Behavioral phenotyping of rodents

Comparative Medicine

Volumn 53, Issue 2, 2003, Pages 140-146

  Crawley, Jacqueline N ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GALANIN RECEPTOR;

ALZHEIMER DISEASE; AMNESIA; ANIMAL BEHAVIOR; ANIMAL FOOD; ANIMAL HEALTH; ANIMAL HOUSING; ANXIETY; BEHAVIORAL SCIENCE; BREEDING; COGNITION; CONDITIONING; DNA MICROARRAY; DRUG ABUSE; EVOKED AUDITORY RESPONSE; EXPERIMENTAL ANIMAL; EXPERIMENTAL MOUSE; GENE INSERTION; GENE MUTATION; GENE TARGETING; GENETIC ENGINEERING; GENETIC MANIPULATION; GENOME; HYPOTHESIS; KNOCKOUT MOUSE; LEARNING; LORDOSIS; MAZE TEST; MEDICAL INSTRUMENTATION; MEMORY; MORPHOLOGICAL TRAIT; MOTOR PERFORMANCE; MOUSE; MOUSE STRAIN; NERVOUS SYSTEM; NEUROLOGIC EXAMINATION; NEUROSCIENCE; NONHUMAN; PEDIGREE ANALYSIS; PHARMACOGENETICS; PHENOTYPE; QUANTITATIVE TRAIT LOCUS MAPPING; REVIEW; SCHIZOPHRENIA; SENILE PLAQUE; SENSORY EVALUATION; SENSORY SYSTEM; SEXUAL BEHAVIOR; SIGNAL TRANSDUCTION; SOCIAL BEHAVIOR; STANDARDIZATION; SWIMMING; TRANSGENIC MOUSE; VALIDATION PROCESS;

ANIMALS; BEHAVIOR, ANIMAL; BEHAVIORAL SCIENCES; GENETICS, BEHAVIORAL; HOUSING, ANIMAL; LABORATORY ANIMAL SCIENCE; MICE; MICE, MUTANT STRAINS; PHENOTYPE; SOCIAL ENVIRONMENT; VETERINARY MEDICINE;

EID: 0037609789     PISSN: 00236764     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (62)

