Megamitochondria formation - Physiology and pathology

Journal of Cellular and Molecular Medicine

Volumn 6, Issue 4, 2002, Pages 497-538

  Wakabayashi, Takashi ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Apoptosis; Chloramphenicol; Ethanol; Free radicals; Hydrazine; Megamitochondria formation; Mitochondria

Indexed keywords

FREE RADICAL;

ANIMAL; CHEMISTRY; HUMAN; INTRACELLULAR MEMBRANE; MEMBRANE FUSION; METABOLISM; MITOCHONDRION; PATHOLOGY; REVIEW; ULTRASTRUCTURE;

ANIMALS; FREE RADICALS; HUMANS; INTRACELLULAR MEMBRANES; MEMBRANE FUSION; MITOCHONDRIA;

EID: 0037686243     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2002.tb00452.x     Document Type: Review

References (234)

1. Wakabayashi T., Structural changes of mitochondria related to apoptosis: swelling and megamitochondria formation, Acta Biochim. Polon., 46: 223-237, 1999
2. Wakabayashi T., Karbowski M., Structural changes of mitochondria related to apoptosis, Biol. Signals Recept., 10: 26-56, 2001
3. Kluck R.M., Bossy-Wetzel E., Green D.R., Newmeyer D.D., The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis, Science, 275: 1132-1136, 1997
4. Yang J., Liu X., Bhalla K., Kim C.N., Ibrado A.M., Cai J., Peng T-I., Pjones D.P., Wang X., Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked, Science, 275: 1129-1132, 1997
5. Susin S.A., Lorenzo H.K., Zamzami N., Marzo I., Snow B.E., Brothers G.M., Mangion J., Jacotot E., Constantini P., Loeffler M., Larochette N., Goodlett D.R., Aebersold R., Siderovski D.P., Penninger J.M., Kroemer G., Molecular characterization of mitochondrial apoptosis-inducing factor, Nature, 397: 441-446, 1999
6. Daugas E., Mitochondrial nuclear translocation of AIF in apoptosis and necrosis, FASEB J., 14: 729-739, 2000
7. Lorenzo H. K., Susin S. A., Penninger J., Kroemer G., Apoptosis inducing-factor (AIF): a phylogenetically old caspase-independent effector of cell death, Cell Death Differ., 6: 516-524, 1999
8. Cauda C., Cohen I., Daugas E., Ravagnan L., Larochette N., Zamzami N., Kroemer G., Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria, Biochemie, 84: 215-222, 2002
9. Du C., Fang M., Li Y., Wang X., Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition, Cell, 102: 33-42, 2000
10. Verhagen A. M., Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP protein, Cell, 102: 43-53, 2000
11. Zamzami N., Marchetti P., Castedo M., Decaudin D., Macho A., Hirsch T., Susin S.A., Petit P.X., Mignotte B., Kroemer G., Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death, J. Exp. Med., 182: 367-377, 1995
12. Susin S.A., Zamzami N., Castedo M., Hirsch T., Marchetti P., Macho P., Daugas E., Gauskens M., Kroemer G., Bcl-2 inhibits the mitochondrial release of an apoptogenic protease, J. Exp. Med., 184: 1331-1342, 1996
13. Decaudin D., Geley S., Hirsch T., Castedo M., Marchetti P., Macho A., Kofler R., Kroemer G., Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptotsis induced by chemotherapeutic agents, Cancer Res., 57: 62-67, 1997
14. Loeffler M., Kroemer G., The mitochondrion in cell death control: certainties and incognia, Exp. Cell Res., 256: 19-26, 2000
15. Bruguera M., Bertarn A., Bombi J.A., Rodes J., Giant mitochondria in hepatocytes. A diagnostic hint for alcoholic liver disease, Gastroenterology, 73: 1383-1387, 1977
16. Yokoo H., Singh S.K., Hawasli A.H., Giant mitochondria in alcoholic liver disease, Arch. Path. Lab. Med., 102: 213-224, 1978
17. Stewart R.V., Dincsoy H.P., The significance of giant mitochondria in liver biopsies as observed by light microscopy, Am. J. Clin. Pathol., 78: 293-298, 1982
18. Uchida T., Kronborg I., Peters R.L., Giant mitochondria in alcoholic liver disease - their identification, frequency and pathologic significance, Liver, 4: 29-38, 1984
19. Junge J., Horn T., Christoffersen P., Megamitochondria as a diagnostic marker for alcohol induced centrolobular and periportal fibrosis in the liver, Virchows Arch. A, 410: 553-558, 1987
20. Teranishi M., Karbowski M., Kurono C., Soji T., Wakabayashi T., Two types of the enlargement of mitochondria related to apoptosis: simple swelling and the formation of megamitochondria, J. Electron Microsc., 48: 637-651, 1999
21. Hales K.G., Fuller M.T., Developmentally regulated mitochondrial fusion mediated by a conseved, novel, predicted GTPase, Cell, 90: 121-129, 1997
22. Bakeeva L.E., Chentsov Y.S., Skulachev V.P., Mitochondrial framework (reticulum mitochondriale9 in rat diaphragm muscle, Biochim. Biophys. Acta, 501: 349-369, 1978
23. Rancourt M.W., Mckee A.P., Pollack W., Mitochondrial profile of a mammalian lymphocyte, J. Ultrastruct. Res., 51: 418-424, 1975
24. Koukl J.F., Volback M.L., Martin A.P., Mitochondrial three-dimensional form in Ascites tumor cells during changes in respiration, J. Ultrastruct. Res., 61: 158-165, 1977
25. Wills E.J., Crystalline structures in the mitochondria of normal human liver parenchymal cells, J. Cell Biol., 24: 511-514, 1965
26. Kmet V.A., Leibetseder J., Adamiker D., Gerontologische Untersuchungen an Rattenlebermitochondrien, Z. Altensforsch., 19: 241-247, 1966
27. Tauchi H., Sato T., Age change in size and and number of mitochondria of human hepatic cells, J. Gerontol., 23: 454-461, 1968
