메뉴 건너뛰기




Volumn 71, Issue 6, 1998, Pages 2454-2464

Expression of NMDAR1, GluR1, GluR7, and KA1 glutamate receptor mRNAs is decreased in frontal cortex of 'neuroleptic-free' schizophrenics: Evidence on reversible up-regulation by typical neuroleptics

Author keywords

Frontal cortex; Glutamate receptor mRNAs; Neuroleptic; Postmortem; Schizophrenia

Indexed keywords

AMPA RECEPTOR; GLUTAMATE RECEPTOR; KAINIC ACID RECEPTOR; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROLEPTIC AGENT;

EID: 0031774346     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.71062454.x     Document Type: Article
Times cited : (160)

References (54)
  • 1
    • 0028843647 scopus 로고
    • Editing for an AMPA receptor subunit mRNA in prefrontal cortex and striatum in Alzheimer's disease, Huntington's disease and schizophrenia
    • Akbarian S., Smith M. A., and Jones E. G. (1995) Editing for an AMPA receptor subunit mRNA in prefrontal cortex and striatum in Alzheimer's disease, Huntington's disease and schizophrenia. Brain Res. 699, 297-304.
    • (1995) Brain Res. , vol.699 , pp. 297-304
    • Akbarian, S.1    Smith, M.A.2    Jones, E.G.3
  • 3
    • 0344404408 scopus 로고    scopus 로고
    • Increased density of glutamate/N-methyl-D-aspartate receptors in putamen from schizophrenic patients
    • Aparicio-Legarza M. I., Davis B., Hutson P. H., and Reynolds G. P. (1998) Increased density of glutamate/N-methyl-D-aspartate receptors in putamen from schizophrenic patients. Neurosci. Lett. 241, 143-146.
    • (1998) Neurosci. Lett. , vol.241 , pp. 143-146
    • Aparicio-Legarza, M.I.1    Davis, B.2    Hutson, P.H.3    Reynolds, G.P.4
  • 4
    • 0028928362 scopus 로고
    • Glutamate receptor subtype expression in human postmortem brain tissue from schizophrenics and alcohol abusers
    • Breese C. R., Freedman R., and Leonard S. S. (1995) Glutamate receptor subtype expression in human postmortem brain tissue from schizophrenics and alcohol abusers. Brain Res. 674, 82-90.
    • (1995) Brain Res. , vol.674 , pp. 82-90
    • Breese, C.R.1    Freedman, R.2    Leonard, S.S.3
  • 5
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P. and Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 6
    • 0024829451 scopus 로고
    • Excitatory amino acid receptors in the vertebrate central nervous system
    • Collingridge G. L. and Lester R. A. J. (1989) Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol. Rev. 40, 143-210.
    • (1989) Pharmacol. Rev. , vol.40 , pp. 143-210
    • Collingridge, G.L.1    Lester, R.A.J.2
  • 8
    • 0028907468 scopus 로고
    • Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluR1 and GluR2 in medial temporal lobe neurons in schizophrenia
    • Eastwood S. L., McDonald B., Burnet P. W., Beckwith J. P., Kerwin R. W., and Harrison P. J. (1995) Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluR1 and GluR2 in medial temporal lobe neurons in schizophrenia. Mol. Brain Res. 29, 211-223.
    • (1995) Mol. Brain Res. , vol.29 , pp. 211-223
    • Eastwood, S.L.1    McDonald, B.2    Burnet, P.W.3    Beckwith, J.P.4    Kerwin, R.W.5    Harrison, P.J.6
  • 9
    • 0030593497 scopus 로고    scopus 로고
    • The effect of chronic haloperidol treatment on glutamate receptor subunit (GluR1, GluR2, KA1, KA2, NR1) mRNAs and glutamate binding protein mRNA in rat forebrain
    • Eastwood S. L., Porter R. H., and Harrison P. J. (1996) The effect of chronic haloperidol treatment on glutamate receptor subunit (GluR1, GluR2, KA1, KA2, NR1) mRNAs and glutamate binding protein mRNA in rat forebrain. Neurosci. Lett. 212, 163-166.
