Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors

Journal of Molecular Biology

Volumn 329, Issue 1, 2003, Pages 93-120

  Katz, Bradley A ^a   Elrod, Kyle ^a   Verner, Erik ^a   Mackman, Richard L ^a,b   Luong, Christine ^a   Shrader, William D ^a   Sendzik, Martin ^a   Spencer, Jeffrey R ^a   Sprengeler, Paul A ^a   Kolesnikov, Aleks ^a   Tai, Vincent W F ^a   Hui, Hon C ^a   Breitenbucher, J Guy ^a,c   Allen, Darin ^a,d   Janc, James W ^a  

^a CELERA   (United States)

^b GILEAD SCIENCES   (United States)

^c JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^d Sunesis Pharmaceuticals Inc   (United States)

Author keywords

Inhibition mechanism; Serine protease; Shift of pKa of His57; Short hydrogen bond; Trypsin

Indexed keywords

HISTIDINE; PHENOL DERIVATIVE; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; THROMBIN; TRYPSIN; UROKINASE;

ACIDITY; ALKALINITY; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ELECTRONICS; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROGEN BOND; INHIBITION KINETICS; IONIZATION; MOLECULAR PROBE; PH; PKA; PRIORITY JOURNAL; PROTEIN MOTIF; REACTION OPTIMIZATION; RNA FINGERPRINTING; STEREOCHEMISTRY; STEREOSPECIFICITY;

EID: 0037693764     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(03)00399-1     Document Type: Article

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