B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65 antigen in nonobese diabetic mice

Journal of Immunology

Volumn 161, Issue 3, 1998, Pages 1163-1168

  Falcone, Marika ^a   Lee, Jae ^a   Patstone, Gail ^a   Yeung, Brian ^a   Sarvetnick, Nora ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLUTAMATE DECARBOXYLASE; HEAT SHOCK PROTEIN 60; LYMPHOCYTE MEMBRANE IMMUNOGLOBULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CELL PROLIFERATION; CELLULAR IMMUNITY; CELLULAR IMMUNODEFICIENCY; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL;

ANIMALS; ANTIBODIES, BLOCKING; ANTIGEN-PRESENTING CELLS; AUTOANTIGENS; B-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; EPITOPES; GLUTAMATE DECARBOXYLASE; IMMUNITY, CELLULAR; ISLETS OF LANGERHANS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, B-CELL; T-LYMPHOCYTE SUBSETS;

EID: 0032145276     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Castano, L., and G. S. Eisenbarth. 1990. Type-1 diabetes: a chronic autoimmune disease of human, mouse, and rat. Annu. Rev. Immunol. 8:647.
2. Birk, O. S., and I. R. Cohen. 1993. T-cell autoimmunity in type 1 diabetes mellitus. Curr. Opin. Immunol. 5:903.
3. Katz, J. D., B. Wang, K. Haskins, C. Benoist, and D. Mathis. 1993. Following a diabetogenic T cell from genesis through pathogenesis. Cell 74:1089.
4. Chen, V., V. Kuchroo, J. Inobe, D. Hafler, and H. Weiner. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265:1237.
5. Katz, J. D., C. Benoist, and D. Mathis. 1995. T helper cell subsets in insulin-dependent diabetes. Science 268:1185.
6. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16: 34.
7. Lee, M., R. Mueller, L. Wicker, L. Peterson, and N. Sarvetnick. 1996. IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity. J. Exp. Med. 183:2663.
8. Pakala, S. V., M. O. Kurrer, and J. D. Katz. 1997. T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised non-obese diabetic (NOD) mice. J. Exp. Med. 186:299.
9. Lafaille, J. J., F. Van de Keere, A. L. Hsu, J. L. Baron, W. Haas, C. S. Raine, and S. Tonegawa. 1997. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J. Exp. Med. 186:307.
10. Forsgren, S., A. Andersson, V. Hillorn, A. Soderstrom, and D. Holmberg. 1991. Immunoglobulin-mediated prevention of autoimmune diabetes in the non-obese diabetic (NOD) mouse. Scand. J. Immunol. 34:445.
11. null mice. J. Exp. Med. 184:2049.
12. Yang, M., B. Charlton, and A. M. Gautam. 1997. Development of insulitis and diabetes in B cell-deficient NOD mice. J. Autoimmun. 10:257.
13. Noorchashm, H., N. Noorchashm, J. Kern, S. Y. Rostami, C. F. Barker, and A. Naji. 1997. B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice. Diabetes 46:941.
14. Signore, A., P. Pozzilli, E. A. M. Gale, D. Andreani, and P. C. L. Beverly. 1989. The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice. Diabetologia 32:282.
15. Goldrath, A. W., L. Barber, K. E. Chen, and S. E. Alters. 1995. Differences in adhesion markers, activation markers, and TCR in islet infiltrating vs peripheral lymphocytes in the NOD mouse. J. Autoimmun. 8:209.
16. Faveeuw, C., M.-C. Gagnerault, G. Kraal, and F. Lepault. 1995. Homing of lymphocytes into islets of Langerhans in prediabetic non-obese diabetic mice is not restricted to autoreactive T cells. Int. Immunol. 7:1905.
17. Lanzavecchia, A. 1985. Antigen-specific interaction between T and B cells. Nature 314:537.
18. Lanzavecchia, A. 1987. Antigen uptake and accumulation in antigen-specific B cells. Immunol. Rev. 99:39.
19. Hodgkin, P. D., and A. Basten. 1995. B cell activation, tolerance, and antigen-presenting function. Curr. Opin. Immunol. 7:121.
20. Mamula, M. J., R.-H. Lin, C. A. Janeway, and J. A. Hardin. 1992. Breaking T cell tolerance with foreign and self coimmunogens. J. Immunol. 149:789.
21. Mamula, M. J., and C. A. Janeway. 1993. Do B cells drive the diversification of immune responses? Immunol. Today 14:151.
22. Elias, A., D. Markovits, T. Reshef, R. van der Zee, and I. R. Cohen. 1990. Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/ Lt) mouse by a 65-kDa heat shock protein. Proc. Natl. Acad. Sci. USA 87:1576.
