메뉴 건너뛰기




Volumn 7, Issue 5, 2003, Pages 572-579

DNA vaccination against mutant huntingtin ameliorates the HDR6/2 diabetic phenotype

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CELL ANTIGEN; COMPLEMENTARY DNA; DNA VACCINE; GLUCOSE; GREEN FLUORESCENT PROTEIN; HUNTINGTIN; INSULIN; NEUROTOXIN; POLYGLUTAMINE;

EID: 0037562002     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1525-0016(03)00063-7     Document Type: Article
Times cited : (54)

References (46)
  • 1
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk, D., et al. (1999). Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400: 173-177.
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1
  • 2
    • 0035812752 scopus 로고    scopus 로고
    • Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies
    • Heppner, F. L., et al. (2001). Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science 294: 178-182.
    • (2001) Science , vol.294 , pp. 178-182
    • Heppner, F.L.1
  • 3
    • 17944388584 scopus 로고    scopus 로고
    • An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy
    • During, M. J., et al. (2000). An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy. Science 287: 1453-1460.
    • (2000) Science , vol.287 , pp. 1453-1460
    • During, M.J.1
  • 4
    • 0034279106 scopus 로고    scopus 로고
    • Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion
    • Hauben, E., et al. (2000). Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion. J. Neurosci. 20: 6421-6430.
    • (2000) J. Neurosci. , vol.20 , pp. 6421-6430
    • Hauben, E.1
  • 5
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • The Huntington's Disease Collaborative Research Group
    • The Huntington's Disease Collaborative Research Group (1993). A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72: 971-983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 7
    • 0036260904 scopus 로고    scopus 로고
    • The immunopathogenesis of paraneoplastic neurological syndromes
    • Sutton, I., and Winer, J. B. (2002). The immunopathogenesis of paraneoplastic neurological syndromes. Clin. Sci. (London) 102: 475-486.
    • (2002) Clin. Sci. (London) , vol.102 , pp. 475-486
    • Sutton, I.1    Winer, J.B.2
  • 8
    • 0026354236 scopus 로고
    • Antibody-mediated clearance of alphavirus infection from neurons
    • Levine, B., et al. (1991). Antibody-mediated clearance of alphavirus infection from neurons. Science 254: 856-860.
    • (1991) Science , vol.254 , pp. 856-860
    • Levine, B.1
  • 9
    • 0026729293 scopus 로고
    • Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system
    • Dietzschold, B., et al. (1992). Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system. Proc. Natl. Acad. Sci. USA 89: 7252-7256.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7252-7256
    • Dietzschold, B.1
  • 10
    • 0034067890 scopus 로고    scopus 로고
    • Control of Sindbis virus infection by antibody in interferon-deficient mice
    • Byrnes, A. P., Durbin, J. E., and Griffin, D. E. (2000). Control of Sindbis virus infection by antibody in interferon-deficient mice. J. Virol. 74: 3905-3908.
