Midbrain dopaminergic neurons: Determination of their developmental fate by transcription factors

Annals of the New York Academy of Sciences

Volumn 991, Issue , 2003, Pages 36-47

  Simon, Horst H ^a   Bhatt, Lavinia ^a   Gherbassi, Daniel ^a   Sgadó, Paola ^a   Alberí, Lavinia ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Dopaminergic neurons; Engrailed; Lmx1b; Neuronal specification; Nurr1; Parkinson's disease; Substantia nigra; Ventral tegmentum

Indexed keywords

ALPHA SYNUCLEIN; DOPAMINE; ENZYME ACTIVATOR; HOMEODOMAIN PROTEIN; NEUROTRANSMITTER; NUCLEAR RECEPTOR RELATED FACTOR 1; STEROID RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GRAILED 1; TRANSCRIPTION FACTOR GRAILED 2; TRANSCRIPTION FACTOR LMX1B; TRANSCRIPTION FACTOR OTX2; TRANSCRIPTION FACTOR PAX2; TRANSCRIPTION FACTOR PAX5; TRANSCRIPTION FACTOR PITX3; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

CELL ACTIVATION; CELL DIVISION; CELL FATE; CELL FUNCTION; CELL MATURATION; CELL POPULATION; CELL SPECIFICITY; CELL SURVIVAL; COMBINATORIAL CHEMISTRY; CONFERENCE PAPER; DOPAMINE METABOLISM; DOPAMINE RELEASE; DOPAMINE UPTAKE; DOPAMINERGIC NERVE CELL; DOPAMINERGIC TRANSMISSION; GENE CONTROL; GENE FUNCTION; HUMAN; MESENCEPHALON; NERVE CELL DIFFERENTIATION; NONHUMAN; PARKINSON DISEASE; PHENOTYPE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SUBSTANTIA NIGRA; VENTRAL TEGMENTUM;

ANIMALIA; MAMMALIA;

EID: 0038051417     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2003.tb07461.x     Document Type: Conference Paper

References (66)