28. Sato T., Tauchi H., The formation of enlarged and giant mitochondria in the aging process of human hepatic cells, Acta Pathol. Jpn., 25: 403-412, 1968
29. Wilson P.D., Franks L.M., The effect of age on mitochondrial structure, Gastroenterologia, 21: 81-94, 1975
30. Luse S., Electron microscopic observation on the adrenal gland, In: The Adrenal Cortex (Moon, H. D., ed) pp. 46-63, Hoeber, New York, 1961
31. Ross, M. H., Electron microscopy of the human foetal adrenal cortex, In: Human Adrenal Cortex (Curie, A. R., Symington, T., Grant, J. K., eds) pp. 558-569, Edinburgh and London, Churchill Livington, 1962
32. Lieber, C. S., Rubin, E., Alcoholic fatty liver in man on a high protein and low fat diet, Am. J. Med., 44: 200-206, 1968
33. Iseri, O. A., Gottlieb, L. S., Alcoholic hyaline and megamitochondria as separate and distinct entities in liver disease associated with alcoholism, Gastroenterology, 60: 1027-1035, 1971
34. Peterson, P., Abnormal mitochondria in hepatocytes in human fatty liver, Acta Path. Microbiol. Scand. Sect. A, 85: 413-420, 1977
35. Sears, J. O., Nunes, J. F. M., Intramitochondrial paracrystalline inclusions in human hepatocytes, Am. J. Clin. Pathol., 71: 479-480, 1979
36. Iancu, T. C., Almagor, G., Intramitochondrial inclusions in hepatocytes. The authors' reply, Am. J. Clin. Pathol., 69: 652-653, 1978
37. Slabodsky-Brousse, N., Feldmann, G., Brousse, J., Dreyfus, P., Etude stéreologique de la fréquence des mitochondriés géantes hépatiques dans la maladie de Gilbert. Comparison avec le sujet normal, Biol. Gastroenterol. (Paris), 7: 179-186, 1974
38. Chedid, A., Jao, W., Port, J., Megamitochondria in hepatic and renal disease, Am. J. Gastroenterol., 73: 319-324, 1980
39. Raffolo, R., Covington, H., Matrix inclusion bodies in the mitochondria of the human liver, Am. J. Pathol., 51: 101-116, 1967
40. Jezequel, A. M., Dégenérscence myélinique des mitochondries de foie human dans un épithelioma du cholédoque et un ictére viral. Etude au microscope électronique, J. Ultrastruct. Res., 3: 210-215, 1959
41. Wills, E. J., Walton, B., A morphological study of unexplained hepatitis following halothane anesthesia, Am. J. Pathol., 91: 11-32, 1978
42. Iancu, T., Elian, E., Ultrastructural changes in aspirin toxicity, Am. J. Clin. Pathol., 66: 570-575, 1976
43. Perez, V., Gorosdisch, S., de Martire, J., Nicholson, R., di Paola, G., Oral contraceptives: Long-term use produces fine structural changes in liver mitochondria, Science, 165: 805-807, 1969
44. Cossel, L., Braulke, H., Storch, W., Intrazisternales Hyalin und Riesenmitokondorien in Hepatozyten und orale Kontrazeptiva, Zbl. Allg. Pathol. Anat., 123: 318-336, 1979
45. Molbert E., Marx R., Elektronenmicroscopische Untersuchungen am Lebengewebe beim Rotor Syndrom, Acta Hepatosplen., 13: 160-175, 1966
46. Steinlieb, I., Mitochondrial and fatty changes in hepatocytes of patients with Wilson's disease, Gastroenterol., 55: 354-367, 1968
47. Steinlieb, I., Feldmann, G., Effects of anticopper therapy on hepatocellular mitochondria in patients with Wilson's disease, Gastroenterol., 71: 457-461, 1976
48. Standborn, E. B., Côté, M. G., Viallet, A., Electron microscopy of a human liver in Wilson's disease (Leptospirosis icterohemorrhagica), J. Path. Bact., 92: 369-374, 1966
49. Partin, J. C., Schubert, W. K., Partin, J. S., Mitochondrial ultrastructure in Reye's syndrome (encephalopathy and fatty degeneration of the viscera), N. Engl. J. Med., 285: 1339-1343, 1971
50. Iancu, T. C., Mason, W. H., Neustein, H. B., Ultrastructural abnormalities of liver cells in Reye's syndrome, Human Pathol., 8: 421-431, 1977
51. Thiéry, J. P., Caroli, J., Etude au microscope electronique de l'amylase hépatique primaire de l'homme, Sem. Hop. Paris, 37: 29-40, 1961
52. Feldmann, G., Maurice, M., Husson, J. M., Fiessinger, J. N., Camilleri, J. P., Benhamou, J. P., Hausset, C., Hepatocyte giant mitochondria: An almost constant lesion in systemic scleroderma, Virchows Arch. Pathol. Anat., 374: 215-227, 1977
53. Shy, G. M., Silberberg, D. H., Appel, S. H., Mishkin, M. M., Godfrey, E. H., A generalized disorder of nervous ststem, skeletal muscle and heart resembling refsum's disease and hurler's syndrome. Part I (clinical, pathologic and biochemical characteristics9, Amer. J. Med., 42: 163-168, 1967
54. Bhagwat, A. G., Ross, R. C., Hepatic intramitochondrial crystalloids, Arch. Pathol., 91: 70-77, 1971
55. Haust, M. D., Crystalloid structures of hepatic mitochondria in children with heparin sulfate mucopolysaccharoidosis (San Fillipo type), Exp. Mol. Pathol., 8: 123-134, 1968
56. Thoenes, W., Feinstrukturen des normalen und funktionssgestören nephron, Nephron. Verh. Dtsch. Ges. Path., 49: 14-45, 1965
57. Thoenes, W., Über Matrixreiche riesenmitochondrien. Elektromikroskopische Beobachtungen am Tubulsepithel der menschlichen Niere bei nephrotische Syndrom, Zeitschrift für Zellforch., 75: 422-433, 1966
58. Datsis, S. A. A., Intramitochondrial filamentous inclusions in chronic glomerulonephritis, Beitr. Pathol., 149: 396-407, 1973
59. Suzuki, T., Furusato, M., Takasaki, S., Ichikawa, E., Giant mitochondria in the epithelial cells of the proximal convoluted tubules of diseased human kidney, Lab. Invest., 33: 578-590, 1975
