메뉴 건너뛰기




Volumn 63, Issue 8, 2003, Pages 1914-1919

A peroxisome proliferator-activated receptor-γ agonist and the p53 rescue drug CP-31398 inhibit the spontaneous immortalization of breast epithelial cells

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 DIMETHYLAMINOPROPYLAMINO) 2 (4 METHOXYSTYRYL)QUINAZOLINE; ANTINEOPLASTIC AGENT; CYCLOOXYGENASE 2 INHIBITOR; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE; SULINDAC SULFIDE;

EID: 0037447175     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (16)

References (50)
  • 1
    • 0024366596 scopus 로고
    • Reversible cellular senescence: Implications for immortalization of normal human diploid fibroblasts
    • Wright, W. E., Pereira-Smith, O. M., and Shay, J. W. Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts. Mol. Cell. Biol., 9: 3088-3092, 1989.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 3088-3092
    • Wright, W.E.1    Pereira-Smith, O.M.2    Shay, J.W.3
  • 2
    • 0026055983 scopus 로고
    • Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts
    • Hara, E., Tsurui, H., Shinozaki, A., Nakada, S., and Oda, K. Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts. Biochem. Biophys. Res. Commun., 179: 528-534, 1991.
    • (1991) Biochem. Biophys. Res. Commun. , vol.179 , pp. 528-534
    • Hara, E.1    Tsurui, H.2    Shinozaki, A.3    Nakada, S.4    Oda, K.5
  • 3
    • 0025729836 scopus 로고
    • Defining the molecular mechanisms of human cell immortalization
    • Shay, J. W., Wright, W. E., and Werbin, H. Defining the molecular mechanisms of human cell immortalization. Biochim. Biophys. Acta, 1072: 1-7, 1991.
    • (1991) Biochim. Biophys. Acta , vol.1072 , pp. 1-7
    • Shay, J.W.1    Wright, W.E.2    Werbin, H.3
  • 4
    • 0035253719 scopus 로고    scopus 로고
    • Cellular senescence as a tumor-protection mechanism: The essential role of counting
    • Wright, W. E., and Shay, J. W. Cellular senescence as a tumor-protection mechanism: the essential role of counting. Curr. Opin. Genet. Dev., 11: 98-103, 2001.
    • (2001) Curr. Opin. Genet. Dev. , vol.11 , pp. 98-103
    • Wright, W.E.1    Shay, J.W.2
  • 5
    • 0025279931 scopus 로고
    • Telomeres shorten during aging of human fibroblasts
    • Harley, C. B., Futcher, A. B., and Greider, C. W. Telomeres shorten during aging of human fibroblasts. Nature (Lond.), 345: 458-460, 1990.
    • (1990) Nature (Lond.) , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 6
    • 0034774859 scopus 로고    scopus 로고
    • Cellular senescence cancer and aging: The telomere connection
    • Campisi, J., Kim, S. H., Lim, C. S., and Rubio, M. Cellular senescence, cancer and aging: the telomere connection. Exp. Gerontol., 36: 1619-1637, 2001.
    • (2001) Exp. Gerontol. , vol.36 , pp. 1619-1637
    • Campisi, J.1    Kim, S.H.2    Lim, C.S.3    Rubio, M.4
  • 7
    • 0037148277 scopus 로고    scopus 로고
    • Protection of mammalian telomeres
    • de Lange, T. Protection of mammalian telomeres. Oncogene, 21: 532-540, 2002.
    • (2002) Oncogene , vol.21 , pp. 532-540
    • De Lange, T.1
  • 8
    • 0025731583 scopus 로고
    • Structure and function of telomeres
    • Blackburn, E. H. Structure and function of telomeres. Nature (Lond.), 350: 569-573, 1991.
    • (1991) Nature (Lond.) , vol.350 , pp. 569-573
    • Blackburn, E.H.1
  • 9
    • 0028305614 scopus 로고
    • Telomeres: No end in sight
    • Blackburn, E. H. Telomeres: no end in sight. Cell, 77: 621-623, 1994.
    • (1994) Cell , vol.77 , pp. 621-623
    • Blackburn, E.H.1
  • 10
    • 0028297039 scopus 로고
    • Mammalian telomere dynamics: Healing, fragmentation shortening and stabilization
    • Greider, C. W. Mammalian telomere dynamics: healing, fragmentation shortening and stabilization. Curr. Opin. Genet. Dev., 4: 203-211, 1994.
