Aging and the kidney

Journal of the American Society of Nephrology

Volumn 7, Issue 8, 1996, Pages 1106-1122

  Epstein, Murray ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; GFR; RBF; Renal concentrating ability; Renal sodium handling

Indexed keywords

POTASSIUM ION; SODIUM ION;

AGING; COMORBIDITY; CREATININE CLEARANCE; DIALYSIS; GLOMERULUS FILTRATION RATE; HEART DISEASE; HUMAN; HYPERTENSION; KIDNEY BLOOD FLOW; KIDNEY FAILURE; KIDNEY FUNCTION; KIDNEY TRANSPLANTATION; PRIORITY JOURNAL; REVIEW; SODIUM ABSORPTION;

EID: 0030405112     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (135)

1. Epstein M: Effects of aging on the kidney. Fed Proc 1979;38:168-172.
2. Roessle R, Roulet F. Nieren, Mass und Zahl in der Pathologie. Berlin: J. Springer; 1932:63-67.
3. Dunnill MS, Halley W: Some observations on the quantitative anatomy of the kidney. J Pathol 1973;110:113-121.
4. Kaplan C, Pasternack B, Shah H, Gallo G: Age-related incidence of sclerotic glomeruli in human kidneys. Am J Pathol 1975;80:227-234.
5. Wald H: The weight of normal adult human kidneys and its variability. Arch Pathol Lab Med 1937;23:493-500.
6. Tauchi H, Tsuboi K, Okutomi J: Age changes in the human kidney of the different races. Gerontologia (Basel) 1971;17:87-97.
7. McLachlan MSF: The aging kidney. Lancet 1978;2:143-145.
8. Goyal VK: Changes with age in the human kidney. Exp Gerontol 1982;17:321-331.
9. Ljungqvist A, Lagergren C: Normal intrarenal arterial pattern in adult and aging human kidney. J Anat 1962;96:285-300.
10. Takazakura E, Sawabu N, Handa A, Takada A, Schinoda A, Takeuchi J: Intrarenal vascular changes with age and disease. Kidney Int 1972;2:224-230.
11. Kappel B, Olsen S: Cortical interstitial tissue and sclerosed glomeruli in the normal human kidney, related to age and sex. Virchows Arch (A) 1980;387:271-277.
12. Shock NW: Current trends in research on the physiological aspects of aging. J Am Geriatr Soc 1967;15:995-1000.
13. Epstein M, Hollenberg NK: Age as a determinant of renal sodium conservation in normal man. J Lab Clin Med 1976;87:411-417.
14. Hollenberg NK, Adams DF, Solomon HS, Rashid A, Abrams HL, Merrill JP: Senescence and the renal vasculature in normal man. Circ Res 1974;34:309-316.
15. Andres R: Physiological factors of aging significant to the clinician [Summary of Remarks]. J Am Geriatr Soc 1969;17:274-277.
16. Goldring W, Chasis H, Ranges HA, et al.: Relations of effective renal blood flow and glomerular filtration to tubular excretory mass in normal man. J Clin Invest 1940;19:739-750.
17. Davies DF, Shock NW: Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J Clin Invest 1950; 29:496-506.
18. Miller JH, McDonald RK, Shock NW: The renal extraction of p-aminohippurate in the aged individual. J Gerontol 1951;6:213-216.
19. Fliser D, Zeier M, Nowack R, Ritz E: Renal functional reserve in healthy elderly subjects. J Am Soc Nephrol 1993;3:1371-1377.
20. Faulstick D, Yiengst MJ, Oussler DA, Shock NW: Glomerular permeability in young and old subjects. J Gerontol 1962;17:40-44.
21. McDonald RK, Solomon DH, Shock NW: Aging is a factor in the renal hemodynamic changes induced by a standard pyrogen. J Clin Invest 1951;30:457-462.
22. Bohler J, Gloer D, Reetze-Bonorden P, Keller E, Schllmeyer PJ: Renal functional reserve in elderly patients. Clin Nephrol 1993;30:145-150.
23. Wesson LG Jr. Renal hemodynamics in physiological states. In: Physiology of the Human Kidney. New York: Grune & Stratton; 1969:96-108.