1. Lumsden, A. & R. KRUMLAUF. 1996. Patterning the vertebrate neuraxis. Science 274: 1109-1115.
2. MCALLISTER, A.K., L.C. KATZ & D.C. LO. 1999. Neurotrophins and synaptic plasticity. Annu. Rev. Neurosci. 22: 295-318.
3. MARTI, E. & P. BOVOLENTA. 2002. Sonic hedgehog in CNS development: one signal, multiple outputs. Trends Neurosci. 25: 89-96.
4. KENNEDY, T.E. 2000. Cellular mechanisms of netrin function: long-range and short-range actions. Biochem. Cell Biol. 78: 569-575.
5. EDLUND, T. & T.M. JESSELL. 1999. Progression from extrinsic to intrinsic signaling in cell fate specification: a view from the nervous system. Cell 96: 211-224.
6. NELSON, E.L., et al. 1996. Midbrain dopaminergic neurons in the mouse: computer-assisted mapping. J. Comp. Neurol. 369: 361-371.
7. MEYER-LINDENBERG, A., et al. 2002. Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia. Nat. Neurosci. 5: 267-271.
8. OBESO, J.A., et al. 2000. Pathophysiology of the basal ganglia in Parkinson's disease. Trends Neurosci. 23: S8-19.
9. JENNER, P., A.H. SCHAPIRA & C.D. MARSDEN. 1992. New insights into the cause of Parkinson's disease. Neurology 42: 2241-2250.
10. HIRSCH, E.C., et al. 1997. Neuronal vulnerability in Parkinson's disease. J. Neural Transm. Suppl. 50: 79-88.
11. BEAL, M.F. 2001. Experimental models of Parkinson's disease. Nat. Rev. Neurosci. 2: 325-334.
12. LEE, S.H., et al. 2000. Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat. Biotechnol. 18: 675-679.
13. KAWASAKI, H., et al. 2000. Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron 28: 31-40.
14. ROLLETSCHEK, A., et al. 2001. Differentiation of embryonic stem cell-derived dopaminergic neurons is enhanced by survival-promoting factors. Mech. Dev. 105: 93-104.
15. SAKURADA, K., et al. 1999. Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. Development 126: 4017-4026.
16. LIE, D.C., et al. 2002. The adult substantia nigra contains progenitor cells with neurogenic potential. J. Neurosci. 22: 6639-6649.
17. RUBENSTEIN, J.L. & P.A. BEACHY. 1998. Patterning of the embryonic forebrain. Curr. Opin. Neurobiol. 8: 18-26.
18. LEE, K.J. & T.M. JESSELL. 1999. The specification of dorsal cell fates in the vertebrate central nervous system. Annu. Rev. Neurosci. 22: 261-294.
19. SIMON, H., A. HORNBRUCH & A. LUMSDEN. 1995. Independent assignment of antero-posterior and dorso-ventral positional values in the developing chick hindbrain. Curr. Biol. 5: 205-214.
20. ACAMPORA, D., et al. 1995. Forebrain and midbrain regions are deleted in Otx2-/-mutants due to a defective anterior neuroectoderm specification during gastrulation. Development 121: 3279-3290.
21. ANG, S.L., et al. 1996. A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain. Development 122: 243-252.
22. SCHWARZ, M., et al. 1997. Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: evidence from targeted mutations. Proc. Natl. Acad. Sci. USA 94: 14518-14523.
23. MCMAHON, A.P. & A. BRADLEY. 1990. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62: 1073-1085.
24. RHINN, M. & M. BRAND. 2001. The midbrain-hindbrain boundary organizer. Curr. Opin. Neurobiol. 11: 34-42.
25. HYNES, M., et al. 1995. Control of neuronal diversity by the floor plate: contact-mediated induction of midbrain dopaminergic neurons. Cell 80: 95-101.
26. HYNES, M., et al. 1995. Induction of midbrain dopaminergic neurons by Sonic hedgehog. Neuron 15: 35-44.
27. YE, W., et al. 1998. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell 93: 755-766.
28. BROCCOLI, V., E. BONCINELLI & W. WURST. 1999. The caudal limit of Otx2 expression positions the isthmic organizer. Nature 401: 164-168.
29. ALTMAN, J. & S.A. BAYER. 1981. Development of the brain stem in the rat. V. Thymidine-radiographic study of the time of origin of neurons in the midbrain tegmentum. J. Comp. Neurol. 198: 677-716.
30. FOSTER, G.A., et al. 1988. Ontogeny of the dopamine and cyclic adenosine-3′:5′-monophosphate-regulated phosphoprotein (DARPP-32) in the pre- and postnatal mouse central nervous system. Int. J. Dev. Neurosci. 6: 367-386.
31. DI PORZIO, U., et al. 1990. Early appearance of tyrosine hydroxylase immunoreactive cells in the mesencephalon of mouse embryos. Int. J. Dev. Neurosci. 8: 523-532.
32. SECHRIST, J. & M. BRONNER-FRASER. 1991. Birth and differentiation of reticular neurons in the chick hindbrain: ontogeny of the first neuronal population. Neuron 7: 947-963.
33. VOORN, P., et al. 1988. The pre- and postnatal development of the dopaminergic cell groups in the ventral mesencephalon and the dopaminergic innervation of the striatum of the rat. Neuroscience 25: 857-887.
