메뉴 건너뛰기




Volumn 24, Issue 3, 2003, Pages 295-301

An introduction to telomeres and telomerase

Author keywords

Cancer marker; Cancer therapy; Immortalization; Telomerase; Telomeres

Indexed keywords

ANTINEOPLASTIC AGENT; TELOMERASE; TELOMERASE INHIBITOR;

EID: 0038115346     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1385/MB:24:3:295     Document Type: Review
Times cited : (12)

References (85)
  • 1
    • 0025731583 scopus 로고
    • Structure and function of telomeres
    • Blackburn, E.H. (1991). Structure and function of telomeres. Nature 350, 569-573.
    • (1991) Nature , vol.350 , pp. 569-573
    • Blackburn, E.H.1
  • 2
    • 0024788528 scopus 로고
    • Structure and function of telomeres
    • Zakian, V.A. (1989). Structure and function of telomeres. Ann. Rev. Gene. 23, 579-604.
    • (1989) Ann. Rev. Gene. , vol.23 , pp. 579-604
    • Zakian, V.A.1
  • 3
    • 0013462065 scopus 로고
    • A highly conserved repetitive DNA sequence (TTAG GG)n, present at the telomeres of human chromosomes
    • Moyzis, R.K, Buckingham JM, Cram L.S., et al. (1988). A highly conserved repetitive DNA sequence (TTAG GG)n, present at the telomeres of human chromosomes. Proc. Natl. Acad. Sci. USA 85, 6622-6626.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 6622-6626
    • Moyzis, R.K.1    Buckingham, J.M.2    Cram, L.S.3
  • 4
    • 0024561587 scopus 로고
    • Molecular cloning of human telomeres in yeast
    • Brown, W.R.A. (1989). Molecular cloning of human telomeres in yeast. Nature 338, 774-776.
    • (1989) Nature , vol.338 , pp. 774-776
    • Brown, W.R.A.1
  • 5
    • 0024535443 scopus 로고
    • Cloning of human telomeres by complementation in yeast
    • Cross, S.H., Allshire, R.C., McKay, S.J., et al. (1989). Cloning of human telomeres by complementation in yeast. Nature 338, 771-774.
    • (1989) Nature , vol.338 , pp. 771-774
    • Cross, S.H.1    Allshire, R.C.2    McKay, S.J.3
  • 6
    • 0025115349 scopus 로고
    • Structure and variability of human chromosome ends
    • de Lange, T., Shiue, L., Myers, R.M., et al. (1990). Structure and variability of human chromosome ends. Mol. Cell Biol. 10, 518-527.
    • (1990) Mol. Cell Biol. , vol.10 , pp. 518-527
    • De Lange, T.1    Shiue, L.2    Myers, R.M.3
  • 7
    • 0025143252 scopus 로고
    • Telomere reduction in human colorectal carcinoma and with ageing
    • Hastie, N.D., Dempster, M., Dunlop, M.G., et al. (1990). Telomere reduction in human colorectal carcinoma and with ageing. Nature 346, 866-868.
    • (1990) Nature , vol.346 , pp. 866-868
    • Hastie, N.D.1    Dempster, M.2    Dunlop, M.G.3
  • 8
    • 0002373792 scopus 로고
    • (Blackburn, E.H. and Greider, C. W., eds.) Cold Spring Harbour Laboratory Press, Cold Spring Harbor, NY
    • Henderson, E. (1995) in Telomeres. (Blackburn, E.H. and Greider, C. W., eds.) Cold Spring Harbour Laboratory Press, Cold Spring Harbor, NY, pp. 11-34,
    • (1995) Telomeres , pp. 11-34
    • Henderson, E.1
  • 9
    • 0023034140 scopus 로고
    • Variability at the telomeres of the human X/Y pseudoautosomal region
    • Cooke, H.J. and Smith, B.A. (1986). Variability at the telomeres of the human X/Y pseudoautosomal region. Cold Spring Harb. Symp. Quant. Biol. 51, 213-219.
