Synthesis and structure-affinity relationships of 1-[ω-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT7 receptor ligands

Journal of Medicinal Chemistry

Volumn 46, Issue 4, 2003, Pages 646-649

  Perrone, Roberto ^a   Berardi, Francesco ^a   Colabufo, Nicola A ^a   Lacivita, Enza ^a   Leopoldo, Marcello ^a   Tortorella, Vincenzo ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

6 [4 (3 BENZISOXAZOLYL) 1 PIPERAZINYL] 1 (2 HYDROXYPHENYL) 1 HEXANONE; KETONE DERIVATIVE; LIGAND; PIPERAZINE DERIVATIVE; SEROTONIN 1A RECEPTOR; SEROTONIN 7 RECEPTOR; SUBSTANCE P; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; ILEUM CONTRACTION; RECEPTOR AFFINITY; SMOOTH MUSCLE RELAXATION;

ANIMALS; BRAIN; CELL LINE; CRICETINAE; GUINEA PIGS; HUMANS; ILEUM; ISOXAZOLES; KETONES; LIGANDS; LIVER; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PIPERAZINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, SEROTONIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037434593     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020994z     Document Type: Article

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