Star-shaped poly(ethylene glycol)-block-polyethlenimine copolymers enhance DNA condensation of low molecular weight polyethylenimines

Biomacromolecules

Volumn 3, Issue 5, 2002, Pages 926-936

  Petersen, Holger ^a   Kunath, Klaus ^a   Martin, Alison L ^b   Stolnik, Snjezana ^b   Roberts, Clive J ^b   Davies, Martyn C ^b   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COPOLYMER; ETHIDIUM BROMIDE; HEXAMETHYLENE DIISOCYANATE; MACROGOL; PLASMID DNA; POLYETHYLENEIMINE; BIOMATERIAL; DNA; MACROGOL DERIVATIVE;

ARTICLE; ATOMIC FORCE MICROSCOPY; BIOCOMPATIBILITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DNA STRUCTURE; GEL PERMEATION CHROMATOGRAPHY; GENE DELIVERY SYSTEM; GENE TARGETING; INFRARED SPECTROSCOPY; IONIC STRENGTH; LIGHT SCATTERING; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SURFACE CHARGE; SYNTHESIS; THERMOGRAVIMETRY; VISCOMETRY; ZETA POTENTIAL; CHEMISTRY; GENE TRANSFER; PLASMID; STRUCTURE ACTIVITY RELATION;

BIOCOMPATIBLE MATERIALS; DNA; GENE TRANSFER TECHNIQUES; MOLECULAR WEIGHT; PLASMIDS; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036737813     PISSN: 15257797     EISSN: None     Source Type: Journal    
DOI: 10.1021/bm025539z     Document Type: Article

References (30)

