Complete suppression of ethanol-induced formation of megamitochondria by 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (4-OH-TEMPO)

Free Radical Biology and Medicine

Volumn 24, Issue 1, 1998, Pages 139-147

  Matsuhashi, Tatsuo ^a   Karbowski, Mariusz ^a   Liu, Xinran ^a   Usukura, Jiro ^a   Wozniak, Michal ^b   Wakabayashi, Takashi ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

4 OH TEMPO; Allopurinol; Ethanol; Free radicals; Lipid peroxidation; Liver; Megamitochondria; Oxidative stress

Indexed keywords

ALCOHOL; ALLOPURINOL; CYTOCHROME A; CYTOCHROME B; CYTOCHROME C OXIDASE; TEMPOL; THIOBARBITURIC ACID REACTIVE SUBSTANCE; AMINE OXIDE; CYTOCHROME; ENZYME INHIBITOR; FREE RADICAL; SCAVENGER; XANTHINE OXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; LIPID PEROXIDATION; LIVER CELL DAMAGE; LIVER MITOCHONDRION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; WEIGHT REDUCTION; ANIMAL; CHEMICAL PHENOMENA; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; ORGAN SIZE; PHOSPHORYLATION; SPIN LABELING; WEIGHT GAIN; WISTAR RAT;

ALLOPURINOL; ANIMALS; CYCLIC N-OXIDES; CYTOCHROMES; DEPRESSION, CHEMICAL; ENZYME INHIBITORS; ETHANOL; FREE RADICAL SCAVENGERS; FREE RADICALS; MALE; MITOCHONDRIA, LIVER; ORGAN SIZE; PHOSPHORYLATION; RATS; RATS, WISTAR; SPIN LABELS; WEIGHT GAIN; XANTHINE OXIDASE;

EID: 0031594745     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(97)00210-4     Document Type: Article

References (61)