    • (1996) Neurosci. Lett. , vol.212 , pp. 163-166
    • Eastwood, S.L.1    Porter, R.H.2    Harrison, P.J.3
  • 10
    • 0031004644 scopus 로고    scopus 로고
    • Immunoautoradiographic evidence for a loss of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate-preferring non-N-methyl-D-aspartate glutamate receptors within the medial temporal lobe in schizophrenia
    • Eastwood S. L., Kerwin R. W., and Harrison P. J. (1997a) Immunoautoradiographic evidence for a loss of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate-preferring non-N-methyl-D-aspartate glutamate receptors within the medial temporal lobe in schizophrenia. Biol. Psychiatry 41, 636-643.
    • (1997) Biol. Psychiatry , vol.41 , pp. 636-643
    • Eastwood, S.L.1    Kerwin, R.W.2    Harrison, P.J.3
  • 11
    • 0031017606 scopus 로고    scopus 로고
    • GluR2 glutamate receptor subunit flip and flop isoforms are decreased in the hippocampal formation in schizophrenia: A reverse transcriptase-polymerase chain reaction (RT-PCR) study
    • Eastwood S. L., Burnet P. W. J., and Harrison P. J. (1997b) GluR2 glutamate receptor subunit flip and flop isoforms are decreased in the hippocampal formation in schizophrenia: a reverse transcriptase-polymerase chain reaction (RT-PCR) study. Mol. Brain. Res. 44, 92-98.
    • (1997) Mol. Brain. Res. , vol.44 , pp. 92-98
    • Eastwood, S.L.1    Burnet, P.W.J.2    Harrison, P.J.3
  • 12
    • 0028947052 scopus 로고
    • Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs
    • Fitzgerald L. W., Deutch A. Y., Gasic G., Heinemann S. F., and Nester E. F. (1995) Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs. J. Neurosci. 15, 2453-2461.
    • (1995) J. Neurosci. , vol.15 , pp. 2453-2461
    • Fitzgerald, L.W.1    Deutch, A.Y.2    Gasic, G.3    Heinemann, S.F.4    Nester, E.F.5
  • 14
    • 0000292303 scopus 로고
    • Circuitry of the prefrontal cortex and the regulation of behavior by representational memory
    • Plum F. and Mountcastle V., eds, American Physiological Society, Bethesda, Maryland
    • Goldman-Rakic P. S. (1987) Circuitry of the prefrontal cortex and the regulation of behavior by representational memory, in Handbook of Physiology (Plum F. and Mountcastle V., eds), pp. 373-417. American Physiological Society, Bethesda, Maryland.
    • (1987) Handbook of Physiology , pp. 373-417
    • Goldman-Rakic, P.S.1
  • 15
    • 0002477679 scopus 로고
    • Prefrontal cortical dysfunction in schizophrenia: The relevance of working memory
    • Caroll B. F. and Barrett J. E., eds, Raven Press, New York
    • Goldman-Rakic P. S. (1991) Prefrontal cortical dysfunction in schizophrenia: the relevance of working memory, in Psychopathology and the Brain (Caroll B. F. and Barrett J. E., eds), pp. 1-13. Raven Press, New York.
    • (1991) Psychopathology and the Brain , pp. 1-13
    • Goldman-Rakic, P.S.1
  • 16
    • 0025967753 scopus 로고
    • Decreased hippocampal expression of a glutamate receptor gene in schizophrenia
    • Harrison P. J., McLaughlin D., and Kerwin R. W. (1991) Decreased hippocampal expression of a glutamate receptor gene in schizophrenia. Lancet 337, 450-452.
    • (1991) Lancet , vol.337 , pp. 450-452
    • Harrison, P.J.1    McLaughlin, D.2    Kerwin, R.W.3
  • 17
    • 0028845078 scopus 로고
    • The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: Selective mRNA vulnerability and comparison with their encoded proteins
    • Harrison P. J., Heath P. R., Eastwood S. L., Bumet P. W. J., McDonald B., and Pearson R. C. A. (1995) The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins. Neurosci. Lett. 200, 151-154.
    • (1995) Neurosci. Lett. , vol.200 , pp. 151-154
    • Harrison, P.J.1    Heath, P.R.2    Eastwood, S.L.3    Bumet, P.W.J.4    McDonald, B.5    Pearson, R.C.A.6
  • 18
    • 0030897885 scopus 로고    scopus 로고
    • Abnormal expression of serotonin transporter mRNA in the frontal and temporal cortex of schizophrenics
    • Hernandez I. and Sokolov B. P. (1997) Abnormal expression of serotonin transporter mRNA in the frontal and temporal cortex of schizophrenics. Mol. Psychiatry 2, 57-64.
