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Rubenstein, J.L.R.1
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Tanabe, Y.1
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Rubenstein, J.L.R.5
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Muhr, J.1
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Ang, S.1
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Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm
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of special interest. Using explants from rat and chick neural plate stage embryos, the authors provide evidence that Shh can specify anterior properties of the medial neural plate in a concentration-dependent manner through induction of BMP7. These findings support the idea that there are regional differences in the inductive properties of the axial mesendoderm that contribute to patterning along the A/P axis.
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Dale JK, Vesque C, Lints TJ, Sampath TK, Furley A, Dood J, Placzek M. Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm. of special interest Cell. 90:1997;257-269 Using explants from rat and chick neural plate stage embryos, the authors provide evidence that Shh can specify anterior properties of the medial neural plate in a concentration-dependent manner through induction of BMP7. These findings support the idea that there are regional differences in the inductive properties of the axial mesendoderm that contribute to patterning along the A/P axis.
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Cell
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Dale, J.K.1
Vesque, C.2
Lints, T.J.3
Sampath, T.K.4
Furley, A.5
Dood, J.6
Placzek, M.7
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20
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0030796030
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Inductive interactions direct early regionalization of the mouse forebrain
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of special interest. Mouse neural plate explants were used to study the role of axial mesendoderm (prechordal mesendoderm) and the anterior neural ridge in patterning the medial and lateral part of the prosencephalic primordium. Evidence for differing competence in response to Shh and FGF8 along the A/P axis is presented. In addition, evidence supporting the role of FGF8 in the anterior neural ridge in regulating BF1 expression, and therefore telencephalic development, is presented.
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Shimamura K, Rubenstein JLR. Inductive interactions direct early regionalization of the mouse forebrain. of special interest Development. 124:1997;2709-2718 Mouse neural plate explants were used to study the role of axial mesendoderm (prechordal mesendoderm) and the anterior neural ridge in patterning the medial and lateral part of the prosencephalic primordium. Evidence for differing competence in response to Shh and FGF8 along the A/P axis is presented. In addition, evidence supporting the role of FGF8 in the anterior neural ridge in regulating BF1 expression, and therefore telencephalic development, is presented.
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Development
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Shimamura, K.1
Rubenstein, J.L.R.2
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21
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0030730266
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Patterning of the chick forebrain anlage by the prechordal plate
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of special interest. The authors provide evidence that prechordal tissues have anteriorizing properties - this is demonstrated through the induction of forebrain-like vesicles in the extraembryonic ectoderm. They also describe a model for induction and medial patterning of the anterior CNS.
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Pera EM, Kessel M. Patterning of the chick forebrain anlage by the prechordal plate. of special interest Development. 124:1997;4153-4162 The authors provide evidence that prechordal tissues have anteriorizing properties - this is demonstrated through the induction of forebrain-like vesicles in the extraembryonic ectoderm. They also describe a model for induction and medial patterning of the anterior CNS.
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Development
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Pera, E.M.1
Kessel, M.2
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22
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0030750888
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The prechordal region lacks neural inducing ability, but can confer anterior character to more posterior neuroepithelium
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of special interest. The authors demonstrate that the prechordal tissues can induce Otx2 and Tlx in the hindbrain - these genes are markers of the forebrain and midbrain, respectively.
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Foley AC, Storey KG, Stern CD. The prechordal region lacks neural inducing ability, but can confer anterior character to more posterior neuroepithelium. of special interest Development. 124:1997;2983-2996 The authors demonstrate that the prechordal tissues can induce Otx2 and Tlx in the hindbrain - these genes are markers of the forebrain and midbrain, respectively.
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(1997)
Development
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Foley, A.C.1
Storey, K.G.2
Stern, C.D.3
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Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube
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Ericson J, Muhr J, Placzek M, Lints T, Jessell TM, Edlund T. Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube. Cell. 81:1995;747-756.
