Nigrostriatal innervation is preserved in Nurr1-null mice, although dopaminergic neuron precursors are arrested from terminal differentiation

Molecular Brain Research

Volumn 84, Issue 1-2, 2000, Pages 67-78

  Witta, Jassir ^a   Baffi, Judit S ^b   Palkovits, Miklós ^c   Mezey, Éva ^b   Castillo, Susan O ^a   Nikodem, Vera M ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Cholecystokinin; DiI; Dopamine; Nurr1; Substantia nigra; Ventral tegmental area

Indexed keywords

1,1' DIOCTADECYL 3,3,3',3' TETRAMETHYLINDOCARBOCYANINE; CELL ENZYME; CELL MARKER; CELL NUCLEUS RECEPTOR; CHOLECYSTOKININ; DOPAMINE RECEPTOR; DOPAMINE TRANSPORTER; NUCLEAR RECEPTOR RELATED FACTOR 1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINE METABOLISM; DOPAMINERGIC NERVE CELL; EXON; MOUSE; NERVE CELL DIFFERENTIATION; NERVE PROJECTION; NEUROEPITHELIUM; NEWBORN; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; SUBSTANTIA NIGRA; VENTRAL TEGMENTUM;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; AXONAL TRANSPORT; CELL COUNT; CELL DIFFERENTIATION; CELL MOVEMENT; CELL SURVIVAL; CHOLECYSTOKININ; DNA-BINDING PROTEINS; DOPAMINE; EXONS; HOMEODOMAIN PROTEINS; HUMANS; IN SITU HYBRIDIZATION; IN SITU NICK-END LABELING; MICE; MICE, KNOCKOUT; NEURONS; NEUROPEPTIDES; PARKINSON DISEASE; RECOMBINATION, GENETIC; RNA, MESSENGER; STEM CELLS; SUBSTANTIA NIGRA; TRANSCRIPTION FACTORS; TYROSINE 3-MONOOXYGENASE; VENTRAL TEGMENTAL AREA;

ANIMALIA;

EID: 0034624242     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(00)00211-4     Document Type: Article

References (38)

1. Differential expression of tyrosine hydroxylase in catecholaminergic neurons of neonatal wild-type and Nurr1-deficient mice
2. Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene
3. The steroid and thyroid hormone receptor superfamily
4. Substantia nigra
5. Developmental mechanisms that generate precise patterns of neuronal connectivity
6. Neurogenesis in the neocortex of adult primates
7. Differential regulation of transcription factor gene expression and phenotypic markers in developing sympathetic neurons
8. Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system
9. Induction of midbrain dopaminergic neurons by Sonic hedgehog
10. Evidence for coexistence of dopamine and CCK in mesolimbic neurones
11. A subpopulation of mesencephalic dopamine neurons projecting to limbic areas contains a cholecystokinin-like peptide: Evidence from immunohistochemistry combined with retrograde tracing
12. Carbocyanine dyes. Novel markers for labelling neurons
13. DiI and DiO: Versatile fluorescent dyes for neuronal labelling and pathway tracing
14. Synaptic transmission: A bidirectional and self-modifiable form of cell-cell communication
15. Selective agenesis of mesencephalic dopaminergic neurons in Nurr1-deficient mice
16. RHS2, a POU domain-containing gene, and its expression in developing and adult rat
17. Rat liver aldehyde dehydrogenase. II. Isolation and characterization of four inducible isozymes
18. High levels of a retinoic acid-generating dehydrogenase in the meso-telencephalic dopamine system
19. Local directional cues control growth polarity of dopaminergic axons along the rostrocaudal axis
20. Expression of nuclear hormone receptors within the rat hippocampus: Identification of novel orphan receptors
21. Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain
22. Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons
23. RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver
24. A subpopulation of dopaminergic neurons in rat ventral mesencephalon contains both neurotensin and cholecystokinin
25. Detection of preprocholecystokinin and preproenkephalin A mRNAs in rat brain by hybridization histochemistry using complementary RNA probes
26. A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmxb1
27. A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons
28. Development of striatal compartmentalization following pre- or postnatal dopamine depletion
29. Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo
30. Immunohistochemical localization of cholecystokinin- and gastrin-like peptides in the brain and hypophysis of the rat
31. Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice
32. Induction of dopaminergic neuron phenotype in the midbrain by sonic hedgehog protein
33. Distribution of messenger RNAs for the orphan nuclear receptors Nurr1 and Nur77 (NGFI-B) in adult rat brain using in situ hybridization
34. Rat nurr1 is prominently expressed in perirhinal cortex, and differentially induced in the hippocampal dentate gyrus by electroconvulsive vs. kindled seizures
35. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate
36. Dopamine neuron agenesis in Nurr1-deficient mice
37. Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system