    • (1997) Mol. Psychiatry , vol.2 , pp. 57-64
    • Hernandez, I.1    Sokolov, B.P.2
  • 20
    • 0025952455 scopus 로고
    • Recent advances in phencyclidine model of schizophrenia
    • Javitt D. C. and Zukin S. R. (1991) Recent advances in phencyclidine model of schizophrenia. Am. J. Psychiatry 148, 1301-1308.
    • (1991) Am. J. Psychiatry , vol.148 , pp. 1301-1308
    • Javitt, D.C.1    Zukin, S.R.2
  • 21
    • 0030862672 scopus 로고    scopus 로고
    • Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine
    • Jentsch J. D., Redmond D. E. Jr., Elsworth J. D., Taylor J. R., Youngren K. D., and Roth R. H. (1997) Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine. Science 277, 953-955.
    • (1997) Science , vol.277 , pp. 953-955
    • Jentsch, J.D.1    Redmond Jr., D.E.2    Elsworth, J.D.3    Taylor, J.R.4    Youngren, K.D.5    Roth, R.H.6
  • 23
    • 0027478586 scopus 로고
    • Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor
    • Karp S. J., Masu M., Eki T., Ozawa K., and Nakanishi S. (1993) Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor. J. Biol. Chem. 268, 3728-3733.
    • (1993) J. Biol. Chem. , vol.268 , pp. 3728-3733
    • Karp, S.J.1    Masu, M.2    Eki, T.3    Ozawa, K.4    Nakanishi, S.5
  • 24
    • 0023853975 scopus 로고
    • Asymmetrical loss of glutamate receptor subtype in left hippocampus in schizophrenia
    • Kerwin R. W., Patel S., Meldrum B. S., Czudek C., and Reynolds G. P. (1988) Asymmetrical loss of glutamate receptor subtype in left hippocampus in schizophrenia. Lancet 1, 583-584.
    • (1988) Lancet , vol.1 , pp. 583-584
    • Kerwin, R.W.1    Patel, S.2    Meldrum, B.S.3    Czudek, C.4    Reynolds, G.P.5
  • 25
    • 0025221418 scopus 로고
    • Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem
    • Kerwin R. W., Patel S., and Meldrum B. S. (1990) Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem. Neuroscience 39, 25-32.
    • (1990) Neuroscience , vol.39 , pp. 25-32
    • Kerwin, R.W.1    Patel, S.2    Meldrum, B.S.3
  • 27
    • 0026612670 scopus 로고
    • 3H] Amino-3-hydroxy-5-methylisoxazole-4-propionic acid binding to human cerebral cortical membranes: Minimal changes in postmortem brains of chronic schizophrenics
    • 3H] Amino-3-hydroxy-5-methylisoxazole-4-propionic acid binding to human cerebral cortical membranes: minimal changes in postmortem brains of chronic schizophrenics. J. Neurochem. 59, 829-837.
    • (1992) J. Neurochem. , vol.59 , pp. 829-837
    • Kurumaji, A.1    Ishimaru, M.2    Toru, M.3
  • 28
    • 0021328315 scopus 로고
    • Frontal lobe dysfunctions in schizophrenia. II: Impairments of psychological and brain functions
    • Levin S. (1984) Frontal lobe dysfunctions in schizophrenia. II: Impairments of psychological and brain functions. J. Psychiatry Res. 18, 27-55.
    • (1984) J. Psychiatry Res. , vol.18 , pp. 27-55
    • Levin, S.1
  • 29
    • 0028142839 scopus 로고
    • Developmental expression of the genes encoding transforming growth factor alpha and its receptor in the hypothalamus of female rhesus macaques
    • Ma Y. J., Costa M. E., and Ojeda S. R. (1994a) Developmental expression of the genes encoding transforming growth factor alpha and its receptor in the hypothalamus of female rhesus macaques. Neuroendocrinology 60, 346-359.
    • (1994) Neuroendocrinology , vol.60 , pp. 346-359
    • Ma, Y.J.1    Costa, M.E.2    Ojeda, S.R.3
  • 30
    • 0028232262 scopus 로고
    • Expression of epidermal growth factor receptor changes in the hypothalamus during the onset of female puberty
    • Ma Y. J., Hill D. F., Junier M. P., Costa M. E., Felder S. E., and Ojeda S. R. (1994b) Expression of epidermal growth factor receptor changes in the hypothalamus during the onset of female puberty. Mol. Cell. Neurosci. 5, 246-262.
