Importance of anemia and transferrin levels in the regulation of intestinal iron absorption in hypotransferrinemic mice

Blood

Volumn 94, Issue 9, 1999, Pages 3185-3192

  Raja, K B ^a   Pountney, D J ^a   Simpson, R J ^a   Peters, T J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFERRIN;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HEMOGLOBIN DETERMINATION; INTESTINE ABSORPTION; IRON ABSORPTION; IRON STORAGE; IRON TRANSPORT; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; RETICULOCYTE COUNT; TRANSFERRIN BLOOD LEVEL;

EID: 0033231035     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.9.3185.421a20_3185_3192     Document Type: Article

References (36)

1. Feder JN, Gnirke A, Thomas W,Tsuchihashi Z, Ruddy DA, Basava A, Dormishian F, Domingo R Jr, Ellis MC, Fullan A, Hinton LM, Jones NL, Kimmel BE, Kronmal GS, Lauer P, Lee VK, Loeb DB, Mapa FA, McClelland E, Meyer NC, Mintier GA, Moeller N, Moore T, Morikang E, Prass CE, Quintana L, Starnes SM, Schatzman RC, Brunke KJ, Drayna DT, Risch NJ, Bacon BR, Wolff RK: A novel MHC class 1-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 13:399, 1996
2. Parkilla S, Waheed A, Britton RS, Bacon BR, Zhou XY, Tomatsu S, Fleming RE, Sly WS: Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis. Proc Natl Acad Sci USA 94:13198, 1997
3. Feder JN, Penny DM, Irrinki A, Lee VK, Lebron JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ, Schatzman RC: The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci USA 95:1472, 1998
4. Bernstein SE: Hereditary hypotransferrinemia with hemosiderosis, a murine disorder resembling human atransferrinemia. J Lab Clin Med 110:690, 1987
5. Kaplan J, Craven C, Alexander J, Kushner J, Lamb J, Bernstein S: Regulation of the distribution of tissue iron. Lessons learned from the hypotransferrinemic mouse. Ann NY Acad Sci 526:124, 1988
6. Heilmeyer L: Die Atransferrinaemien. Acta Haematol 36:40, 1966
7. Goya N, Miyazaki S, Kodate S, Ushio E: A family of congenital atransferrinemia. Blood 40:239, 1972
8. Huggenvik JI, Craven CM, Idzerda RL, Bernstein S, Kaplan J, McKnight GS: A splicing defect in the mouse transferrin gene leads to congenital atransferrinemia. Blood 74:482, 1989
9. Simpson RJ, Lombard M, Raja KB, Thatcher R, Peters TJ: Iron absorption by hypotransferrinaemic mice. Br J Haematol 78:565, 1991
10. Buys SS, Martin CB, Eldridge M, Kushner JP, Kaplan J: Iron absorption in hypotransferrinemic mice. Blood 78:3288, 1991
11. Raja KB, Simpson RJ, Peters TJ: Intestinal iron absorption studies in mouse models of iron-overload. Br J Haematol 86:156, 1994
12. Raja KB, Maxwell PH, Ratcliffe PJ, Salisbury JR, Simpson RJ, Peters TJ: Iron metabolism in transgenic mice with hypoplastic anaemia due to incomplete deficiency of erythropoietin. Br J Haematol 96:248, 1997
13. Raja KB, Simpson RJ, Peters TJ: Plasma clearance of transferrin in control and hypotransferrinaemic mice: Implications for regulation of transferrin turnover. Br J Haematol 89:177, 1995
14. Mancini G, Carbonara AO, Heremans JF: Immunochemical quantification of antigens by single radial immunodiffusion. Int J Immunochem 2:235, 1965
15. Vanderkooi JM, Erecinska M, Silver IA: Oxygen in mammalian tissue: Methods of measurement and affinities of various reactions. Am J Physiol 260:C1131, 1991
