Repeated administration of the novel antipsychotic olanzapine does not modulate NMDA-sensitive glutamate and 5HT2 serotonin receptors in rats

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 367, Issue 6, 2003, Pages 615-620

  Gandolfi, Ottavio ^a   Voltattorni, Manuela ^a   Gaggi, Renato ^a   Dall'Olio, Rossella ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

5HT2A receptors; Antipsychotic drugs; Frontal cortex; Olanzapine; Repeated administrations

Indexed keywords

DIZOCILPINE; GLUTAMATE RECEPTOR; GLYCINE; KETANSERIN; N METHYL DEXTRO ASPARTIC ACID; OLANZAPINE; SEROTONIN 2 RECEPTOR; SEROTONIN 2A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; MALE; NONHUMAN; RAT; RECEPTOR DENSITY; SYNAPTIC MEMBRANE;

ANIMALS; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; MALE; N-METHYLASPARTATE; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUTAMATE; RECEPTORS, SEROTONIN, 5-HT2;

EID: 0037966071     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-003-0761-0     Document Type: Article

References (48)

1. 2A receptors in rabbit. J Pharmacol Exp Ther 299:1066-1072
2. Arvanov VL, Wang RY (1997) NMDA-evoked response in pyramidal neurons of the rat medial prefrontal cortex slices consists of NMDA and non-NMDA components. Brain Res 768:361-364
3. Banerjee SP, Zuck LG, Yablonsky-Alter E, Lidsky TI (1995) Glutamate agonist activity: implications for antipsychotic drug action and schizophrenia. Neuroreport 6:2500-2504
4. Baron BM, Harrison BL, Miller FP, Mc Donald IA, Salituro FG, Schmidt CJ, Sorensen SM, White HS, Palfreyman MG (1990) Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site. Mol Pharmacol 38:554-561
5. Callaghan JI, Bergham RF, Ptak LR, Beasley CM (1999) olanzapine pharmacokinetic and pharmacodynamic profile. Clin Pharmacokinet 37:177-193
6. Ceulemans DL, Gelders YG, Hoppenbrouwers ML, Reyntjens AJ, Janssen PA (1985) Effect of serotonin antagonism in schizophrenia: a pilot study with setoperone. Psychopharmacology 85: 329-332
7. Corbett R, Camacho F, Woods AT, Kerman LL, Fishkin RJ, Brooks K, Dunn RW (1995) Antipsychotic agents antagonize non-competitive N-methyl-D-aspartate antagonist-induced behaviors. Psychopharmacology 120:67-74
8. Dall'Olio R, Gandolfi O, Gaggi R (2000) Blockade of the serotonergic system counteracts the dizocilpine-induced changes in dopaminergic function. Behav Pharmacol 11:29-36
9. Duncan GE, Leipzig JN, Mailman RB, Lieberman JA (1998) Differential effect of clozapine and haloperidol on ketamine-induced brain metabolic activation. Brain Res 812:65-75
10. Fletcher EJ, MacDonald JF (1993) Haloperidol interacts with the strychnine-insensitive glycine site at the NMDA receptor in cultured mouse hippocampal neurones. Eur J Pharmacol 235: 291-295
11. Gandolfi O, Dall'Olio R (1996) Modulatory role of dopamine on excitatory amino acid receptors. Prog Neuropsychopharmacol Biol Psychiatry 20:659-671
12. 3H]-ketanserin recognition sites. Life Sci 36:713-721
13. Giardino L, Bortolotti F, Orazzo C, Pozza M, Monteleone P, Calza L, Maj M (1997) Effect of chronic clozapine administration on 3H-MK 801 binding sites in the rat brain: a side-preference action in cortical areas. Brain Res 762:216-218
14. Jardemark KE, Liang X, Arvanov V, Wang RY (2000) Subchronic treatment with either clozapine, olanzapine or haloperidol produces a hyposensitive response of the rat cortical cells to N-methyl-D-aspartate. Neuroscience 100:1-9
15. 3H]MK 801 binding sites in postmortem brain regions of schizophrenic patients. J Neural Transm 77:231-236
16. Krystal JH, Karper LP, Seibyl JP, Freeman GK, Delaney R, Bremmer JD, Heninger GR, Bowers Jr MB, Charney DS (1994) Subanesthetic effects of the non-competitive NMDA antagonist, ketamine, in humans: psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry 51: 199-214
17. 2C receptors after chronic treatment with clozapine, chlorpromazine and three putative atypical antipsychotic drugs. Neuropsychopharmacology 13:139-150
18. 3H] ligand for serotonin receptor binding site. Binding properties, brain distribution, and functional role. Mol Pharmacol 21:301-314
