SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases

Mechanisms of Development

Volumn 116, Issue 1-2, 2002, Pages 129-139

  Feller, Stephan M ^a   Wecklein, Heike ^b   Lewitzky, Marc ^a   Kibler, Eike ^b   Raabe, Thomas ^b  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Daughter of Sevenless; Drk; Drosophila; Eye development; Receptor tyrosine kinase; SH3 domain

Indexed keywords

ADAPTOR PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; PHOSPHOTYROSINE; PROTEIN; PROTEIN DOS; PROTEIN DRK; PROTEIN SH3; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; COMPLEMENTARY DNA; CORKSCREW PROTEIN, DROSOPHILA; DAUGHTER OF SEVENLESS PROTEIN, DROSOPHILA; DRK PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; EYE PROTEIN; MEMBRANE PROTEIN; PROTEIN TYROSINE PHOSPHATASE; SEV PROTEIN, DROSOPHILA;

ANIMAL TISSUE; ARTICLE; AUTOPHOSPHORYLATION; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL FATE; CONTROLLED STUDY; DROSOPHILA; ENZYME SUBSTRATE; EYE DEVELOPMENT; HUMAN; HUMAN CELL; MUTATIONAL ANALYSIS; NONHUMAN; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; CELL LINE; CHEMISTRY; EYE; GENE; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; NUCLEOTIDE SEQUENCE; SITE DIRECTED MUTAGENESIS; TRANSGENIC ANIMAL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; ANIMALS, GENETICALLY MODIFIED; BASE SEQUENCE; BINDING SITES; CELL LINE; DNA, COMPLEMENTARY; DROSOPHILA; DROSOPHILA PROTEINS; EYE; EYE PROTEINS; GENES, INSECT; HUMAN; MEMBRANE GLYCOPROTEINS; MUTAGENESIS, SITE-DIRECTED; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; SUPPORT, NON-U.S. GOV'T; ANIMALS; HUMANS;

EID: 0035996968     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(02)00147-8     Document Type: Article

References (38)

1. Mutational analysis of the SRC homology 2 domain protein-tyrosine phosphatase corkscrew
2. Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye
3. In vivo functional analysis of the daughter of sevenless protein in receptor tyrosine kinase signaling
4. Autonomous control of cell and organ size by chico, a Drosophila homolog of vertebrate IRS1-4
5. Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation
6. Multiple functions of the EGF receptor in Drosophila eye development
7. Crk family adaptors-signalling complex formation and biological roles
8. Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1
9. Diversity in protein recognition by PTB domains
10. Cloning of p97/Gab2, the major SHP-2 bindng protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
11. Daughter of Sevenless is a substrate of the phosphotyrosine phosphatase corkscrew and functions during sevenless signaling
12. Recruitment of the protein tyrosine phosphatase CSW by DOS is an essential step during signaling by the sevenless receptor tyrosine kinase
13. A Grb2-associated docking protein in EGF- and insulin-receptor signalling
14. Cell-penetrating SH3 domain blocker peptides inhibit proliferation of primary blast cells from CML patients
15. A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP
16. The white gene as a marker in a new P-element vector for gene tranfer in Drosophila
17. The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif
18. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
19. Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases
20. SH3 domains: Complexity in moderation
21. Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor requires a functional Grb2 binding site involving tyrosine 1356
22. A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos
23. Protein modules and signalling networks
24. Protein-protein interactions define specificity in signal transduction
25. Signaling through scaffold, anchoring, and adaptor proteins
26. The Sevenless signaling pathway: Variations of a common theme
27. Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila
28. Dos, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila
29. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
30. Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
31. Cell signaling by receptor tyrosine kinases
32. The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction
33. Ras1 activation and binds to Sevenless and Sos proteins in vitro
34. SH2 domains recognize specific phosphopeptide sequences
35. Small wing encodes a phospholipase C-γ that acts as a negative regulator of R7 development in Drosophila
36. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis
37. The IRS-signalling system during insulin and cytokine action
38. Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1