    • (1994) Mol. Cell. Neurosci. , vol.5 , pp. 246-262
    • Ma, Y.J.1    Hill, D.F.2    Junier, M.P.3    Costa, M.E.4    Felder, S.E.5    Ojeda, S.R.6
  • 31
    • 0030090886 scopus 로고    scopus 로고
    • Differential regulation of hippocampal AMPA and kainate receptor subunit expression by haloperidol and clozapine
    • Meador-Woodruff J. H., King R. E., Damask S. P., and Bovenkerk K. A. (1996) Differential regulation of hippocampal AMPA and kainate receptor subunit expression by haloperidol and clozapine. Mol. Psychiatry 1, 41-53.
    • (1996) Mol. Psychiatry , vol.1 , pp. 41-53
    • Meador-Woodruff, J.H.1    King, R.E.2    Damask, S.P.3    Bovenkerk, K.A.4
  • 32
    • 0030900732 scopus 로고    scopus 로고
    • Activation of glutamatergic neurotransmission by ketamine: A novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex
    • Moghaddam B., Adams B., Verma A., and Daly H. (1997) Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J. Neurosci. 17, 2921-2927.
    • (1997) J. Neurosci. , vol.17 , pp. 2921-2927
    • Moghaddam, B.1    Adams, B.2    Verma, A.3    Daly, H.4
  • 33
    • 0030752914 scopus 로고    scopus 로고
    • Cloning and localization of exon 5-containing isoforms of the NMDAR1 subunit in human and rat brains
    • Nash N. R., Heilman C. J., Rees H. D., and Levey A. I. (1997) Cloning and localization of exon 5-containing isoforms of the NMDAR1 subunit in human and rat brains. J. Neurochem. 69, 485-493.
    • (1997) J. Neurochem. , vol.69 , pp. 485-493
    • Nash, N.R.1    Heilman, C.J.2    Rees, H.D.3    Levey, A.I.4
  • 34
    • 0028606035 scopus 로고
    • RNA editing of human kainate receptor subunits
    • Nutt S. L. and Kamboj R. K. (1994) RNA editing of human kainate receptor subunits. Neuroreport 5, 2625-2629.
    • (1994) Neuroreport , vol.5 , pp. 2625-2629
    • Nutt, S.L.1    Kamboj, R.K.2
  • 36
    • 0028850552 scopus 로고
    • Glutamate receptor dysfunction and schizophrenia
    • Olney J. W. and Farber N. B. (1995) Glutamate receptor dysfunction and schizophrenia. Arch. Gen. Psychiatry 52, 998-1007.
    • (1995) Arch. Gen. Psychiatry , vol.52 , pp. 998-1007
    • Olney, J.W.1    Farber, N.B.2
  • 38
    • 0021759199 scopus 로고
    • Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of human beta-actin cDNA
    • Ponte P., Ng S. Y., Engel J., Gunning P., and Kedes L. (1984) Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of human beta-actin cDNA. Nucleic Acids Res. 12, 1687-1696.
    • (1984) Nucleic Acids Res. , vol.12 , pp. 1687-1696
    • Ponte, P.1    Ng, S.Y.2    Engel, J.3    Gunning, P.4    Kedes, L.5
  • 39
    • 0030933984 scopus 로고    scopus 로고
    • Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia
    • Porter R. H. P., Eastwood S. L., and Harrison P. J. (1996) Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia. Brain Res. 751, 217-231.
    • (1996) Brain Res. , vol.751 , pp. 217-231
    • Porter, R.H.P.1    Eastwood, S.L.2    Harrison, P.J.3
  • 41
    • 0027234701 scopus 로고
    • The molecular biology of mammalian glutamate receptor channels
    • Seeburg P. H. (1993) The molecular biology of mammalian glutamate receptor channels. Trends Neurosci. 16, 359-365.
    • (1993) Trends Neurosci. , vol.16 , pp. 359-365
    • Seeburg, P.H.1
  • 43
    • 0031891430 scopus 로고    scopus 로고
    • RNA quantitative analysis from fixed and paraffin-embedded tissues: Membrane hybridization and capillary electrophoresis
    • Stanta G. and Bonin S. (1998) RNA quantitative analysis from fixed and paraffin-embedded tissues: membrane hybridization and capillary electrophoresis. Biotechniques 24, 271-276.
