Experimental diabetes is associated with functional activation of protein kinase Cε and phosphorylation of troponin I in the heart, which are prevented by angiotensin II receptor blockade

Circulation Research

Volumn 81, Issue 6, 1997, Pages 1027-1033

  Malhotra, Ashwani ^a   Reich, David ^a   Reich, Daniel ^a   Nakouzi, Antonio ^a   Sanghi, Vinay ^a   Geenen, David L ^a   Buttrick, Peter M ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Angiotensin II type 1 receptor; Diabetes mellitus; Protein kinase C

Indexed keywords

ANGIOTENSIN RECEPTOR; PROTEIN KINASE C; TROPONIN;

ACTIN MYOSIN INTERACTION; ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CARDIOMYOPATHY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXPERIMENTAL DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SARCOMERE; SIGNAL TRANSDUCTION; TARGET CELL;

EID: 0030784596     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.81.6.1027     Document Type: Article

References (55)

1. Fern FS, Sonnenblick EH. Diabetic cardiomyopathy. Prog Cardiovasc Dis. 1985;27:255-270.
2. Malhotra A, Penpargkul S, Fein FS, Sonnenblick EH, Scheuer J. The effect of streptozotocin induced diabetes in rats on cardiac contractile proteins. Circ Res. 1981;49:1243-1250.
3. Pierce GN, Dhalla NS. Cardiac myofibrillar ATPase activity in diabetic rats. J Mol Cell Cardiol. 1981;13:1063-1069.
4. Sugden P, Bogoyevitch MA. Intrucellular signalling through protein kinases in the heart. Cardiovasc Res 1995;30:478-492.
5. Steinberg SF, Goldberg M, Rybin V. Protein kinase C isoform diversity in the heart. J Mol Cell Candiol. 1995;271:141-153.
6. 2+-stimulated actomyosin Mg ATPase activity. J Biol Chem. 1991;266:4974-4978.
7. +-stimulated actomyosin MgATPase activity. Biophys Res Commun. 1993;193:254-260.
8. Noland TA, Raynor RL, Jideama NM, Guo X, Kazanietz MG, Blumberg PM, Solaro RJ, Kuo JF. Differential regulation of cardiac actomyosin S-l MgATPasc by protein kinase C isozyme: specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants. Biochemistry. 1996;35:14923-14931.
9. Jideama NM, Noland TA, Raynor RL, Blobe GC, Fabbeo D, Kazanietz MG, Blumberg PM, Hannun YA, Kuo JF. Phosphorylation specificities of protein kinase C isozymes for bovine troponin I and troponin T and sites within these proteins and regulation of myofilament proteins. J Biol Chern. 1996;271:23277-23283.
10. 2+ accumulation in cardiac sarcoplasmic reticulum. J Biol Chem. 1990;265:4302- 4308.
11. 1-adrenoceptor-mediated inotropic responses in the rat left ventricular papillary muscle. Br J Pharmacol. 1990;100:207-210.
12. 2+ in adult rat cardiac myoeytes. Circ Res. 1990;66:1143-1155.
13. Dosemeci A, Dhallan RS, Cohen NM, Lederer WJ, Rogers TB. Phorbol ester increases calcium current and stimulates the effects of angiotensin II on cultured neonatal rat heart myoeytes. Circ Res. 1988;62:347-357.
14. Xiang H, McNeill JH. Protein kinase C is altered in diabetic rat hearts, Biochem Biophys Res Commun. 1992;187:703-710
15. Considine RV, Nyce MR, Allen LE, Morales LM, Triester S, Serrano J, Colberg J, Lanza-Jacoby S, Caro JF. Protein kinase C is increased in the liver of humans and rats with non-insulin dependent diabetes: an alteration not due to hyperglycemia. J Clin Invest. 1995;95:2938-2944.
16. Inoguchi T, Battan R, Handler E, Sportsman J, Heath W, King GL. Preferential elevation of protein kinase C isoform βII and diacylglyccrol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci U S A. 1992;89:11059-11063.
17. Inoguchi T, Xia P, Kunisaki M, Higashi S, Feener EP, King GL. Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues. Am J Physiol. 1994;267:E369-E379.
18. Bogoyevitch MA, Parke PJ, Sugden PH. Characterization of protein kinase C isotype expression in adult rat heart: protein kinase C-∈ is a major isotype present, and it is activated by phorbol esters, epinephrine, and endothelin. Circ Res. 1993;72:757-767.
19. Rybin VO, Steinberg SF. Protein kinase C isoform expression and regulation in the developing rat heart. Circ Res. 1994;74:299-309.
20. Disatnik MH, Buraggi G, Mochly-Rosen D. Localization of protein kinase C isozymes in cardiac myoeytes. Exp Cell Res. 1994;210:287-297.
21. Disatnik MH, Jones SN, Mochly-Rosen D. Stimulus-dependent subcellular localization of activated protein kinase C: a study with acidic fibroblast growth factor and transforming growth factor-beta 1 in cardiac myoeytes. J Mol Cell Cardiol. 1995;27:2473-2481.
22. 2+ stimulated MgATPase activity in reconstituted aetomyosin and isolated myofibrils. and decreases actin-myosin interactions. J Mol Cell Cordiol. 1993;25:53-65.
23. Chang RSL, Siegl PKS, Clineschmidt BV, Mantlo NB, Chakravarty PK, Greenlee WJ, Patchett AA, Lotti VJ. In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist. J Pharmacol Exp Ther. 1992;262:133-138.