    • (1986) Cold Spring Harb. Symp. Quant. Biol. , vol.51 , pp. 213-219
    • Cooke, H.J.1    Smith, B.A.2
  • 10
    • 0029040101 scopus 로고
    • Developmental and tissue specific regulation of mouse telomerse and telomere length
    • Prowse, K.R. and Greider, C.W. (1995). Developmental and tissue specific regulation of mouse telomerse and telomere length. Proc. Natl. Acad. Sci. USA 92, 4818-4822.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4818-4822
    • Prowse, K.R.1    Greider, C.W.2
  • 11
    • 0024362809 scopus 로고
    • Human telomeres contain at least three types of G-rich repeats distributed non-randomly
    • Allshire, R.C., Dempster, M., and Hastie, N.D. (1989). Human telomeres contain at least three types of G-rich repeats distributed non-randomly. Nucleic Acid Res. 17, 4611-4627
    • (1989) Nucleic Acid Res. , vol.17 , pp. 4611-4627
    • Allshire, R.C.1    Dempster, M.2    Hastie, N.D.3
  • 13
    • 0030006735 scopus 로고    scopus 로고
    • In situ analysis of changes in telomere size during replicative ageing and cell transformation
    • Henderson, S., Allsopp, R., Spector, D., et al. (1996). In situ analysis of changes in telomere size during replicative ageing and cell transformation. J. Biol. Chem. 134, 1-12.
    • (1996) J. Biol. Chem. , vol.134 , pp. 1-12
    • Henderson, S.1    Allsopp, R.2    Spector, D.3
  • 14
    • 0029810884 scopus 로고    scopus 로고
    • Telomerase regulation during entry into the cell cycle in normal human T cells
    • Buchkovich, K.J. and Greider, C.W. (1996). Telomerase regulation during entry into the cell cycle in normal human T cells. Mol. Biol. Cell 134, 1443-1454
    • (1996) Mol. Biol. Cell , vol.134 , pp. 1443-1454
    • Buchkovich, K.J.1    Greider, C.W.2
  • 15
    • 0032489351 scopus 로고    scopus 로고
    • Reversing time: Origin of telomerase
    • Nakamura, T.M. and Cech, T.R. (1998). Reversing time: origin of telomerase. Cell 92, 587-590.
    • (1998) Cell , vol.92 , pp. 587-590
    • Nakamura, T.M.1    Cech, T.R.2
  • 16
    • 0029894199 scopus 로고    scopus 로고
    • Regulated expression of telomerase activity in human T lymphocyte development and activation
    • Weng, N.P., Levine, B.L., June, C.H., and Hodes, R.J. (1996). Regulated expression of telomerase activity in human T lymphocyte development and activation. J. Exp. Med. 183, 2471-2479.
    • (1996) J. Exp. Med. , vol.183 , pp. 2471-2479
    • Weng, N.P.1    Levine, B.L.2    June, C.H.3    Hodes, R.J.4
  • 17
    • 0029973653 scopus 로고    scopus 로고
    • Regulation of telomerase activity in immortl cell lines
    • Holt, S.E., Wright, W.E., and Shay, J.W. (1996). Regulation of telomerase activity in immortl cell lines. Mol. Cell Biol. 16, 2932-2939.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 2932-2939
    • Holt, S.E.1    Wright, W.E.2    Shay, J.W.3
  • 18
    • 0031816339 scopus 로고    scopus 로고
    • Telomerase in cancer: Diagnostic, prognostic and therapeutic implications
    • Shay, J.W. (1998). Telomerase in cancer: Diagnostic, prognostic and therapeutic implications. Cancer J. Sci. Am.4, S1, S26-S34.
    • (1998) Cancer J. Sci. Am. , vol.4 S1
    • Shay, J.W.1
  • 19
    • 0033901748 scopus 로고    scopus 로고
    • Telomere length in male germ cells is inversely correlated with telomerase activity
    • Achi, M.V., Ravindranath, N., and Dym, M. (2000). Telomere length in male germ cells is inversely correlated with telomerase activity. Biol. Reprod. 63, 591-598.
    • (2000) Biol. Reprod. , vol.63 , pp. 591-598
    • Achi, M.V.1    Ravindranath, N.2    Dym, M.3
  • 20
    • 0030659644 scopus 로고    scopus 로고
    • Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
    • Weinrich, S.I., Pruzan, R., Ma, L., et al. (1997). Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 17, 498-502.
    • (1997) Nat. Genet. , vol.17 , pp. 498-502
    • Weinrich, S.I.1    Pruzan, R.2    Ma, L.3
  • 21
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in tetrahymena extracts
    • Greider, C.W. and Blackburn, E.H. (1985). Identification of a specific telomere terminal transferase activity in tetrahymena extracts. Cell 43, 405-413.
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 22
    • 0025021235 scopus 로고
    • Functional evidence for an RNA template in telomerase
    • Shippen-Lentz, D. and Blackburn, E.H. (1990). Functional evidence for an RNA template in telomerase. Science 269, 546-552.
    • (1990) Science , vol.269 , pp. 546-552
    • Shippen-Lentz, D.1    Blackburn, E.H.2
  • 23
    • 0029154735 scopus 로고
    • Functional characterization and developmental regulation of mouse telomerase RNA
    • Blasco, M.A., Funk, W., Villeponteau. B., and Greider, C.W. (1995). Functional characterization and developmental regulation of mouse telomerase RNA. Science 269, 1267-1270.