24. Davidson AJ, Talner LB, Downs WM: A study of the angiographic appearance of the kidney in an aging normotensive population. Radiology 1969;92:975-983.
25. McLachlan MS, Guthrie JC, Anderson CK, Fulker MJ: Vascular and glomerular changes in the aging kidney. J Pathol 1977;121:65-78.
26. Lewis WH Jr, Alving AS: Changes with age in the renal function in adult men. Am J Physiol 1938;123:500-515.
27. Rowe JW: Clinical research on aging: Strategies and directions. N Engl J Med 1977;297:1332-1336.
28. Rowe JW, Andres R, Tobin JD, Norris AH, Shock NW: The effect of age on creatinine clearance in man: A cross-sectional and longitudinal study. J Gerontol 1976;31:155-163.
29. Lindeman RD, Tobin JD, Shock NW: Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc 1985;33:278-285.
30. Lew SQ, Bosch JP: Effect on diet on creatinine clearance and excretion in young and elderly healthy subjects and in patients with renal disease. J Am Soc Nephrol 1991;2:856-865.
31. Kampmann J, Siersbaek-Nielsen K, Kristensen M, et al.: Rapid evaluation of creatinine clearance. Acta Med Scand 1974;196:517-520.
32. Cockroft DW, Gault MH: Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31-41.
33. Jeliffe RW: Estimation of creatinine clearance when urine cannot be collected. Lancet 1971;1:975-976.
34. Reidenberg MM: Kidney function and drug action. N Engl J Med 1985;313:816-817.
35. Sarubbi FA, Hull JH: Amikacin serum concentrations: Prediction of levels and dosage guidelines. Ann Intern Med 1978;84:612-618.
36. Food and Drug Administration, Center for Drug Evaluation and Research. Guidelines for the Study of Drugs Likely to Be Used in Elderly. Rockville, MD: US Department of Health and Human Services; 1989.
37. Physicians Desk Reference. 49th Ed. Montvale, NJ: Medical Economics Data Production; 1995.
38. Malmrose LC, Gray SL, Peiper CF, et al.: Measured versus estimated creatinine clearance in a high-functioning elderly sample: MacArthur Foundation study of successful aging. J Am Geriatr Soc 1993;41: 715-721.
39. Gral T, Young M: Measured versus estimated creatinine clearance in the elderly as an index of renal function. J Am Geriatr Soc 1980;28:492-496.
40. Drusano GL, Muncie AL, Hoopes JM, Damron DJ, Warren JW: Commonly used methods of estimating creatinine clearance are inadequate for elderly debilitated nursing home patients. J Am Geriatr Soc 1988; 36:437-441.
41. Goldberg TH, Finkelstein MS: Difficulties in estimating glomerular filtration rate in the elderly. Arch Intern Med 1987;147:1430-1433.
42. Beck CL, Pucino F, Carlson JD: Evaluation of creatinine clearance estimation in an elderly male population. Pharmacotherapy 1988;8:183-188.
43. Jelliffe RW: Creatinine clearance: Bedside estimate. Ann Intern Med 1973;79:604-605.
44. Rowe JW, Anders R, Tobin JD, et al.: Age-adjusted standards for creatinine clearance [Letter]. Ann Intern Med 1976;84:567-569.
45. Siersbaek-Nielsen K, Hansen JM, Kampmann J, et al.: Rapid evaluation of creatinine clearance. Lancet 1971; 1:1133-1134.
46. Friedman JR, Norman DC, Yoshikawa TT: Correlation of estimated renal function parameters versus 24-hour creatinine clearance in ambulatory elderly. J Am Geriatr Soc 1989;37:145-149.
47. Sawyer WT, Canaday BR, Poe TE, et al.: Variables affecting creatine clearance prediction. Am J Hosp Pharm 1983;40:2175-2180.
48. Mawer GE, Knowles BR, Lucas SB, et al.: Computer-assisted prescribing of kanamycin for patients with insufficiency. Lancet 1972;1:12-15.
49. Baylis C, Fredericks M, Wilson C, Munger K, Collins R: Renal vasodilatory response to intravenous glycine in the aging rat kidney. Am J Kidney Dis 1990;15:244-251.