60. Vacher-Lavenu, M. C., Desligneres, S., Abelanet, R., Daudet-Monsac, M., Oncocytoma renal a mitochondries géantes, Étude optique et ultrastructurale à propos de deux observations, Arch. Anat. Cytol. Pathol., 31: 29-36, 1983
61. Galle, P., Morel-Maroger, L., Les lésions rénales du saturnisme humain et experimental, Nephron, 2: 273-286, 1965
62. Besis, M., Breton-Gorius, J., Pathologie et asynchronisme de development des organelles cellulaires au cours des leucemies aigues granulocytaires, Nouv. Rev. Fr. Hematol., 9: 245-277, 1969
63. Ghadially, F. N., Skinnder, L. F., Giant mitochondria in erythroleukaemia, J. Pathol., 114: 113-117, 1974
64. Dallman, P. R., Goodman, J. R., Enlargement of mitochondrial compartment in iron and copper deficiency, Blood, 35: 496-505, 1970
65. Yanagihara, E. T., Naeim, F., Gale, R., Austin, G., Waisman, J., Acute lymphoblastic leukemia with giant intracytoplasmic inclusions, Am. J. Clin. Pathol., 74: 345-349, 1980
66. Blackburn, W. R., Vinijchikul, K., The pancreas in Kwashiorkor, Lab. Invest., 20: 305-318, 1969
67. Tandler, B., Shipkey, F. H., Ultrastructure of Warthin's tumor. I. Mitochondria, J. Ultrastruct. Res., 11: 292-305, 1964
68. Tandler, B., Erlandson, R. A., Giant mitochondria in a pleomorphic adenoma of the submandibular gland, Ultrastruct. Pathol., 4: 85-96, 1983
69. David, R., Kim, K. M., Dense-core metrical mitochondrial bodies in oncocytic adenoma of the thyroid, Arch. Pathol. Lab. Med., 107: 178-182, 1983
70. Luft, R., Ikkos, D/., Palmieli, G., Ernster, L., Afzelius, B., A case of severe hypermetabolism of nonthyroid origin with a defect in the maintenance of mitochondrial respiratory control: A correlated clinical, biochemical and morphological study, J. Clin. Invest., 41: 1776-1804, 1962
71. Adachi, M., Torii, J., Volk, B. W., Breit, P., Wolintz, A., Schneck, L., Electron microscopic and enzyme histochemical studies of cerebellum, ocular and skeletal muscles in chronic progressive ophthalmoplegia with cerebellar ataxia, Acta Neuropathol., 23: 300-312, 1973
72. Kapati, G., Carpenter, S., Larbrisseau, A., Lafontaine, R., The Kearns-Shy syndrome. A multiple disease with mitochondrial abnormality demonstrated in skeletal muscle and skin, J. Neurol. Sci., 19: 133-151, 1973
73. Hug, G., Schubert, W. K., Idiopathic cardiomyopathy. Mitochondrial and cytoplasmic alterations in heart and liver, Lab. Invest., 22: 541-552, 1970
74. Kraus, B., Cain, H., Giant mitochondria in the human myocardium - Morphogenesis and fate, Virchows Arch. B Cell Path., 33: 77-89, 1980
75. Hibbs, R. G., Ferrans, V. J., Black, W. C., Weilbaecher, D. G., Walsh, J. J., Burch, G. E., Alcoholic cardiomyopathy. An electron microscopic study, Am. Heart J., 69: 766-779, 1965
76. Alexander, C. S., Idiopathic heart disease. II. Electron microscopic examination of myocardium specimens in alcoholic heart disease, Am. J. Med., 41: 229-234, 1966
77. Szanto, P. B., Larsen, K., Miles, B., Sutten, G. S., Gunmar, R. M., Tobin, J. R., Ultrastructural alterations in human and experimental alcoholic cardiomyopathy, Am. J. Pathol., 50: 55a, 1967
78. Harmjanz, D., Reale, E., Luciano, L., Ostertag, P., Die Endomyokardbiopsie als Hilfsmittel der Diagnostik von Myocardkrankwegen, Verch. Dtsch. Ges. Inn. Med., 77: 1263-1267, 1971
79. Sekiguchi, M., Yu, Z-X., Take, M., Ultrastructural feature of endomyocardium in patients with eosinophilic heart disease. An endomyocardial biopsy study, Jap. Circ. J., 48: 1375-1383, 1984
80. Ernster, L., Ikkos, D., Luft, R., Enzyme activities of human skeletal muscle mitochondria. A tool in clinical metabolic research, Nature, 184: 1851-1854, 1959
81. Shy, G. M., Gonatas, N. K., Perez, N., two childhood myopathies with abnormal mitochondria. I. Megaconial myopathy. II. Pleoconial myopathy, Brain, 89: 133-158, 1966
82. Price, H.M., Gordon, G. B., Hunsat, T. L., Pearson, C. M., Myopathy with atypical mitochondria in type I skeletal muscle fibers. A histochemical and ultrastructural study, J. Neuropathl. Exp. Neurol., 26: 475-497, 1967
83. Hulsmann, W. C., Bothlem, J., Meijer, A. E. F. H., Fleury, P., Schllens, J. P. M., Myopathy with abnormal structure and function of muscle mitochondria, J. Neurol. Neurosurg. Psichiat., 30: 519-527, 1967
84. Olson, W., Engel, W. K., Walsh, G. O., Einaugler, R., Oculocraniosomatic neuromuscular disease with "ragged" fibers - Histochemical and ultrastructural changes in limb muscles of a group of patients with idiopathic progressive external ophthalmoplegia, Arch. Neurol., 26: 193-211, 1972
85. Afifi, A. K., Ibrahim, Z. N., Bergman, R. A., Haydar, N. A., Mire, J., Bahuth, N., Kaylani, F., Morphologic features of hyparmetabolic mitochondrial disease - A ligh-microscopic histochemical and electron-microscopic study, J. Neurol. Sci., 15: 271-290, 1972
86. Shibasaki, H., Santa, T., Kuroiwa, Y., Late onset mitochondrial myopathy, J. Neurol. Sci., 18: 301-310, 1973
87. Schneck, L., Adachi, M., Briet, P., Wolintz, A., Volk, B. W., Ophthalmoplegia plus with morphological and chemical studies of cerebellal and muscle tissue, J. Neurol. Sci., 19: 37-44, 1973
88. DiMauro, S., Schotland, D. L., Lee, C. P., Bonilla, E., Conn, JR. H., Biochemical and ultrastructural studies of mitochondria in Luft's disease:: Implications for "Mitochondrial Myopathy", Trans. Am. Neurol. Assoc., 97: 265-267, 1973