    • (1994) Curr. Opin. Genet. Dev. , vol.4 , pp. 203-211
    • Greider, C.W.1
  • 11
    • 0025787643 scopus 로고
    • Telomere loss: Mitotic clock or genetic time bomb?
    • Harley, C. B. Telomere loss: mitotic clock or genetic time bomb? Mutat. Res., 256: 271-282, 1991.
    • (1991) Mutat. Res. , vol.256 , pp. 271-282
    • Harley, C.B.1
  • 12
    • 0032483020 scopus 로고    scopus 로고
    • Can ends justify the means?: Telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells
    • Sedivy, J. M. Can ends justify the means?: telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells. Proc. Natl. Acad. Sci. USA. 95: 9078-9081, 1998.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9078-9081
    • Sedivy, J.M.1
  • 15
    • 0030697342 scopus 로고    scopus 로고
    • Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
    • Bryan, T. M., Englezou, A., Dalla-Pozza, L., Dunham, M. A., and Reddel, R. R. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat. Med., 3: 1271-1274, 1997.
    • (1997) Nat. Med. , vol.3 , pp. 1271-1274
    • Bryan, T.M.1    Englezou, A.2    Dalla-Pozza, L.3    Dunham, M.A.4    Reddel, R.R.5
  • 16
    • 0032567967 scopus 로고    scopus 로고
    • Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
    • Vaziri, H., and Benchimol, S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol., 8: 279-282, 1998.
    • (1998) Curr. Biol. , vol.8 , pp. 279-282
    • Vaziri, H.1    Benchimol, S.2
  • 18
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay, J. W., and Bacchetti, S. A survey of telomerase activity in human cancer. Eur. J. Cancer, 33: 787-791, 1997.
    • (1997) Eur. J. Cancer , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 19
    • 0031887947 scopus 로고    scopus 로고
    • Careful histological confirmation and microdissection reveal telomerase activity in otherwise telomerase-negative breast cancers
    • Carey, L. A., Hedican, C. A., Henderson, G. S., Umbricht, C. B., Dome, J. S., Varon, D., and Sukumar, S. Careful histological confirmation and microdissection reveal telomerase activity in otherwise telomerase-negative breast cancers. Clin. Cancer Res., 4: 435-440, 1998.
    • (1998) Clin Cancer Res. , vol.4 , pp. 435-440
    • Carey, L.A.1    Hedican, C.A.2    Henderson, G.S.3    Umbricht, C.B.4    Dome, J.S.5    Varon, D.6    Sukumar, S.7
  • 21
    • 0028936194 scopus 로고
    • Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni Syndrome
    • Shay, J. W., Tomlinson, G., Piatyszek, M. A., and Gollahon, L. S. Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni Syndrome. Mol. Cell. Biol., 15: 425-432, 1995.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 425-432
    • Shay, J.W.1    Tomlinson, G.2    Piatyszek, M.A.3    Gollahon, L.S.4
  • 23
    • 0032537762 scopus 로고    scopus 로고
    • Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation
    • Brenner, A. J., Stampfer, M. R., and Aldaz, C. M. Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation. Oncogene. 17: 199-205, 1998.
    • (1998) Oncogene , vol.17 , pp. 199-205
    • Brenner, A.J.1    Stampfer, M.R.2    Aldaz, C.M.3
  • 25
    • 0027496456 scopus 로고
    • The frequency of immortalization of human fibroblast and mammary epithelial cells transfected with SV40 large T-antigen
    • Shay, J. W., Van der Haegen, B. A., Ying, Y., and Wright, W. E. The frequency of immortalization of human fibroblast and mammary epithelial cells transfected with SV40 large T-antigen. Exp. Cell Res., 209: 45-52, 1993.
    • (1993) Exp. Cell Res. , vol.209 , pp. 45-52
    • Shay, J.W.1    Van der Haegen, B.A.2    Ying, Y.3    Wright, W.E.4
  • 26
    • 0024426688 scopus 로고
    • Quantitation of the frequency of immortalization of normal diploid fibroblasts by SV40 large T-antigen
    • Shay, J. W., and Wright, W. E. Quantitation of the frequency of immortalization of normal diploid fibroblasts by SV40 large T-antigen. Exp. Cell Res., 184: 109-118, 1989.