    • (1995) Science , vol.269 , pp. 1267-1270
    • Blasco, M.A.1    Funk, W.2    Villeponteau, B.3    Greider, C.W.4
  • 24
    • 0029096515 scopus 로고
    • The RNA component of human telomerase
    • Feng, J., Funk, W.D., Wang, S.S., et al. (1995). The RNA component of human telomerase. Science 269, 1236-1241.
    • (1995) Science , vol.269 , pp. 1236-1241
    • Feng, J.1    Funk, W.D.2    Wang, S.S.3
  • 25
    • 0030819894 scopus 로고    scopus 로고
    • Telomerase catalytic subunit homologs from fission yeast and human
    • Nakamura, T.M., Morin, G.B., Chapman, K.B., et al. (1997). Telomerase catalytic subunit homologs from fission yeast and human. Science 277, 955-959.
    • (1997) Science , vol.277 , pp. 955-959
    • Nakamura, T.M.1    Morin, G.B.2    Chapman, K.B.3
  • 26
    • 0030892905 scopus 로고    scopus 로고
    • Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancer
    • Soder, A.I., Hoare, S.R., Muir, S., et al. (1997). Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancer. Oncogene 14, 1013-1021.
    • (1997) Oncogene , vol.14 , pp. 1013-1021
    • Soder, A.I.1    Hoare, S.R.2    Muir, S.3
  • 27
    • 0031569813 scopus 로고    scopus 로고
    • Mapping of the gene for the mouse telomerase RNA component, Terc, to chromosome 3 by fluorescence in situ hybridization and mouse chromosome painting
    • Soder, A.I., Hoare, S.F., Muire, S., et al. (1997). Mapping of the gene for the mouse telomerase RNA component, Terc, to chromosome 3 by fluorescence in situ hybridization and mouse chromosome painting. Genomics 41, 293-294.
    • (1997) Genomics , vol.41 , pp. 293-294
    • Soder, A.I.1    Hoare, S.F.2    Muire, S.3
  • 28
    • 0030938901 scopus 로고    scopus 로고
    • Reverse transcriptase motifs in the catalytic subunit of telomerase
    • Lingner, J., Hughes, T.R., Shevchenko, A., et al. (1997). Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276, 561-567.
    • (1997) Science , vol.276 , pp. 561-567
    • Lingner, J.1    Hughes, T.R.2    Shevchenko, A.3
  • 29
    • 0030745448 scopus 로고    scopus 로고
    • hEST2, the putative human telomerase catalytic subunit gene, is upregulated in tumor cells and during immortalization
    • Meyerson, M., Counter, C.M., Eaton, E.N., et al. (1997). hEST2, the putative human telomerase catalytic subunit gene, is upregulated in tumor cells and during immortalization. Cell 90, 785-795.
    • (1997) Cell , vol.90 , pp. 785-795
    • Meyerson, M.1    Counter, C.M.2    Eaton, E.N.3
  • 30
    • 0030681073 scopus 로고    scopus 로고
    • Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types
    • Killian, A., Bowtell, D.D.L., Abud, H.E., et al. (1997). Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Human Mol. Genet. 6, 2011-2019.
    • (1997) Human Mol. Genet. , vol.6 , pp. 2011-2019
    • Killian, A.1    Bowtell, D.D.L.2    Abud, H.E.3
  • 31
    • 0031036350 scopus 로고    scopus 로고
    • A mammalian telomerase associated protein
    • Harrington. L., McPhail, T., Mar, V., et al. (1997). A mammalian telomerase associated protein. Science 275, 973-977.
    • (1997) Science , vol.275 , pp. 973-977
    • Harrington, L.1    McPhail, T.2    Mar, V.3
  • 32
    • 0032510333 scopus 로고    scopus 로고
    • Cloning and characterization of human and mouse telomerase RNA gene promoter sequences
    • Zhao, J-.Q., Hoare, S.F., McFarlane, R., et al. (1998). Cloning and characterization of human and mouse telomerase RNA gene promoter sequences. Oncogene 16, 1345-1350.
    • (1998) Oncogene , vol.16 , pp. 1345-1350
    • Zhao, J.-Q.1    Hoare, S.F.2    McFarlane, R.3
  • 33
    • 0035137710 scopus 로고    scopus 로고
    • Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions
    • Bachand, F. and Autexier, C. (2001). Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions. Mol. Cell. Biol. 21, 1888-1897.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1888-1897
    • Bachand, F.1    Autexier, C.2
  • 34
    • 0034523665 scopus 로고    scopus 로고
    • An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity
    • Yi, X.M., White, D.M., Aisner, D.L., et al. (2000). An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity. Neoplasia 2, 433-440.