89. Hyman, B. N., Patten, B. M., Dodson, R. F., Mitochondrial abnormalities in progressive external ophthalmoplegia, Am. J. Ophthalmol., 83: 362-371, 1977
90. Fukuhara, N., Tokiguchi, S., Shirakawa, K., Tsubaki, T., Myoclonus epilepsy associated with ragged-red fibers (mitochondrial abnormalities): Disease entity or a syndrome?, J. Neurol. Sci., 47: 117-133, 1980
91. Peregrini, G., Moggio, M., Cheldi, A., Scarlato, G., Pistone, F. M., Picco, P., Familial megaconial myopathy: A resal neurologic entity, Acta Neuropthol (Berl)., 59: 70-74, 1983
92. Morgan-Hughes, J. A., The Mitochondrial Myopathy, In: Myology, vol. 2 (Engel, A. G., Banker, B. Q., eds) pp. 1709-1743, McGraw-Hill, new York, 1986
93. Zintz, R., Villger, W., Electronmicroscopische Befunde bei 3 Fallen von chronisch progressiver okulärer Muskeldystrophie, Ophthalmologica, 153: 439-459, 1967
94. DiMauro, A. N., Ziter, A. F., Rallison, M. L., Bray, P. F., Familiar myopathy with abnormal muscle mitochondria, Arch. Neurol., 18: 338-401, 1968
95. Ketelsen, U.-P., Berger H., Freund-Mölbert, E., Feinstrukturelle befunde bei der progressiven okulären Muskeldystrophie unter besonderer Berücksichtung der Mitochondrienveränderungen, Beitr. Path. Anat., 138: 223-242, 1968
96. Lessell, S., Kuwabara, T., Feldman, R. G., Myopathy and succinylcholine sensitivity, Am. J. Ophthal., 68: 789-796, 1969
97. Morgan-Hughes, J. A., Mair, W. G. P., Atypical muscle mitochondria in oculoskeletal myopathy, Brain, 215-224, 1973
98. Tamura, S., Santa, T., Kuroiwa, Y., Familial oculocranioskeletal neuromuscular disease with abnormal muscle mitochondria, Brain, 97: 665-672, 1974
99. Jankowicz, E., Berger, H., Kurasz, S., Winogrodzka, W., Eljasz, L., Familial progressive external ophthalmoplegia with abnormal muscle mitochondria, Eur. Neurol., 15: 318-324, 1977
100. Santa, T., Hosokawa, S., Tamura, K., Kuroiwa, Y., Clinico-patological study of 10 cases with ocular myopathy - with special reference to mitochondrial abnormalities -, Clinical Neurol., 15: 683-693, 1975
101. Okaura, K., Santa, T., Nagae, K., Omae, T., Congenital oculoskeletal myopathy with abnormal muscle and liver mitochondria, J. Neurol. Sci., 27: 79-91, 1976
102. Shy, G. M., Gonatas, N. K., Human myopathy with giant abnormal mitochondria, Science, 145: 493-496, 1964
103. Fisher, E. R., Danowski, T. S., Mitochondria myopathy, Am. J. Clin. Pathol., 51: 619-630, 1969
104. Shafiq, S. A., Milhorat, A. T., Gorycki, M. A., Giant mitochondria in human muscle with inclusions, Arch. Neurol., 17: 666-671, 1967
105. Chou, S. M., "Megaconial" mitochondria observed in a case of chronic polymyositis, Acta Neuropathol. (Berl), 12: 68-80, 1969
106. Norris, F. H., Jr., Panner, B. J., Hypothyroid myopathy. Clinical, electronmyographical and ultrastructural observation, Arch. Neurol., 14: 574-589, 1966
107. Engel, A. G., Dale, A. J. D., Autophagic glycogenosis of late onset with mitochondrial abnormalities: light and lectron microscopic observations, Mayo Clin. Proc., 43: 233-270, 1968
108. Suzuki, K., Rapin, I., Giant neuronal mitochondria in an infant with microcephaly and seizure disorder, Arch. Neurol., 20: 62-72, 1969
109. Sandbank, U., Lerman, P., Progressive cerebral polydystrophy - Alpers' disease. Disorganized giant neuronal mitochondria on electron microscopy, J. Neurol. Neurosurg. Psychiatry, 35: 749-755, 1972
110. Shapiro, Y., Cederbaum, S. D., Cancilla, P. A., Nielsen, D., Lippe, B. M., Familial polydystrophy, mitochondrial myopathy, and lactate academia, Neurol., 25: 614-621, 1975
111. Sabatini, D. D., Derobertis, E. D. P., Bleichmar, H. B., Submicroscopic study of the pituitary action on the adrenal cortex of the rat, Endocrinol., 70: 390-406, 1962
112. Volk, T. L., Scarpelli, D. G., Mitochondrial gigantism in the adrenal cortex following hypophysectomy, Lab. Invest., 15: 707-714, 1966
113. Canick, J. A., Purvis, J. L., The maintenance of mitochondrial size in the rat adrenal cortex zona fasciculate by ACTH, Exp. Mol. Pathol, 16: 79-93, 1972
114. Racela, A. Jr., Azarnoff, D., Svovoda, D., Mitochondrial cavitation and hypertrophy in rat adrenal cortex due to aminoglutethimide, Lab. Invest., 21: 52-60, 1969
115. Paget, G. E., Thorp, J. M., An effect of thyroxin on the fine structure of the rat liver cell, Nature, 199: 1307-1308, 1963
116. Shamoto, M., Age difference in the ultrastructure of hepatic cells of thyroxine-treated rats, J. Gerontol, 23: 1-8, 1968
117. Reid, I. M., Donaldson, I. A., Heitzman, R. J., Effects of anabolic steroids on liver cell ultrastructure in sheep, Vet. Pathol., 15: 753-762, 1978
118. Kimberg, D. V., Loeb, J. N., Effects of cortisone administration on rat liver mitochondria support for the concept of mitochondrial fusion, J. Cell Biol., 55: 635-643, 1972
119. Noda, K., Kuwahara, Y., The occurrence of mitochondrial variations including large mitochondria in osteoclasts following calcitonin treatment, J. Electron Microsc., 42: 218-226, 1993
120. Lieber, C. S., Jones, D. P., DeCarli, L. M., Effects of prolonged ethanol intake: production of fatty liver despite adequate diet, J. Clin. Invest., 44: 1009-1021, 1965
121. Iseri, O. A., Lieber, C. S., Gottlieb, L. S., The ultrastructure of fatty liver induced by prolonged ethanol ingestion, Am. J. Pathol., 48: 535-555, 1966