    • (2000) J. Virol. , vol.74 , pp. 3905-3908
    • Byrnes, A.P.1    Durbin, J.E.2    Griffin, D.E.3
  • 11
    • 0035836675 scopus 로고    scopus 로고
    • Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease
    • Lecerf, J. M., et al. (2001). Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease. Proc. Natl. Acad. Sci. USA 98: 4764-4769.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 4764-4769
    • Lecerf, J.M.1
  • 13
    • 0028283985 scopus 로고
    • Glutamine repeats as polar zippers: Their possible role in inherited neurodegenerative diseases
    • Perutz, M. F., Johnson, T., Suzuki, M., and Finch, J. T. (1994). Glutamine repeats as polar zippers: Their possible role in inherited neurodegenerative diseases. Proc. Natl. Acad. Sci. USA 91: 5355-5358.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5355-5358
    • Perutz, M.F.1    Johnson, T.2    Suzuki, M.3    Finch, J.T.4
  • 14
    • 0035862874 scopus 로고    scopus 로고
    • Abnormalities in the functioning of adipocytes from R6/2 mice that are transgenic for the Huntington's disease mutation
    • Fain, J. N., Del Mar, N. A., Meade, C. A., Reiner, A., and Goldowitz, D. (2001). Abnormalities in the functioning of adipocytes from R6/2 mice that are transgenic for the Huntington's disease mutation. Hum. Mol. Genet. 10: 145-152.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 145-152
    • Fain, J.N.1    Del Mar, N.A.2    Meade, C.A.3    Reiner, A.4    Goldowitz, D.5
  • 15
    • 0037101835 scopus 로고    scopus 로고
    • Dysregulation of gene expression in the R6/2 model of polyglutamine disease: Parallel changes in muscle and brain
    • Luthi-Carter, R., et al. (2002). Dysregulation of gene expression in the R6/2 model of polyglutamine disease: Parallel changes in muscle and brain. Hum. Mol. Genet. 11: 1911-1926.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 1911-1926
    • Luthi-Carter, R.1
  • 16
    • 0032919205 scopus 로고    scopus 로고
    • Formation of polyglutamine inclusions in non-CNS tissue
    • Sathasivam, K., et al. (1999). Formation of polyglutamine inclusions in non-CNS tissue. Hum. Mol. Genet. 8: 813-822.
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 813-822
    • Sathasivam, K.1
  • 17
    • 0021927818 scopus 로고
    • Diabetes mellitus in Huntington disease
    • Farrer, L. A. (1985). Diabetes mellitus in Huntington disease. Clin. Genet. 27: 62-67.
    • (1985) Clin. Genet. , vol.27 , pp. 62-67
    • Farrer, L.A.1
  • 18
    • 0035160931 scopus 로고    scopus 로고
    • Report on the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
    • Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
    • Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2001). Report on the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 24: S5-S20.
    • (2001) Diabetes Care , vol.24
  • 19
    • 0015521813 scopus 로고
    • Increased frequency of diabetes mellitus in patients with Huntington's chorea
    • Podolsky, S., Leopold, N. A., and Sax, D. S. (1972). Increased frequency of diabetes mellitus in patients with Huntington's chorea. Lancet 1: 1356-1358.
    • (1972) Lancet , vol.1 , pp. 1356-1358
    • Podolsky, S.1    Leopold, N.A.2    Sax, D.S.3
  • 20
    • 0017369458 scopus 로고
    • Abnormal glucose tolerance and arginine tolerance tests in Huntington's disease
    • Podolsky, S., and Leopold, N. A. (1977). Abnormal glucose tolerance and arginine tolerance tests in Huntington's disease. Gerontology 23: 55-63.
    • (1977) Gerontology , vol.23 , pp. 55-63
    • Podolsky, S.1    Leopold, N.A.2
  • 21
    • 16044373842 scopus 로고    scopus 로고
    • Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
    • Mangiarini, L., et al. (1996). Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87: 493-506.
    • (1996) Cell , vol.87 , pp. 493-506
    • Mangiarini, L.1
  • 22
    • 0033009587 scopus 로고    scopus 로고
    • Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes
    • Hurlbert, M. S., et al. (1999). Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes. Diabetes 48: 649-651.
    • (1999) Diabetes , vol.48 , pp. 649-651
    • Hurlbert, M.S.1
  • 23
    • 0033613212 scopus 로고    scopus 로고
    • Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells
    • Kazantsev, A., Preisinger, E., Dranovsky, A., Goldgaber, D., and Housman, D. (1999). Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells. Proc. Natl. Acad. Sci. USA 96: 11404-11409.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 11404-11409
    • Kazantsev, A.1    Preisinger, E.2    Dranovsky, A.3    Goldgaber, D.4    Housman, D.5
  • 24
    • 0029082383 scopus 로고
    • Inactivation of the mouse Huntington's disease gene homolog Hdh
    • Duyao, M. P., et al. (1995). Inactivation of the mouse Huntington's disease gene homolog Hdh. Science 269: 407-410.
