Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76

EMBO Journal

Volumn 22, Issue 11, 2003, Pages 2571-2582

  Harkiolaki, Maria ^a   Lewitzky, Marc ^a   Gilbert, Robert J C ^b   Jones, E Yvonne ^b,c   Bourette, Roland P ^d   Mouchiroud, Guy ^d   Sondermann, Holger ^e,f   Moarefi, Ismail ^e,g   Feller, Stephan M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Division of Structural Biology   (United Kingdom)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^d CENTRE DE GÉNÉTIQUE MOLÉCULAIRE ET CELLULAIRE   (France)

^e MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^f University of California Berkeley   (United States)

^g Sireen AG   (Germany)

Author keywords

Crystal structure; Gads; Mona; SH3 domain dimer; SLP 76

Indexed keywords

ADAPTOR PROTEIN; EPITOPE; PROTEIN GADS; PROTEIN MONA; PROTEIN SLP 76; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; COMPLEMENT FIXATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIMERIZATION; HUMAN GENOME; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ELECTROSTATICS; HUMANS; HYDROGEN BONDING; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PHYLOGENY; PROTEIN BINDING; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SRC HOMOLOGY DOMAINS;

ANIMALIA; DOMINGOA HAEMATOCHILA;

EID: 0037526105     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg258     Document Type: Article

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