23. Kaufman, D. L., M. Clare-Salzier, J. Tian, T. Forsthuber, G. S. P. Ting, P. Robinson, M. A. Atkinson, E. E. Sercarz, A. J. Tobin, and P. V. Lehmann. 1993. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366:69.
24. Tisch, R., X.-D. Yang, S. M. Singer, R. S. Liblau, L. Fugger, and H. O. McDevitt. 1993. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366:72.
25. Elias, D., and I. R. Cohen. 1994. Peptide therapy for diabetes in NOD mice. Lancet 343:704.
26. Kitamura, D., J. Roes, R. Kuhn, and K. Rajewsky. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene. Nature 350:423.
27. Lee, D. S., J. Tian, T. Phan, and D. L. Kaufman. 1993. Cloning and sequence analysis of a murine cDNA encoding glutamate decarboxylase (GAD65). Biochim. Biophys. Acta 1216:157.
28. Nemazee, D. A. 1985. Immune complexes can trigger specific, T-cell dependent, autoanti-IgG antibody production in mice. J. Exp. Med. 161:242.
29. Manca, F., D. Fenoglio, A. Kunkl, C. Cambiaggi, M. Sasso, and F. Celada. 1988. Differential activation of T cell clones stimulated by macrophages exposed to antigen complexes with monoclonal antibodies. J. Immunol. 140:2893.
30. Melms, A., R. Weissert, W. E. F. Klinkert, B. C. G. Schalke, S. Tzartos, and H. Wekerle. 1993. Specific immune complexes augment in vitro acetylcholine receptor-specific T-cell proliferation. Neurology 43:583.
31. Roth, R., R. J. Gee, and M. J. Mamula. 1997. B lymphocytes as autoantigen-presenting cells in the amplification of autoimmunity. Ann. N. Y. Acad. Sci. 815: 88.
32. + T cells. J. Immunol. 154:4915.
33. Palmer, J. P. 1987. Insulin autoantibodies: their role in the pathogenesis of IDDM. Diabetes Metab. Rev. 3:1005.
34. Rowley, M. J., I. R. Mackaj, Q. Y. Chen, W. J. Knowles, and P. Z. Zimmet. 1992. Antibodies to glutamic acid decarboxylase discriminate major types of diabetes mellitus. Diabetes 41:548.
35. Gao, Y. L., C. S. Raine, and C. F. Brosnan. 1994. Humoral response to hsp 65 in multiple sclerosis and other neurological conditions. Neurology 44:941.
36. Zanetta, J. P., C. Tranchant, S. Kuchler-Bopp, S. Lehmann, and J. M. Warter. 1994. Presence of anti-CSL antibodies in the cerebrospinal fluid of patients: a sensitive and specific test in the diagnosis of multiple sclerosis. J. Neuroimmunol. 52:175.
37. Luan, J. J., R. C. Monteiro, C. Sautes, G. Fluteau, L. Eloy, W. H. Fridman, J.-F. Bach, and H.-J. Garchon. 1996. Defective FcγRII gene expression in macrophages of NOD mice. J. Immunol. 157:4707.
38. Shieh, D.-C., J. G. Cornelius, W. E. Winter, and A. B. Peck. 1993. Insulin-dependent diabetes in the NOD mouse model: detection and characterization of autoantibody bound to the surface of pancreatic β islets before development of the insulitis lesion in prediabetic NOD mice. Autoimmunity 15:123.
39. Bendelac, A., C. Boitard, P. Bedosa, H. Bazin, J.-F. Bach, and C. Carnaud. 1988. Adoptive T cell transfer of autoimmune nonobese diabetic mouse diabetes does not require recruitment of host B lymphocytes. J. Immunol. 141:2625.
40. Lin, R.-H., M. J. Mamula, J. A. Hardin, and C. A. Janeway. 1991. Induction of autoreactive B cells allows priming of autoreactive T cells. J. Exp. Med. 173: 1433.
41. Mamula, M. J., S. Fatenejad, and S. J. Craft. 1994. B cells process and present lupus autoantigens that initiate autoimmune T cell responses. J. Immunol. 152: 1453.
42. Ron, Y., and J. Sprent. 1987. T cell priming in vivo: a major role for B cells in presenting antigen to T cells in lymph nodes. J. Immunol. 138:2848.
43. Kurt-Jones, E. A., D. Liano, K. A. Hayglass, B. Benacerraf, M.-S. Sy, and A. K. Abbas. 1988. The role of antigen-presenting B cells in T cell priming in vivo. J. Immunol. 140:3773.
44. Liu, Y., L. Ramarathinam, Y. Guo, D. Huszar, M. Trounstine, and M. Zhao. 1995. Gene-targeted B-deficient mice reveal a critical role for B cells in the CD4 T cell response. Int. Immunol. 7:1353.
45. Ronchese, F., and B. Hausmann. 1993. B lymphocytes in vivo fail to prime naive T cells but can stimulate antigen-experienced T lymphocytes. J. Exp. Med. 177: 679.
46. Epstein, M. M., F. Di Rosa, D. Jankovic, A. Sher, and P. Matzinger. 1995. Successful T cell priming in B-cell-deficient mice. J. Exp. Med. 182:915.
47. Fuchs, E. J., and P. Matzinger. 1992. B cells turn off virgin but not memory T cells. Science 258:1156.