The fallacy of behavioral phenotyping without standardisation

Genes, Brain and Behavior

Volumn 1, Issue 1, 2002, Pages 9-13

  Van der Staay, F J ^a   Steckler, T ^b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

Behavior; Behavioral phenotyping; Knockout; Mouse; Mutant; Standardization; Transgenic

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; BEHAVIOR; GENE MUTATION; INTERMETHOD COMPARISON; MOUSE; NEUROSCIENCE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; STANDARDIZATION; TASK PERFORMANCE; TAXONOMY; TRANSGENIC MOUSE; ANIMAL; ANIMAL BEHAVIOR; BEHAVIOR GENETICS; ENVIRONMENT; GENETICS; MOUSE MUTANT; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; REPRODUCIBILITY; STANDARD;

ANIMALIA; MUS MUSCULUS;

ANIMALS; BEHAVIOR, ANIMAL; ENVIRONMENT; GENETICS, BEHAVIORAL; MICE; MICE, MUTANT STRAINS; PHENOTYPE; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS;

EID: 0001856264     PISSN: 16011848     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1601-1848.2001.00007.x     Document Type: Review

References (31)

1. Aléman, C.L, Más, R.M., Rodeiro, I., Nao, M., Hernández, C., Menéndez, R. Gámez, R. (1997) Reference database of the main physiological parameters in Sprague-Dawley rats from 6 to 32 months. Laboratory Animals 32, 457-466.
2. Arndt, S.S. & Surjo, D, (2001) Methods for the behavioral phenotyping of mouse mutants. How to keep the overview. Behav Brain Res 125, in press.
3. Catalano, P.J., McDaniel, K.L. & Moser, V.C. (1997) The IPCS collaborative study on neurobehavioral screening methods: VI. agreement and the reliability of the data. Neurotoxicology 18, 1057-1064.
4. Crabbe, J.C., Wahlsten, D. & Dudek, B.C. (1999) Genetics of mouse behavior: interactions with laboratory environment. Science 284, 1670-1672.
5. Crawley, J.N., Belknap, J.K., Collins, A., Crabbe, J.C., Frankel, W., Henderson, N., Hitzemann, R.J., Maxson, S.C., Miner, L.L., Silva, A.J., Wehner, J.M., Wynshaw-Boris, A. & Paylor, R. (1997) Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology 132, 107-124.
6. A receptor mutant mouse studies, Nature Neurosci 3, 1059.
7. D'Mello, G.D. & Steckler, T. (1996) Animal models in cognitive behavioural pharmacology: an overview. Cogn Brain Res 3, 345-352.
8. Gershenfeld, H.K. & Paul, S.M. (1998) Towards a genetics of anxious temperament: from mice to men. Acta Psychiat Scand 98, 56-65.
9. Grootendorst, J., de Kloet, E.R., Vossen, C., Dalm, S. & Oitzl, M.S. (2001) Repeated exposure to rats has persistent genotype-dependent effects on learning and locomotor activity of apolipoprotein E knockout and C57BL/6 mice. Behav Brain Res 125, in press.
10. Hrabe de Angelis, M.H., Flaswinkel, H., Fuchs, H., Rathkolb, B., Soewarto, D., Marschall, S., Heffner, S., Pargent, W., Wuensch, K., Jung, M., Reis, A., Richter, T., Alessandrini, F., Jakob, T., Fuchs, E., Kolb, H., Kremmer, E., Schaeble, K., Rollinski, B., Roscher, A., Peters, C., Meitinger, T., Strom, T., Steckler, T., Holsboer, F., Klopstock, T., Gekeler, F., Schindewolf, C., Jung, T., Avraham, K., Behrendt, H., Ring, J., Zimmer, A., Schughart, K., Pfeffer, K., Wolf, E. & Balling, R. (2000) Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nature Genet 25, 444-447.
11. Isaacson, R.L., Douglas, R.J., Lubar, J.F. & Schmaltz, L.W. (1971) A Primer of Physiological Psychology. Harper & Row, New York.