1. Collins, F. S., A. Patrinos, E. Jordan, A. Chakravarti, R. Gesteland, and L. Walters. 1998. New goals for the U.S. Human Genome Project: 1998-2003. Science 282:682-689.
2. Crusio, W. E. and R. T. Gerlai. 1999. Handbook of molecular-genetic techniques for brain and behavior research. In J. P. Huston (ed.), Techniques in the behavioral and neural sciences, vol. 13. Elsevier, Amsterdam.
3. Jones, B. C. and P. Morméde (ed.). 1999. Neurobehavioral genetics: methods and applications. CRC Press, Boca Raton, Fla.
4. Nadeau, J. H. and W. N. Frankel. 2000. The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs. Nat. Genet. 25:381-384.
5. Belknap, J. K., R. Hitzemann, J. C. Crabbe, T. J. Phillips, K. J. Buck, and R. W. Williams. 2001. QTL analysis and genomewide mutagenesis in mice: complementary genetic approaches to the dissection of complex traits. Behav. Genet. 31:5-15.
6. Mody, M., Y. Cao, Z. Cui, K.-Y. Tay, A. Shyong, E. Shimizu, K. Pham, P. Schultz, D. Welsh, and J. Z. Tsien. 2001. Genome-wide gene expression profiles of the developing mouse hippocampus. Proc. Natl. Acad. Sci. USA 98:8862-8867.
7. Anagnostopoulos, A. V., L. E. Mobraaten, J. J. Sharp, and M. T. Davisson. 2001. Transgenic and knockout databases: behavioral profiles of mouse mutants. Physiol. Behav. 73:675-689.
8. Licinio, J. and M.-L. Wong (ed.). 2002. Pharmacogenomics: the search for individualized therapies. John Wiley & Sons, Inc., New York.
9. Gold, L. H. and J. N. Crawley. 2002. Special issue on transgenics and knockouts with mutations in genes for neuropeptides and their receptors. Neuropeptides 36:2-3.
10. Crawley, J. N. 2000. What's wrong with my mouse? Behavioral phenotyping of transgenic and knockout mice. John Wiley & Sons, Inc., New York.
11. Silver, L. M. 1995. Mouse genetics: concepts and applications. Oxford University Press, New York.
12. Vandenbergh, J. G. 2000. Use of house mice in biomedical research. ILAR J. 41:133-135.
13. Abel, T., K. C. Martin, D. Bartsch, and E. R. Kandel. 1998. Memory suppressor genes: inhibitory constraints on the storage of long-term memory. Science 279:338-341.
14. Ward, J. M., J. F. Mahler, R. R. Maronpot, J. P. Sundberg, and R. M. Frederickson (ed.). 2000. Pathology of genetically engineered mice. Iowa State University Press, Ames, Iowa.
15. Brayton, C., M. Justice, and C. A. Montgomery. 2001. Evaluating mutant mice: anatomic pathology. Vet. Pathol. 38:1-19.
16. Yaspo, M. L. 2001. Taking a functional genomics approach in molecular medicine. Trends Mol. Med. 7:494-501.
17. Watson, J. B. 1914. Behavior: an introduction to comparative psychology. Henry Holt, New York.
18. Pavlov, I. 1941. Lectures on conditioned reflexes, International Publishers, New York.
19. Hull, C. 1943. Principles of behavior. Appleton-Century, New York.
20. Marler P., and W. J. Hamilton (ed.). 1968. Mechanisms of animal behavior. John Wiley & Sons, New York.
21. Lorenz, K. Z. 1981. The foundations of ethology. Springer, N.Y.
22. Koob, G. F., C. L. Ehlers, and D. J. Kupfer. 1989. Animal models of depression. Birkhauser, Boston
23. Becker, J. B., S. M. Breedlove, and D. Crews. 1993. Behavioral endocrinology. MIT Press, Cambridge, Mass.
24. Campbell, I. L. and L. H. Gold. 1996. Transgenic modeling of neuropsychiatric disorders. Mol. Psychiatr. 1:105-120.
25. Crawley, J. N. and R. Paylor. 1997. A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice. Horm. Behav. 31:197-211.
26. Rogers D. C., D. N. C. Jones, P. R. Nelson, C. M. Jones, C. A. Quilter, T. L. Robinson, and J. J. Hagan. 1999. Use of SHIRPA and discriminant analysis to characterize marked differences in the behavioural phenotype of six inbred mouse strains. Behav. Brain Res. 105:207-217.
27. Nelson, R. J. and S. Chiavegatto. 2000. Aggression in knockout mice. ILAR J. 41:153-162.
28. Cryan, J. F., A. Markou, and I. Lucki. 2002. Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol. Sci. 23:238-245.
29. Branchi, I. and L. Ricceri. 2002. Transgenic and knock-out mouse pups: the growing needs for behavioral analysis. Genes Brain Behav. 1:135-141.
30. Crabbe, J. C. 2002. Genetics contributions to addiction. Annu. Rev. Psychol. 53:435-462.
31. Gold, L. H. 1999. Hierarchical strategy for phenotypic analysis in mice. Psychopharmacology 147:2-4.
32. Brown, R. E., L. Stanford, and H. M. Schellinck. 2000. Developing standardized behavioral tests for knockout and mutant mice. ILAR J. 41:163-174.
33. Norflus, F., C. J. Tifft, M. P. McDonald, G. Goldstein, J. N. Crawley, A. Hoffmann, K. Sandhoff, K. Suzuki, and R. L. Proia. 1998. Bone marrow transplantation prolongs life span and ameliorates neurologic manifestations in Sandhoff disease mice. J. Clin. Invest. 101:1881-1888.
34. Steiner, R. A., J. G. Hohmann, A. Holmes, C. C. Wrenn, G. Cadd, A. Juréus. D. K. Clifton, M. Luo, M. Gutshall, S. Y. Ma, E. J. Mufson, and J. N. Crawley. 2001. Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 98:4184-4189.