50. Rao KV, Kasiske BL, Odlund MD, Ney AL, Andersen RC: Influence of cadaver donor age on posttransplant renal function and graft outcome. Transplantation 1990;49:91-95.
51. Darmady EM: Transplantation and the ageing kidney. Lancet 1974;2:1046-1047.
52. Yuge J, Cecka JM. Sex and age effects in renal transplantation. In: Terasaki PI, Ed. Clinical Transplants 1991. Los Angeles: UCLA Tissue Typing Laboratory; 1992:257-267.
53. Matas AJ, Simmons RL, Kjellstrand M, et al.: Transplantation of the aging kidney. Transplantation 1976; 21:160-161.
54. Sakellariou G, Daniilidis M, Alexopoulus E, et al.: Does the donor age influence graft survival in renal transplantation? Transplant Proc 1987;19:2071-2073.
55. Terasaki PI, Koyama H, Cecka JM, Gjertson DW: The hyperfiltration hypothesis in human renal transplantation. Transplantation 1994;57;1450-1454.
56. Ito Y, Iwaki Y, Terasaki PI. Donor and recipient age effect. In: Terasaki PI, Ed. Clinical Transplants. Los Angeles: UCLA Tissue Typing Laboratory; 1986:189-197.
57. Ogden DA: Consequences of renal donation in man. Am J Kidney Dis 1983;2:501-511.
58. Neuringer JR, Brenner BM: Hemodynamic theory of progressive renal disease: A 10-year update in brief review. Am J Kidney Dis 1993;22:98-104.
59. Hakim RM, Goldszer RC, Brenner BM: Hypertension and proteinuria: Long term sequelae of uninephrectomy in humans. Kidney Int 1984;25:930-936.
60. Najarian JS, Chavers BM, McHugh LE, et al.: Twenty years or more of follow-up of living kidney donors. Lancet 1992;340:807-810.
61. Vincenti F, Amend WJC, Kaysen G, et al: Long-term renal function in kidney donors: Sustained compensatory hyperfiltration with no adverse effects. Transplantation 1983;36:626-629.
62. Jones J, Payne WD, Matas AJ: The living donor: Risks, benefits and related concerns. Transplant Rev 1993;7-115-128.
63. Weidmann P, Demyttenaere-Bursztein S, Maxwell MH, DeLima J: Effect of aging on plasma renin and aldosterone in normal man. Kidney Int 1975;8:325-333.
64. Crane MG, Harris JJ: Effect of aging on renin activity and aldosterone excretion. J Lab Clin Med 1976;87: 947-959.
65. Sporn N, Lancestremere RG, Papper S: Differential diagnosis of oliguria in aged patients. N Engl J Med 1962;267:130-132.
66. Shannon RP, Wei JY, Rosa RM, Epstein FH, Rowe JH: The effect of age and sodium depletion on cardiovascular response to orthostasis. Hypertension 1986;8:438-443.
67. Luft FC, Grim CE, Fineberg N, Weinberger MC: Effects of volume expansion and contraction in normotensive whites, blacks and subjects of different ages. Circulation 1979;59:644-650.
68. Luft FC, Weinberger MH, Fineberg NS, Miller JZ, Grim CE: Effects of age on renal sodium homeostasis and its relevance to sodium sensitivity. Am J Med 1987; 82[Suppl 1B]:S9-S15.
69. Kirkland JL, Lye M, Levy DW, Banerjee AK: Patterns of urine flow and electrolyte excretion in healthy elderly people. Br Med J 1983;287:1665-1667.
70. Masilamani S, Baylis C: Defective pressure natriuresis in the ageing kidney [Abstract]. J Am Soc Nephrol 1993;4:516.
71. Baylis C: Renal responses to acute angiotensin II inhibition and administered angiotensin II in the aging, conscious, chronically catheterized rat. Am J Kidney Dis 1993;22:842-850.
72. Noth RH, Lassman N, Tan SY, Fernández-Cruz A, Mulrow PJ: Age and the renin-aldosterone system. Arch Int Med 1977;137:1414-1417.
73. Tsunoda K, Abe K, Goto T: Effect of age on the renin-angiotensin-aldosterone system in normal subjects: Simultaneous measurement of active and inactive renin, renin substrate and aldosterone in plasma. J Clin Endocrinol Metab 1986;62:384-389.