    • (2000) Neoplasia , vol.2 , pp. 433-440
    • Yi, X.M.1    White, D.M.2    Aisner, D.L.3
  • 35
    • 0034010312 scopus 로고    scopus 로고
    • Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells
    • Koyanagi, Y., Kobayashi, D., Yajima, T., et al. (2000). Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells. Anticancer Res. 20, 773-778.
    • (2000) Anticancer Res. , vol.20 , pp. 773-778
    • Koyanagi, Y.1    Kobayashi, D.2    Yajima, T.3
  • 36
    • 0037913809 scopus 로고    scopus 로고
    • Upregulated telomerase activity and high mRNA lew els of the catalytic telomerase subunit hTERT in Hodgkin and Reed Stemberg cells
    • Krams, M., Claviez, A., Klapper, W., et al. (2000). Upregulated telomerase activity and high mRNA lew els of the catalytic telomerase subunit hTERT in Hodgkin and Reed Stemberg cells. Blood 96, 3142.
    • (2000) Blood , vol.96 , pp. 3142
    • Krams, M.1    Claviez, A.2    Klapper, W.3
  • 38
    • 0031027618 scopus 로고    scopus 로고
    • Control of telomere length by the human telomeric protein TRF1
    • Steensel, van B. and de Lange, T. (1997). Control of telomere length by the human telomeric protein TRF1. Nature 385, 740-743.
    • (1997) Nature , vol.385 , pp. 740-743
    • Van Steensel, B.1    De Lange, T.2
  • 39
    • 0032553473 scopus 로고    scopus 로고
    • Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
    • Smith, S., Giriat, I., Schmitt, A., and de Lange, T. (1998). Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science 282, 1484-7.
    • (1998) Science , vol.282 , pp. 1484-1487
    • Smith, S.1    Giriat, I.2    Schmitt, A.3    De Lange, T.4
  • 40
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end to end fusions
    • Steensel, van B., Smogorzewska, A., and de Lange, T. (1998). TRF2 protects human telomeres from end to end fusions. Cell 92, 401-483.
    • (1998) Cell , vol.92 , pp. 401-483
    • Van Steensel, B.1    Smogorzewska, A.2    De Lange, T.3
  • 41
    • 0034709645 scopus 로고    scopus 로고
    • The 5'-end of hTERT mRNA is a good target for hammerhead ribozyme to suppress telomerase activity
    • Yokoyama, Y., Takahashi, Y., Shinohara, A., et al. (2000). The 5'-end of hTERT mRNA is a good target for hammerhead ribozyme to suppress telomerase activity. Bichem. Biophs. Res. Comm. 273, 316-321.
    • (2000) Bichem. Biophs. Res. Comm. , vol.273 , pp. 316-321
    • Yokoyama, Y.1    Takahashi, Y.2    Shinohara, A.3
  • 42
    • 0025787643 scopus 로고
    • Telomere loss: Mitotic clock or genetic time bomb?
    • Harley, C.B. (1991). Telomere loss: mitotic clock or genetic time bomb? Mutation Res. 256, 271-282.
    • (1991) Mutation Res. , vol.256 , pp. 271-282
    • Harley, C.B.1
  • 43
    • 0026751536 scopus 로고
    • Tetrahymena telomerase RNA levels increase during macronuclear development
    • Avilion, A.A., Harrington, L.A., and Greider, C.W. (1992). Tetrahymena telomerase RNA levels increase during macronuclear development. Dev. Genet. 13, 80-86.
    • (1992) Dev. Genet. , vol.13 , pp. 80-86
    • Avilion, A.A.1    Harrington, L.A.2    Greider, C.W.3
  • 44
    • 0028425458 scopus 로고
    • Accumulation of telomerase RNA and telomere protein transcripts during telomere synthesis in Euplotes
    • Price, C.M., Adams, A.K., and Vermeesch, J.R. (1994). Accumulation of telomerase RNA and telomere protein transcripts during telomere synthesis in Euplotes. J. Eukaryot. Microbio. 41, 267-275.
    • (1994) J. Eukaryot. Microbio. , vol.41 , pp. 267-275
    • Price, C.M.1    Adams, A.K.2    Vermeesch, J.R.3
  • 45
    • 0013351733 scopus 로고    scopus 로고
    • The RNA components of human mouse telomerases
    • Villeponteau, B. (1996). The RNA components of human mouse telomerases. Cell Dev. Biol. 7, 15-21.