19. Lieberman JA, Kane J M, Alvit J (1987) Provocative tests with psychostimulant drugs in schizophrenia. Psychopharmacology 91:415-433
20. 3H]MDL 100,907. Naunyn Schmiedeberg's Arch Pharmacol 356:446-454
21. Lowry OH (1951) Protein measurement with the pholin phenol reagent. J Biol Chem 193:265-275
22. Malhotra AK, Pinals DA, Weingartner H, Sirocco K, Missar CD, Pickar D, Breier A (1996) NMDA receptor function and human cognition: the effect of ketamine in healthy volunteers. Neuropsychopharmacology 14:301-307
23. Mansbach RS, Geyer MA (1989) Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat. Neuropsychopharmacology 2:299-308
24. McCoy L, Richfield EK (1996) Chronic antipsychotic treatment alters glycine-stimulated NMDA receptor binding in rat brain. Neurosci Lett 213:137-141
25. Meltzer HY (1996) Pre-clinical pharmacology of atypical antipsychotic drugs: a selective review. Br J Psychiatry 29 (Suppl): 23-31
26. i values. J Pharmacol Exp Ther 251:238-246
27. 2 receptor by in situ hybridization histochemistry. Correlation with the distribution of receptor sites. Brain Res 524:139-143
28. Meshul CK, Bunker GL, Mason JN, Allen C, Janovsky A. (1996) Effects of subchronic clozapine and haloperidol on striatal glutamatergic synapses. J Neurochem 67:1965-1973
29. Munson PJ, Rodbard DL (1980) Ligand: a versatile computerized approach for characterization of ligand binding system. Anal Biochem 107:220-239
30. Ninan I, Kulkami SK (1999) Preferential inhibition of dizocilpine-induced hyperlocomotion by olanzapine. Eur J Pharmacol 368: 1-7
31. Noga JT, Hyde TM, Herman MM, Spurney CF, Bigelow LB, Weinberger DR, Kleinman JE (1997) Glutamate receptors in the post-mortem striatum of schizophrenic, suicide, and control brains. Synapse 27:168-176
32. 3H]glycine to synaptic membranes in rat brain, treated with Triton X-100. Neuropharmacology 28:1263-1270
33. Ossowska K, Pietraszek M, Wardas J, Nowak G, Wolfarth S (1999) Chronic haloperidol and clozapine administration increases the number of cortical NMDA receptors in rats. Naunyn Schmiedeberg's Arch Pharmacol 359:280-287
34. Pazos A, Palacios JM (1985) Quantitative autoradiographic mapping of serotonin receptors in the rat brain. 1. Serotonin-1 receptors. Brain Res 346:205-230
35. 2 binding affinity. Neuropsychopharmacology 1:101-107
36. 2A receptors: molecular biology and mechanisms of regulation. Crit Rev Neurobiol 12:319-338
37. Sanders-Bush E (1990) Adaptive regulation of central serotonin receptors linked to phosphoinositide hydrolysis. Neuropsychopharmacology 3:411-416
38. Scatchard G (1949) The attraction of proteins for small molecules and ions. Ann NY Acad Sci 51:660-672
39. Simpson MDC, Slater P, Royston MC, Deakin JFW (1992) Alterations in phencyclidine and sigma binding sites in schizophrenic brains. Schizophr Res 6:41-48
40. Sokolov BP (1998) Expression of NMDAR1, GluR1, GluR7, and KA1 glutamate receptor mRNAs is decreased in frontal cortex of 'neuroleptic-free' schizophrenics: evidence on reversible upregulation of typical neuroleptics. J Neurochem 71:2454-2464
41. 3H]TCP) to the NMDA-phencyclidine receptor complex. Neuropharmacology 28:1-7
42. Swerdlow NR, Bakshi V, Geyer MA (1996) Seroquel restores sensorimotor gating in phencyclidine-treated rats. J Pharmacol Exp Ther 279:1290-1299
43. Tarazi FL, Florijn WJ, Creese I (1996) Regulation of ionotropic glutamate receptors following subchronic and chronic treatment with typical and atypical antipsychotics. Psychopharmacology 128:371-379
44. Tascedda F, Blom JM, Brunello N, Zolin K, Gennarelli M, Colzi A, Bravi D, Carra S, Racagni G, Riva MA (2001) Modulation of glutamate receptors in response to the novel antipsychotic olanzapine in rats. Biol Psychiatry 50:117-22
45. Weissman AD, Casanova MF, Kleinman JE, London ED, De Souza EB (1991) Selective loss of cerebral cortical sigma, but not PCP binding sites in schizophrenia. Biol Psychiatry 54:41-54
46. Wiley JL, Kennedy KL (2002) Evaluation of the efficacy of antipsychotic attenuation of phencyclidine-disrupted prepulse inhibition in rats. J Neurol Transm 109:523-535
47. 2 receptors in reserpinized rats. Neuropharmacology 26:1489-1497
48. 2A and muscarinic receptors. Psychopharmacology 141:267-278