16. Paxson CL, Smith LH: Blood volume of the mouse. Exp Haematol 17:42, 1968
17. Drabkin DL, Austin JH: Spectrophotometric studies. I. Spectrophotometric constants for common haemoglobin derivatives in the human, dog and rabbit blood. J Biol Chem 98:719, 1932
18. Simpson RJ, Peters TJ: Forms of soluble iron in mouse stomach and duodenal lumen: Significance for mucosal uptake. Br J Nutr 63:79, 1990
19. Foy AL, Williams HL, Cortell S, Conrad ME: A modified procedure for the determination of nonheme iron in tissue. Anal Biochem 18:559, 1967
20. Bjarnason I, Peters TJ: In vitro determination of small intestinal permeability: Demonstration of a persistent defect in patients with coeliac disease. Gut 25:145, 1984
21. 2 and microvascular responses during glucose exposure. Am J Physiol 238:H164, 1980
22. Germann R, Haisjackl M, Hasibeder W, Sparr H, Luz G, Plattner R, Pemthaler H, Friesenecker B, Falk M: Dopamine and mucosal oxygenation in the porcine jejunum. J Appl Physiol 77:2845, 1994
23. Haisjackl M, Luz G, Sparr H, Germann R, Salak N, Friesenecker B, Deusch E, Meusburger S, Hasibeder W: The effects of progressive anemia on jejunal mucosal and serosal tissue oxygenation in pigs. Anesth Analg 84:538, 1997
24. Simpson RJ, Deenmamode J, McKie AT, Raja KB, Salisbury JR, Iancu TC, Peters TJ: Time-course of iron overload and biochemical, histopathological and ultrastructural evidence of pancreatic damage in hypotransferrinaemic mice. Clin Sci 93:453, 1997
25. 3+) absorption, Br J Haematol 73:254, 1989
26. 3+) absorption, hypoxia and erythropoiesis. Br J Haematol 68:373, 1988
27. Sauer JP, Chapman CW, Gallagher NI: Effects of altered erythropoiesis on iron absorption. Lab Invest 20:558, 1969
28. Flanagan PR, Haist J, Valberg LS: Comparative effects of iron-deficiency induced by bleeding and a low-iron diet on the intestinal absorptive interactions of iron, cobalt, manganese, zinc, lead and cadmium. J Nutr 110:1754, 1980
29. Raja KB, Simpson RJ, Peters TJ: Assessment of intestinal bloof-flux by laser Doppler fluxmetry in mice with altered intestinal iron absorption. Br J Haematol 89:874, 1995
30. Bradbury MWB, Raja KB, Ueda F: Contrasting uptakes of 59Fe into spleen, liver, kidney and some other soft tissues in normal and hypotransferrinaemic mice: Influence of antibody against the transferrin receptor. Biochem Pharmacol 47:969, 1994
31. Zhou XY, Tomatsu S, Fleming RE, Parkilla S, Waheed A, Jiang JX, Fei Y, Brunt EM, Ruddy DA, Prass CE, Schatzman RC, O'Neill R, Britton RS, Bacon BR, Sly WS: HFE gene knockout produces a mouse model of hereditary hemochromatosis. Proc Natl Acad Sci USA 95:2492, 1998
32. Conrad ME, Crosby WH: Intestinal mucosal mechanisms controlling iron absorption. Blood 22:406, 1963
33. Parkilla S, Waheed A, Britton RS, Feder JN, Tsuchihasni Z, Schatzman RC, Bacon BR, Sly WS: Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal trace. Proc Natl Acad Sci USA 94:2534, 1997
34. Fleming MD, Trenor CCI, Su MA, Foernzler D, Beier DR, Dietrich WF, Andrews NC: Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 16:383, 1997
35. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA: Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388:482, 1997
36. Fleming MD, Romano MA, Su MA, Garrick LM, Garrick MD, Andrews NC: Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci USA 95:1148, 1998