    • (1996) Cell Dev. Biol. , vol.7 , pp. 15-21
    • Villeponteau, B.1
  • 46
    • 0030916582 scopus 로고    scopus 로고
    • The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit
    • Bryan, T.M., Marusic, L., Bacchetti, S., et al. (1997). The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit, Human Mol. Genet. 6, 921-926.
    • (1997) Human Mol. Genet. , vol.6 , pp. 921-926
    • Bryan, T.M.1    Marusic, L.2    Bacchetti, S.3
  • 47
    • 0030931491 scopus 로고    scopus 로고
    • Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
    • Blasco, M., Lee, H.-W., Hande, M., et al (1997). Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91, 25-34.
    • (1997) Cell , vol.91 , pp. 25-34
    • Blasco, M.1    Lee, H.-W.2    Hande, M.3
  • 48
    • 0032499210 scopus 로고    scopus 로고
    • Essential role of mouse telomerase in highly proliferative organs
    • Lee, H.-W., Blasco, M.A., Gottlieb, G.J, et al. (1998). Essential role of mouse telomerase in highly proliferative organs. Nature 392, 569-574.
    • (1998) Nature , vol.392 , pp. 569-574
    • Lee, H.-W.1    Blasco, M.A.2    Gottlieb, G.J.3
  • 49
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into no.mal cells
    • Bodnar, A.G., Ouellette, M., Frolkis, M., et al. (1998). Extension of life-span by introduction of telomerase into no.mal cells. Science 279, 349-352.
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1    Ouellette, M.2    Frolkis, M.3
  • 50
    • 0002888471 scopus 로고    scopus 로고
    • Telomere dynamics and telomerase activity in cell senescence and cancer
    • Bacchetti, S. (1996). Telomere dynamics and telomerase activity in cell senescence and cancer. Cell Dev. Biol. 7, 31-39.
    • (1996) Cell Dev. Biol. , vol.7 , pp. 31-39
    • Bacchetti, S.1
  • 51
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay, J.W. and Bacchetti, S. (1997). A survey of telomerase activity in human cancer. Eur. J. Cancer 33, 787-791.
    • (1997) Eur. J. Cancer , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 52
    • 0028564951 scopus 로고
    • Specific association of human telomerase activity with immortal cells and cancer
    • Kim, N.W., Piatyszek, M.A., Prowse, K.R., et al. (1994). Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011-2014.
    • (1994) Science , vol.266 , pp. 2011-2014
    • Kim, N.W.1    Piatyszek, M.A.2    Prowse, K.R.3
  • 53
    • 0035067993 scopus 로고    scopus 로고
    • Telomerase activity and clinical progression in chronic lymphoproliferative disorders of B-cell lineage
    • Ballon, G., Trentin, L., de Rossi, A., and Semenzato, G. (2001). Telomerase activity and clinical progression in chronic lymphoproliferative disorders of B-cell lineage. Leuk. Lymphoma 41, 35.
    • (2001) Leuk. Lymphoma , vol.41 , pp. 35
    • Ballon, G.1    Trentin, L.2    De Rossi, A.3    Semenzato, G.4
  • 54
    • 0034436355 scopus 로고    scopus 로고
    • Comparison of human telomerase reverse transcriptase messenger RNA and telomerase activity as urine markers for diagnosis of bladder carcinoma
    • Bialkowska-Hobrzanska, H., Bowles, L., Bukala, B., et al. (2000). Comparison of human telomerase reverse transcriptase messenger RNA and telomerase activity as urine markers for diagnosis of bladder carcinoma. Mol. Diag 5, 267-277.
    • (2000) Mol. Diag , vol.5 , pp. 267-277
    • Bialkowska-Hobrzanska, H.1    Bowles, L.2    Bukala, B.3
  • 55
    • 0034069940 scopus 로고    scopus 로고
    • Telomerase activity is frequently found in metaplastic and malignant human nasopharyngeal tissues
    • Chang, J.T.C., Liao, C.T., Jung, S.M., et al. (2000). Telomerase activity is frequently found in metaplastic and malignant human nasopharyngeal tissues. Br. J. Cancer 82, 1946-1951.
    • (2000) Br. J. Cancer , vol.82 , pp. 1946-1951
    • Chang, J.T.C.1    Liao, C.T.2    Jung, S.M.3
  • 56
    • 0033660012 scopus 로고    scopus 로고
    • Telomerase activity by TRAP assay and telomerase RNA (hTR) expression are predictive of outcome in neuroblastoma
    • Choi, L.M.R., Kim, N.W., Zuo, J.J., et al. (2000). Telomerase activity by TRAP assay and telomerase RNA (hTR) expression are predictive of outcome in neuroblastoma. Med. Pediatr. Oncol. 35, 647-650.