122. Porta, E. A., Koch, O. R., Hartroff, W. S., Recent advance in molecular pathology: A review of the effects of alcohol on the liver, Exp. Mol. Pathol., 12: 104-132, 1970
123. Rubin, E., Beattie, D. S., Lieber, C. S., Effects of ethaol on the biogenesis of mitochondrial membranes and associated mitochondrial functions, Lab. Invest., 23: 620-627, 1970
124. Rubin, E., Lieber, C. S., Fatty liver, alcohol hepatitis and cirrhosis produced by alcohol in primates, N. Engl. J. Med., 290: 128-135, 1974
125. Koch, O. R., Roatta de Conti, L. L., Bolanos, L. P., Stoppani, A. D. M., Ultrastructural and biochemical aspects of liver mitochondria during recovery from ethanol-induced alterations, Am. J. Pathol., 90: 325-344, 1978
126. Leo, M. A., Arai, M., Santos, M., Lieber, C. S., Hepatotoxicity of vitamin A and ethanol in the rat, Gastroenterol., 82: 194-205, 1982
127. Rømert, P., Mathiessen, M. F., Alcohol-induced injury of mitochondria in hepatocytes of mini-pig fetus, Virchows Arch. Pathol. Anat., 399: 299-305, 1983
128. Tomi, M., Suzuki, T., Yasuda, H., Sekiguchi, H., Takaki, F., Electron microscopic studies of the liver. (4) Electron microscopic observation of liver cell of rat by fasting, Jikei Med. J., 8: 85-102, 1961
129. Herdson, P. B., Carvin, P. J., Jennings, R. B., Fine structural changes produced in rat liver by partial starvation, Am. J. Pathol., 45: 157-181, 1964
130. Svovoda, D. J., Hggins, J., Ultrastructural changes produced by protein and related deficiencies in the rat liver, Am. J. Pathol., 45: 353-379, 1964
131. Svovoda, D., Grady, H., Higgins, J., The effects of chronic protein deficiency in rats, Lab. Invest., 15: 731-749, 1966
132. Riede, U. N., Hodel, J., Matt, C. H. V., Rasser, Y., Rohr, H. P., Einfluss des Hungers auf die quantitative Cytoarchitektur der Rattenleberzelle. II. Chronischer partieller Hunger, Beitr. Path. Bd., 150: 246-260, 1973
133. Rohr, H. P., Riede, U. N., Experimental metabolic disorders and subcellular reaction pattern, Curr. Top. Pathol., 58: 1-48, 1973
134. Tandler, B., Erlandson, R. A., Smith, A. L., Wynder, E. L., Riboflavin and mouse hepatic cell structure and function. I. Ultrastructural alterations in simple deficiency, Am. J. Pathol., 52: 69-95, 1968
135. Tandler, B., Erlandson, R. A., Smith, A. L., Wynder, E. L., Riboflavin and mouse cell structure and function. II. Division of mitochondria during recovery from simple deficiency, J. Cell Biol., 41: 477-493, 1969
136. Tandler, B., Hoppel, C. L., Effects of riboflavin deficiency on liver cells. In: Methods and Achievements in Experimental Pathology (Bajus, E., Jasmin, G., eds) vol. 6, pp. 25-48, karger, Basel, 972
137. Hoppel, C. L., Tandler, B., Riboflavin and mouse hepatic structure and function. Mitochondrial oxidative metabolism in severe deficiency state, J. Nutrition, 105: 562-570, 1975
138. Hoppel, C. L., Tandler, B., Relationship between hepatic mitochondrial oxidative metabolism and morphology during riboflavin deficiency and recovery in mice, J. Nutrition, 106: 73-76, 1976
139. Kobayashi, K., Yamamoto, T., Omae, T., Ultrastructural changes of renal tubules in the riboflavin deficiency mouse, Virchows Arch. B Cell Pathol., 34: 99-109, 1980
140. Bruni, C., Hegsted, D. M., Effects of choline-deficient diet on the rat hepatocyte, Am. J. Pathol., 61: 413-428, 1970
141. Bózner, A., Knieriem, H. J., Meessen, H., Reinauer, H., Ultrastructure and biochemistry of the myocardium of the rat in thiamine deficiency and after injection of thiamine, Virchows Arch. B Cell Pathol., 2: 125-143, 1969
142. Wu, B. C., Valle, R. T., White, L. A., Sohal, R. S., Arcos, J. C., Argus, M. F., Burch, G. E., Mitochondrial ultrastructure and energy transduction in rat heart during progressive thiamine deficiency, Virchows Arch. B. Cell Pathol., 9: 97-114, 1971
143. Wilson, J. W., LeDuc, E. H., Mitochondrial changes in the liver of essential fatty acid-deficient mice, J. Cell Biol., 16: 281-296, 1963
144. Dallmann, P. R., Goodman, J. R., Enlargement of mitochondrial compartment in iron and copper deficiency, Blood, 35: 496-505, 1970
145. Zaragorá, R., Renau-Piqueras, J., Portlés, M., Hernández-Yago, Jordá, A., Grisolía, S., Rats fed prolonged high protein diets show an increase in nitrogen metabolism and liver mitochondria, Arch. Biochem. Biophys., 258: 426-435, 1987
146. Albring, M., Radsak, K., Thoenes, W., Chloramphenicol-induced giant hepatic mitochondria, Naturwissenschaften, 62: 43-44, 1975
147. Mazzocchi, G., Neri, G., Robba, C., Belloni, A. S., Nussdorfer, G. G., Investigations on the turnover of adrenocortical mitochondria. X. A correlated biochemical and stereological study of the effects of chronic treatment with chloramphenicol on the mitochondria of the zona fasciculate, Am. J. Anat., 153: 67-80, 1978
148. Pikó, L., Chase, D. G., Role of the mitochondrial genome during early development in mice. Effects of ethidium bromide and chloramphenicol, J. Cell Biol., 58: 357-358,
149. Albring, M., Radsak, K., Thoenes, W., Giant mitochondria. II. Induction of matrix enriched megamitochondria in mouse liver parenchymal cells by ethidium bromide, Virchows Arch. Abt. B Zellpath., 14: 373-377, 1973
150. Rhor, H. P., Wacker, M., v. Pein, A., Ethidium bromide and hepatic mitochondrial structure in mice. A morphometric analysis, Pathol. Eur., 11: 129-135, 1976