35. Holmes, A., R. J. Yang, J. N. Crawley. 2002b. Evaluation of an anxiety-related phenotype in galanin overexpressing transgenic mice. J. Mol. Neurosci. 18:151-165.
36. Crawley, J. N., C. R. Gerfen, R. McKay, M. A. Rogawski, D. R. Sibley, and P Skolnick (ed.). 1998. Current protocols in neuroscience. John Wiley & Sons, Inc., New York.
37. Crawley, J. N. 1999. Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests. Brain Res. 835:18-26.
38. Contarino, A., S. C. Heinrichs, and L. H. Gold. 1999. Understanding CRF neurobiology: contributions from mutant mice. Neuropeptides 33:1-12.
39. Bale, T. L., A. Contarino, G. W. Smith, R. Chan, L. H. Gold, P. E. Sawchenko, G. F. Koob, W. W. Vale, and K. F. Lee. 2000. Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nat. Genet. 24:410-414.
40. Tully, T. 1998. Toward a molecular biology of memory: the light's coming on! Nat. Neurosci. 7:543-545.
41. Silva, A. J., J. H. Kogan, P. W. Frankland, and S. Kida. 1998. CREB and memory. Ann. Rev. Neurosci. 21:127-148.
42. Schenk, D., R. Barbour, W. Dunn, G. Gordon, H. Grajeda, T. Guido, K. Hu, J. Huang, K. Johnson-Wood, K. Khan, D. Kholodenko, M. Lee, Z. Liao, I. Lieberburg, T. Motter, L. Mutter, F. Soriano, G. Shopp, N. Vasquez, C. Vandevert, S. Walker, M. Wogulis, T. Yednock, D. Games, and P. Seubert. 1999. Immunization with amyloid-β attenuates Alzheimer disease-like pathology in the PDAPP mouse. Nature 400:173-177.
43. Holmes, A. and R. J. Rodgers. 1998. Responses of Swiss-Webster mice to repeated plus-maze experience: further evidence for a qualitative shift in emotional state? Pharmacol. Biochem. Behav. 60:473-488.
44. McIlwain, K. L., M. Y. Merriweather, L.A. Yuva-Paylor, and R. Paylor. 2001. The use of behavioral test batteries: effects of training history. Physiol. Behav. 73:705-718.
45. Gingrich, J. A. and R. Hen. 2000. The broken mouse: the role of development, plasticity and environment in the interpretation of phenotypic changes in knockout mice. Curr. Opin. Neurobiol. 10:146-152.
46. Wehner, J. M. and A. Silva. 1996. Importance of strain differences in evaluations of learning and memory processes in null mutants. Mental Retard. Dev. Dis. Res. Rev. 2:243-248.
47. Crawley, J. N., J. K. Belknap, A. Collins, J. C. Crabbe, W. Frankel, N. Henderson, R. J. Hitzemann, S. C. Maxson, L. L. Miner, A. J. Silva, J. M. Wehner, A. Wynshaw-Boris, and R. Paylor. 1997. Behavioral phenotypes of inbred strains of mice. Psychopharmacology 132:107-124.
48. Holmes, A., C. C. Wrenn, A. P. Harris, K. E. Thayer, and J. N. Crawley. 2002a. Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice. Genes Brain Behav. 1:55-69.
49. Cook, M. N., V. J. Bolivar, M. P. McFadyen, and L. Flaherty. 2002. Behavioral differences among 129 substrains: implications for knockout and transgenic mice. Behav. Neurosci. 116:600-611.
50. Hsiao, K. 1998. Strain dependent and invariant features of transgenic mice expressing Alzheimer amyloid precursor protein. Prog. Brain. Res. 117:335-341.
51. Wolfer, D. P., U. Müller, M. Stagliar, and H.-P. Lipp. 1997. Assessing the effects of the 129/Sv genetic background on swimming navigation learning in transgenic mutants: a study using mice with a modified β-amyloid precursor protein gene. Brain Res. 771:1-13.
52. Frankel, W. N., L. Taylor, B. Beyer, B. L. Tempel, and H. S. White. 2001. Electroconvulsive thresholds of inbred mouse strains. Genomics 74:306-312.
53. Ferraro, T. N., G. T. Golden, G. G. Smith, D. DeMuth, R. J. Buono, and W. H. Berrettini. 2002. Mouse strain variation in maximal electroshock seizure threshold. Brain Res. 936:82-86.
54. Elmer, G. I., J. O. Pieper, S. S. Negus, and J. H. Woods. 1998. Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests. Pain 75(1):129-140.
55. Crabbe, J. C., D. Wahlsten, and B. C. Dudek. 1999. Genetics of mouse behavior: interactions with laboratory environment. Science 284:1670-1672.
56. Wahlsten, D. 2001. Standardizing tests of mouse behavior: reasons, recommendations, and reality. Physiol. Behav. 73:695-704.
57. LeRoy, I., M. Carlier, and P. L. Roubertoux. 2001. Sensory and motor development in mice: genes, environment and their interactions. Behav. Brain Res. 125:57-64.
58. Surjo, D., and S. S. Arndt. 2001. The mutant mouse behaviour network: a medium to present and discuss methods for the behavioural phenotyping. Physiol. Behav. 73:691-694.
59. van der Staay, F. J. and T. Steckler. 2002. The fallacy of behavioral phenotyping without standardization. Genes Brain Behav. 1:9-13.
60. Price, C., A. Mohammed, J. Fotheringham, and J. Feldon (ed.). 2002. Environmental manipulations in rodents and primates: insights into pharmacology, biochemistry and behavior. Pharmacol. Biochem. Behav. 73:829-283.
61. Würbel, H. 2002. Behavioral phenotyping enhanced beyond (environmental) standardization. Genes Brain Behav. 1:3-8.
62. Crawley, J. N. 2000. Behavioral phenotyping of mutant mice, p. 18-22. In Rachel Wood (ed.), New technologies for life sciences. A trends guide. Elsevier, London.