74. Annat G, Vinvent M, Tourniaire A, Sassard J: Relationship between blood pressure and plasma renin, aldosterone and dopamine-β-hydroxylase in the elderly. Gerontology 1981;27:266-270.
75. Weidman P, Beretta-Piccoli C, Ziegler WH, Keusch G, Gluck Z, Reubi F: Age versus urinary sodium for judging renin, aldosterone, and catecholamine levels: Studies in normal subjects and patients with essential hypertension. Kidney Int 1978;14:619-628.
76. Jung FF, Kennefick TM, Ingelfinger JR, Voral JP, Anderson S: Down-regulation of the intrarenal renin-angiotensin system in the ageing rat. J Am Soc Nephrol 1995;8:1573-1580.
77. Skøtt P, Ingerslev J, Damkjaer Nielseon M, Giese J: The renin-angiotensin-aldosterone system in normal 85-year old people. Scand J Clin Lab Invest 1987;47: 6974.
78. Bauer JH: Age-related changes in the renin-aldosterone system: Physiological effects and clinical implications. Drugs Aging 1993;3:238-245.
79. Duggan J, Kilfeather S, O'Brien E, O'Malley K, Nussberger J: Effects of aging and hypertension on plasma angiotensin II and platelet angiotensin II receptor density. Am J Hypertens 1992;5:687-693.
80. Lewicki JA, Protter AA. Physiological studies of the natriuretic peptide family. In: Laragh JH, Brenner BM, Eds. Hypertension: Pathophysiology, Diagnosis and Management, 2nd Ed. New York: Raven Press, 1995: 1029-1054.
81. Ohashi M, Fujio N, Nawata H, et al.: High plasma concentration of human atrial natriuretic polypeptide in aged men. J Clin Endocrinol Metab 1987;64:81-85.
82. Ibayashi H: Pharmacokinetics of synthetic α-human atrial natriuretic polypeptide in normal men: Effect of aging. Regul Pept 1987;19:265-272.
83. Haller BG, Zust H, Shaw S, Gnadinger MP, Uehlinger DE, Weidman P: Effects of posture and aging on circulating atrial natriuretic peptide levels in man. J Hypertens 1987;5:551-556.
84. Heim JM, Gottmann K, Weil J, Strom TM, Gerger R: Effects of a bolus dose of atrial natriuretic factor in young and elderly volunteers. Eur J Clin Invest 1989; 19:265-271.
85. Tan AC, Jansen TL, Thien T, Kloppenborg PW, Benraad TJ: Comparison of cyclic guanosine monophosphate response to infusion of atrial natriuretic peptide in young and elderly subjects. J Am Geriatr Soc 1993; 41:1241-1244.
86. Tan AC, Jansen TL, Termond ET, et al.: Kinetics of atrial natriuretic peptide in young and elderly subjects. Eur J Clin Pharmacol 1992;42:449-452.
87. Tan AC, Hoefnagels WH, Swenkels LM, Kloppenborg PW, Benraad TJ: The effect of volume expansion on atrial natriuretic peptide and cyclic guanosine monophosphate levels in young and aged subjects. J Am Geriatr Soc 1990;38:1215-1219.
88. Arendt RM, Gerbes AL, Ritter D, et al.: Molecular weight heterogeneity of plasma ANF in cardiovascular disease. Klin Wochenschr 1986;64[Suppl 6]:S97-S102.
89. Bengele HH, Mathias R, Perkins JH, McNamara ER, Alexander EA: Impaired renal and extrarenal potassium adaptation in old rats. Kidney Int 1983;23:684-690.
90. Goldman R: Aging of the excretory system. In: Finch CE, Hayflick L, Eds. Handbook of The Biology of Aging. New York: Van Nostrand Reinhold; 1977:409-431.
91. Rowe JW, Shock NW, DeFronzo RA: The influence of age on the renal response to water deprivation in man. Nephron 1976;17:270-278.
92. Helderman JH, Vestal RE, Rowe JW, Tobin JD, Andres R, Robertson GL: The response of arginine vasopressin to intravenous ethanol and hypertonic saline in man: The impact of aging. J Gerontol 1978;33:39-47.
