Interleukin 12 mRNA expression in islets correlates with β-cell destruction in NOD mice

Journal of Autoimmunity

Volumn 9, Issue 5, 1996, Pages 645-651

  Rabinovitch, Alex ^a   Suarez Pinzon, Wilma L ^a   Sorensen, Ole ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

IFN ; IL 12; IL 2; Insulitis; NOD mice

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HELPER CELL; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 0030271678     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1996.0084     Document Type: Article

References (32)

1. 1. Castano L., Eisenbarth G.S. 1990. Type-1 diabetes: a chronic autoimmune disease of human, mouse and rat. Annu. Rev. Immunol. 8: 647-679
2. 2. Rossini A.A., Greiner D.L., Friedman H.P., Mordes J.P. 1993. Immunopathogenesis of diabetes mellitus. Diabetes Rev. 1: 43-75
3. 3. Bach J.F. 1994. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocrine Rev. 15: 516-542
4. 4. Mandrup-Poulsen T., Helqvist S., Wogensen L.D., Møvig J., Pociot F., Johannesen J., Nerup J. 1990. Cytokines and free radicals as effector molecules in the destruction of pancreatic beta cells. Curr. Top. Microbiol Immunol. 164: 169-193
5. 5. Rabinovitch A. 1993. Roles of cytokines in IDDM pathogenesis and islet β-cell destruction. Diabetes Rev. 1: 215-240
6. 6. Rabinovitch A. 1994. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation? Diabetes 43: 613-621
7. 7. Pukel C., Baquerizo H., Rabinovitch A. 1988. Destruction of rat islet cell monolayers by cytokines: synergistic interactions of interferon-γ, tumor necrosis factor, lymphotoxin, and interleukin 1. Diabetes 37: 133-136
8. 8. Campbell I.L., Iscaro A., Harrison L.C. 1988. IFN-γ and tumor necrosis factor-α. Cytotoxicity to murine islets of Langerhans. J. Immunol. 141: 2325-2329
9. 9. Sarvetnick N., Liggitt D., Pitts S.L., Hansen S.E., Stewart T.A. 1988. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. Cell 52: 773-782
10. 10. Sarvetnick N., Shizuru J., Liggitt D., Martin L., McIntyre B., Gregory A., Parslow T., Stewart T. 1990. Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ. Nature 346: 844-847
11. 11. Campbell I.L., Kay T.W.H., Oxbrow L., Harrison L.C. 1991. Essential role for interferon-γ and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J. Clin. Invest. 87: 739-742
12. 12. Debray-Sachs M., Carnaud C., Boitard C., Cohen H., Gresser I., Bedossa P., Bach J.-F. 1991. Prevention of diabetes in NOD mice treated with antibody to murine IFN-γ. J. Autoimmun. 4: 237-248
13. 13. Nicoletti F., Meroni P.L., Landolfo S., Gariglio M., Guzzardi S., Barcellini W., Lunetta M., Mughini L., Zanussi C. 1990. Prevention of diabetes in BB/Wor rats treated with monoclonal antibodies to interferon-γ. Lancet 336: 319 (Abstr.)
14. 14. Haskins K., McDuffie M. 1990. Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T-cell clone. Science 249: 1433-1436
15. 15. Wegmann D.R., Gill R.G., Norbury-Glaser M., Schloot N., Daniel D. 1994. Analysis of the spontaneous T cell response to insulin in NOD mice. J. Autoimmunity 7: 833-843
16. 16. Healey D., Ozegbe P., Arden S., Chandler P., Hutton J., Cooke A. 1995. In vivo activity and in vitro specificity of CD4+ Th1 and Th2 T cells derived from the spleens of diabetic NOD mice. J. Clin. Invest. 95: 2979-2985
17. 17. Katz J.D., Benoist C., Mathis D. 1995. T helper cell subsets in insulin-dependent diabetes. Science 268: 1185-1188
18. 18. Rabinovitch A., Suarez-Pinzon W.L., Sorensen O., Bleackley R.C., Power R.F. 1994. IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J. Immunol. 154: 4874-4882
19. 19. Rothe H., Faust A., Schade U., Kleemann R., Bosse G., Hibino T., Martin S., Kolb H. 1994. Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-γ, but not of interleukin-4. Diabetologia 37: 1154-1158.
20. 20. Muir A., Peck A., Clare-Salzler M., Song Y.-H., Cornelius J., Luchetta R., Krischer J., Maclaren N. 1995. Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-γ transcription. J. Clin. Invest. 95: 628-634
21. 21. Shehadeh N., LaRosa F., Lafferty K.J. 1993. Altered cytokine activity in adjuvant inhibition of autoimmune diabetes. J. Autoimmunity 6: 291-300
22. 22. Rabinovitch A., Sorensen O., Suarez-Pinzon W.L., Power R.F., Rajotte R.V., Bleackley R.C. 1994. Analysis of cytokine mRNA expression in syngeneic islet grafts of NOD mice: interleukin 2 and interferon gamma mRNA expression correlate with graft rejection and interleukin 10 with graft survival. Diabetologia 37: 833-837
23. 23. Trinchieri G. 1995. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific immunity. Annu. Rev. Immunol. 13: 251-276
24. 24. Trembleau S., Penna G., Bosi E., Mortara A., Gately M.K. and Adorini L. 1995. Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J. Exp. Med. 181: 817-821
25. 25. Gotoh M., Maki J., Kiyoizumi T., Satomi S., Monaco A.P. 1985. An improved method for isolation of mouse pancreatic islets. Transplantation 40: 437-438
26. 26. Jarpe A.J., Hickman M.R., Andersen J.T., Winter W.E., Peck A.B. 1991. Flow cytometric enumeration of mononuclear cell populations infiltrating the islets of Langerhans in prediabetic NOD mice: development of a model of autoimmune insulitis for Type 1 diabetes. Regional Immunol. 3: 305-317
27. 27. Sadelain M.W.J., Qin H.-Y., Lauzon J., Singh B. 1990. Prevention of type I diabetes in NOD mice by adjuvant immunotherapy. Diabetes 39: 583-589
28. 28. Wang T., Singh B., Warnock G.L., Rajotte R.V. 1992. Prevention of recurrence of IDDM in islet-transplanted diabetic NOD mice by adjuvant immunotherapy. Diabetes 41: 114-117
29. 29. Chirgwin J.M., Przybyla A.E., MacDonald R.J., Rutter K.T. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18: 5294-5299
30. 30. Kennedy M.K., Torrance D.S., Picha K.S., Mohler K.M. 1992. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149: 2496-2505.
31. 31. Trembleau S., Penna G., Gregori S., Magram T., Gately M.K., Adorini L. 1995. The role of endogenous IL-12 in the development of spontaneous diabetes in NOD mice. Autoimmunity 21: 23
32. 32. Rothe H., Burkart V., Faust A., Kolb H. 1996. Interleukin-12 gene expression is associated with rapid development of diabetes mellitus in non-obese diabetic mice. Diabetologia 39: 119-122