    • (1998) Biotechniques , vol.24 , pp. 271-276
    • Stanta, G.1    Bonin, S.2
  • 44
    • 0026766877 scopus 로고
    • Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing
    • Sugihara H., Moriyoshi K., Ishii T., Masu M., and Nakanishi S. (1992) Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing. Biochem. Biophys. Res. Commun. 185, 826-832.
    • (1992) Biochem. Biophys. Res. Commun. , vol.185 , pp. 826-832
    • Sugihara, H.1    Moriyoshi, K.2    Ishii, T.3    Masu, M.4    Nakanishi, S.5
  • 45
    • 0030866468 scopus 로고    scopus 로고
    • Age-related abnormalities in expression of mRNAs encoding synapsin 1A, synapsin 1B, and synaptophysin in the temporal cortex of schizophrenics
    • Tcherepanov A. A. and Sokolov B. P. (1997) Age-related abnormalities in expression of mRNAs encoding synapsin 1A, synapsin 1B, and synaptophysin in the temporal cortex of schizophrenics. J. Neurosci. Res. 49, 639-644.
    • (1997) J. Neurosci. Res. , vol.49 , pp. 639-644
    • Tcherepanov, A.A.1    Sokolov, B.P.2
  • 47
    • 0027397467 scopus 로고
    • Excitatory aminoacid receptors in schizophrenia
    • Ulas J. and Cotman C. W. (1993) Excitatory aminoacid receptors in schizophrenia. Schizophr. Bull. 19, 105-117.
    • (1993) Schizophr. Bull. , vol.19 , pp. 105-117
    • Ulas, J.1    Cotman, C.W.2
  • 48
    • 0027251058 scopus 로고
    • Chronic haloperidol treatment enhances binding to NMDA receptors in rat cortex
    • Ulas J., Nguyen L., and Cotman C. W. (1993) Chronic haloperidol treatment enhances binding to NMDA receptors in rat cortex. Neuroreport 4, 1049-1051.
    • (1993) Neuroreport , vol.4 , pp. 1049-1051
    • Ulas, J.1    Nguyen, L.2    Cotman, C.W.3
  • 49
    • 0023783753 scopus 로고
    • Schizophrenia and the frontal lobe
    • Weinberger D. R. (1988) Schizophrenia and the frontal lobe. Trends Neurosci. 11, 367-370.
    • (1988) Trends Neurosci. , vol.11 , pp. 367-370
    • Weinberger, D.R.1
  • 50
    • 0027320711 scopus 로고
    • A connectionist approach to the prefrontal cortex
    • Weinberger D. R. (1993) A connectionist approach to the prefrontal cortex. J. Neuropsychiatry Clin. Neurosci. 5, 241-253.
    • (1993) J. Neuropsychiatry Clin. Neurosci. , vol.5 , pp. 241-253
    • Weinberger, D.R.1
  • 52
    • 0025810536 scopus 로고
    • Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells
    • Werner P., Voigt M., Keinanen K., Wisden W., and Seeburg P. H. (1991) Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells. Nature 351, 742-744.
    • (1991) Nature , vol.351 , pp. 742-744
    • Werner, P.1    Voigt, M.2    Keinanen, K.3    Wisden, W.4    Seeburg, P.H.5
  • 53
    • 0025342419 scopus 로고
    • Excitatory amino acid receptors in the brain: Membrane binding and receptor autoradiographic approaches
    • Young A. B. and Fagg G. E. (1990) Excitatory amino acid receptors in the brain: membrane binding and receptor autoradiographic approaches. Trends Pharmacol. Sci. 11, 126-133.
    • (1990) Trends Pharmacol. Sci. , vol.11 , pp. 126-133
    • Young, A.B.1    Fagg, G.E.2
  • 54
    • 0029918297 scopus 로고    scopus 로고
    • Quantitative RT-PCR for neuroendocrine studies
    • Zamorano P. L., Mahesh V. B., and Brann D. W. (1996) Quantitative RT-PCR for neuroendocrine studies. Neuroendocrinology 63, 397-407.
    • (1996) Neuroendocrinology , vol.63 , pp. 397-407
    • Zamorano, P.L.1    Mahesh, V.B.2    Brann, D.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.