93. Rowe JW Minaker KL, Sparrow D, Robertson GL: Age-related failure of volume-pressure-mediated vasopressin release. J Clin Endocrinol Metab 1982;54:661-664.
94. Rondeau E, De Lima J, Caillens H, et al.: High plasma antidiuretic hormone in patients with cardiac failure: Influence of age. Miner Electrolyte Metab 1982;8:267-274.
95. Duggan J, Kilfeather S, Lightman SL: The association of age with plasma arginine vasopressin and plasma osmolality. Age Ageing 1993;22:332-336.
96. Faull CM, Holmes C, Baylis PH: Water balance in elderly people: Is there a deficiency of vasopressin? Age Ageing 1993;22:114-120.
97. Chiodera P, Capretti L, Marchesi M, et al.: Abnormal arginine vasopressin response to cigarette smoking and metoclopramide (but not to insulin-induced hypoglycemia) in elderly subjects. J Gerontol 1991;46:M6-M10.
98. Frolkis VV, Golovchenko SF, Medved VI, Frolkis RA: Vasopressin and cardiovascular system in aging. Gerontology 1982;28:290-302.
99. Kirkland J, Lye M, Goddard C, Vargas E, Davies I: Plasma arginine vasopressin in dehydrated elderly patients. Clin Endocrinol 1984;20:451-456.
100. Bevilacqua M, Norbiato G, Chebat E, et al.: Osmotic and nonosmotic control of vasopressin release in the elderly: Effect of metoclopramide. J Clin Endocrinol Metab 1987;65:1243-1247.
101. Coiro V, Butturini A, Gnudi R, Delsignore R, Volpi R, Chiodera P: Nicotinic involvement in arginine-vasopressin response to insulin-induced hypoglycemia in normal men. Metabolism 1986;35:577-579.
102. Phillips PA, Rolls BY, Ledingham JG, Forsling ML, Morton JJ, Crowe MJ: Reduced thirst after water deprivation in healthy elderly men. N Engl J Med 1984; 311:753-759.
103. Lindeman RD, Lee TD, Yiengst MJ, Shock NW: Influence of age, renal disease, hypertension, diuretics and calcium on the antidiuretic responses to suboptimal infusions of vasopressin. J Lab Clin Med 1966;68:206-223.
104. Crowe MJ, Forsling M, Rolls B, Phillips PA, Ledingham JG, Smith BF: Altered water excretion in healthy men. Age Ageing 1987;16:285-293.
105. Bengele HH, Mathias RS, Perkins JH, Alexander EA: Urinary concentrating defect in the aged rat. Am J Physiol 1981;240:F147-F150.
106. Kleinfeld M, Casimir M, Borra S: Hyponatremia as observed in a chronic disease facility. J Am Geriatr Soc 1979;27:156-161.
107. Sunderam SG, Mankikar GD: Hyponatraemia in the elderly. Age Ageing 1983;12:77-80.
108. Challah S, Wing AJ, Bauer R, et al.: Negative selection of patients for dialysis and transplantation in the United Kingdom. Br Med J 1984;288:1119-1122.
109. Weinstock Brown, W. Geriatric dialysis patients. In: Henrich WL, Ed. Principles and Practice of Dialysis. Baltimore: Williams & Wilkins; 1994:339-360.
110. Westlie L, Umen A, Nestrud S, Kjellstrand CM: Mortality, morbidity and life satisfaction in the very old dialysis patient. ASAIO Trans 1984;30:20-31.
111. Agodoa LY, Eggers PW: Renal replacement therapy in the United States: Data from the United States Renal Data System. Am J Kidney Dis 1995;25:119-133.
112. United States Renal Data System: USRDS 1995 Annual Data Report. Am J Kidney Dis 1995;26[Suppl 2]:S1-S186.
113. Port FK: End-stage disease: Magnitude of the problem, prognosis of future trends and possible solutions. Kidney Int 1995;48[Suppl 50]:S3-S6.
114. Ismail N, Hakim RM, Oreopoulos DG, Patrikarea A: Renal replacement therapies in the elderly: Part 1. Hemodialysis and chronic peritoneal dialysis. Am J Kidney Dis 1993;22:759-782.
