Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated aryl hydrocarbon receptor transformation and CYP1A1 induction by the phosphatidylinositol 3-kinase inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1- benzopyran-4-one (LY294002)

Biochemical Pharmacology

Volumn 60, Issue 5, 2000, Pages 635-642

  Guo, Meng ^a   Joiakim, Aby ^a   Reiners Jr , John J ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

Aryl hydrocarbon receptor; CYP1A1; LY294002; Phosphatidylinositol 3 kinase; TCDD

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; ETHOXYRESORUFIN DEETHYLASE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

ARTICLE; BREAST EPITHELIUM; CELL CULTURE; CELL LINE; CONTROLLED STUDY; CYTOSTASIS; CYTOTOXICITY; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR BINDING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; CELL DIVISION; CELL LINE, TRANSFORMED; CHROMONES; CYTOCHROME P-450 CYP1A1; DNA; DRUG INTERACTIONS; ENZYME INDUCTION; ENZYME INHIBITORS; HUMANS; MORPHOLINES; RECEPTORS, ARYL HYDROCARBON; TETRACHLORODIBENZODIOXIN; TRANS-ACTIVATION (GENETICS);

EID: 0034284781     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00379-8     Document Type: Article

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