12. Kaplan, R.M. & Saccuzzo, D.P. (1997) Psychological Testing. Principles, Applications, and Issues, 4th edn. Brooks/Cole Publishing Co, Pacific Grove, CA.
13. Laviola, G. & Terranova, M.L. (1998) The developmental psychobiology of behavioural plasticity in mice: the role of social experiences in the family unit. Neurosci Biobehav Rev 23, 197-213.
14. Lederhendler, I. & Schulkin, J. (2000) Behavioral neuroscience, challenges for the era of molecular biology. Trends Neurosci 23, 451-454.
15. Lehner, P.N. (1996) Handbook of Ethological Methods, 2nd edn. Cambridge Univerisity Press, Cambridge.
16. McKernan, R.M., Rosahl, T.W., Reynolds, D.S., Sur, C., Wafford, K.A., Atack, J.R., Farrar, S., Myers, J., Cook, G., Ferris, P., Garrett, L., Bristow, L., Marshall, G., Macaulay, A., Brown, N., Howell, O., Moore, K.W., Carling, R.W., Street, L.J., Castro, J.L., Ragan, C.I., Dawson, G.R. & Whiting, P.J. (2000) Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA (A) receptor alpha1 subtype. Nature Neurosci 3, 587-592.
17. Moser, V.C. (1990) Approaches for assessing the validity of the functional observational battery. Neurotoxicol Teratol 12, 483-488.
18. Rampon, C., Tang, Y.P., Goodhouse, J., Shimizu, E., Kyin, M. & Tsien, J.Z. (2000) Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. Nature Neurosci 3, 238-244.
19. Rudolph, U., Crestani, F., Benke, D., Brunig, I., Benson, J.A., Fritschy, J.M., Martin, J.R., Bluethmann, H. & Möhler, H. (1999) Benzodiazepine actions mediated by specific gamma-aminobutyric acid (A) receptor subtypes. Nature 401, 796-800.
20. Runkel, P.J. & McGrath, J.E. (1972) Research on Human Behavior. A Systematic Guide to Method. Holt, Rinehart and Winston, New York.
21. Sarter, M., Hagan, J. & Dudchenko, P. (1992) Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part II. Psychopharmacology 107, 461-473.
22. van der Staay, F.J. (2000) The Study of Behavioral Dysfunctions: an Evaluation of Selected Animal Models. Graduate School of Behavioral and Cognitive Neurosciences (BCN), University Groningen, The Netherlands.
23. van der Staay, F.J. & Steckler, T. (2001) Behavioural phenotyping of mouse mutants. Behav Brain Res 125, in press.
24. Steckler, T. & Muir, J.L. (1996) Measurement of cognitive function: relating rodent performance with human minds. Cogn Brain Res 3, 215-225.
25. Surjo, D. & Arndt, S.S. (2001) The mutant mouse behaviour-network 'MMB'. A medium to present and discuss methods for the behavioural phenotyping. Physiol Behav 73, 691-694.
26. Trullas, R. & Skolnick, P. (1993) Differences in fear motivated behaviors among inbred mouse strains. Psychopharmacology 111, 323-331.
27. Tsien, J.Z., Huerta, PT. & Tonegawa, S. (1996) The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell 87, 1327-1338.
28. Wainwright, P.E. (2001) The role of nutritional factors in behavioural development in laboratory mice. Behav Brain Res 125, in press.
29. Willner, P. (1991) Behavioural models in psychopharmacology. In Willner, P. (ed.), Behavioural Models in Psychopharmacology. Cambridge University Press, Cambridge, pp. 3-18.
30. Würbel, H. (2000) Behaviour and the standardization fallacy. Nature Genet 26, 263.
31. Würbel, H. (2002) Behavioural phenotyping enhanced: beyond (environmental) standardization. Genes Brain Behav 1, 3-8.