    • (1989) Exp. Cell Res. , vol.184 , pp. 109-118
    • Shay, J.W.1    Wright, W.E.2
  • 27
    • 0345101728 scopus 로고    scopus 로고
    • Upper Saddle River. NJ: Prentice-Hall, Inc.
    • Ryu, T. (ed.). Biostastical Analysis, Ed. 4. Upper Saddle River. NJ: Prentice-Hall, Inc., 1999.
    • (1999) Biostastical Analysis, Ed. 4
    • Ryu, T.1
  • 28
    • 0026705751 scopus 로고
    • Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
    • Kliewer, S. A., Umesono, K., Noonan, D. J., Heyman, R. A., and Evans, R. M. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature (Lond.), 358: 771-774, 1992.
    • (1992) Nature (Lond.) , vol.358 , pp. 771-774
    • Kliewer, S.A.1    Umesono, K.2    Noonan, D.J.3    Heyman, R.A.4    Evans, R.M.5
  • 30
    • 0036637235 scopus 로고    scopus 로고
    • Chemoprevention: An essential approach to controlling cancer
    • Sporn, M. B., and Suh, N. Chemoprevention: an essential approach to controlling cancer. Nature Rev. Cancer, 2: 537-543, 2002.
    • (2002) Nature Rev. Cancer , vol.2 , pp. 537-543
    • Sporn, M.B.1    Suh, N.2
  • 31
    • 0037138743 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs as anticancer agents: Mechanistic, pharmacologic, and clinical issues
    • Thun, M. J., Henley, S. J., and Patron, C. Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. J. Natl. Cancer Inst. (Bethesda), 94: 252-266, 2002.
    • (2002) J. Natl. Cancer Inst. (Bethesda) , vol.94 , pp. 252-266
    • Thun, M.J.1    Henley, S.J.2    Patron, C.3
  • 32
    • 0036440486 scopus 로고    scopus 로고
    • Role of cyclooxygenase-2 in breast cancer
    • Singh, B., and Lucci, A. Role of cyclooxygenase-2 in breast cancer. J. Surg. Res, 108: 173-179, 2002.
    • (2002) J. Surg. Res , vol.108 , pp. 173-179
    • Singh, B.1    Lucci, A.2
  • 33
    • 0037049885 scopus 로고    scopus 로고
    • Inhibition of cell transformation by sulindac sulfide is confined to specific to oncogenic pathways
    • Gala, M., Sun, R., and Yang, V. W. Inhibition of cell transformation by sulindac sulfide is confined to specific to oncogenic pathways. Cancer Lett., 175: 89-94, 2002.
    • (2002) Cancer Lett. , vol.175 , pp. 89-94
    • Gala, M.1    Sun, R.2    Yang, V.W.3
  • 34
    • 0032542763 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer
    • Hwang, D., Scollard, D., Byrne, J., and Levine, E. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. J. Natl. Cancer Inst. (Bethesda), 90: 455-460, 1998.
    • (1998) J. Natl. Cancer Inst. (Bethesda) , vol.90 , pp. 455-460
    • Hwang, D.1    Scollard, D.2    Byrne, J.3    Levine, E.4
  • 35
    • 0035496616 scopus 로고    scopus 로고
    • Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2
    • Gupta, R. A., and Dubois, R. N. Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nature Rev. Cancer, 1: 11-21, 2001.
    • (2001) Nature Rev. Cancer , vol.1 , pp. 11-21
    • Gupta, R.A.1    Dubois, R.N.2
  • 36
    • 0034655238 scopus 로고    scopus 로고
    • Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor
    • Harris, R. E., Alshafie, G. A., Abou-Issa, H., and Seibert, K. Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor. Cancer Res., 60: 2101-2103, 2000.
    • (2000) Cancer Res. , vol.60 , pp. 2101-2103
    • Harris, R.E.1    Alshafie, G.A.2    Abou-Issa, H.3    Seibert, K.4
  • 37
    • 0035882534 scopus 로고    scopus 로고
    • Cyclooxygenase inhibitors retard murine mammary tumor progression by reducing tumor cell migration, invasiveness and angiogenesis
    • Rozic, J. G., Chakraborty, C., and Lala, P. K. Cyclooxygenase inhibitors retard murine mammary tumor progression by reducing tumor cell migration, invasiveness and angiogenesis. Int. J. Cancer, 93: 497-506, 2001.
