2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 15, 2002, Pages 2019-2022

  Mackman, Richard L ^a,b   Hui, Hon C ^a   Breitenbucher, J Guy ^a,c   Katz, Bradley A ^a   Luong, Christine ^a   Martelli, Arnold ^a   McGee, Danny ^a,d   Radika, Kesavan ^a   Sendzik, Martin ^a   Spencer, Jeffrey R ^a   Sprengeler, Paul A ^a   Tario, James ^a,b   Verner, Erik ^a   Wang, Jing ^a,e  

^a CELERA   (United States)

^b GILEAD SCIENCES   (United States)

^c R W Johnson P R I   (United States)

^d Corixa ^*  (United States)

^e EXELIXIS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 HYDROXY 3 ETHOXYPHENYL) 1H BENZIMIDAZOLE 6 CARBOXAMIDINE; AMIDINE; PLASMINOGEN ACTIVATOR INHIBITOR; UNCLASSIFIED DRUG; BENZIMIDAZOLE DERIVATIVE; CELL SURFACE RECEPTOR; SERINE PROTEINASE INHIBITOR; UROKINASE;

ARTICLE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYDROGEN BOND; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; METABOLISM; PROTEIN BINDING; STEREOISOMERISM; X RAY CRYSTALLOGRAPHY;

AMIDINES; BENZIMIDAZOLES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; MODELS, MOLECULAR; PROTEIN BINDING; RECEPTORS, CELL SURFACE; SERINE PROTEINASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; URINARY PLASMINOGEN ACTIVATOR;

STAPHYLOCOCCUS PHAGE 3A;

EID: 0037025460     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00311-6     Document Type: Article

References (23)