151. Rifkin, R. J., Gahagan-Chase, P. A., Morphologic and biochemical effects of a chelating agent, α,α′-dipyridyl, on kidney and liver in rats, Lab. Invest., 28: 480-488, 1970
152. Asano, M., Wakabayashi, T., Ishikawa, K., Kihimoto, H., Induction of mgamitochondria in mouse hepatocytes by nialamide, J. Electron Microsc., 26: 141-144, 1977
153. Suzuki, K., Giant hepatic mitochondria: Production in mice fed with cuprizone, Science, 163: 81-82, 1969
154. Suzuki, K., Kikkawa, Y., Status spongiosus of CNS and hepatic changes by cuprizone (biscyclohexanone oxaldihydrazone), Am. J. Pathol., 54: 307-325, 1969
155. Wakabayashi, T., Green, D. E., On the mechanism of cuprizone-induced formation of megamitochondria in mouse liver, Bioenergetics, 6: 179-192, 1974
156. Flatmark, T., Kryvi, H., Tangelás, A., Induction of megamitochondria by cuprizone (biscyclohexanone oxaldihydrazone). Evidence for an inhibition of mitochondrial division process, Eur. J. Cell Biol., 23: 141-148, 1980
157. Asano, M., Wakabayashi, T., Induction of giant mitochondria in mouse hepatocytes by diethyldithiocarbmate (DDC), J. Electron Microsc., 23: 189-191, 1974
158. Wakabayashi, T., Asano, M., Kawamoto, S., Induction of megamitochondria in the mouse liver by isonicotinic acid derivatives, Exp. Mol. Pathol., 31: 387-399, 1979
159. Wakabayashi, T., Horiuchi, M., Sakaguchi, M., Misawa, K., Onda, H., Iijima, M., Allmann, D. W., Mechanism of hepatic megamitochondria formation by ammonia derivatives. Correlation between structure of chemicals and their ability to induce the formation of megamitochondria, Eur. J. Biochem., 143: 455-465, 1984
160. Wakabayashi, T., Horiuchi, M., Sakaguchi, M., Onda, H., Misawa, K., Induction of megamitochondria in mouse and rat livers by hydrazine, Exp. Mol. Pathol., 39: 139-153, 1983
161. Aguas, A. P., Carlota, M., Proenca, C., Martins e Silva, J., Giant mitochondria in rat liver cells after short-term administration of propylthiouracil, J. Submicrosc. Cytol., 13: 385-390, 1981
162. Lafontaine, J. G., Allard, C., A light and electron microscope study of the morphological changes induced in rat liver cells by the azo dye 2-MEDAB, J. Cell Biol., 22: 143-172, 1964
163. Gambetti, P., Mellman, W. J., Gonatas, N. K., The fine structure of puromycin induced changes in mouse entorhinal cortex, J. Cell Biol., 36: 379-390, 1968
164. Suzuki, T., Mostofi, F. K., Intramitochondrial filamentous bodies in the thick limb of Henle of the rat kidney, J. Cell Biol., 33: 605-623, 1967
165. Wicken, D. E. L., Brender, D., Shorey, C. D., Macdonald, G. J., Reserpine: Effect on structure of heart muscle, Science, 157: 1332-1334, 1967
166. Sun, S. C., Sohal, R. S., Colcolough, H. L., Burch, G. E., Histochemical and electron microscopic studies on the effects of reserpine on the heart muscle of mice, J. Pharmacol. Chemotherap., 161: 210-221, 1968
167. Hiott, D. W., Howell, R. D., Acute electron microscopic changes in myocardial cells induced by high doses of quinidine, Toxicol. Appl. Pharmacol., 18: 964-970, 1971
168. Shar, A. J., Sahgal, V., Muschler, G., Subramani, M., Singh, H., Morphogenesis of the mitochondrial alterations in muscle diseases, J. Neurol. Sci., 55: 25-37, 1982
169. Wollenberger, A., Schulze, W., Mitochondrial alterations in the myocardium of dogs with aortic stenosis, J. Biophys. Biochem. Cytol., 10: 285-288, 1961
170. Schaffner, P., Pelig, P., Changes in hepatic structure in rat produced by breathing pure oxygen, J. Cell Biol., 27: 505-517, 1965
171. Blair, D. M., Stenger, R. J., Hopkins, R. W., Simeone, F. A., Hepatocellular ultrastructure in dogs with hypovolemic shock, Lab. Invest., 18: 172-178, 1968
172. Sun, C. N., Dhalla, N. S., Olson, R. E., Formation of gigantic mitochondria in hypoxic isolated perfused rat hearts, Experientia, 25: 763-764, 1969
173. Hanzliková, V., Schaffino, S., Mitochondrial changes in ischemic skeletal muscle, J. Ultrastruct. Res., 60: 121-133, 1977
174. Lozada, B. B., Laguens, R. P., Hypoxia and th heart ultrastructure with special reference to the protective action of coronary drug Persantin, Cardiologia (Suppl 1) 49: 33-43, 1966
175. Ghadially, F. N., Mitochondria, In: Ultrastructural pathology of the cell (Ghadially, F. N., ed), Butterworths, London and Boston, pp. 101-185, 1979
176. Schiaffino, S., Severin, E., Hanzlikova, V., Intermembrane inclusions induced by anoxia in heart and skeletal muscle mitochondria, Virchows Arch. B Cell Path., 31: 169-179, 1979
177. Hug, G., Bosken, J., Bove, K., Linnemann, Jr., C. C., McAdams, L., Reye's syndromein liver of mice after treatment with chemical agents and encephalomyocarditis virus, Lab. Invest., 95: 85-109, 1981
178. Maeda, S., Pathology of experimental radiation pancreatitis. II. Correlation between ultrastructural changes of the myocardium mitochondria and succinic dehydrogenase activity in rabbit heart receiving a single dose of X-ray irradiation, Acta Pathol. Jpn., 32: 199-218, 1982
179. Laguens, R. P. Lozada, B. B., Gomez Dumm, C. L., Beramendi, A. R., Effects of acute and exhaustive exercise upon the fine structure of heart mitochondria, Experientia, 22: 244-246, 1965