115. Mion C, Oul̀es R, Canaud B, et al.: Maintenance dialysis in the elderly: A review of 15 years experience in Languedoc-Roussillon. Proc EDTA-ERA 1984;21:490-509.
116. Panarello G, De Baz H, Cecchin E, Tesio F: Dialysis for the elderly: Survival and risk factors. Adv Perit Dial 1989;5:49-51.
117. Williams AJ, Nicholl JP, el Nahas AM, Moorhead PJ, Plant MJ, Brown CB: Continuous ambulatory peritoneal dialysis and haemodialysis in the elderly. QJ Med 1990;274:215-223.
118. Held PJ, Port FK, Turenne MN, Gaylin DS, Hamburger RJ, Wolfe RA: Continuous ambulatory peritoneal dialysis and hemodialysis: A comparison of patient mortality with adjustment for comorbid conditions. Kidney Int 1994;45:1163-1169.
119. Avram MR, Pena C, Burrell D, Antignani A, Avram MM: Hemodialysis and the elderly patient: Potential advantages as to quality of life, urea generation, serum creatinine, and less interdialytic weight gain. Am J Kidney Dis 1990;16:342-345.
120. Chester AC, Rakowski TA, Argy WP Jr, Giacalone A, Schreiner GE: Hemodialysis in the eighth and ninth decades of life. Arch Intern Med 1979;139:1001-1005.
121. Holley JL, Foulks CJ: The utility of a structured evaluation of elderly patients for continuous peritoneal dialysis. Perit Dial Int 1991;11:162-165.
122. Gentile DE and the Geriatric Advisory Committee: Peritoneal dialysis in geriatric patients: A survey of clinical practice. Adv Perit Dial 1990;6[Suppl 6]:S29-S32.
123. Nissenson AR: Chronic peritoneal dialysis in the elderly. Geriatr Nephrol Urol 1991;1:3-12.
124. Nissenson AR, Diaz-Buxo JA, Adcock A, Nelms M: Peritoneal dialysis in the geriatric patient. Am J Kidney Dis 1990;16:335-338.
125. Diaz-Buxo JA, Adcock A, Nelms M: Experience with continuous cyclic peritoneal dialysis in the geriatric patient. Adv Perit Dial 1990;6[Suppl]:S61-S64.
126. Mattern WD, Morris CR, Heffley DL: A three-year experience with CCPD in a university-based dialysis and transplantation program. Clin Nephrol 1988;30[Suppl 1]:S49-S52.
127. Ismail N, Hakim RM, Helderman H: Renal replacement therapies in the elderly: Part II. Renal transplantation. Am J Kidney Dis 1994;23:1-15.
128. Pirsch JD, Stratta RJ, Armbrust MJ, D'alessandro AM, Sollinger HW, Kalayoglu M, Beizer FO: Cadaveric renal transplantation with cyclosporine in patients more than 60 years of age. Transplantation 1989;47:259-261.
129. Eggers PW: Health care policies/economics of the geriatric renal population. Am J Kidney Dis 1990;16:384-391.
130. Hunsicker LG: Impact of cyclosporine on cadaveric renal transplantation: A summary statement. Am J Kidney Dis 1985;6:335-341.
131. DeLuca L, Cardella CJ: How can the care of elderly dialysis patients be improved? Semin Dial 1992;5:28-29.
132. Velez RL, Brinker KR, Vergne-Marini PJ, Nesser DA, Long DL, Trevino G, Dickerman RM, Helfsick GB: Renal transplantation with cyclosporine in the elderly population. Transplant Proc 1991;23:1749-1752.
133. Fox RA. Immunology of aging. In: Brockelhurst JC, Ed. Textbook of Geriatric Medicine and Gerontology. New York: Churchill Livingstone; 1985:82-104.
134. Miller RA: The cell biology of aging: Immunological model. J Gerontol 1989;44:B4-B8.
135. Ringden O, Ost L, Klintmalm G, Tillegard A, Fechman I, Wilczek H, Groth CG: Improved outcome in renal transplant recipients above 55 years of age treated with cyclosporine and low dose of steroids. Transplant Proc 1983;15[Suppl 1]:S2507-S2512.