Insulin Receptor-mediated p62dok Tyrosine Phosphorylation at Residues 362 and 398 Plays Distinct Roles for Binding GTPase-activating Protein and Nck and Is Essential for Inhibiting Insulin-stimulated Activation of Ras and Akt

Journal of Biological Chemistry

Volumn 276, Issue 46, 2001, Pages 42843-42850

  Wick, Michael J ^a   Dong, Lily Q ^a   Hu, Derong ^a   Langlais, Paul ^b   Liu, Feng ^a,b  

^a University of Texas Health Science Center at San Antonio   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYME INHIBITION; ENZYMES; MUTAGENESIS; SUBSTRATES;

INSULIN SIGNALING PATHWAYS; PHOSPHORYLATION;

INSULIN;

ADAPTOR PROTEIN; AMINO ACID; BINDING PROTEIN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 10; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; INSULIN; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHENYLALANINE; PROTEIN KINASE B; PROTEIN NCK; PROTEIN P62; RAS PROTEIN; TYROSINE; UNCLASSIFIED DRUG; AKT1 PROTEIN, HUMAN; COMPLEMENTARY DNA; DNA BINDING PROTEIN; DOK1 PROTEIN, HUMAN; GAP ASSOCIATED PROTEIN P62; GAP-ASSOCIATED PROTEIN P62; GLUTATHIONE TRANSFERASE; GUANOSINE TRIPHOSPHATASE; NCK PROTEIN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN; PROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; RNA BINDING PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CATALYSIS; CATALYST; CELL LINE; CHO CELL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HORMONE ACTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; BINDING SITE; CELL CULTURE; CHEMISTRY; GENETIC TRANSFECTION; HAMSTER; METABOLISM; MUTATION; PHOSPHORYLATION; PLASMID; PROTEIN TERTIARY STRUCTURE; SERODIAGNOSIS; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACIDS; ANIMALS; BINDING SITES; BLOTTING, WESTERN; CELL LINE; CELLS, CULTURED; CHO CELLS; CRICETINAE; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GLUTATHIONE TRANSFERASE; GRB10 ADAPTOR PROTEIN; GTP PHOSPHOHYDROLASES; GTPASE-ACTIVATING PROTEINS; HUMANS; MAP KINASE SIGNALING SYSTEM; MUTAGENESIS, SITE-DIRECTED; MUTATION; ONCOGENE PROTEINS; PHOSPHOPROTEINS; PHOSPHORYLATION; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION; TYROSINE;

EID: 0035900720     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M102116200     Document Type: Article

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