Antisense inhibition of urokinase: Effect on malignancy in a human osteosarcoma cell line

International Journal of Cancer

Volumn 77, Issue 1, 1998, Pages 153-160

  Haeckel, Carsten ^a   Krueger, Sabine ^a   Roessner, Albert ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA;

ARTICLE; CELL CULTURE; CELL FUNCTION; CELL PROLIFERATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSFECTION; GENOME; HUMAN; HUMAN CELL; NORTHERN BLOTTING; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

ANIMALS; BONE NEOPLASMS; CELL DIVISION; CHICK EMBRYO; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM INVASIVENESS; OLIGONUCLEOTIDES, ANTISENSE; OSTEOSARCOMA; TUMOR CELLS, CULTURED; URINARY PLASMINOGEN ACTIVATOR;

EID: 0032479278     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19980703)77:1<153::AID-IJC23>3.0.CO;2-E     Document Type: Article

References (28)

1. ACHBAROU, A., KAISER, S., TREMBLAY, G., STE-MARIE, L.G., BRODT, P., GOLTZMAN, D. and RABBANI, A., Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo. Cancer Res., 54, 2372-2377 (1994).
2. BLASI, F., Urokinase and urokinase receptor: a paracrine/autocrine system regulating cell migration and invasiveness. BioEssays, 15, 105-111 (1993).
3. DUFFY, M.J., The role of proteolytic enzymes in cancer invasion and, metastasis, clin. Exp. Metastasis, 10, 145-155 (1992).
4. ENDO, Y., SEIKI, M., UCIDA, H., NOGUCHI, M., KIDA, M., SATO, H., MAI, M. and SASAKI, T., Experimental metastasis of oncogene-transformed NIH 3T3 cells in chick embryo. Jpn. J. Cancer Res., 83, 274-280 (1992).
5. FIBBI, G., ZICHE, M., MORBIDELLI, L., MAGNELLI, L. and DEL ROSSO, M., Interaction of urokinase with specific receptors stimulates mobilization of bovine adrenal capillary endothelial cells. Exp. Cell Res., 179, 385-395 (1988).
6. HELÉNE, C. and TOULME, J.J., Specific regulation by antisense, sense and antigene nuceic acids. Biochim. biophys. Acta, 1049, 99-125 (1990).
7. KANSE, S.M., KOST, C., WILHELM, O.G., ANDREASEN, P.A. and PREISSNER, K.T., The urokinase receptor is a major vitronectin-binding protein on endothelial cells. Exp. Celt Res., 224, 344-353 (1996).
8. KARIKO, K., KUO, A., BOYD, D., OKADA, S.S., CINES, D.B. and BARNATHAN, E.S., Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line. Cancer 53, 3109-3117 (1993).
9. KOBAYASHI, H., OHI, H., SUGIMURA, M., SHINOHARA, H., FUJII, T. and TERAO, T., Inhibition of in vitro ovarian cancer cell invasion by modulation of urokinase plasminogen activator and cathepsin B. Cancer Res., 52, 3610-3614 (1992).
10. KOOK, Y.H., ADAMSKI, J., ZELENT, A. and OSSOWSKI, L., The effect of antisense inhibition of urokinase receptor in human squamous cell carcinoma on malignancy. EMBO J., 13, 3983-3991 (1994).
11. LU, H., MABILAT, C., YEH, P., GUITTON, J.D., LI, H., POUCHELET, M., SHOEVAERT, D., LEBRAND, Y., SORIA, J. and SORIA, C., Blockage of urokinase receptor reduces in vitro the motility and the deformability of endothelial cells. FEBS Lett., 380, 21-24 (1996).
12. MCGUIRE, P.O. and ALEXANDER, S.M., Inhibition of urokinase synthesis and cell surface binding alters the motile behavior of embryonic endocardial-derived mesenchymal cells in vitro. Development, 118, 931-939 (1993).