34. LAW, S.W., et al. 1992. Identification of a new brain-specific transcription factor, NURR1. Mol. Endocrinol. 6: 2129-2135.
35. SCEARCE, L.M., et al. 1993. RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver. J. Biol. Chem. 268: 8855-8861.
36. ZETTERSTRÖM, R.H., et al. 1997. Dopamine neuron agenesis in Nurr1-deficient mice. Science 276: 248-250.
37. BACKMAN, C., et al. 1999. A selective group of dopaminergic neurons express Nurr1 in the adult mouse brain. Brain Res. 851: 125-132.
38. CASTILLO, S.O., et al. 1998. Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene. Mol. Cell. Neurosci. 11: 36-46.
39. SAUCEDO-CARDENAS, O., et al. 1998. Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc. Natl. Acad. Sci. USA 95: 4013-4018.
40. WALLEN, A., et al. 1999. Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice. Exp. Cell Res. 253: 737-746.
41. WITTA, J., et al. 2000. Nigrostriatal innervation is preserved in Nurr1-null mice, although dopaminergic neuron precursors are arrested from terminal differentiation. Mol. Brain Res. 84: 67-78.
42. JOYNER, A.L., et al. 1985. Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene. Cell 43: 29-37.
43. JOYNER, A.L. & G.R. MARTIN. 1987. En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis [published erratum appears in 1987. Genes Dev. 1(5): 521]. Genes Dev. 1: 29-38.
44. KORNBERG, T., et al. 1985. The engrailed locus of Drosophila: in situ localization of transcripts reveals compartment-specific expression. Cell 40: 45-53.
45. KORNBERG, T. 1981. Engrailed: a gene controlling compartment and segment formation in Drosophila. Proc. Natl. Acad. Sci. USA 78: 1095-1099.
46. TABATA, T., et al. 1995. Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis. Development 121: 3359-3369.
47. WURST, W., A.B. AUERBACH & A.L. JOYNER. 1994. Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum. Development 120: 2065-2075.
48. LUNDELL, M.J., et al. 1996. The engrailed and huckebein genes are essential for development of serotonin neurons in the Drosophila CNS. Mol. Cell. Neurosci. 7: 46-61.
49. CONDRON, B.G., N.H. PATEL & K. ZINN. 1994. Engrailed controls glial/neuronal cell fate decisions at the midline of the central nervous system. Neuron 13: 541-554.
50. SAUERESSIG, H., J. BURRILL & M. GOULDING. 1999. Engrailed-1 and netrin-1 regulate axon pathfinding by association interneurons that project to motor neurons. Development 126: 4201-4212.
51. SIMON, H.H., et al. 2001. Fate of midbrain dopaminergic neurons controlled by the engrailed genes. J. Neurosci. 21: 3126-3134.
52. DAVIS, C.A. & A.L. JOYNER. 1988. Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development. Genes Dev. 2: 1736-1744.
53. GARDNER, C.A. & K.F. BARALD. 1992. Expression patterns of engrailed-like proteins in the chick embryo. Dev. Dyn. 193: 370-388.
54. MILLEN, K.J., et al. 1994. Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants. Development 120: 695-706.
55. JOYNER, A.L., et al. 1991. Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science 251: 1239-1243.
56. LIU, A. & A.L. JOYNER. 2001. EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region. Development 128: 181-191.
57. KRUGER, R., et al. 1998. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat. Genet. 18: 106-108.
58. POLYMEROPOULOS, M.H., et al. 1997. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276: 2045-2047.
59. CHEN, H., et al. 1998. Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome. Nat. Genet. 19: 51-55.
60. KNOERS, N.V., et al. 2000. Nail-patella syndrome: identification of mutations in the LMX1B gene in Dutch families. J. Am. Soc. Nephrol. 11: 1762-1766.
61. MIDT, M.P., et al. 2000. A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b. Nat. Neurosci. 3: 337-341.
62. ADAMS, K.A., et al. 2000. The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer. Development 127: 1857-1867.
63. SMIDT, M.P., et al. 1997. A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons. Proc. Natl. Acad. Sci. USA 94: 13305-13310.
64. CAZORLA, P., et al. 2000. A response element for the homeodomain transcription factor Ptx3 in the tyrosine hydroxylase gene promoter. J. Neurochem. 74: 1829-1837.
65. RIEGER, D.K., et al. 2001. A double-deletion mutation in the Pitx3 gene causes arrested lens development in aphakia mice. Genomics 72: 61-72.
66. SEMINA, E.V., et al. 2000. Deletion in the promoter region and altered expression of Pitx3 homeobox gene in aphakia mice. Hum. Mol. Genet. 9: 1575-1585.