    • (1995) Science , vol.269 , pp. 407-410
    • Duyao, M.P.1
  • 25
    • 0035969336 scopus 로고    scopus 로고
    • Evaluation of R6/2 HD transgenic mice for therapeutic studies in Huntington's disease: Behavioral testing and impact of diabetes mellitus
    • Luesse, H. G., et al. (2001). Evaluation of R6/2 HD transgenic mice for therapeutic studies in Huntington's disease: Behavioral testing and impact of diabetes mellitus. Behav. Brain Res. 126: 185-195.
    • (2001) Behav. Brain Res. , vol.126 , pp. 185-195
    • Luesse, H.G.1
  • 26
    • 0035112910 scopus 로고    scopus 로고
    • Enhancing vaccines with immune stimulatory CpG DNA
    • Krieg, A. M., and Davis, H. L. (2001). Enhancing vaccines with immune stimulatory CpG DNA. Curr. Opin. Mol. Ther. 3: 15-24.
    • (2001) Curr. Opin. Mol. Ther. , vol.3 , pp. 15-24
    • Krieg, A.M.1    Davis, H.L.2
  • 27
    • 0034110465 scopus 로고    scopus 로고
    • Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila
    • Marsh, J. L., et al. (2000). Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila. Hum. Mol. Genet. 9: 13-25.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 13-25
    • Marsh, J.L.1
  • 28
    • 0034703869 scopus 로고    scopus 로고
    • Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells
    • Trettel, F., et al. (2000). Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells. Hum. Mol. Genet. 9: 2799-2809.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 2799-2809
    • Trettel, F.1
  • 29
    • 0035336658 scopus 로고    scopus 로고
    • Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release
    • Jana, N. R., Zemskov, E. A., Wang, G., and Nukina, N. (2001). Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release. Hum. Mol. Genet. 10: 1049-1059.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1049-1059
    • Jana, N.R.1    Zemskov, E.A.2    Wang, G.3    Nukina, N.4
  • 30
    • 0035818590 scopus 로고    scopus 로고
    • Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death
    • Parker, J. A., et al. (2001). Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death. Proc. Natl. Acad. Sci. USA 98: 13318-13323.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 13318-13323
    • Parker, J.A.1
  • 31
    • 0033119123 scopus 로고    scopus 로고
    • Nuclear and neuropil aggregates in Huntington's disease: Relationship to neuropathology
    • Gutekunst, C. A., et al. (1999). Nuclear and neuropil aggregates in Huntington's disease: Relationship to neuropathology. J. Neurosci. 19: 2522-2534.
    • (1999) J. Neurosci. , vol.19 , pp. 2522-2534
    • Gutekunst, C.A.1
  • 32
    • 0032590053 scopus 로고    scopus 로고
    • Huntington aggregates may not predict neuronal death in Huntington's disease
    • Kuemmerle, S., et al. (1999). Huntington aggregates may not predict neuronal death in Huntington's disease. Ann. Neurol. 46: 842-849.
    • (1999) Ann. Neurol. , vol.46 , pp. 842-849
    • Kuemmerle, S.1
  • 33
    • 0032475931 scopus 로고    scopus 로고
    • Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions
    • Saudou, F., Finkbeiner, S., Devys, D., and Greenberg, M. E. (1998). Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell 95: 55-66.
    • (1998) Cell , vol.95 , pp. 55-66
    • Saudou, F.1    Finkbeiner, S.2    Devys, D.3    Greenberg, M.E.4
  • 34
    • 0028931102 scopus 로고
    • CpG motifs in bacterial DNA trigger direct B-cell activation
    • Krieg, A. M., et al. (1995). CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374: 546-549.
    • (1995) Nature , vol.374 , pp. 546-549
    • Krieg, A.M.1
  • 35
    • 0033583924 scopus 로고    scopus 로고
    • Peripheral injections of Freund's adjuvant in mice provoke leakage of serum proteins through the blood-brain barrier without inducing reactive gliosis
    • Rabchevsky, A. G., Degos, J. D., and Dreyfus, P. A. (1999). Peripheral injections of Freund's adjuvant in mice provoke leakage of serum proteins through the blood-brain barrier without inducing reactive gliosis. Brain Res. 832: 84-96.