13. MEISSAUER, A., KRAMER, M.D., HOFMAN, M., ERKELL, L.J., JACOB, E., SCHIRRMACHER, V. and BRUNNER, G., Urokinase-type and tissue-type plasminogen activators are essential for in vitro invasion of human melanoma cells. Exp. Cell Res., 192, 453-459 (1991).
14. MONTGOMERY, A.M.P., DECLERCK, Y.A., LANGLEY, K.E., REISFELD, R.A. and MUELLER, B.M., Melanoma-mediated dissolution of extracellular matrix: contribution of urokinase-dependent and metalloproteinase-dependent proteolytic pathways. Cancer Res., 53, 693-700 (1993).
15. OSSOWSKI, L., Plasminogen activator dependent pathways in the dissemination of human tumor cells in the chick embryo. Cell, 52, 321-328 (1988).
16. OSSOWSKI, L., CLUNIE, G., MASUCCI, M.T. and BLASI, F., in vivo paracrine interaction between urokinase and its receptor: effect on tumor cell invasion. J. Cell Biol., 115, 1107-1112 (1991a).
17. OSSOWSKI, L. and REICH, E., Antibodies to plasminogen activator inhibit human tumor metastasis. Cell, 35, 611-619 (1983).
18. OSSOWSKI, L., RUSSO-PAYNE, H. and WILSON, E.L., Inhibition of urokinase plasminogen activator by antibodies: the effect on dissemination of a human tumor in nude mouse. Cancer Res., 51, 274-281 (1991b).
19. QUAX, P.H.A., PEDERSEN, N., MASUCCI, M.T., WEENING-VERHOEFF, E.J.D., DANO, K., VERHEIJEN, J.H.,and BLASI, F., Complementation between urokinase-producing and receptor producing cells in extracellular matrix degradation. Cell Regul., 2, 793-803 (1991).
20. RABBANI, S.A., DESJARDINS, J., BELL, A.W., BANVILLE, D., MAZAR, A., HENKIN, J. and GOLTZMAN, D., An amino-terminal fragment of urokinase isolated from a prostate cancer cell line (PC-3) is mitogenic for osteoblastlike cells. Biochem., biophys. Res. Commun., 173, 1058-1064 (1990).
21. SCHMITT, M., JAENICKE, F., MONIWA, N., CHUCHOLOWSKI, N., PACHE, L. and GRAEFF, H., Tumor-associated urokinase-type plasminogen activator: biological and clinical significance. Biol. Chem. Hoppe-Seyler, 373, 611-622 (1992).
22. STETLER-STEVENSON, W.G., AZNAVOORIAN, S. and LIOTTA, L.A., Tumor cell interactions with the intercellular matrix during invasion and metastasis. Ann. Rev. Cell Biol., 9, 541-573 (1993).
23. WALTZ, D.A. and CHAPMAN, H.A., Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy. J. Biol. Chem., 269, 14746-14750 (1994).
24. WALTZ. D.A., SAILOR, L.Z. and CHAPMAN, H.A., Cytokines induce urokinase-dependent adhesion of myeloid cells. J. Clin. Invest., 91, 1541-1552 (1993).
25. WEI, Y., LUKASHEV, M., SIMON, D.I., BODARY, S.C., ROSENBERG, S., DOYLE, M.V. and CHAPMAN, H.A., Regulation of integrin function by the urokinase receptor. Science, 273, 1551-1555 (1996).
26. WEI, Y., WALTZ, D.A., RAO, N., DRUMMOND, R.J., RosENBERG, S. and CHAPMAN, H., Identification of the urokinase receptor as an adhesion receptor for vitronectin. J. biol. Chem., 269, 32380-32388 (1994).
27. WILHELM, O., SCHMITT, M., HOEHL, S., SENEKOWITSCH, R. and GRAEFF, H., Antisense inhibition of urokinase reduces spread of human ovarian cancer in mice. Clin. exp. Metastasis, 13, 296-302 (1995).
28. Yu, H. and SCHULTZ, R.M., Relationship between secreted urokinase plasminogen activator activity and metastatic potential in murine B16 cells transfected with human urokinase sense and antisense genes. Cancer Res., 50, 7623-7633 (1990).