1. Warning A. J., Rottenberg H., Ohnishi T., Rubin E. Membranes and phospholipids of liver mitochondria from chronic alcoholic rats are resistant to membrane disordering by alcohol. Proc. Natl Acad. Sci. USA. 78:1981;2582-2586.
2. Shaw S., Jayatilleke E., Ross W. A., Gordon E. R., Lieber C. S. Ethanol-induced lipid peroxidation: Potentiation by long-term alcohol feeding and attenuation by methionine. J. Lab. Clin. Med. 98:1981;417-424.
3. French S. W., Ruebner B. H., Mezey E., Tamura T., Halsted C. H. Effects of chronic ethanol feeding on hepatic mitochondria in the monkey. Hepatology. 3:1983;34-40.
4. Wakabayashi T., Adachi K., Popinigis J. Effects of alkyl alcohol and related chemicals on rat liver structure and function. I. Induction of two distinct types of megamitochondria. Acta Pathol. Jpn. 41:1991;405-413.
5. Adachi K., Wakabayashi T., Popinigis J. Effects of alkyl alcohols and related chemicals on rat liver structure and function. II. Some biochemical properties of ethanol-, propanol- and butanol-treated rat liver mitochondria. Acta Pathol. Jpn. 41:1991;414-427.
6. Thayer W. S., Rottenberg H. Comparative effects of chronic ethanol consumption on the properties mitochondria from rat brain and liver. Alcohol: Clin. Exp. Res. 16:1992;1-4.
7. Quintanilla M. E., Tampier L. Ethanol intake: Effect on liver and brain mitochondrial function and acetaldehyde oxidation. Alcoholism. 9:1992;375-380.
8. Adachi K., Momota M., Teranishi Y., Ueki R., Hagiwara M., Wakabayashi T., Popinigis J. Effects of alkyl alcohols and related chemicals on rat liver structure and function. III. Physicochemical properties of ethanol-, propanol- and butanol-treated rat liver mitochondrial membranes. Acta Pathol. Jpn. 42:1992;549-557.
9. Nordman R., Ribiere C., Rouach H. Implication of free radical mechanism in ethanol-induced cell injury. Free Radic. Biol. Med. 12:1992;219-240.
10. Lieber C. Biochemical factors in alcoholic liver disease. Semin. Liver Dis. 13:1993;136-153.
11. Thayer W., Rubin E. Molecular alterations in the respiratory chain of rat liver after chronic ethanol consumption. J. Biol. Chem. 256:1981;6090-6097.
12. 1 ATPase. J. Biol. Chem. 262:1987;13285-13289.
13. Coleman W. B., Carol C. C. Effects of chronic ethanol consumption on the synthesis of polypeptides encoded by the hepatic mitochondrial genome. Biochim. Biophys. Acta. 1019:1990;142-150.
14. Kiessling K. H., Tobe U. Degeneration of liver mitochondria in rat after prolonged alcohol consumption. Exp. Cell Res. 33:1964;350-364.
15. Porta E. A., Hartroft W. S., de la Iglesia F. A. Hepatic changes associated with chronic alcoholism in rats. Lab. Invest. 14:1964;1437-1455.
16. Klein S. M., Cohen G., Lieber C. S., Cederbaum A. I. Increased microsomal oxidation of hydroxy radical scavengers and ethanol after chronic consumption of ethanol. Arch. Biochem. Biophys. 223:1983;425-432.
17. Shaw S., Jayatilleke E., Lieber C. S. The effect of chronic alcohol feeding on lipid peroxidation in microsomes: Lack of relationship to hydroxy radical generation. Biochem. Biophys. Res. Commun. 118:1984;233-238.
18. Reinke L. A., Lai E. K., DuBose C. M., McCay P. B. Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: Correlation with radical formation in vitro. Proc. Natl Acad. Sci. USA. 84:1987;9223-9227.
19. Shaw S., Jayyatilleke E. The role of cellular oxidases and catalytic iron in the pathogenesis of ethanol-induced liver injury. Life Sci. 50:1992;2045-2052.
20. Antosiewicz J., Nishizawa Y., Liu X. R., Usukura J., Wakabayashi T. Suppression of the hydrazine-induced formation of megamitochondria in the rat liver by α-tocopherol. Exp. Mol. Pathol. 60:1994;173-187.
21. 10. Toxicol. Pathol. 23:1995;667-676.
22. Matsuhashi T., Liu X. R., Wozniak M., Antosiewicz J., Wakabayashi T. Mechanism of the formation of megamitochondria in the mouse liver by chloramphenicol. Toxicol. Lett. 86:1996;47-54.
23. Takeshita T., Utsumi H., Hamada A. Whole mouse measurement of radical clearance in lung of whole mouse. Biochem. Biophys. Res. Commun. 177:1991;874-889.
24. Takeshita T., Utsumi H., Hamada A. Whole mouse measurement of paramagnetism-loss of nitroxide radical in lung with a L-band ESR spectrometer. Biochem. Mol. Biol. Int. 29:1993;17-24.
25. Rachmilewicz D., Karmeli F., Okon E., Samuni A. A novel antiulcerogenic stable radical prevents gastric mucosal lesions in rats. Gut. 35:1994;1181-1188.
26. Wintersberger E. Proteinsynthese in isolierten Hefe-Miotochondrien. Biochem. Z. 341:1965;409-419.
27. Albring M., Radsak K., Thoenes W. Chloramphenicol-induced giant hepatic miochondria. Naturwissenschaften. 62:1975;43-44.
28. Moorhouse P. C., Grootveld M., Halliwell B., Quinlann J. C., Gutteridge J. M. C. Allopurinol and oxypurinol are hydroxy radical scavengers. FEBS Lett. 213:1987;23-28.
29. Park M. K., Rouach H., Orfanekki M. T., Janvier B., Nordman R. Influence of allopurinol and desferrioxamine on the ethanol-induced oxidative stress in rat liver and cerebellum. Adv. Biosci. 71:1988;135-140.
30. Houze P., Rouach H., Genti M., Orfanelli M., Nordmann R. Effects of allopurinol on the hepatic and cerebellar iron, selenium, zinc and copper status following acute ethanol administration to rats. Free Radic. Res. Commun. 12-13:1991;663-668.
31. DeCarli L. M., Lieber C. S. Fatty liver in the rat after prolonged intake of ethanol with a nutritionally adequate new liquid diet. J. Nutr. 91:1967;331-336.
