Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase c activity in cultured aortic smooth muscle cells

Diabetologia

Volumn 44, Issue 5, 2001, Pages 614-620

  Yu, H Y ^a   Inoguchi, T ^a   Kakimoto, M ^a   Nakashima, N ^a   Imamura, M ^a   Hashimoto, T ^a   Umeda, F ^a   Nawata, H ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Aortic smooth muscle cell; Diacylglycerol; Insulin resistance; Mitogen activated protein kinase; Non esterified fatty acids; Protein kinase C

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; DIACYLGLYCEROL; FATTY ACID; LONG CHAIN FATTY ACID COENZYME A LIGASE; MITOGEN ACTIVATED PROTEIN KINASE; OLEIC ACID; PALMITIC ACID; PROTEIN KINASE; PROTEIN KINASE C; STEARIC ACID;

ANIMAL CELL; AORTA; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SYNTHESIS; INSULIN RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RISK FACTOR; SMOOTH MUSCLE FIBER;

ANIMALS; AORTA; ARACHIDONIC ACID; CATTLE; CELLS, CULTURED; COENZYME A LIGASES; DIGLYCERIDES; ENZYME INHIBITORS; FATTY ACIDS, NONESTERIFIED; INDOLES; KINETICS; MALEIMIDES; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; OLEIC ACID; PALMITIC ACID; PROTEIN KINASE C; STEARIC ACIDS; TETRADECANOYLPHORBOL ACETATE; TRIAZENES;

EID: 0035011093     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051668     Document Type: Article

References (47)

1. Fatty acids, lipotoxicity and insulin secretion
2. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
3. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM
4. β-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-β-cell relationship
5. Prolonged increase of plasma non-esterified fatty acids desensitizes the insulin secretory response to glucose in vivo in rats
6. Mechanism of the stimulation of insulin release by saturated fatty acids
7. More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase .I interaction as a key event in pancreatic β-cell signalling
8. Stimulation of insulin secretion by long-chain non-esterified fatty acids
9. Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat
10. Reversibility of the effects on local circulation of high lipid concentrations in blood
11. Insulin resistant lipolysis in abdominally-obese hypertensives: Role of the renin-angiotensin system
12. Obesity hypertension is more closely related to impairment of insulin's fatty acid than glucose lowering action
13. Growth factors in health and disease
14. Preferential increase of protein kinase C isoform beta II and diacylglycerol concentrationss in the aorta and heart of diabetic rats: Differential reversibility to glycemic control by islet cell transplantation
15. Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues
16. Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia
17. Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose
18. Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose concentrationss
19. Correlation of diacylglycerol concentrations and protein kinase C activity in rat retina to retinal circulation
20. Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C
21. Role of protein kinase C in the mediation of increased fibronectin accumulation by mesangial cells grown in high-glucose medium
22. Amelioration of vascular dysfunctions in diabetic rats bv an oral PKC β inhibitor
23. Mitogen-activated protein kinase cascade is activated in glomeruli Of diabetic rats and glomerular mesangial cells cultured under high glucose conditions
24. Characterization of protein kinase Cβ isoform activation on the gene expression of transforming growth factor-β, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats
25. Inhibition of intercellular communication via gap junction in cultured aortic endothelial cells by elevated glucose and phorbol ester
26. High glucose induced alteration of gap junction permeability and phosphorylation of connexin-43 in cultured aortic smooth muscle cells
27. Endothelium and growth factors in vascular remodeling of hypertension
28. Proliferation of human and mouse astrocytes in vitro: Signalling through the protein kinase C pathway
29. TPA-induced contraction of isolated rabbit vascular smooth muscle
30. Activation of mitogen-activated protein kinases and phospholipase D in A7r5 vascular smooth muscle cells
31. Extra cellular signal-regulated kinases
32. The mitogen-activated protein kinase signal transduction pathway
33. Analysis of long-chain free fatty acid binding to bovine serum albumin by determination of stepwise equilibrium constants
34. A rapid method of total lipid extraction and purification
35. Characterization of glucose-induced in situ protein kinase C activity in cultured vascular smooth muscle cells
36. Secretagogue-induced diacylglycerol accumulation in isolated pancreatic islets: Mass spectrometric characterization of the fatty acyl content indicates multiple mechanisms of generation
37. Inhibition of acyl-CoA synthetase by triacsins
38. Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation
39. Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: Evidence for functionally separate pools of acyl-CoA
40. Further studies on the specificity of diacylglycerol for protein kinase C activation
41. Stimulation of islet protein kinase C translocation by palmitate requires metabolism of the fatty acid
42. Palmitate and oleate induce the immediate-early response genes c-fos and nur-77 in the pancreatic β cell line INS-1
43. Free fatty acid-induced insulin resistance is associated with activation of protein kinase CO and alterations in the insulin signalling cascade
44. The insulin signalling system
45. Oleic acid-induced mitogenic signalling in vascular smooth muscle cells: A role for protein kinase C
46. Oleic acid and angiotensin II induce a synergistic mitogenic response in vascular smooth muscle cells
47. Short term metabolic and haemodynamic effects of GR79 236 in normal and fructose-fed rats