180. Karbowski, M., Kurono, C., Nishizawa, Y., Soji, T., Wakabayashi, T., Induction of megamitochondria by some chemicals inducing oxidative stress in primary culture rat hepatocytes, Biochim. Biophys. Acta, 1349: 242-250, 1997
181. Karbowski, M., Kurono, C., Wozniak, M., Ostrowski, M., Teranishi, M., Nishizawa, Y., Usukura, J., Soji, T., Wakabayashi, T., Free radical-induced megamitochondria formation and apoptosis, Free Radic. Biol. Med., 26: 396-409, 1999
182. Teranishi, M., Karbowski, M., Kurono, C., Soji, T., Wakabayashi, T., Two types of the enlargement of mitochondria related to apoptosis: simple swelling and the formation of megamitochondria, J. Electron Microsc., 48: 637-651, 1999
183. Teranishi, M., Spodnik, J. H., Karbowski, M., Kurono, C., Soji, T., Wakabayashi, T., Swelling of free radical-induced megamitochondria causes apoptosis, Exp. Mol. Pathol, 68: 104-123, 1999
184. Karbowski, M., Kurono, C., Wozniak, M., Ostrowski, M., Teranishi, M., Soji, T., Wakabayashi, T., Cycloheximide and 4-OH-TEMPO suppress chloramphenicol-induced apoptosis in RL-34 cells via the suppression of the formation of megamitochondria, Biochim. Biophys. Acta, 1449: 25-40, 1999
185. Soslau, G., Nass, M. M. K., Effects of ethidium bromide on the ctochrome content and ultrastructure of L cell mitochondria, J. Cell Biol., 51: 514-524, 1971
186. King, M. E., Godman, G. C., King, D. W., Respiratory enzymes and mitochondrial morphology of HeLa and L cells treated with chloramphenicol and ethidium bromide, J. Cell Biol., 53: 127-142, 1972
187. Nass, M. M. E., Differential effects of ethidium bromide on mitochondrial and nuclear DNA synthesis in vivo in cultured mammalian cells, Exp. Cell Res., 72: 211-222, 1972
188. McGill, M., Inhibition of mitochondria-specific protein synthesis in human lymphocytes and platelets is dependent upon the stage of cellular differentiation, Cytogenet. Cell Genet., 26: 117-126, 1980
189. Kletmann, W., Kato, K., Gabara, B., Koprowski, H., Sato, N., Stable altration in HeLa cell mitochondria following ethidium bromide treatment, Exp. Cell Res., 78: 47-58, 1973
190. Pathak, S. M., Porter, C. W., Dave, C., Morphological evidence for an antimitochondrial action of methylglyoxal-bis(guanylhydrazone), Cancer Res., 37: 2246-2250, 1977
191. Mashimo, K., Sato, S., Watanabe, T., An experimental model for alcohol cardiomyopathy. Appearance of giant mitochondria in the cultured myocardial cells, J. Clin. Exp. Med., 148: 269-270, 1989
192. Mikami, K., Sato, S., Watanabe, T., Acute effects of ethanol on cultured myocardial cells: an ultrastructural study, Alcohol and Alcoholism, 25: 651-660, 1990
193. Arai, M., Nishizawa, Y., Liu, XR, Usukura, J., Awaya, S., Wakabayashi, T., Confocal imaging of megamitochondria formation induced by ethanol and hydrazine in cultured cells (RL-34), Bioimages, 1: 25-30, 1995
194. Vanderheiden, M. G., Chandel, N. S., Williamson, E. K., Schumacker, P. T., Thamson, C. B., Bcl-XL regulates the membrane potential and volume homeostasis of mitochondria, Cell, 91: 627-637, 1997
195. Ne'eman, Z., Pinson, A., Oxygen and extracellular fluid restriction in cultured heart cells: electron microscopy studies. Cardiovascular Res., 24: 555-559, 1990
196. Yaffe, M. P., The machinery of mitochondrial inheritance and behavior, Science, 283: 1493-1497, 1999
197. Burgess, S. M., Delannoy, M., Jensen, R. E., MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of mitochondria, J. Cell Biol., 126: 1375-1391, 1994
198. Boldogh, L., Vojtov, N., Karmon, S., Pon, L. A., Interacion between mitochondria and the actin cytoskeleton in budding yeast requires two integral mitochondrial outer membrane proteins, mmm1P and mdm10p. J. Cell Biol., 141: 1371-1381, 1998
199. Berger, K. H., Sogo, L. F., Yaffe, M. P., Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission years, J. Cell Biol., 136: 545-553, 1997
200. Sogo, L. F., Yaffe, M. P., Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane, J. Cell Biol., 126: 1361-1373, 1994
201. Smirnova, E., Shurland, D-L., Rayazantsev, S. N., van der Blick, A. M., A human dynamin-related protein controls the distribution of mitochondria, J. Cell Biol., 143: 351-358, 1998
202. Wakabayashi, T. Adachi, K., Popinigis, J., Effects of alkyl alcohols and related chemicals on rat liver structure and function. I. Induction of two distinct rtypes of mitochondria, Acta Pathol. Jpn., 41: 405-413, 1991
203. Wakabayashi, T., Horiuchi, M., Adachi, K., Koyania, T., Induction of megamitochondria in rat hepatocytes by 1-octadecanol, J. Electron Microsc., 33: 326-328, 1984
204. Wakabayashi, T., Teranishi, M., Karbowski, M., Nishizawa, Y., Usukura, J., Kurono, C., Soji, T., Functional aspects of megamitochondria isolated from hydrazine- and ethanol-treated rat liver, Path. Int., 50: 20-33, 2000
205. Wakabayashi, t., Asano, m., Kurono, C., Mechanism of the formation of megamitochondria induced by copper-chelating agents. I. On the formation process of megamitochondria in cuprizone-treated mouse liver, Acta Pathol., Jpn., 25: 15-37, 1975
206. Hasumura, Y., Teschke, r., lieber, C. S., Characteristics of acetaldehyde oxidation in rat liver mitochondria, J. Biol. Chem., 251: 4908-4913, 1976
207. Matsuzaki, S., Lieber, C. S., Increased susceptibility of hepatic mitochondria to the toxicity of aldehyde after chronic ethanol consumption, Biochem. Biophys. Res. Commun., 75: 1059-1065, 1977