24. Chen TB, Lotti VJ, Chang RSL. Characterization of the binding of [3H]L-158,809: a new potent and selective nonpeptide angiotensin II receptor (AT1) antagonist radioligand. Mol Pharmacol. 1992;42:1077-1082.
25. Siegi PKS, Chang RSL, Mantlo NB, Chakravarty PK, Ondeyka DL, Greenlee WJ, Patchett AA, Sweet CS, Lotti VJ. In vivo pharmacology of L-158,809, a new highly potent and selective nonpeptide angiotensin II receptor antagonist. J Pharmacol Exp Ther. 1992;262:139-144.
26. Geenen DL, Malhotra A, Buttrick PM. Angiotensin receptor 1 blockade does not prevent physiological cardiac hypertrophy in the adult rat. J Appl Physiol. 1996;81:816-821.
27. Wittenberg BA, Wittenberg JB. Myoglobin-mediated oxygen delivery to mitochondria of isolated cardiac myoeytes. Proc Nat Acad Sci U S A. 1987;84:7503-7507.
28. Damron DS, Darvish A, Murphy L, Sweet W, Moravec CS, Bond M. Arachidonic acid-dependent phosphorylation of troponin I and myosin light chain 2 in cardiac myocytes. Circ Res. 1995;76:1011-1019.
29. Zar JH. Biostatistical Analysis. Englewood Cliffs, NJ: Prentice Hall; 1974:151-155.
30. Sechi LA, Griffin CA Schambelan M. The cardiac renin-angiotensin system in STZ-induced diabetes. Diabetes. 1994;43:1180-1184.
31. Brown L, Sernia C. Angiotensin receptors in cardiovascular diseases, Clin Exp Pharmacol Physiol. 1994;21:811-818.
32. Schunkert H, Sadoshima J, Cornelius T, Kagaya Y, Weinberg EO, Izunio S, Reigger G, Lorell BH. Angiotensin II-induced growth responses in isolated adult rat hearts: evidence for load-dependent induction of cardiac protein synthesis by angiotensin II. Circ Res. 1995;76:489-497
33. Sadoshima J, Izumo S. Signal transduction pathways of angiotensin II-induced c-fos gene expression of cardiac myocytes in vitro: roles of phospholipid-derivcd second messengers. Circ Res. 1993;73:424-438.
34. Gu X, Bishop SP. Increased protein kinase C and isozyme redistribution in pressure-overload cardiac hypertrophy in the rat. Circ Res. 1994;75:926-931.
35. Mochly-Rosen D, Henrich CJ, Cheever L, Khauer H, Simpson PC. A protein kinase C isozyme is translocated to cytoskcletal elements on activation. Cell Regul. 1990;1:693-706.
36. Johnson JA, Gray MA, Chen C, Mochly-Rosen D. A protein kinase C translocation inhibitor as an isoenzyme-selective antagonist of cardiac function. J Biol Chem. 1996;271:24962-24966.
37. Kraft AS, Anderson WB, Cooper HL, Sando JJ. Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells. J Biol Chem. 1982;257:13193-13196.
38. 2+?, phospholipid dependent protein kinase associated with plasma membrane. Nature. 1983;301:621-623.
39. Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D. Cloning of an intracellular receptor for protein kinase C: a homolog of the β subunit of G proteins. Proc Natl Acad Sci U S A. 1994;91: 839-843.
40. Mohammadi K, Rouet-Benzineb P, Laplace M, Crozatier B. Protein kinase C activity and expression in rabbit left ventricular hypertrophy. J Mol Cell Cardiol. 1997;29:1687-1694.
41. Venema RC, Kuo JF. Protein kinase C-mediated phosphorylation of troponin I and C-protein in isolated myocardial cells is associated with inhibition of myofibrillar actomyosin MgATPase. J Biol Chem. 1993;268:2705-2711.
42. 2+-stimulated MgATPase of reconstituted actomyosin S-1. J Biol Chem. 1995;270:25445-25454.
43. Liu X, Takeda N, Dhalla NS. Troponin I phosphorylation in heart homogenate from diabetic rat. Biochim Biophys Acta, 1996;1316:78-84.
44. Malhotra A, Lopez C, Nakouzi A. Troponin subunits contribute to altered myosin ATPase activity in diabetic cardiomyopathy. Mol Cell Biochcm. 1995;151:165-172.
45. 2+] and pH in rat skinned cardiac myocytes. Am J Physiol. 1996;269:H1656-H1663.
46. Malhotra A, Sanghi V. Regulation of contractile proteins in diabetic heart. Cardiovasc Res. 1997;34:230-240.
47. 2+ in cardiac myocytes. Circ Res. 1992;71:870-882.
48. + exchanger. Circ Res, 1991;68:269-279.
49. Venema RC, Raynor RL, Noland TA, Kuo JF. Role of protein kinase C tn the phosphorylation of cardiac myosin light chain 2. Biochem J. 1993:294:401-406.
50. 2+ dependence of the kinetics of tension development in skeletal muscle fibers. Biophys J. 1996;70:2333-2340.
51. Parving HH, Rossing P, Hommel E, Smidt UM. Angiotensinconverting enzyme inhibition in diabetic nephropathy: ten years' experience. Am J Kidney Dis. 1995;26:99-107.
52. 1-adrenergic agonist and activated β-protein kinase C in hypertrophy of cardiac myocytes. J Biol Chem. 1994;269:3775-3782.
53. Sadoshima J, Xu Y, Slayter HS, Izumo S. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell. 1993;75:977-984.
54. Shubeita HE, Martinson EA, van Bilsen M, Chien KR. Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes. Proc Natl Acad Sci U S A. 1992;89:1305-1309.
55. Weber KT, Sun Y, Tyagi SC, Clentjens JP, The collagen network of the myocardium. J Mol Cell Cardiol. 1994;26:279-292.