1. Uherek, C.; Wels, W. DNA-carrier proteins for targeted gene delivery. Adv. Drug Delivery Rev. 2000, 44, 153-166.
2. Felgner, P. L.; Ringold, G. M. Cationic liposome-mediated transfection. Nature 1989, 337, 387-388.
3. For a review see: De Smedt, S. C.; Demeester, J.; Hennink, W. E. Cationic polymer based gene delivery systems. Pharm. Res. 2000, 17, 113-126.
4. Boussif, O.; Lezoualc'h, F.; Zanta, M. A.; Mergny, M. D.; Scherman, D.; Demeneix, S., Behr, J. P. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 7297-7301.
5. Pollard, H.; Remy, J.-S.; Loussouarn, G.; Demolombe, S.; Behr, J.-P.; Escande, D. Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells. J. Biol. Chem. 1998, 273, 7507-7511.
6. Harpe, A. v.; Petersen, H.; Li, Y.; Kissel, T.; Characterization of commercially available and synthesized polyethylenimines for gene delivery. J. Controlled Release 2000, 69, 309-322.
7. Ferrari, S.; Moro, E.; Pettenazzo, A.; Behr, J. P.; Zacchello, F.; Scarpa, M. ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo. Gene Ther. 1997, 4, 1100-1106.
8. Godbey, W. T.; Wu, K. K.; Mikos, A. G. Size matters: Molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle. J. Biomed. Mater. Res. 1999, 45, 268-275.
9. Remy, J.-S.; Abdallah, B.; Zanta, M. A.; Boussif, O.; Behr, J.-P.; Demeneix, B. Gene Transfer with lipospermines and polyethylenimins; Adv. Drug Delivery Rev. 1998, 30, 85-95.
10. Fischer, D.; Harpe, A. v.; Kissel, T. Polyethylenimine: Polymer Structure Influences the Physicochemical and Biological Effects of Plasmid/PEI Complexes. Biomaterials and Drug Delivery toward New Millennium; Park, K. D., Kwon, I. C., Yui, N., Jeong, S. Y., Park, K., Eds.; Han Rim Wam Publishing Co.: Seoul, Korea, 2000; pp 195-211.
11. Bieber, T.; Elsässer, H.-P. Preparation of a Low Molecular Weight Polyethylenimine for Efficient Cell Transfection. BioTechniques 2001, 30, 74-81.
12. Fischer, D.; Bieber, T., Li, Y.; Elsässer, H.-P.; Kissel, T. A Novel Non-Viral Vector for DNA Delivery Based on Low Molecular Weight, Branched Polyethylenimine: Effect of Molecular Weight on Transfection Efficiency and Cytotoxicity. Pharm. Res. 1999, 16, 1273-1279.
13. Ngyugen, H.-K.; Lemieux, P.; Vinogradov, S. V.; Gebhart, C. L.; Guerin, N.; Paradis, G.; Bronich, T. K.; Alakhov, V. Y.; Kabanov, A. V. Evaluation of polyether-polyethylenimine graft copolymers as gene transfer agents. Gene Ther. 2000, 7, 126-138.
14. QIAGEN plasmid purification handbook, QIAGEN, 1997.
15. Li, Y.; Kissel, T. Synthesis, characteristics and in vitro degradation of star-block copolymers consisting of L-lactide, glycolide and branched multi-arm poly(ethylene oxide). Polymer 1998, 39, 4421-4427.
16. Braunlin, W. H.; Strick, T. J.; Record, M. T. Equilibrium dialysis studies of polyamine binding to DNA. Biopolymers 1982, 21, 1301-1314.
17. Tang, M. X.; Szoka, F. C. The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes. Gene Ther. 1997, 4, 823-832.
18. Olins, D. E.; Olins, A. L.; von Hippel, P. H. Model nucleoprotein complexes: studies on the interaction of cationic homopolypeptides with DNA. J. Mol. Biol. 1967, 24, 157-176.
19. Boussif, O.; Zanta, M. A.; Behr, J. P. Optimized galenics improve in vitro gene transfer with cationic molecules up to a 1000-fold. Gene Ther. 1996, 3, 1074-1080.
20. Boussif, O. Transfert de genes medie par des polymeres cationiques. Ph.D. Thesis, Louis Pasteur University, Strasbourg, France, 1996.
21. Gosselin, M. A.; Guo, W.; Lee, R. J. Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine. Bioconjugate Chem. 2001, 12, 989-994.
22. Godbey, W. T.; Wu, K. K.; Mikos, A. G. Poly(ethylenimine) and its role in gene delivery. J. Controlled Release 1999, 60, 149-160.
23. Papisov, I. M.; Litmanovich, A. A. Molecular "recognition" in interpolymer interactions and matrix polymerization. Adv. Polym. Sci. 1988, 90, 139-179.
24. Perales, J. C.; Ferkol, T.; Beegen, H.; Ratnoff, O. D.; Hanson, R. W. Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 4086-4090.
25. Ogris, M.; Steinlein, P.; Kursa, M.; Mechtler, K.; Kircheis, R.; Wagner, E. The size of the DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells. Gene Ther. 1998, 5, 1425-1433.
26. Luo, D.; Saltzman, W. M. Enhancement of transfection by physical concentration of DNA at the cell surface. Nat. Biotechnol. 2000, 18, 893-895.
27. Mislick, K. A.; Baldeschwieler, J. D. Evidence for the role of proteoglycans in cation-mediated gene transfer. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 12349-12354.
28. Kirchler, A.; Behr, J.-P.; Erbacher, P. Polyethylenimines: a family of potent polymers for nucleic acid delivery. In Nonviral Vectors for Gene Therapy; Huang, H. C., Hung, M. C., Wagner, E., Eds.; Academic Press: San Diego, CA, 1999.
29. Plank, C.; Tang, M. X.; Wolfe, A. R.; Szoka, F. C. Branched cationic peptides for gene delivery: Role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes. Human Gene Ther. 1999, 10, 319-332.
30. Wolfert, M. A.; Seymour, L. W. Atomic force microscopic analysis of the influence of the molecular weight of poly(L)lysine on the size of polyelectrolyte complexes formed with DNA. Gene Ther. 1996, 3, 269-273.