    • (2000) Med. Pediatr. Oncol. , vol.35 , pp. 647-650
    • Choi, L.M.R.1    Kim, N.W.2    Zuo, J.J.3
  • 57
    • 0034714384 scopus 로고    scopus 로고
    • Telomerase activity as a marker of breast carcinoma in fine- needle aspirated samples
    • Hiyama, E., Saeki, T., Hiyama, K., et al. (2000). Telomerase activity as a marker of breast carcinoma in fine- needle aspirated samples. Cancer Cytopathol. 90, 235-238.
    • (2000) Cancer Cytopathol. , vol.90 , pp. 235-238
    • Hiyama, E.1    Saeki, T.2    Hiyama, K.3
  • 58
    • 0032774031 scopus 로고    scopus 로고
    • Telomerase activity distinguishes between neuroblastomas with good and poor prognosis
    • Poremba, C., Willenbring, H., Hero, B., et al. (1999). Telomerase activity distinguishes between neuroblastomas with good and poor prognosis. Ann. Oncol. 10, 715-721.
    • (1999) Ann. Oncol. , vol.10 , pp. 715-721
    • Poremba, C.1    Willenbring, H.2    Hero, B.3
  • 59
    • 0032915890 scopus 로고    scopus 로고
    • Correlation of telomerase activity with development and progression of adult T-cell leukemia
    • Uchida, N., Otsuka, T., Arima, F., et al. (1999). Correlation of telomerase activity with development and progression of adult T-cell leukemia. Leukemia Res. 23, 311-316.
    • (1999) Leukemia Res. , vol.23 , pp. 311-316
    • Uchida, N.1    Otsuka, T.2    Arima, F.3
  • 60
    • 0037575685 scopus 로고    scopus 로고
    • High tumour telomerase activity correlates with shortened patient survival and more advanced tumour stage in gastric but not in oesophageal adenocarcinoma
    • Usselmann, B., Newbold, M., Morris, A., and Nwokolo, C.U. (2001). High tumour telomerase activity correlates with shortened patient survival and more advanced tumour stage in gastric but not in oesophageal adenocarcinoma. Gut 48, 176.
    • (2001) Gut , vol.48 , pp. 176
    • Usselmann, B.1    Newbold, M.2    Morris, A.3    Nwokolo, C.U.4
  • 61
    • 0033168057 scopus 로고    scopus 로고
    • Telomerase activity and human telomerase reverse transcriptase mRNA expression in soft tissue tumors: Correlation with grade, histology, and proliferative activity
    • Yan, P., Coindre, J.M., Benhattar, J., et al. (1999). Telomerase activity and human telomerase reverse transcriptase mRNA expression in soft tissue tumors: Correlation with grade, histology, and proliferative activity. Cancer Res. 59, 3166-3170.
    • (1999) Cancer Res. , vol.59 , pp. 3166-3170
    • Yan, P.1    Coindre, J.M.2    Benhattar, J.3
  • 62
    • 0034020930 scopus 로고    scopus 로고
    • Expression of telomerase activity and telomerase RNA in human soft tissue sarcomas
    • Yoo, J. and Robinson, R.A. (2000). Expression of telomerase activity and telomerase RNA in human soft tissue sarcomas. Arch. Pathol. Lab. Med. 124, 393-397.
    • (2000) Arch. Pathol. Lab. Med. , vol.124 , pp. 393-397
    • Yoo, J.1    Robinson, R.A.2
  • 63
    • 0032789719 scopus 로고    scopus 로고
    • Change in telomerase activity during human colorectal carcinogenesis
    • Yoshida, R., Kiyozuka, Y., Ichiyoshi, H., et al. (1999). Change in telomerase activity during human colorectal carcinogenesis. Anticancer Res. 19, 2167-2172
    • (1999) Anticancer Res. , vol.19 , pp. 2167-2172
    • Yoshida, R.1    Kiyozuka, Y.2    Ichiyoshi, H.3
  • 65
    • 0034054160 scopus 로고    scopus 로고
    • Limitations of urinary telomerase activity measurement in urothelial cancer
    • Arai, Y., Yajima, T., Yagihashi, A., et al. (2000). Limitations of urinary telomerase activity measurement in urothelial cancer. Clin. Chim. Acta. 296, 35-44.
