3. Nucleic Acids Res., 22: 749-755, 1994.
18. Deed, R. W., Bianchi, S. M., Atherton, G. T., Johnston, D., Santibanez-Koref, M., Murphy, J. J., and Norton, J. D. An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types Oncogene, 8: 599-607, 1993.
19. Biggs, J., Murphy, E. V., and Israel, M. A. A human Id-like helix-loop-helix protein expressed during early development. Proc. Natl. Acad. Sci. USA, 89: 1512-1516, 1992.
20. Sun, X. H., Copeland, N. G., Jenkins, N. A., and Baltimore, D. Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol. Cell. Biol., 11: 5603-5611, 1991.
21. Kawaguchi, N., DeLuca, H. F., and Noda, M. Id gene expression and its suppression by 1,25-dihydroxyvitamin D3 in rat osteoblastic osteosarcoma cells. Proc. Natl. Acad. Sci. USA, 89: 4569-4572, 1992.
22. Kreider, B. L., Benezra, R., Rovera, G., and Kadesch, T. Inhibition of myeloid differentiation by the helix-loop-helix protein Id. Science (Washington DC), 255: 1700-1702, 1992.
23. Peverali, F. A., Ramqvist, T., Saffrich, R., Pepperkok, R., Barone, M. V., and Philipson, L. Regulation of G1 progression by E2A and Id helix-loop-helix proteins. EMBO J., 13: 4291-4301, 1994.
24. Iavarone, A., Garg, P., Lasorella, A., Hsu, J., and Israel, M. A. The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. Genes Dev., 8: 1270-1284, 1994.
25. Ishiguro, A., Spinn, K. S., Shiohara, M., Tobler, A., Gombart, A. F., Israel, M. A., Norton, J. D., and Koeffler, H. P. Id2 expression increases with differentiation of human myeloid cells. Blood. 87: 5225-5231, 1996.
26. Chen, H., Weng, Y. C., Schatteman, G. C., Sanders, L., Christy, R J., and Christy, B. A. Expression of the dominant-negative regulator Id4 is induced during adipocyte differentiation. Biochem. Biophys. Res. Commun., 256: 614-619, 1999.
27. Florio, M., Hernandez, M. C., Yang, H., Shu, H. K., Cleveland, J. L., and Israel, M. A. Id2 promotes apoptosis by a novel mechanism independent of dimerization to basic helix-loop-helix factors. Mol. Cell. Biol., 18: 5435-5444, 1998.
28. Zhuang, Y., Soriano, P., and Weintraub, H. The helix-loop-helix gene E24 is required for B cell formation. Cell, 79: 875-884, 1994.
29. Yan, W., Young, A. Z., Soares, V. C., Kelley, R., Benezra, R., and Zhuang, Y. High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice. Mol. Cell. Biol., 17: 7317-7327, 1997.
30. Barone, M. V., Pepperkok. R., Peverali, F. A., and Philipson, L. Id proteins control growth induction in mammalian cells. Proc. Natl. Acad. Sci. USA, 91: 4985-4988, 1994.
31. Engel, I., and Murre, C. Ectopic expression of E47 or E12 promotes the death of E2A-deficient lymphomas. Proc. Natl. Acad. Sci. USA, 96: 996-1001, 1999.
32. Park, S. T., Nolan, G. P., and Sun, X. H. Growth inhibition and apoptosis due to restoration of E2A activity in T cell acute lymphoblastic leukemia cells. J. Exp. Med., 189: 501-508, 1999.
33. Prabhu, S., Ignatova, A., Park, S. T., and Sun, X. H. Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins. Mol. Cell. Biol., 17: 5888-5896, 1997.
34. Pagliuca, A., Cannada-Bartoli, P., and Lania, L. A role for Sp and helix-loop-helix transcription factors in the regulation of the human Id4 gene promoter activity. J. Biol. Chem., 273: 7668-7674, 1998.
35. Di Rocco, G., Pennuto, M., Illi, B., Canu, N., Filocamo, G., Trani, E., Rinaldi, A. M., Possenti, R., Mandolesi, G., Sirinian, M. I., Jucker, R., Levi, A., and Nasi, S. Interplay of the E box, the cyclic AMP response element, and HTF4/HEB in transcriptional regulation of the neurospecific, neurotrophin-inducible vgf gene. Mol. Cell. Biol., 17: 1244-1253, 1997.
36. Deed, R. W., Hara, E., Atherton. G. T., Peters, G., and Norton, J. D. Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation. Mol. Cell. Biol., 17: 6815-6821, 1997.
37. Hara, E., Hall, M., and Peters, G. Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors. EMBO J., 16: 332-342, 1997.
38. Hara, E., Smith, R., Parry, D., Tahara, H., Stone, S., and Peters, G. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol. Cell. Biol., 16: 859-867, 1996.
39. Kinsella, T., and Nolan, G. P. Episomal vectors rapidly and stably produce high-tiler recombinant retrovirus. Hum. Gene Ther., 7: 1405-1413, 1996.
40. Lamm, G. M., Steinlein, P., Cotton, M., and Christofori, G. A rapid, quantitative and inexpensive method for detecting apoptosis by flow cytometry in transiently transfected cells. Nucleic Acids Res., 25: 4855-4857, 1997.
41. Kowalik, T. F., De Gregon, J., Schwarz, K., and Nevins, J. R. E2F-1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J. Virol., 69: 2491-2500, 1995.
42. Sofer-Levi, Y., and Resnitzky, D. Apoptosis induced by ectopic overexpression of cyclin D1 but not cyclin E. Oncogene, 13: 2431-2437, 1996.
43. Norton, J. D., and Atherton, G. T. Coupling of cell growth and apoptosis functions of Id proteins. Mol. Cell. Biol., 18: 2321-2381, 1998.
44. Park, S. T., and Sun, X. H. The Tall oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition. J. Biol. Chem., 273: 7030-7037, 1998.