Bcl-XL and calyculin a prevent translocation of bax to mitochondria during apoptosis

Biochemical and Biophysical Research Communications

Volumn 291, Issue 5, 2002, Pages 1258-1264

  Ganju, Neema ^a   Eastman, Alan ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Bax; Bcl XL; Bid; Calyculin A; Caspase; Cytochrome c; Protein phosphatase

Indexed keywords

ANISOMYCIN; CALYCULIN A; CASPASE 8; CYTOCHROME C; PROTEIN BAX; PROTEIN BCL XL; PROTEIN BID; STAUROSPORINE;

APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; INCUBATION TIME; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

HOMO;

EID: 0036291021     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2002.6584     Document Type: Article

References (38)

1. Apoptotic pathways: The roads to ruin
2. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
3. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
4. Cleavage of Bid by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
5. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis
6. Differential modulation of apoptosis sensititivity in CD95 type I and type II cells
7. Nonionic detergents induce dimerization among members of the Bcl-2 family
8. Movement of Bax from the cytosol to mitochondria during apoptosis
9. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
10. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
11. Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations
12. Simultaneous release of adenylate kinase and cytochrome c in cell death
13. The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification, DNA digestion, and apoptosis
14. The temporal relationship between protein phosphatase, ICE/CED-3 proteases, intracellular acidification, and DNA fragmentation in apoptosis
15. The temporal relationship between protein phosphatase, mitochondrial cytochrome c release and caspase activation in apoptosis
16. Identification of deoxyribonuclease II as an endonuclease involved in apoptosis
17. 2+ associated with apoptosis
18. Release of cytochrome c, Bax migration, Bid cleavage, and activation of caspase 2,3, 6, 7, 8, and 9 during endothelial cell apoptosis
19. Caspase-8 activation and Bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis
20. Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis
21. Phosphorylation of Bid by casein kinases I and II regulates its cleavage by caspase 8
22. Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane
23. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis
24. Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane
25. TNF-α signals apoptosis through a Bid-dependent conformational change in Bax that is inhibited by E1B 19K
26. Bid-dependent and Bid-independent pathways for Bax insertion into mitochondria
27. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
28. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
29. Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells
30. Multiple Bcl-2 family members demonstrate selective dimerizations with Bax
31. BCL-2 and BCL-XL sequester BH3 domain-only molecules preventing Bax-and Bak-mediated mitochondrial apoptosis
32. Bcl-2 activates the transcription factor NFkB through the degradation of the cytoplasmic inhibitor IkBα
33. Linkage of the BH4 domain of Bcl-2 and the nuclear factor κB signaling pathway for suppression of apoptosis
34. Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase
35. Bcl-2 targets the protein kinase Raf-1 to mitochondria
36. Suppression of signaling through transcription factor NF-AT by interactions between calcineurin and Bcl-2
37. Bcl-2 targets protein phosphatase 1α to Bad
38. Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A