    • (2000) Clin. Chim. Acta , vol.296 , pp. 35-44
    • Arai, Y.1    Yajima, T.2    Yagihashi, A.3
  • 66
    • 0031932663 scopus 로고    scopus 로고
    • Telomerase expression in normal epthelium, reactive atypia, squamous dysplasia and squamous cell carcinoma of the uterine cervix
    • Shroyer, K.R., Thompson, L.C., Enomoto, T., et al. (1998). Telomerase expression in normal epthelium, reactive atypia, squamous dysplasia and squamous cell carcinoma of the uterine cervix. Am. J. Clin. Patrol. 109, 153-162.
    • (1998) Am. J. Clin. Patrol. , vol.109 , pp. 153-162
    • Shroyer, K.R.1    Thompson, L.C.2    Enomoto, T.3
  • 67
    • 0031895821 scopus 로고    scopus 로고
    • Telomerase activity in the female reproductive tract and neoplasms
    • Yokoyama, Y., Takahashi, Y., Shinohara, A., et al. (1998). Telomerase activity in the female reproductive tract and neoplasms. Gynecol. Oncol. 68, 145-149.
    • (1998) Gynecol. Oncol. , vol.68 , pp. 145-149
    • Yokoyama, Y.1    Takahashi, Y.2    Shinohara, A.3
  • 68
    • 0032057280 scopus 로고    scopus 로고
    • Telomerase activity in malignant and benign bladder conditions
    • Mayfield, M.P., Shah, T., Flannigan, G.M., et al. (1998). Telomerase activity in malignant and benign bladder conditions. Int. J. Mol. Med. 1, 835-840.
    • (1998) Int. J. Mol. Med. , vol.1 , pp. 835-840
    • Mayfield, M.P.1    Shah, T.2    Flannigan, G.M.3
  • 69
    • 0030923688 scopus 로고    scopus 로고
    • Clinical implications of telomerase in cancer
    • Kim, N.W. (1997). Clinical implications of telomerase in cancer. Eur. J. Cancer 33, 781-786.
    • (1997) Eur. J. Cancer , vol.33 , pp. 781-786
    • Kim, N.W.1
  • 70
    • 0032887083 scopus 로고    scopus 로고
    • Telomerase activity and prognosis in primary breast cancers
    • Carey, L.A., Kim, N.W., Goodman, S., et al. (1999). Telomerase activity and prognosis in primary breast cancers. J. Clin. Oncol. 17, 3075-3081.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 3075-3081
    • Carey, L.A.1    Kim, N.W.2    Goodman, S.3
  • 71
    • 0033672470 scopus 로고    scopus 로고
    • Telomere maintenance by recombination in human cells
    • Dunham, M.A., Neumann, A.A., Fasching, C.L., et al. (2000). Telomere maintenance by recombination in human cells. Nat. Genet. 26, 447-450.
    • (2000) Nat. Genet. , vol.26 , pp. 447-450
    • Dunham, M.A.1    Neumann, A.A.2    Fasching, C.L.3
  • 72
    • 0036360313 scopus 로고    scopus 로고
    • Analysis of telomerase RNA gene expression by in situ hybridization
    • (Double, J.A. and Thompson, M.J., eds.) Humana Press, Totowa, NJ
    • Keith, W.N., Sarvesvaran, J., and Downey, M. (2002). Analysis of Telomerase RNA Gene Expression by in situ hybridization. In: Methods in Molecular Biology vol. 191, Telomeres and Telomerase (Double, J.A. and Thompson, M.J., eds.) Humana Press, Totowa, NJ, pp. 65.
    • (2002) Methods in Molecular Biology Vol. 191, Telomeres and Telomerase , vol.191 , pp. 65
    • Keith, W.N.1    Sarvesvaran, J.2    Downey, M.3
  • 73
    • 0036650910 scopus 로고    scopus 로고
    • Immunohistochemical detection of telomerase reverse transcriptase in colorectal adenocarcinoma and benign colonic mucosa
    • Wei, R. and Younes, M., (2002). Immunohistochemical detection of telomerase reverse transcriptase in colorectal adenocarcinoma and benign colonic mucosa. Human Pathol. 33, 693-696.
    • (2002) Human Pathol. , vol.33 , pp. 693-696
    • Wei, R.1    Younes, M.2
  • 74
    • 0037194588 scopus 로고    scopus 로고
    • Identification of serum anti-human telomerase reverse transcriptase (hTERT) auto-antibodies during progrssion to hepatocellular carcinoma
    • Masutomi, K., Kaneko, S., Yasukawa, M., et al. (2002). Identification of serum anti-human telomerase reverse transcriptase (hTERT) auto-antibodies during progrssion to hepatocellular carcinoma. Oncogene 21, 5946-5950.