32. Wakabayashi T., Asano M., Kawamoto S. Induction of megamitochondria in the mouse liver by isonicotinic acid derivatives. Exp. Mol. Pathol. 31:1979;387-399.
33. 1 and c in mitochondria. Arch. Biochem. Biophys. 107:1964;537-543.
34. Wakabayashi T., Asano M., Kurono C. Mechanism of the formation of megamitochondria induced by copper-chelating agents. I. On the formation process of megamitochondria in cuprizone-treated mouse liver. Acta Pathol. Jpn. 25:1975;39-49.
35. Lowry O. H., Rosenbrough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
36. Beuge J. A., Aust S. D. Microsomal lipid oxidation. Methods Enzymol. 105:1984;337-341.
37. Dillard C. J., Tappel A. L. Fluorescent damage products of lipid peroxidation. Methods Enzymol. 105:1984;337-341.
38. Wakabayashi T., Horiuchi M., Sakaguchi M., Misawa K., Onda H., Iijima M., Allmann D. W. Mechanism of hepatic megamitochondria formation by ammonia derivatives. Correlation between structure of chemicals and their ability to induce the formation of megamitochondria. Eur. J. Biochem. 143:1984;455-465.
39. Wakabayashi T., Yamashita K., Adachi K., Kawai M., Iijima M., Gekko T., Tsudzuki T., Popinigis J., Momota M. Changes in physicochemical properties of mitochondrial membranes during the formation process of megamitochondria induced by hydrzine. Toxicol. Appl. Pharmacol. 87:1987;235-248.
40. Adachi K., Matsuhashi T., Nishizawa Y., Usukura J., Momota M., Popinigis J., Wakabayashi T. Further studies on physicochemical properties of mitochondrial membranes during the formation process of megamitochondria in the rat liver by hydrazine. Exp. Mol. Pathol. 61:1994;134-151.
41. Di Luzio N. R. Prevention of the acute ethanol-induced fatty liver by antioxidants. Physiologists. 6:1963;169-173.
42. Di Luzio N. R., Haryman A. D. Role of lipid peroxidation in the pathogenesis of ethanol-induced fatty liver. Fed. Proc. 26:1967;1436-1442.
43. Abbondanza A., Battelli M. G., Soffritti M., Cessi C. Xanthine oxidase status in ethanol-intoxicated rat liver. Alcohol. Clin. Exp. Res. 13:1989;841-844.
44. Moorehouse P. C., Grootveld M., halliwell B., Quinlan J. C., Gutteridge J. M. C. Allopurinol and oxypurinol are hydroxy radical scavengers. FEBS Lett. 213:1987;23-28.
45. Houze P., Rouach H., Gentil M., Orfanelli M. T., Nordmann R. Effect of allopurinol on the hepatic and cerebellar iron, selenium, zinc and copper status following acute ethanol administration to rats. Free Radic. Res. Commun. 12-13:1991;663-668.
46. Porta E. A., Gomez-Dumm C. L. A. A new experimental approach in the study of chronic alcoholism. I. Effects of high alcoholic intake in rats fed a laboratory diet. Lab. Invest. 18:1968;352-364.
47. Bergtsson G., Smith-Kielland A., Morland J. Ethanol effects on protein synthesis in nonparenchymal liver cells, hepatocytes, and density population of hepatocytes. Exp. Mol. Pathol. 41:1984;44-57.
48. Singh M., LaSure M. M., Bockman D. E. Pancreatic acinar cell function and morphology in rats chronically fed an ethanol diet. Gastroenterology. 82:1982;425-4344.
49. Banks W. L. Jr., Kleine E. S., Higgins E. S. Hepatic composition and metabolism after ethanol consumption in rats fed purified diet. J. Nutr. 100:1969;581-594.
50. Boveris A., Frage C. G., Varsavsky A. I., Koch O. R. Increased chemiluminescence and superoxide production in the rat liver of chronically ethanol-treated rats. Arch. Biochem. Biophys. 227:1983;534-541.
51. Reed W. D., Mezey E. Effects of chronic ethanol feeding on enzymes of rat brain and liver mitochondria. Life Sci. 11:1972;847-857.
52. Chedid A., Mendenhall C. L., Tosch T., Chen T., Rabin L., Garcia-Pont P., Goldberg S. J., Kiernan T., Seeff L. B., Sorrell M., Tambrurro C., Weesner R. E., Zetterman R. The Veterans Administration Cooperative study of alcoholic hepatitis. Gastroenterology. 90:1986;1858-1864.
53. Uchida T., Kronborg I., Peters R. L. Giant mitochondria in the alcoholic liver diseases - Their identification, frequency and pathologic significance. Liver. 4:1984;29-38.
54. Junge J., Horn T., Christoffersen P. megamitochondria as a diagnostic marker for alcoholic induced centrilobular and periportal fibrosis in the liver. Virchow Arch. A. 410:1987;553-558.
55. Robertson N. J., Kendall C. H. Liver giant mitochondria revised. J. Clin. Pathol. 45:1992;412-415.
56. Suematsu T., matsumura T., Sato N., Miyamoto T., Ooka T., Kamada T., Abe H. Lipid peroxidation in alcoholic liver disease in humans. Alcohol. Clin. Exp. Res. 5:1981;427-430.
57. Mazzanti R., Moscarella S., Bensi G., Altavilla E., Gentilini P. Hepatic lipid peroxidation and aldehyde dehydrigenase activity in alcoholic and non-alcoholic liver disease. Alcohol Alcohol. 24:1989;121-128.
58. Shaw S., Rubin K. P., Lieber C. S. Depressed hepatic glutathione and increased diene conjugates in alcoholic liver disease. Digest. Dis. Sci. 28:1983;585-589.
59. Altomare E., Vendemiale G., Albano O. Hepatic glutathione content in patients with alcoholic and non alcoholic liver diseases. Life Sci. 43:1988;991-998.
60. Bjorneboe G. E. A., Johnson J., Bjorneboe A., Bache-Wiig J. E., Morland J., Drevon C. A. Diminished serum concentration of vitamin E in alcoholics. Ann. Nutr. Metab. 32:1988;56-61.
61. Bjorneboe G. E. A., Johnson J., Bjorneboe A., Morland J., Drevon C. A. Effect of heavy alcoholic consumption and serum concentrations of fat-soluble vitamins and selenium. Alcohol Alcohol. 1:1987;533-537.