208. Thompson, J. A., Reitz, R. C., Effect of ethanol ingestion and fat levels on mitochondrial lipids in male and female rats, Lipids, 13: 540-550, 1978
209. Schilling, R. J., Reitz, R. C., A mechanism of ethanol-induced damage to liver mitochondrial structure and function, Biochim. Biophys. Acta, 603: 266-277, 1980
210. Adachi, K., Wakabayashi, T., Popinigis, J., Effects of alkyl alcohols and related chemicals on rat liver structure and function. II. Some biochemical properties of ethano-, propanol- and butanol-treated rat liver mitochondria, Acta Pathol. Jpn., 41: 414-427, 1991
211. Cederbaum, A. I., Lieber, C. S., Rubin, E., Effects of chronic ethanol treatment on mitochondrial functions: Damage to coupling site I, Arch. Biochem. Biophys., 165: 560-569, 1974
212. Worsfold, M., Park, D. C., Pennington, R. J., Familiar "mitochondrial" myopathy. A myopathy associated with disordered oxidative metabolism in muscle fibers. Part 2. Biochemical findings, J. Neurol. Sci., 19: 261-274, 1973
213. Gimeno, A., Trueba, J. L., Blanco, M., Gosalvez, M., Mitochondrial functions in five cases of human neuromuscular disorders, J. Neurol. Neurosurg. Psychiat., 36: 806-812, 1973
214. Walter, G. F., Myoencephalopathies with abnormal mitochondria: a review, Clin. Neuropathol., 2: 101-113, 1983
215. Thayler, W. S., Rubin, E., Molecular alterations in the respiratory chain of rat liver after chronic ethanol consumption, J. Biol. Chem., 256: 6090-6097, 1981
216. 3, conent and changes in phospholipids, Biochim. Biophys. Acta, 797: 320-327, 1984
217. Zaragoza, R., Renau-Piqueras, J., Portoles, M., Hernandez-Yago, J., Jorda, A., Grisolia, S., Rats fed prolonged high protein diet show an increase in nitrogen metabolism and liver mitochondria, Arch. Biochem. Biophys., 258: 426-435, 1987
218. Ahkong, Q. F., Fisher, D., Tampion, W., Lucy, J. A., Mechanism of cell fusion. Nature, 253: 194-195, 1975
219. Lucy, J. A., In: Structure of Biological Membranes (Abrahamson, S. and Pascher, I., eds), pp. 275-291, Plenum Press, New York, London, 1976
220. Poste, G., Allison, A. C., Membrane fusion, Biochim. Biophys. Acta, 300: 421-465, 1973
221. Matsuhashi, T., Liu, X-R., Usukura, J., Wozniak, M., Wakabayashi, T., Mechanism of the formation of megamitochondria in the mouse liver by chloramphenicol, Toxicol. Lett., 86: 47-54, 1996
222. Wakabayashi, T., Yamashita, K., Adachi, K., Kawai, K., Iijima, M., Gekko, K., Tsudzuki, T., Popinigis, J., Momota, M., Changes in physicochemical properties of mitochondria membrane during the formation process of megamitochondria induced by hydrazine, Toxicol. Appl. Pharmacol., 87: 235-248, 1987
223. Adachi, K., Momota, M., Teranishi, Y., Ueki, R., Hagiwara, T., Wakabayashi, T., Effects of alkyl alcohols and related chemicals on rat liver structure and function. III. Physicochemical properties of ethanol-, propanol- and butanol-treated rat liver membrane, Acta Pathol. Jpn., 42: 544-557, 1992
224. Adachi, K., Matsuhashi, T., Nishizawa, Y., Usukura, J., Momota, M., Popinigis, J., Wakabayashi, T., Further stidies on physicochemical properties of mitochondrial membranes during the formation process of megamitochondria in the rat livers by hydrazine, Exp. Mol. Pathol., 61: 134-151, 1994
225. Matsuhashi, T., Karbowski, M., Liu, X-R., Usukura, J., Nishizawa, Y., WoŸniak, M., Wakabayashi, T., Complete suppression of ethanol-induced formation of megamitochondria by 4-hydroxy-2,2,6,6-tetramerthyl-piperidine-1- oxyl (4-OH-TEMPO), Free Radic. Biol. Med., 24: 139-147, 1998
226. 10, Toxicol. Parthol., 23: 667-676, 1995
227. Matsuhashi, T., Liu, X-R., Nishizawa, Y., Karbowski, M., Antosiewicz, J., Wakabayashi, T., Role of free radicals in the mechanism of hydrazine-induced formation of megamitocxhondria, Free Radic. Biol. Med., 23: 285-293, 1997
228. Antosiewivz, J., Nishizawa, Y., Liu, X-R., Usukura, J., Wakabayashi, T., Suppression of the hydrazine-induced formation of megamitochondria in the rat liver by α-tocopherol, Exp. Mol. Pathol., 60: 173-187, 1994
229. Matsuhashi, T., Liu, X-R., Nishizawa, Y., Usukura, J., WoŸniak, M., Wakabayashi, T., Mechanism of the formation of megamitochondria in the mouse liver by chloramphenicol, Toxicol. Lett., 86: 47-54, 1996
230. Wakabayashi, T., Adachi, K., Matsuhashi, T., WoŸniak, M., Antosiewicz, J., Karbowski, M., Suppression of the formation of megamitochondria by scavengers for free radicals, Molec. Aspects Med., 18 (Suppl): s51-s61, 1997
231. Chance, B., Sies, H., Boveris, A., Hydroperoxide metabolism in mammalian organs, Physiol. Rev., 59: 527-605, 1979
232. Forman, H. J., Boveris, A., Superoxide radical and hydrogen peroxide in mitochondria, In: Free Radicals in Biology (Pryer, W. A., ed), vol. 5, pp. 65-90, New York and London, Academic Press, 1982
233. Adachi, K., Matsuhashi, T., Nishizawa, Y., Usukura, J., Popinigis, J., Wakabayashi, T., Studies on urea synthesis in the liver of rats tratd chronically with ethanol using perfused livers, isolated hepatocytes and mitochondria, Biochem. Pharmacol., 50: 1391-1399, 1995
234. Gdrodum, E. I., Ultrastructural changes in the mitochondria f brown adipose cells during hibernation cycle of Citellus Lateralis, Cell Tissue Res., 185: 231-237, 1977