Allelic exclusion at the TCRβ locus

Current Opinion in Immunology

Volumn 14, Issue 2, 2002, Pages 230-234

  Khor, Bernard ^a   Sleckman, Barry P ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; PROTEIN P56; RAF PROTEIN; RAG1 PROTEIN; RAS PROTEIN; SIGNAL PEPTIDE;

ALLELE; ALLELIC EXCLUSION; CELL LINE; CELL SURFACE; CHROMATIN STRUCTURE; DNA MODIFICATION; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; FEEDBACK SYSTEM; GENE ACTIVATION; GENE CONTROL; GENETIC VARIABILITY; GERM LINE; METHYLATION; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; THYMOCYTE; TRANSCRIPTION REGULATION; TRANSGENE; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; GENE EXPRESSION REGULATION; GENE REARRANGEMENT; HUMAN; PHYSIOLOGY; T LYMPHOCYTE; T LYMPHOCYTE RECEPTOR GENE;

ALLELES; ANIMALS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE REARRANGEMENT, T-LYMPHOCYTE; GENES, T-CELL RECEPTOR BETA; HUMANS; T-LYMPHOCYTES;

EID: 0036525695     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(02)00326-6     Document Type: Review

References (59)

1. Differential activity of allelic γ-globulin genes in antibody-producing cells
2. Cellular localization of immunoglobulins with different allotypic specificities in rabbit lymphoid tissues
3. Clonal selection and learning in the antibody system
4. Regulation of TCR α and β gene allelic exclusion during T-cell development
5. Exclusion and inclusion of α and β T cell receptor alleles
6. T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: Implications for T cell allelic exclusion and antigen-specific repertoire
7. Expression of two T cell receptor α chains: Dual receptor T cells
8. Allelic exclusion of the T cell receptor α-chain: Developmental regulation of a post-translational event
9. Marked differences in the efficiency of expression of distinct αβ T cell receptor heterodimers
10. Allelic inclusion of T cell receptor α genes poses an autoimmune hazard due to low-level expression of autospecific receptors
11. Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function
12. Somatic generation of antibody diversity
13. The RAG proteins and V(D)J recombination: Complexes, ends, and transposition
14. Identification of genes involved in repair of DNA double-strand breaks in mammalian cells
15. V(D)J recombination and double-strand break repair
16. Factors and forces controlling V(D)J recombination
17. Accessibility control of antigen-receptor variable-region gene assembly: Role of cis-acting elements
18. V(D)J recombination becomes accessible
19. Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule
20. Comparative genomics of the human and mouse T cell receptor loci
21. A transcriptional enhancer 3′ of the Cβ2 in the T cell receptor β locus
22. Promoter element for transcription of unrearranged T-cell receptor β-chain gene in pro-T cells
23. A developmental stage-specific promoter directs germline transcription of D β J β gene segments in precursor T lymphocytes
24. Control of V(D)J recombinational accessibility of the D β 1 gene segment at the TCR β locus by a germline promoter
25. Regulation of V(D)J recombination by transcriptional promoters
26. Gene-targeted deletion and replacement mutations of the T-cell receptor β-chain enhancer: The role of enhancer elements in controlling V(D)J recombination accessibility
27. Deletion of the mouse T-cell receptor β gene enhancer blocks αβ T-cell development
28. Chromatin remodeling by the T cell receptor (TCR)-β gene enhancer during early T cell development: Implications for the control of TCR-β locus recombination
29. Structure and function of the pre-T cell receptor
30. Different initiation of pre-TCR and γδ TCR signalling
31. 2+ mobilization and activation of NF-κB and NFAT
32. Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains
33. Receptors and signals in early thymic selection
34. Ordered rearrangement of immunoglobulin heavy chain variable region segments
35. The roles of preB and B cell receptors in the stepwise allelic exclusion of mouse IgH and L chain gene loci
36. Allelic exclusion in B and T lymphopoiesis
37. In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes
38. Exit of the pre-TCR from the ER/cis-Golgi is necessary for signaling differentiation, proliferation, and allelic exclusion in immature thymocytes
39. The CD3-γδε and CD3-ζη modules are each essential for allelic exclusion at the T cell receptor β locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-β, -γ, and -δ loci
40. Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor β locus
41. lck controls allelic exclusion of T-cell receptor β-chain genes
42. Allelic exclusion of the T cell receptor β locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein
43. lck
44. Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes
45. Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion
46. Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors
47. Activated Ras signals differentiation and expansion of CD4+8+ thymocytes
48. Assembly of productive T cell receptor δ variable region genes exhibits allelic inclusion
49. Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression
50. Asynchronous replication and allelic exclusion in the immune system
51. κ chain monoallelic demethylation and the establishment of allelic exclusion
52. Structure and function in the nucleus
53. Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes
54. Productive T-cell receptor β-chain gene rearrangement: Coincident regulation of cell cycle and clonality during development in vivo
55. Two waves of recombinase gene expression in developing thymocytes
56. Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro
57. + thymocyte differentiation
58. Regulation of Vβ germline transcription in RAG-deficient mice by the CD3ε-mediated signals: Implication of Vβ transcriptional regulation in TCR β allelic exclusion
59. A change in the structure of Vβ chromatin associated with allelic exclusion