Epoxycyclohexenone inhibits Fas-mediated apoptosis by blocking activation of pro-caspase-8 in the death-inducing signaling complex

Journal of Biological Chemistry

Volumn 278, Issue 13, 2003, Pages 11213-11220

  Miyake, Yasunobu ^a,b   Kakeya, Hideaki ^a   Kataoka, Takao ^b   Osada, Hiroyuki ^a  

^a Discovery Research Institute   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYMES; IMMUNOLOGY; IRRADIATION;

APOPTOSIS;

BIOCHEMISTRY;

CASPASE 8; CASPASE 9; CELL RECEPTOR; CYCLOHEXANONE DERIVATIVE; DEATH RECEPTOR; ENZYME PRECURSOR; EPOXYCYCLOHEXENONE; FAS ANTIGEN; FAS LIGAND; UNCLASSIFIED DRUG; CASP8 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; CASPASE; CYCLOHEXANONE; PRIMER DNA; TUMOR NECROSIS FACTOR RECEPTOR;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; CELL CULTURE; DRUG EFFECT; FLOW CYTOMETRY; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY;

ANTIGENS, CD95; APOPTOSIS; BASE SEQUENCE; CASPASE 8; CASPASE 9; CASPASES; CYCLOHEXANONES; DNA PRIMERS; ENZYME ACTIVATION; ENZYME PRECURSORS; FLOW CYTOMETRY; HUMANS; RECEPTORS, TUMOR NECROSIS FACTOR; TUMOR CELLS, CULTURED;

EID: 0037500252     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209610200     Document Type: Article

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