Dioxolane guanosine 5′-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase: Steady state and pre-steady state kinetic analyses

Journal of Biological Chemistry

Volumn 278, Issue 21, 2003, Pages 18971-18979

  Jeffrey, Jerry L ^a,c   Feng, Joy Y ^a   Qi, C C Richard ^a,d   Anderson, Karen S ^b   Furman, Phillip A ^a,e  

^a Triangle Pharmaceuticals   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GLAXOSMITHKLINE   (United States)

^d Clinical Data Inc   (United States)

^e Furman Consulting Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DRUG PRODUCTS; ENZYME INHIBITION; PHOSPHATES;

DRUG RESISTANCE;

VIRUSES;

1,3 DIOXOLANE DERIVATIVE; AMDOXOVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; 2'-DEOXYGUANOSINE 5'-PHOSPHATE; 3'-AZIDO-3'-DEOXYTHYMIDINE 5'-TRIPHOSPHATE; CYTIDINE TRIPHOSPHATE; DEOXYCYTIDINE PHOSPHATE; DEOXYGUANOSINE PHOSPHATE; DIOXOLANE GUANOSINE; DIOXOLANE GUANOSINE 5' TRIPHOSPHATE; DIOXOLANE GUANOSINE 5'-TRIPHOSPHATE; DRUG DERIVATIVE; GUANOSINE; GUANOSINE TRIPHOSPHATE; LAMIVUDINE; LAMIVUDINE TRIPHOSPHATE; PYRIMIDINE NUCLEOTIDE; RNA DIRECTED DNA POLYMERASE; THYMIDINE PHOSPHATE; VIRUS DNA; ZIDOVUDINE; ZIDOVUDINE 5' TRIPHOSPHATE;

ARTICLE; CATALYSIS; CATALYST; CELL CULTURE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; KINETICS; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; STRUCTURE ANALYSIS; VIRUS MUTATION; ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIBIOTIC RESISTANCE; BIOSYNTHESIS; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METABOLISM; MUTATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

ACQUIRED IMMUNODEFICIENCY SYNDROME; CYTIDINE TRIPHOSPHATE; DEOXYCYTIDINE MONOPHOSPHATE; DEOXYGUANINE NUCLEOTIDES; DIOXOLANES; DNA, VIRAL; DRUG RESISTANCE, VIRAL; GUANOSINE; GUANOSINE TRIPHOSPHATE; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; LAMIVUDINE; MUTATION; REVERSE TRANSCRIPTASE INHIBITORS; SUBSTRATE SPECIFICITY; THYMIDINE MONOPHOSPHATE; THYMINE NUCLEOTIDES; ZIDOVUDINE;

EID: 0038143190     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M210113200     Document Type: Article

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