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Edlund, T.6
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Control of anteroposterior and dorsoventral domains of Nkx6.1 gene expression relative to Nkx genes during vertebrate CNS development
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of special interest
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Qiu M, Shimamura K, Sussel L, Chen S, Rubenstein JLR. Control of anteroposterior and dorsoventral domains of Nkx6.1 gene expression relative to Nkx genes during vertebrate CNS development. of special interest Mech Dev. 1998; Evidence is presented that different members of the Nkx gene family have distinct spatial patterns of expression along the A/P axis of the chick and mouse ventral CNS: Nkx2.2 is expressed along the entire axis, whereas Nkx2.1 is restricted to the forebrain (although in the early chick neural plate, Nkx2.1 expression extends more posteriorly), and Nkx6.1 and Nkx6.2 are largely excluded from the forebrain. They are also expressed in different patterns along the D/V axis. Like other Nkx genes, expression of Nkx6.1 is induced by the axial mesendoderm and by Shh. BMP7 represses Nkx6.1 expression. While the notochord can induce Nkx6.1 expression in the anterior neural plate, Shh does not, suggesting that the notochord produces additional molecules that can regulate ventral patterning. Repression of Nkx2.1 in the posterior neural plate takes place in the absence of underlying tissues.
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(1998)
Mech Dev
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Qiu, M.1
Shimamura, K.2
Sussel, L.3
Chen, S.4
Rubenstein, J.L.R.5
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25
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0030057596
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The T/ebp null mouse: Thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary
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of special interest. This paper demonstrates that Nkx2.1 (also known as T/ebp and TTF-1 is essential for ventral forebrain development.
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Kimura S, Hara Y, Pineau T, Fernandez-Salguero P, Fox CH, Ward JM, Gonzalez FJ. The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. of special interest Genes Dev. 10:1996;60-69 This paper demonstrates that Nkx2.1 (also known as T/ebp and TTF-1 is essential for ventral forebrain development.
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Kimura, S.1
Hara, Y.2
Pineau, T.3
Fernandez-Salguero, P.4
Fox, C.H.5
Ward, J.M.6
Gonzalez, F.J.7
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26
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12644299614
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Mutations affecting the development of the embryonic zebrafish brain
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of special interest. This work describes a nonbiased genetic screen used to identify twenty-four genetic loci that affect aspects of brain development. Four genes that affect D/V patterning of the brain were identified: one-eyed pinhead, uncle freddy, bozozok, and three new alleles of cyclops (see [92]). This work should facilitate the identification of novel brain patterning molecules.
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Schier AF, Nauhauss SCF, Harvey M, Malicki J, Solnica-Krezel L, Stainier DYR, Zwartkruis F, Abdelilah S, Stemple DL, Rangini Z, et al. Mutations affecting the development of the embryonic zebrafish brain. of special interest Development. 123:1996;165-178 This work describes a nonbiased genetic screen used to identify twenty-four genetic loci that affect aspects of brain development. Four genes that affect D/V patterning of the brain were identified: one-eyed pinhead, uncle freddy, bozozok, and three new alleles of cyclops (see [92]). This work should facilitate the identification of novel brain patterning molecules.
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(1996)
Development
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Schier, A.F.1
Nauhauss, S.C.F.2
Harvey, M.3
Malicki, J.4
Solnica-Krezel, L.5
Stainier, D.Y.R.6
Zwartkruis, F.7
Abdelilah, S.8
Stemple, D.L.9
Rangini, Z.10
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27
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0031040286
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The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail
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of special interest. Zebrafish with the one-eyed pinhead mutation are cyclopic and lack both prechordal mesendoderm formation and goosecoid expression. There are no clear A/P defects, suggesting that the prechordal mesendoderm does not regulate A/P patterning; however, there are ventral defects throughout the CNS regions. Of note, Shh is expressed in the notochord; the authors suggest that one-eyed pinhead is either downstream of Shh or in a parallel pathway.
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Schier AF, Neuhauss SC, Helde KA, Talbot WS, Driever W. The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail. of special interest Development. 124:1997;327-342 Zebrafish with the one-eyed pinhead mutation are cyclopic and lack both prechordal mesendoderm formation and goosecoid expression. There are no clear A/P defects, suggesting that the prechordal mesendoderm does not regulate A/P patterning; however, there are ventral defects throughout the CNS regions. Of note, Shh is expressed in the notochord; the authors suggest that one-eyed pinhead is either downstream of Shh or in a parallel pathway.
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Development
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Schier, A.F.1
Neuhauss, S.C.2
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Driever, W.5
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