    • (2001) Int. J. Cancer , vol.93 , pp. 497-506
    • Rozic, J.G.1    Chakraborty, C.2    Lala, P.K.3
  • 39
    • 0036183630 scopus 로고    scopus 로고
    • The mechanisms of action of PPARs
    • Berger, J., and Moller, D. E. The mechanisms of action of PPARs. Annu. Rev. Med., 53: 409-435, 2002.
    • (2002) Annu. Rev. Med. , vol.53 , pp. 409-435
    • Berger, J.1    Moller, D.E.2
  • 40
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
    • Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., and Kliewer, S. A. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J. Biol. Chem., 270: 12953-12956, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 41
    • 0028180070 scopus 로고
    • mPPAR gamma 2: Tissue-specific regulator of an adipocyte enhancer
    • Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., and Spiegelman, B. M. mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev., 8: 1224-1234, 1994.
    • (1994) Genes Dev. , vol.8 , pp. 1224-1234
    • Tontonoz, P.1    Hu, E.2    Graves, R.A.3    Budavari, A.I.4    Spiegelman, B.M.5
  • 42
    • 0034847431 scopus 로고    scopus 로고
    • Prospects for prevention and treatment of cancer with selective PPARgamma modulators (SPARMs)
    • Sporn, M. B., Suh, N., and Mangelsdorf, D. J. Prospects for prevention and treatment of cancer with selective PPARgamma modulators (SPARMs). Trends Mol. Med., 7: 395-400, 2001.
    • (2001) Trends Mol. Med. , vol.7 , pp. 395-400
    • Sporn, M.B.1    Suh, N.2    Mangelsdorf, D.J.3
  • 43
    • 0001295227 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor modulators as potential chemopreventive agents
    • Kopelovich, L., Fay, J. R., Glazer, R. I., and Crowell, J. A. Peroxisome proliferator-activated receptor modulators as potential chemopreventive agents. Mol. Cancer Ther., 1: 357-363, 2002.
    • (2002) Mol Cancer Ther. , vol.1 , pp. 357-363
    • Kopelovich, L.1    Fay, J.R.2    Glazer, R.I.3    Crowell, J.A.4
  • 44
    • 0032555196 scopus 로고    scopus 로고
    • Ligands for peroxisome proliferator-activated receptor γ and retinoic acid receptor inhibit growth and induce apoptosis in human breast cancer cells in vitro and in BNX mice
    • Elstner, E., Müller, C., Koshizuka, K., Williamson, E. A., Park, D., Asou, H., Shintaku, P., Said, J. W., Herber, D., and Koeffler, H. P. Ligands for peroxisome proliferator-activated receptor γ and retinoic acid receptor inhibit growth and induce apoptosis in human breast cancer cells in vitro and in BNX mice. Proc. Natl. Acad. Sci. USA, 95: 8806-8811, 1998.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8806-8811
    • Elstner, E.1    Müller, C.2    Koshizuka, K.3    Williamson, E.A.4    Park, D.5    Asou, H.6    Shintaku, P.7    Said, J.W.8    Herber, D.9    Koeffler, H.P.10
  • 46
    • 0037151079 scopus 로고    scopus 로고
    • An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis
    • Kim, Y., Suh, N., Sporn, M., and Reed, J. C. An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis. J. Biol. Chem., 277: 22320-22329, 2002.
    • (2002) J. Biol. Chem. , vol.277 , pp. 22320-22329
    • Kim, Y.1    Suh, N.2    Sporn, M.3    Reed, J.C.4
  • 47
    • 0026669469 scopus 로고
    • p53 function and dysfunction
    • Vogelstein, B., and Kinzler, K. W. p53 function and dysfunction. Cell, 70: 523-526, 1992.
    • (1992) Cell , vol.70 , pp. 523-526
    • Vogelstein, B.1    Kinzler, K.W.2
  • 48
    • 0033601370 scopus 로고    scopus 로고
    • Pharmacological rescue of mutant p53 conformation and function
    • Foster, B. A., Coffey, H. A., Morin, M. J., and Rastinejad, F. Pharmacological rescue of mutant p53 conformation and function. Science (Wash. DC), 286: 2507-2510, 1999.
    • (1999) Science (Wash. DC) , vol.286 , pp. 2507-2510
    • Foster, B.A.1    Coffey, H.A.2    Morin, M.J.3    Rastinejad, F.4
  • 49


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.