    • (2002) Oncogene , vol.21 , pp. 5946-5950
    • Masutomi, K.1    Kaneko, S.2    Yasukawa, M.3
  • 75
    • 0035262502 scopus 로고    scopus 로고
    • Telomerase:Biology and phase I trials
    • Kelland, L.R.. (2001) Telomerase:Biology and phase I trials. THE LANCET Oncology 2, 95-101.
    • (2001) THE LANCET Oncology , vol.2 , pp. 95-101
    • Kelland, L.R.1
  • 76
    • 0032828652 scopus 로고    scopus 로고
    • Inhibition of telomerase limits the growth of human cancer cells
    • Hahn, W.C., Stewart, S.A., Brooks, M.W., et al. (1999) Inhibition of telomerase limits the growth of human cancer cells. Nat. Med. 5, 1164-1170.
    • (1999) Nat. Med. , vol.5 , pp. 1164-1170
    • Hahn, W.C.1    Stewart, S.A.2    Brooks, M.W.3
  • 77
    • 0033568462 scopus 로고    scopus 로고
    • Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
    • Zhang, L., Mar, V., Zhou, W., et al. (1999) Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev. 13, 2388-2399.
    • (1999) Genes Dev. , vol.13 , pp. 2388-2399
    • Zhang, L.1    Mar, V.2    Zhou, W.3
  • 78
    • 0036562687 scopus 로고    scopus 로고
    • Telomere maintenance as a target for anticancer drug discovery
    • Neidle, S. and Parkinson, G. (2002). Telomere maintenance as a target for anticancer drug discovery. Nat. Rev. Drug Disc. 1, 383-393.
    • (2002) Nat. Rev. Drug Disc. , vol.1 , pp. 383-393
    • Neidle, S.1    Parkinson, G.2
  • 79
    • 0032566005 scopus 로고    scopus 로고
    • Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA
    • Kondo, S., Kondo, Y., Li, G., et al. (1998) Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA. Oncogene 16, 3323-3330.
    • (1998) Oncogene , vol.16 , pp. 3323-3330
    • Kondo, S.1    Kondo, Y.2    Li, G.3
  • 80
    • 0032403264 scopus 로고    scopus 로고
    • Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cells
    • Yokoyama, Y., Takahashi, Y., Shinohara, A., et al. (1998). Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cells. Cancer Res. 58, 5406-5410.
    • (1998) Cancer Res. , vol.58 , pp. 5406-5410
    • Yokoyama, Y.1    Takahashi, Y.2    Shinohara, A.3
  • 81
    • 0033150534 scopus 로고    scopus 로고
    • Cellular delivery of peptide nucleic acids and inhibition of human telomerase
    • Hamilton, S.E., Simmons, C.G., Kathiriya, I.S., et al. (1999). Cellular delivery of peptide nucleic acids and inhibition of human telomerase. Chem. Biol. 6, 343-351.
    • (1999) Chem. Biol. , vol.6 , pp. 343-351
    • Hamilton, S.E.1    Simmons, C.G.2    Kathiriya, I.S.3
  • 82
    • 0025877846 scopus 로고
    • Inhibition of telomerase by G-quartet DNA structures
    • Zahler, A.M., Williamson, J.R., Cech, T.R., et al. (1991). Inhibition of telomerase by G-quartet DNA structures. Nature 350, 718-720.
    • (1991) Nature , vol.350 , pp. 718-720
    • Zahler, A.M.1    Williamson, J.R.2    Cech, T.R.3
  • 83
    • 0032718247 scopus 로고    scopus 로고
    • The development of telomerase inhibitors: The G-quartet approach
    • Mergny, J.-L., Mailliet, P., Lavelle, F., et al. (1999). The development of telomerase inhibitors: the G-quartet approach. Anticancer Drug Des. 14, 327-339.
    • (1999) Anticancer Drug Des. , vol.14 , pp. 327-339
    • Mergny, J.-L.1    Mailliet, P.2    Lavelle, F.3
  • 84
    • 0034760505 scopus 로고    scopus 로고
    • Potent Inhibition of Telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes
    • Gowan, S.M., Heald, R., Stevens, M.F.G., et al. (2001) Potent Inhibition of Telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes. Mol. Pharmacol, 60, 981-988.
    • (2001) Mol. Pharmacol. , vol.60 , pp. 981-988
    • Gowan, S.M.1    Heald, R.2    Stevens, M.F.G.3
  • 85
    • 0034597794 scopus 로고    scopus 로고
    • Telomere states and cell fates
    • Blackburn, E.H. (2000) Telomere states and cell fates. Nature 408, 53-56.
    • (2000) Nature , vol.408 , pp. 53-56
    • Blackburn, E.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.