    • (1999) Brain Res. , vol.832 , pp. 84-96
    • Rabchevsky, A.G.1    Degos, J.D.2    Dreyfus, P.A.3
  • 36
    • 0026444002 scopus 로고
    • Afferent and efferent arms of the humoral immune response to CSF-administered albumins in a rat model with normal blood-brain barrier permeability
    • Cserr, H. F., DePasquale, M., Harling-Berg, C. J., Park, J. T., and Knopf, P. M. (1992). Afferent and efferent arms of the humoral immune response to CSF-administered albumins in a rat model with normal blood-brain barrier permeability. J. Neuroimmunol. 41: 195-202.
    • (1992) J. Neuroimmunol. , vol.41 , pp. 195-202
    • Cserr, H.F.1    DePasquale, M.2    Harling-Berg, C.J.3    Park, J.T.4    Knopf, P.M.5
  • 37
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard, F., et al. (2000). Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 6: 916-919.
    • (2000) Nat. Med. , vol.6 , pp. 916-919
    • Bard, F.1
  • 38
    • 84984755327 scopus 로고    scopus 로고
    • A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    • Morgan, D., et al. (2000). A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 408: 982-985.
    • (2000) Nature , vol.408 , pp. 982-985
    • Morgan, D.1
  • 39
    • 0034700471 scopus 로고    scopus 로고
    • A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
    • Janus, C., et al. (2000). A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 408: 979-982.
    • (2000) Nature , vol.408 , pp. 979-982
    • Janus, C.1
  • 40
    • 0036240395 scopus 로고    scopus 로고
    • Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
    • Dodart, J. C., et al. (2002). Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat. Neurosci. 5: 452-457.
    • (2002) Nat. Neurosci. , vol.5 , pp. 452-457
    • Dodart, J.C.1
  • 41
    • 0036127580 scopus 로고    scopus 로고
    • Set back to Alzheimer vaccine studies
    • Birmingham, K., and Frantz, S. (2002). Set back to Alzheimer vaccine studies. Nat. Med. 8: 199-200.
    • (2002) Nat. Med. , vol.8 , pp. 199-200
    • Birmingham, K.1    Frantz, S.2
  • 42
    • 0037112201 scopus 로고    scopus 로고
    • Cerebral hemorrhage after passive anti-Abeta immunotherapy
    • Pfeifer, M., et al. (2002). Cerebral hemorrhage after passive anti-Abeta immunotherapy. Science 298: 1379.
    • (2002) Science , vol.298 , pp. 1379
    • Pfeifer, M.1
  • 43
    • 0036317750 scopus 로고    scopus 로고
    • Immunization delays the onset of prion disease in mice
    • Sigurdsson, E. M., et al. (2002). Immunization delays the onset of prion disease in mice. Am. J. Pathol. 161: 13-17.
    • (2002) Am. J. Pathol. , vol.161 , pp. 13-17
    • Sigurdsson, E.M.1
  • 44
    • 0033757718 scopus 로고    scopus 로고
    • Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice
    • Dragatsis, I., Levine, M. S., and Zeitlin, S. (2000). Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice. Nat. Genet. 26: 300-306.
    • (2000) Nat. Genet. , vol.26 , pp. 300-306
    • Dragatsis, I.1    Levine, M.S.2    Zeitlin, S.3
  • 45
    • 0033578220 scopus 로고    scopus 로고
    • Instability of the CAG repeat in immortalized fibroblast cell cultures from Huntington's disease transgenic mice
    • Manley, K., Pugh, J., and Messer, A. (1999). Instability of the CAG repeat in immortalized fibroblast cell cultures from Huntington's disease transgenic mice. Brain Res. 835: 74-79.
    • (1999) Brain Res. , vol.835 , pp. 74-79
    • Manley, K.1    Pugh, J.2    Messer, A.3
  • 46
    • 0034154560 scopus 로고    scopus 로고
    • Minding the Cs and Gs
    • Krieg, A. M. (2000). Minding the Cs and Gs. Mol. Ther. 1: 209-210.
    • (2000) Mol. Ther. , vol.1 , pp. 209-210
    • Krieg, A.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.